Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus. Neurobiology of learning and memory. 2024-02-09. PMID:38336097. |
in addition, immunohistochemistry targetingΔfosb (neuronal activity),brain-derived neurotrophic factor (bdnf) and thedna oxidative damage (8ohdg) in hippocampal subfields ca1, ca2, ca3, and dentate gyrus (dg), and in basolateral amygdala and striatum were performed. |
2024-02-09 |
2024-02-12 |
mouse |
Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus. Neurobiology of learning and memory. 2024-02-09. PMID:38336097. |
our results showed that long-term cr prevented short-term memory impairment related to aging and increased 8ohdg in hippocampal dg. |
2024-02-09 |
2024-02-12 |
mouse |
Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus. Neurobiology of learning and memory. 2024-02-09. PMID:38336097. |
in conclusion, while the effects of long-term cr on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8ohdg in dg. |
2024-02-09 |
2024-02-12 |
mouse |
Qian-Qian Wei, Yong-Yu Yin, Yong-Xing Qiao, Han Ni, Shuo-Yu Han, Yishan Yao, Yun-Feng Li, Li-Ming Zhang, Junxu L. Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) via regulating the synaptic plasticity in hippocampus. European journal of pharmacology. 2024-02-08. PMID:38331342. |
in addition, yl-ipa08 also enhanced the dendritic complexity and dendritic spine density of hippocampal dentate gyrus (dg) granule neurons. |
2024-02-08 |
2024-02-11 |
mouse |
Naoki Yamamoto, Jun Yokose, Kritika Ramesh, Takashi Kitamura, Sachie K Ogaw. Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice. Molecular brain. vol 17. issue 1. 2024-02-05. PMID:38317261. |
in this study, using a molecular marker for vb and retrograde tracers, we identified that the outer layer of vb neurons in the medial ec (mec) directly project to both dorsal and ventral hippocampal dentate gyrus (dg), with a significant preference for the ventral dg. |
2024-02-05 |
2024-02-09 |
mouse |
Masoud Mohammadi, Zohreh Tavassoli, Sohrab Anvari, Mohammad Javan, Yaghoub Fathollah. Avoidance and escape conditioning adjust adult neurogenesis to conserve a fit hippocampus in adult male rodents. Journal of neuroscience research. vol 102. issue 1. 2024-01-29. PMID:38284841. |
recording field potentials at performant pathway (pp)-hippocampal dentate gyrus (dg) synapses in transverse slices from the dorsal (d), intermediate (i), and ventral (v) hippocampus showed differences in paired-pulse responses and long-term potentiation in rats. |
2024-01-29 |
2024-01-31 |
mouse |
Masoud Mohammadi, Zohreh Tavassoli, Sohrab Anvari, Mohammad Javan, Yaghoub Fathollah. Avoidance and escape conditioning adjust adult neurogenesis to conserve a fit hippocampus in adult male rodents. Journal of neuroscience research. vol 102. issue 1. 2024-01-29. PMID:38284841. |
evaluation of the levels of neurogenesis markers (ki67 and brdu/neun) by immunofluorescence assay in the ddg, idg, and vdg revealed a long-axis disparity in the hippocampal dentate baseline cell proliferation and exposure to the bm and pa task changed the profile of baseline cell proliferation along the dg in both rats and mice. |
2024-01-29 |
2024-01-31 |
mouse |
Chia-Hsuan Fu, Jason C You, Carrie Mohila, Robert A Rissman, Daniel Yoshor, Angela N Viaene, Jeannie Chi. Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Frontiers in neurology. vol 14. 2024-01-26. PMID:38274865. |
to test whether dg Δfosb expression is indicative of cognitive impairment in epilepsies with different etiologies, we assessed Δfosb expression in surgically-resected hippocampal tissue from 33 patients with childhood epilepsies who had undergone wechsler intelligence scale for children (wisc) testing prior to surgery. |
2024-01-26 |
2024-01-28 |
human |
Chia-Hsuan Fu, Jason C You, Carrie Mohila, Robert A Rissman, Daniel Yoshor, Angela N Viaene, Jeannie Chi. Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Frontiers in neurology. vol 14. 2024-01-26. PMID:38274865. |
we previously found that, compared with cognitively-intact subjects, the activity-dependent expression of Δfosb in the hippocampal dentate gyrus (dg) was increased in individuals with mild cognitive impairment (mci) and in individuals with ad. |
2024-01-26 |
2024-01-28 |
human |
Kelli Somelar-Duracz, Monika Jürgenson, Janeli Viil, Alexander Zharkovsky, Külli Jaak. 'Unpredictable chronic mild stress does not exacerbate memory impairment or altered neuronal and glial plasticity in the hippocampus of middle-aged vitamin D deficient mice'. The European journal of neuroscience. 2024-01-25. PMID:38269959. |
while vdd caused cell loss and altered glial response in the dg of the hippocampus, these effects were not exacerbated by ucms and could contribute to mechanisms regulating altered stress response. |
2024-01-25 |
2024-01-27 |
mouse |
Alexandra Zvozilova, Alexandra Reichova, Mojmir Mach, Jan Bakos, Romana Koprdov. Effect of a New Substance with Pyridoindole Structure on Adult Neurogenesis, Shape of Neurons, and Behavioral Outcomes in a Chronic Mild Stress Model in Rats. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255918. |
administration of sme1ec2m3 significantly increased sox2-positive cells in the hippocampal dentate gyrus (dg) in cms compared to control animals. |
2024-01-23 |
2024-01-25 |
rat |
Isaac Vingan, Victoria Sook Keng Tung, Shwetha Phatarpekar, A Iván Hernández, Oleg V Evgrafov, Juan Marcos Alarco. Spatially Resolved Transcriptomic Signatures of Hippocampal Subregions and bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260257. |
we found that training induced differentially expressed genes (degs) in the ca1 and ca3 hippocampal subregions were enriched with genes involved in synaptic transmission and synaptic plasticity, while degs in the dentate gyrus (dg) were enriched with genes involved in energy balance and ribosomal function. |
2024-01-23 |
2024-01-25 |
Not clear |
Alfredo Zuniga, Jiawei Han, Isaac Miller-Crews, Laura A Agee, Hans A Hofmann, Michael R Dre. Extinction Training Suppresses Activity of Fear Memory Ensembles Across the Hippocampus and Alters Transcriptomes of Fear-Encoding Cells. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260411. |
contextual fear conditioning has been shown to activate a set of "fear ensemble" cells in the hippocampal dentate gyrus (dg) whose reactivation is necessary and sufficient for expression of contextual fear. |
2024-01-23 |
2024-01-25 |
Not clear |
Ning Jiang, Yiwen Zhang, Caihong Yao, Fang Chen, Yupei Liu, Yuzhen Chen, Yan Wang, Muhammad Iqbal Choudhary, Xinmin Li. Hemerocallis citrina Baroni ameliorates chronic sleep deprivation-induced cognitive deficits and depressive-like behaviours in mice. Life sciences in space research. vol 40. 2024-01-20. PMID:38245346. |
furthermore, hce suppressed sd-induced microglial activation in the prefrontal cortex (pfc) and the ca1 and dentate gyrus (dg) regions of the hippocampus. |
2024-01-20 |
2024-01-23 |
mouse |
Hamideh Mostafaee, Faezeh Idoon, Mina Mohasel-Roodi, Fatemeh Alipour, Nasim Lotfi, Akram Sadegh. The Effects of Induced Type I Diabetes on Developmental Regulation of GDNF, NRTN, and NCAM proteins in the Dentate Gyrus of male Rat offspring. Journal of chemical neuroanatomy. 2024-01-14. PMID:38219812. |
therefore, this study aimed to investigate the impacts of the mentioned neurotrophic factors in the hippocampal dentate gyrus (dg) of rat offspring born to diabetic mothers. |
2024-01-14 |
2024-01-17 |
rat |
Ji-Wei Tan, Juan Ji An, Hannah Deane, Haifei Xu, Guey-Ying Liao, Baoji X. Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and hippocampus-dependent cognitive functions. Molecular psychiatry. 2024-01-11. PMID:38212372. |
at the center of the hippocampal tri-synaptic loop are synapses formed between mossy fiber (mf) terminals from granule cells in the dentate gyrus (dg) and proximal dendrites of ca3 pyramidal neurons. |
2024-01-11 |
2024-01-14 |
mouse |
Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
we recorded field postsynaptic potentials (fpsps) after electrical stimulation in the ca1 region and in the dentate gyrus (dg) of hippocampal slices of ihka and healthy mice using a multielectrode array (mea). |
2024-01-11 |
2024-01-13 |
mouse |
Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
these results point to increased neuronal excitability in the dg but not in the ca1 region of the hippocampus of ihka mice. |
2024-01-11 |
2024-01-13 |
mouse |
Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
this method, in which the excitability of hippocampal slices from ihka mice is investigated using a mea, can now be further explored as a potential new model to screen for new interventions that can restore dg function and potentially lead to novel therapies for mtle. |
2024-01-11 |
2024-01-13 |
mouse |
He Huang, Ning Wang, Jia-Tao Lin, Yong-Kang Qiu, Wei-Feng Wu, Qiang Liu, Chen Chen, Hai-Bi Wang, Yan-Ping Liu, Wei Dong, Jie Wan, Hui Zheng, Cheng-Hua Zhou, Yu-Qing W. Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells. Molecular neurobiology. 2024-01-10. PMID:38200350. |
for the interventional study, lentivirus (lv) overexpressing mfn2 (lv-mfn2) or control lv vehicle was microinjected into the hippocampal dentate gyrus (dg) 4 days before ketamine administration. |
2024-01-10 |
2024-01-13 |
rat |