| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ni-Chung Lee, Pei-Chun Hsu, Yu-Han Liu, Hao-Chun Wang, Tsu-I Chen, Yin-Hsiu Chien, Wuh-Liang Hw. Nigrostriatal tract defects in mice with aromatic l-amino acid decarboxylase deficiency. Neurobiology of disease. 2024-10-21. PMID:39433135. |
in the present study, we analyzed a mouse model of congenital dopamine and serotonin deficiency, namely, the aromatic l-amino acid decarboxylase (aadc) deficiency (ddc |
2024-10-21 |
2024-10-24 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
dopamine is synthesized in the dopaminergic neurons of the sn by the actions of tyrosine hydroxylase (th) and dihydroxyphenylalanine decarboxylase (ddc). |
2024-10-16 |
2024-10-19 |
mouse |
| Anna Kaplinsky, Reut Halperin, Gadi Shlomai, Amit Tiros. Role of epigenetic regulation on catecholamine synthesis in pheochromocytoma and paraganglioma. Cancer. 2024-06-14. PMID:38872410. |
catecholamines are synthesized by several enzymes: phenylalanine hydroxylase (encoded by pah), tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (ddc), dopamine β-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt). |
2024-06-14 |
2024-06-16 |
Not clear |
| Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D Wagner, Geoffrey A Kerchner, Lu Tian, Carlos Cruchaga, Victor W Henderson, Thomas J Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L Posto. Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease. Acta neuropathologica. vol 147. issue 1. 2024-03-12. PMID:38467937. |
ddc, which catalyzes the final step in dopamine synthesis, particularly stands out as a novel hit with a compelling mechanistic link to pd pathogenesis. |
2024-03-12 |
2024-03-14 |
human |
| Yoshiaki Soejima, Nahoko Iwata, Koichiro Yamamoto, Atsuhito Suyama, Yasuhiro Nakano, Fumio Otsuk. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338864. |
orexin a treatment reduced the mrna levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (th), 3,4-dihydroxyphenylalanie decarboxylase (ddc) and dopamine β-hydroxylase (dbh), in a concentration-dependent manner. |
2024-02-10 |
2024-02-12 |
rat |
| Anna T Reischl-Hajiabadi, Jürgen G Okun, Dirk Kohlmüller, Georgi Manukjan, Sebastian Hegert, Jürgen Durner, Elfriede Schuhmann, Friederike Hörster, Ulrike Mütze, Patrik Feyh, Georg F Hoffmann, Wulf Röschinger, Nils Janzen, Thomas Oplade. Newborn screening for aromatic l-amino acid decarboxylase deficiency - Strategies, results, and implication for prevalence calculations. Molecular genetics and metabolism. 2024-02-01. PMID:38302374. |
aromatic l-amino acid decarboxylase deficiency (aadcd) is a rare, autosomal-recessive neurometabolic disorder caused by variants in dopa decarboxylase (ddc) gene, resulting in a severe combined deficiency of serotonin, dopamine, norepinephrine, and epinephrine. |
2024-02-01 |
2024-02-04 |
Not clear |
| S Birendra Kumar, Aishwarya Girish, Samruddhi Sutar, Suheeth Amberi Premanand, Vrinda Garg, Arvind Kumar Yadav, Rohit Shukla, T P Krishna Murthy, Tiratha Raj Sing. A computational study on structural and functional consequences of nsSNPs in human dopa decarboxylase. Journal of biomolecular structure & dynamics. 2024-01-09. PMID:38193892. |
the dopa decarboxylase (ddc) gene plays an important role in the synthesis of biogenic amines such as dopamine, serotonin, and histamine. |
2024-01-09 |
2024-01-10 |
human |
| Nikolaos S Lotsios, Nikolaos Arvanitis, Alexandros G Charonitakis, George Mpekoulis, Efseveia Frakolaki, Niki Vassilaki, Diamantis C Sideris, Dido Vassilacopoulo. Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress. Current issues in molecular biology. vol 45. issue 12. 2023-12-22. PMID:38132481. |
l-dopa decarboxylase (ddc) is the enzyme that converts l-dopa to dopamine (da). |
2023-12-22 |
2023-12-24 |
human |
| Vassilina Tsopela, Evangelos Korakidis, Despoina Lagou, Katerina I Kalliampakou, Raphaela S Milona, Eirini Kyriakopoulou, George Mpekoulis, Ioanna Gemenetzi, Elli-Anna Stylianaki, Constantinos D Sideris, Aggelina Sioli, Dionysis Kefallinos, Diamantis C Sideris, Vassilis Aidinis, Aristides G Eliopoulos, Konstantinos Kambas, Dido Vassilacopoulou, Niki Vassilak. L-Dopa decarboxylase modulates autophagy in hepatocytes and is implicated in dengue virus-caused inhibition of autophagy completion. Biochimica et biophysica acta. Molecular cell research. 2023-10-01. PMID:37778471. |
the enzyme l-dopa decarboxylase (ddc) synthesizes the catecholamine dopamine and the indolamine serotonin. |
2023-10-01 |
2023-10-07 |
human |
| Vassilina Tsopela, Evangelos Korakidis, Despoina Lagou, Katerina I Kalliampakou, Raphaela S Milona, Eirini Kyriakopoulou, George Mpekoulis, Ioanna Gemenetzi, Elli-Anna Stylianaki, Constantinos D Sideris, Aggelina Sioli, Dionysis Kefallinos, Diamantis C Sideris, Vassilis Aidinis, Aristides G Eliopoulos, Konstantinos Kambas, Dido Vassilacopoulou, Niki Vassilak. L-Dopa decarboxylase modulates autophagy in hepatocytes and is implicated in dengue virus-caused inhibition of autophagy completion. Biochimica et biophysica acta. Molecular cell research. 2023-10-01. PMID:37778471. |
as dopamine affects autophagy in neuronal cells, we investigated the possible association of ddc with autophagy in human hepatocytes and examined whether ddc mediates the relationship between denv infection and autophagy. |
2023-10-01 |
2023-10-07 |
human |
| Marta Del Campo, Lisa Vermunt, Carel F W Peeters, Anne Sieben, Yanaika S Hok-A-Hin, Alberto Lleó, Daniel Alcolea, Mirrelijn van Nee, Sebastiaan Engelborghs, Juliette L van Alphen, Sanaz Arezoumandan, Alice Chen-Plotkin, David J Irwin, Wiesje M van der Flier, Afina W Lemstra, Charlotte E Teunisse. CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease. Nature communications. vol 14. issue 1. 2023-09-13. PMID:37704597. |
the dopamine biosynthesis enzyme ddc was the strongest dysregulated protein, and could efficiently discriminate dlb from controls and ad (auc:0.91 and 0.81 respectively). |
2023-09-13 |
2023-10-07 |
Not clear |
| Julia Sepel Loreto, Sabrina Antunes Ferreira, Pâmela de Almeida, João Batista Teixeira da Rocha, Nilda Vargas Barbos. Screening for Differentially Expressed Memory Genes on a Diabetes Model Induced by High-Sugar Diet in Drosophila melanogaster: Potential Markers for Memory Deficits. Molecular neurobiology. 2023-09-12. PMID:37698834. |
interestingly, the flies fed on hsd presented a decreased expression of the tyrosine hydroxylase (ple) and dopa decarboxylase (ddc) genes, signals of a possible dopamine deficiency. |
2023-09-12 |
2023-10-07 |
drosophila_melanogaster |
| George Mpekoulis, Katerina I Kalliampakou, Raphaela S Milona, Despoina Lagou, Anastasios Ioannidis, Edison Jahaj, Christos T Chasapis, Dionysis Kefallinos, Ioannis Karakasiliotis, Anastasia Kotanidou, Stylianos Chatzipanagiotou, Dido Vassilacopoulou, Alice G Vassiliou, Emmanouil Angelakis, Niki Vassilak. Significance of Catecholamine Biosynthetic/Metabolic Pathway in SARS-CoV-2 Infection and COVID-19 Severity. Cells. vol 12. issue 1. 2023-01-08. PMID:36611805. |
the sars-cov-2 infection was previously associated with the expression of the dopamine biosynthetic enzyme l-dopa decarboxylase (ddc). |
2023-01-08 |
2023-08-14 |
Not clear |
| Mohammed H Al Mughram, Mohini S Ghatge, Glen E Kellogg, Martin K Saf. Elucidating the Interaction between Pyridoxine 5'-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614085. |
one such b6 enzyme is dopa decarboxylase (ddc), which is required for the biosynthesis of key neurotransmitters, e.g., dopamine and serotonin. |
2023-01-08 |
2023-08-14 |
Not clear |
| Aakansha Sharma, Vatsala Tripathi, Vinod Kuma. Hypothalamic molecular correlates of photoperiod-induced spring migration in intact and castrated male redheaded buntings. Molecular and cellular endocrinology. 2022-12-16. PMID:36526025. |
these included genes associated with the appetitive phase of reproduction (spring migration drive, th and ddc genes encoding for tyrosine hydroxylase and dopamine decarboxylase enzymes, respectively), sleep/awake state (pmch gene encoding for pro-melanin concentrating hormone; hcrt and hcrtr2 encoding for the hypocretin/orexin and its receptor, respectively) and neurogenesis (dcx and neun coding for doublecortin and neuronal nuclear proteins, respectively). |
2022-12-16 |
2023-08-14 |
Not clear |
| Steven Lehrer, Peter H Rheinstei. α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. Journal of proteins and proteomics. vol 13. issue 2. 2022-10-24. PMID:36277464. |
a second enzyme, dopa decarboxylase (ddc), catalyzes the conversion of l-dopa to dopamine. |
2022-10-24 |
2023-08-14 |
Not clear |
| Shubhangini Tiwari, Neelam Yadav, Sarika Sing. COVID-19 and Parkinson's Disease: Possible Links in Pathology and Therapeutics. Neurotoxicity research. 2022-07-13. PMID:35829997. |
alongside, angiotensin-converting enzyme 2 (ace2) receptor, essentially required by sars-cov-2 to enter the cell and dopamine decarboxylase (ddc), required for dopamine synthesis is known to co-regulate in the non-neuronal cells. |
2022-07-13 |
2023-08-14 |
Not clear |
| Minghao Yan, Haibo Jin, Chun Pan, Hexing Hang, Dongmei Li, Xiaodong Ha. Movement Disorder and Neurotoxicity Induced by Chronic Exposure to Microcystin-LR in Mice. Molecular neurobiology. 2022-06-22. PMID:35732866. |
meanwhile, mc-lr induced the accumulation of alpha synuclein (α-syn) in da neurons and decreased the proteins of tyrosine hydroxylase (th), dopa decarboxylase (ddc) and dopamine transporter (dat), resulting in a reduction in dopamine (da) content, which are pathological features of parkinson's disease (pd). |
2022-06-22 |
2023-08-14 |
mouse |
| Sihan Lin, Kai Wang, Bingbing Yang, Bo Li, Xiuli Shen, Zhiqiang D. Dopamine receptor (DAR) and dopa decarboxylase (DDC) mediate hepatopancreas antibacterial innate immune reactions in Procambarus clarkii. International journal of biological macromolecules. 2022-06-09. PMID:35679960. |
dopa is decarboxylated by dopa decarboxylase (ddc) to form dopamine, which is a significant signaling molecule in the neuroendocrine system. |
2022-06-09 |
2023-08-14 |
Not clear |
| George Mpekoulis, Vassilina Tsopela, Anna Chalari, Katerina I Kalliampakou, Georgios Panos, Efseveia Frakolaki, Raphaela S Milona, Diamantis C Sideris, Dido Vassilacopoulou, Niki Vassilak. Dengue Virus Replication Is Associated with Catecholamine Biosynthesis and Metabolism in Hepatocytes. Viruses. vol 14. issue 3. 2022-03-26. PMID:35336971. |
in turn, dv apart from its negative impact on ddc, inhibits tyrosine hydroxylase, dopamine beta-hydroxylase, monoamine oxidase, and vmat2 expression. |
2022-03-26 |
2023-08-13 |
Not clear |