| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Merle, L Durussel, P D Delmas, P Clézardi. Decorin inhibits cell migration through a process requiring its glycosaminoglycan side chain. Journal of cellular biochemistry. vol 75. issue 3. 2000-01-24. PMID:10536375. |
several studies overwhelmingly support the notion that decorin (dcn) is involved in matrix assembly, and in the control of cell adhesion and proliferation. |
2000-01-24 |
2023-08-12 |
Not clear |
| B Merle, L Durussel, P D Delmas, P Clézardi. Decorin inhibits cell migration through a process requiring its glycosaminoglycan side chain. Journal of cellular biochemistry. vol 75. issue 3. 2000-01-24. PMID:10536375. |
dcn impeded the migration-promoting effect of matrix molecules (fibronectin, collagen type i) known to interact with the proteoglycan. |
2000-01-24 |
2023-08-12 |
Not clear |
| K Imai, A Hiramatsu, D Fukushima, M D Pierschbacher, Y Okad. Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release. The Biochemical journal. vol 322 ( Pt 3). 1997-05-09. PMID:9148753. |
we have examined the susceptibility of dcn to five different matrix metalloproteinases (mmps): mmp-1 (tissue collagenase), mmp-2 (gelatinase a), mmp-3 (stromelysin 1), mmp-7 (matrilysin) and mmp-9 (gelatinase b). |
1997-05-09 |
2023-08-12 |
Not clear |
| S Kimoto, S L Cheng, S F Zhang, L V Aviol. The effect of glucocorticoid on the synthesis of biglycan and decorin in human osteoblasts and bone marrow stromal cells. Endocrinology. vol 135. issue 6. 1995-01-06. PMID:7988427. |
as glucocorticoids have marked effects on extracellular matrix protein synthesis in bone, and because proteoglycans are important components of bone matrix and may condition the differentiation and biological activities of osteoblasts, we studied the effects of dexamethasone (dex) on the synthesis of small proteoglycans [decorin (dcn) and biglycan (bgn)] in adult human bmsc and human osteoblasts (hob). |
1995-01-06 |
2023-08-12 |
human |
| S Kimoto, S L Cheng, S F Zhang, L V Aviol. The effect of glucocorticoid on the synthesis of biglycan and decorin in human osteoblasts and bone marrow stromal cells. Endocrinology. vol 135. issue 6. 1995-01-06. PMID:7988427. |
time-course analysis indicated that as little as 1 day of treatment with dex was sufficient to decrease bgn mrna and increase dcn mrna (when observed) levels in bmsc; the regulation spanned a 4-week interval, during which the extracellular matrix of bmsc was mineralized. |
1995-01-06 |
2023-08-12 |
human |