| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Zhang, Yan Ge, Qian Cheng, Qi Zhang, Lin Fang, Junnian Zhen. Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget. vol 9. issue 4. 2019-11-20. PMID:29435195. |
decorin (dcn), an extracellular matrix (ecm) protein, belongs to the small leucine-rich proteoglycan family. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wen Zhang, Yan Ge, Qian Cheng, Qi Zhang, Lin Fang, Junnian Zhen. Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget. vol 9. issue 4. 2019-11-20. PMID:29435195. |
dcn, an extracellular matrix (ecm) protein that belongs to the small leucine-rich proteoglycan family, is widely distributed and plays multifunctional roles in the stroma and epithelial cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wen Zhang, Yan Ge, Qian Cheng, Qi Zhang, Lin Fang, Junnian Zhen. Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget. vol 9. issue 4. 2019-11-20. PMID:29435195. |
however, the paradigm has been shifted; it has become increasingly evident that in addition to being a matrix structural protein, dcn affects a wide range of biological processes, including cell growth, differentiation, proliferation, adhesion, spread and migration, and regulates inflammation and fibrillogenesis [4-7]. |
2019-11-20 |
2023-08-13 |
Not clear |
| Midori Edamatsu, Rinako Miyano, Atsushi Fujikawa, Fuminari Fujii, Tetsuya Hori, Takeshi Sakaba, Toshitaka Oohash. Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons. Journal of neurochemistry. vol 147. issue 6. 2019-09-27. PMID:30125937. |
dcn neurons are enwrapped in densely organized extracellular matrix structures, known as perineuronal nets (pnns). |
2019-09-27 |
2023-08-13 |
mouse |
| Thu Thi Vu, Jubert Marquez, Long Thanh Le, Anh Thi Tuyet Nguyen, Hyoung Kyu Kim, Jin Ha. The role of decorin in cardiovascular diseases: more than just a decoration. Free radical research. vol 52. issue 11-12. 2019-04-29. PMID:30468093. |
decorin (dcn) is a proteoglycan constituent of the extracellular matrix (ecm) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. |
2019-04-29 |
2023-08-13 |
Not clear |
| Katsuma Miyachi, Takaaki Yamada, Mika Kawagishi-Hotta, Yuichi Hasebe, Yasushi Date, Seiji Hasegawa, Masaru Arima, Yohei Iwata, Tsukane Kobayashi, Shigeki Numata, Naoki Yamamoto, Satoru Nakata, Kazumitsu Sugiura, Hirohiko Akamats. Extracellular proteoglycan decorin maintains human hair follicle stem cells. The Journal of dermatology. vol 45. issue 12. 2019-04-04. PMID:30320452. |
in this study, we focused on the extracellular matrix proteoglycan decorin (dcn) as a candidate factor for maintaining the human hfsc niche. |
2019-04-04 |
2023-08-13 |
human |
| Qi Yu, Kedao Xin, Yu Miao, Zhaobin Li, Shen Fu, Shudong Hu, Qing Zhang, Shumin Zho. Anti-tumor responses to hypofractionated radiation in mice grafted with triple negative breast cancer is associated with decorin induction in peritumoral muscles. Acta biochimica et biophysica Sinica. vol 50. issue 11. 2019-03-11. PMID:30124739. |
decorin (dcn) is a small poteoglycan of matrix which has an inhibitory effect on the breast cancer and is secreted by muscle under certain conditions. |
2019-03-11 |
2023-08-13 |
mouse |
| Le Xiao, Caroline Bornmann, Laetitia Hatstatt-Burklé, Peter Scheiffel. Regulation of striatal cells and goal-directed behavior by cerebellar outputs. Nature communications. vol 9. issue 1. 2018-12-28. PMID:30087345. |
here, we elaborate the cell-type specificity of a broad connectivity matrix from the deep cerebellar nuclei (dcn) to the dorsal striatum in mice. |
2018-12-28 |
2023-08-13 |
mouse |
| Tina P Dale, Shazia Mazher, William R Webb, Jing Zhou, Nicola Maffulli, Guo-Qiang Chen, Alicia J El Haj, Nicholas R Forsyt. Tenogenic Differentiation of Human Embryonic Stem Cells. Tissue engineering. Part A. vol 24. issue 5-6. 2018-12-11. PMID:28548630. |
conversely, when hescs were cultured in the presence of bmp12/13 and dorsomorphin col3a1, dcn, and tnc gene expression and tendon matrix formation were inhibited. |
2018-12-11 |
2023-08-13 |
human |
| Jingcheng Deng, Yuan Shi, Zhen Gao, Wenjie Zhang, Xiaoli Wu, Weigang Cao, Wei Li. Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells. Tissue engineering. Part A. vol 24. issue 5-6. 2018-12-11. PMID:28562226. |
after 5 days of asc coculture treatment, the expression levels of collagen i (col 1), collagen iii (col 3), fibronectin (fn), tgf-β1, interleukin-6 (il-6), interleukin-8 (il-8), connective tissue growth factor (ctgf), and alpha-smooth muscle actin (α-sma) in hsfs decreased significantly while the expression levels of decorin (dcn) and mmp-1/timp-1 (matrix metalloproteinase/tissue inhibitor of mmp) ratio increased significantly. |
2018-12-11 |
2023-08-13 |
Not clear |
| Svenja Hinderer, Katrin Sudrow, Maria Schneider, Monika Holeiter, Shannon Lee Layland, Martina Seifert, Katja Schenke-Laylan. Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells. Scientific reports. vol 8. issue 1. 2018-11-27. PMID:29311692. |
decorin (dcn) is an important small leucine-rich proteoglycan present in the extracellular matrix (ecm) of many organs and tissues. |
2018-11-27 |
2023-08-13 |
human |
| Masayuki Hayashi, Kyoko Kido, Kyoko Hodat. Microarray analysis of Longissimus thoracis muscle gene expressions in vitamin A-restricted Japanese Black steers in middle fattening stage. Animal science journal = Nihon chikusan Gakkaiho. vol 89. issue 1. 2018-02-22. PMID:28960613. |
the gene list of the r group included cd36, lpl, gpam, dgat2, and scd and additional genes annotated 'ppar signaling pathway,' 'lipid biosynthesis' and 'mitochondrion,' whereas that of the s group included col1a2, fn1 and dcn and additional genes annotated 'extracellular matrix.' |
2018-02-22 |
2023-08-13 |
cattle |
| J Y Peng, K X Gao, H Y Xin, P Han, G Q Zhu, B Y Ca. Molecular cloning, expression analysis, and function of decorin in goat ovarian granulosa cells. Domestic animal endocrinology. vol 57. 2017-12-13. PMID:27565237. |
decorin (dcn), a component of the extracellular matrix (ecm), participates in ecm assembly and influences cell proliferation and apoptosis in many mammalian tissues and cells. |
2017-12-13 |
2023-08-13 |
Not clear |
| Yang Lin, Eric A Lewallen, Emily T Camilleri, Carolina A Bonin, Dakota L Jones, Amel Dudakovic, Catalina Galeano-Garces, Wei Wang, Marcel J Karperien, Annalise N Larson, Diane L Dahm, Michael J Stuart, Bruce A Levy, Jay Smith, Daniel B Ryssman, Jennifer J Westendorf, Hee-Jeong Im, Andre J van Wijnen, Scott M Riester, Aaron J Kryc. RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 11. 2017-08-28. PMID:26909883. |
our studies establish reduced levels of mrnas encoding cartilage related extracellular matrix (ecm) proteins (i.e., col1a1, col2a1, col10a1, acan, dcn, hapln1, tnc, and comp) in stored cartilage. |
2017-08-28 |
2023-08-13 |
Not clear |
| Yei-Tsung Chen, Juan Wang, Abby S Y Wee, Quek-Wei Yong, Edgar Lik-Wui Tay, Chin Cheng Woo, Vitaly Sorokin, Arthur Mark Richards, Lieng-Hsi Lin. Differential MicroRNA Expression Profile in Myxomatous Mitral Valve Prolapse and Fibroelastic Deficiency Valves. International journal of molecular sciences. vol 17. issue 5. 2017-03-15. PMID:27213335. |
the possible involvement of micrornas in the pathogenesis of dmvd were further suggested by the presences of in silico predicted target sites on a number of genes reported to be involved in extracellular matrix homeostasis and marker genes for cellular composition of mitral valves, including decorin (dcn), aggrecan (acan), fibromodulin (fmod), α actin 2 (acta2), extracellular matrix protein 2 (ecm2), desmin (des), endothelial cell specific molecule 1 (esm1), and platelet/ endothelial cell adhesion molecule 1 (pecam1), as well as inverse correlations of selected microrna and mrna expression in mmvp and fed groups. |
2017-03-15 |
2023-08-13 |
Not clear |
| Yongcan Xu, Qiuyuan Xia, Qiu Rao, Shanshan Shi, Qunli Shi, Henghui Ma, Zhenfeng Lu, Hui Chen, Xiaojun Zho. DCN deficiency promotes renal cell carcinoma growth and metastasis through downregulation of P21 and E-cadherin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-13. PMID:26547587. |
decorin (dcn), as an important component of the extracellular matrix (ecm), is a small leucine-rich proteoglycan and synthesized by fibroblasts. |
2017-02-13 |
2023-08-13 |
Not clear |
| Sunny A Abbah, Dilip Thomas, Shane Browne, Timothy O'Brien, Abhay Pandit, Dimitrios I Zeugoli. Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture. Scientific reports. vol 6. 2017-01-06. PMID:26860065. |
herein, we report that the delivery of dcn and il-10 transgenes from a collagen hydrogel system supresses the constitutive expression of tgf-β1 and a range of pro-fibrotic extracellular matrix genes. |
2017-01-06 |
2023-08-13 |
human |
| X G Han, D K Wang, F Gao, R H Liu, Z G B. Bone morphogenetic protein 2 and decorin expression in old fracture fragments and surrounding tissues. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-11. PMID:26400336. |
decorin (dcn) can promote the formation of bone matrix and calcium deposition to control bone morphogenesis. |
2016-07-11 |
2023-08-13 |
Not clear |
| Marcos C Borges, Venkatesan Narayanan, Renato V Iozzo, Mara S Ludwi. Deficiency of decorin induces expression of Foxp3 in CD4⁺CD25⁺ T cells in a murine model of allergic asthma. Respirology (Carlton, Vic.). vol 20. issue 6. 2016-02-17. PMID:25712878. |
decorin (dcn), an extracellular matrix proteoglycan, has several important biological functions, and its deposition is altered in the airway wall of humans with asthma and animal models of asthma. |
2016-02-17 |
2023-08-13 |
mouse |
| Zhixiang Tong, Aidan B Zerdoum, Randall L Duncan, Xinqiao Ji. Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors. Tissue engineering. Part A. vol 20. issue 13-14. 2015-03-04. PMID:24456068. |
the initial 3-day vibratory culture resulted in an increased production of hyaluronic acids (ha), tenascin-c (tnc), decorin (dcn), and matrix metalloproteinase-1 (mmp1). |
2015-03-04 |
2023-08-12 |
Not clear |