| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Lieveld, E Bodson, G De Boeck, B Nouman, A M Cleton-Jansen, E Korsching, M S Benassi, P Picci, G Sys, B Poffyn, N A Athanasou, P C W Hogendoorn, R G Forsyt. Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis. Virchows Archiv : an international journal of pathology. vol 465. issue 6. 2015-01-21. PMID:25304290. |
our findings show that several genes related to extracellular matrix integrity (lum, dcn, and dpt) are differentially expressed and may serve as biomarkers for metastatic and recurrent gctb. |
2015-01-21 |
2023-08-13 |
Not clear |
| Thomas Neill, Annabel Torres, Simone Buraschi, Renato V Iozz. Decorin has an appetite for endothelial cell autophagy. Autophagy. vol 9. issue 10. 2014-12-16. PMID:23989617. |
dcn (decorin), an extracellular matrix constituent and archetypical small leucine-rich proteoglycan (slrp), acts as a soluble tumor repressor. |
2014-12-16 |
2023-08-12 |
Not clear |
| Thomas Neill, Annabel Torres, Simone Buraschi, Renato V Iozz. Decorin has an appetite for endothelial cell autophagy. Autophagy. vol 9. issue 10. 2014-12-16. PMID:23989617. |
therefore, dcn and perhaps other members of this class of matrix constituents may represent a novel control of autophagy from the outside of the cells. |
2014-12-16 |
2023-08-12 |
Not clear |
| J D Twomey, P I Thakore, D A Hartman, E G H Myers, A H Hsie. Roles of type VI collagen and decorin in human mesenchymal stem cell biophysics during chondrogenic differentiation. European cells & materials. vol 27. 2014-08-19. PMID:24668596. |
human mesenchymal stem cells (hmscs) induced towards chondrogenesis develop a pericellular matrix (pcm), rich in type vi collagen (colvi) and proteoglycans such as decorin (dcn). |
2014-08-19 |
2023-08-12 |
human |
| M Adam, H F Urbanski, V T Garyfallou, U Welsch, F M Köhn, J Ullrich Schwarzer, L Strauss, M Poutanen, A Mayerhofe. High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function. International journal of andrology. vol 35. issue 4. 2014-07-21. PMID:22413766. |
decorin (dcn), a component of the extracellular matrix of the peritubular wall and the interstitial areas of the human testis, can interact with growth factor (gf) signalling, thereby blocking downstream actions of gfs. |
2014-07-21 |
2023-08-12 |
mouse |
| Jennifer L Fetting, Justin A Guay, Michele J Karolak, Renato V Iozzo, Derek C Adams, David E Maridas, Aaron C Brown, Leif Oxburg. FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development (Cambridge, England). vol 141. issue 1. 2014-03-11. PMID:24284212. |
on the basis of these studies, we propose a mechanism for progenitor cell retention in the foxd1 null in which misexpressed dcn produced by prematurely differentiated interstitial cells accumulates in the extracellular matrix, inhibiting bmp7-mediated transition of nephron progenitor cells to a compartment in which they can respond to epithelial induction signals. |
2014-03-11 |
2023-08-12 |
Not clear |
| Yuan-Zhi Xu, Kai-Jun Zhao, Zhi-Gang Yang, Yu-Hui Zhang, Yong-Wei Zhang, Bo Hong, Jian-Min Li. Decreased plasma decorin levels following acute ischemic stroke: correlation with MMP-2 and differential expression in TOAST subtypes. Molecular medicine reports. vol 6. issue 6. 2014-02-26. PMID:23026977. |
the present study aimed to investigate whether plasma concentrations of dcn are altered in patients following an ais and whether they are correlated with matrix metalloproteinase-2 (mmp-2) levels and other laboratory and clinical variables. |
2014-02-26 |
2023-08-12 |
human |
| Abdu Selim Hamid, Jinran Li, Yali Wang, Xiaodong Wu, Hassan Abdellah Ahmed Ali, Zhenwu Du, Lihua Bo, Yucheng Zhang, Guizhen Zhan. Recombinant human decorin upregulates p57KIP² expression in HepG2 hepatoma cell lines. Molecular medicine reports. vol 8. issue 2. 2014-02-13. PMID:23754492. |
decorin (dcn), a functional component of the extracellular matrix, has been implicated in the suppression of cell proliferation by upregulating p21, a cyclin-cdk inhibitor. |
2014-02-13 |
2023-08-12 |
human |
| Oliver Jungmann, Katerina Nikolovska, Christian Stock, Jan-Niklas Schulz, Beate Eckes, Christoph Riethmüller, Rick T Owens, Renato V Iozzo, Daniela G Seidle. The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. PloS one. vol 7. issue 12. 2013-05-21. PMID:23226541. |
we utilized a 3d cell culture model to investigate the impact of the altered extracellular matrix on dcn(-/-) fibroblasts. |
2013-05-21 |
2023-08-12 |
mouse |
| Oliver Jungmann, Katerina Nikolovska, Christian Stock, Jan-Niklas Schulz, Beate Eckes, Christoph Riethmüller, Rick T Owens, Renato V Iozzo, Daniela G Seidle. The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. PloS one. vol 7. issue 12. 2013-05-21. PMID:23226541. |
we discovered that a decorin-deficient matrix leads to abnormal nuclear morphology in the dcn(-/-) fibroblasts. |
2013-05-21 |
2023-08-12 |
mouse |
| Katarzyna Ratajczak-Wielgomas, Jerzy Gosk, Jerzy Rabczyński, Katarzyna Augoff, Marzenna Podhorska-Okołów, Andrzej Gamian, Roman Rutowsk. Expression of MMP-2, TIMP-2, TGF-β1, and decorin in Dupuytren's contracture. Connective tissue research. vol 53. issue 6. 2013-05-03. PMID:22512703. |
to investigate the mechanisms underlying matrix deposition in dupuytren's disease, the expression of gelatinase a (mmp-2), the tissue inhibitor of metalloproteinase-2 (timp-2), transforming growth factor beta 1 (tgf-β1), decorin (dcn), and periostin was studied. |
2013-05-03 |
2023-08-12 |
Not clear |
| Katarzyna Ratajczak-Wielgomas, Jerzy Gosk, Jerzy Rabczyński, Katarzyna Augoff, Marzenna Podhorska-Okołów, Andrzej Gamian, Roman Rutowsk. Expression of MMP-2, TIMP-2, TGF-β1, and decorin in Dupuytren's contracture. Connective tissue research. vol 53. issue 6. 2013-05-03. PMID:22512703. |
tgf-β1, dcn, and periostin are involved in extracellular matrix (ecm) homeostasis in dupuytren's contracture. |
2013-05-03 |
2023-08-12 |
Not clear |
| Wenxi He, Tiejun Qu, Qing Yu, Zhihua Wang, Hanguo Wang, Jing Zhang, Anthony J Smit. Lipopolysaccharide enhances decorin expression through the Toll-like receptor 4, myeloid differentiating factor 88, nuclear factor-kappa B, and mitogen-activated protein kinase pathways in odontoblast cells. Journal of endodontics. vol 38. issue 4. 2012-12-11. PMID:22414830. |
decorin (dcn), one of the major matrix proteoglycans, is known to affect the mineralization of teeth. |
2012-12-11 |
2023-08-12 |
Not clear |
| Leping Ye, Binghai Zhao, Kaiming Yuan, Yanhui Chu, Changchong Li, Connie Zhao, Qing-Quan Lian, Ren-Shan G. Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure. Toxicology letters. vol 209. issue 3. 2012-04-16. PMID:22237054. |
the other genes were primarily included in the categories of cytoskeletal structure (tpm1, tnnt2, actn3, myoz2, tmod1, and mfap5), extracellular matrix (ckm, lum, tnnc1, art3, dcn, col17a1, aspn, ctsk, itm2a, spock2 and orm1), transporting (cox8h, cox6a2 and scnn1a) and secreted proteins (scgb3a1, nppb and spp1). |
2012-04-16 |
2023-08-12 |
rat |
| M Adam, J U Schwarzer, F M Köhn, L Strauss, M Poutanen, A Mayerhofe. Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling. Human reproduction (Oxford, England). vol 26. issue 10. 2012-03-25. PMID:21791437. |
myofibroblastic, peritubular cells in the walls of seminiferous tubules produce low levels of the extracellular matrix (ecm) protein decorin (dcn), which has the ability to interfere with growth factor (gf) signaling. |
2012-03-25 |
2023-08-12 |
human |
| Zhongqi Chen, Jiajie Sun, Zhuanjian Li, Xianyong Lan, Chunlei Zhang, Yujiao Qu, Yanli Liu, Xingtang Fang, Chuzhao Lei, Hong Che. Novel SNPs in the caprine stearoyl-CoA desaturase (SCD) and decorin (DCN) genes that are associated with growth traits in Chinese goat breeds. Molecular biology reports. vol 38. issue 5. 2011-10-21. PMID:20401695. |
stearoyl-coa desaturase (scd) is an iron-containing enzyme involving in the biosynthesis of monounsaturated fatty acids (mufa) in mammary gland and adipose tissue, while decorin (dcn) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain, contributing multifunctionally to matrix assembly, modulation of the activity of growth factors and cell migration and proliferation. |
2011-10-21 |
2023-08-12 |
Not clear |
| Cinzia L Marchica, Valentina Pinelli, Marcos Borges, Jaryd Zummer, Venkatesan Narayanan, Renato V Iozzo, Mara S Ludwi. A role for decorin in a murine model of allergen-induced asthma. American journal of physiology. Lung cellular and molecular physiology. vol 300. issue 6. 2011-08-11. PMID:21378022. |
decorin (dcn) is an extracellular matrix proteoglycan, which affects airway mechanics, airway-parenchymal interdependence, airway smooth muscle proliferation and apoptosis, and transforming growth factor-β bioavailability. |
2011-08-11 |
2023-08-12 |
mouse |
| Linda Harkness, Amer Mahmood, Nicholas Ditzel, Basem M Abdallah, Jens V Nygaard, Moustapha Kasse. Selective isolation and differentiation of a stromal population of human embryonic stem cells with osteogenic potential. Bone. vol 48. issue 2. 2011-05-02. PMID:20869473. |
when cultured in osteogenic differentiation media, up regulation of osteoblastic lineage markers (dlx5, msx2, runx2, sparc, alp, col1a1, bglap, ibsp, dcn, lox-l4) and production of in vitro mineralized matrix was detected. |
2011-05-02 |
2023-08-12 |
mouse |
| Juliane C T Sanches, Carolyn J P Jones, John D Aplin, Renato V Iozzo, Telma M T Zorn, Sergio F Oliveir. Collagen fibril organization in the pregnant endometrium of decorin-deficient mice. Journal of anatomy. vol 216. issue 1. 2010-06-29. PMID:19900179. |
in the present study we utilized wild-type (dcn(+/+)) and decorin-deficient (dcn(-/-)) time-pregnant mice to investigate the evolution of non-decidualized and decidualized collagen matrix in the uterine wall of these animals. |
2010-06-29 |
2023-08-12 |
mouse |
| Jack L Lewis, David A Krawczak, Ted R Oegema, Jennifer J Westendor. Effect of decorin and dermatan sulfate on the mechanical properties of a neocartilage. Connective tissue research. vol 51. issue 2. 2010-06-01. PMID:20001848. |
to further examine the role of decorin in the extracellular matrix development and subsequent material properties of cartilage, tissue (neocartilage) was grown in a 3d culture model using a pure population of genetically modified chondrocytes stably overexpressing decorin (dcn) or decorin lacking dermatan sulfate (mdcn). |
2010-06-01 |
2023-08-12 |
mouse |