| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshiyuki Mochida, Duenpim Parisuthiman, Suchaya Pornprasertsuk-Damrongsri, Phimon Atsawasuwan, Marnisa Sricholpech, Adele L Boskey, Mitsuo Yamauch. Decorin modulates collagen matrix assembly and mineralization. Matrix biology : journal of the International Society for Matrix Biology. vol 28. issue 1. 2009-06-19. PMID:19049867. |
decorin (dcn) is one of the major matrix proteoglycans in bone. |
2009-06-19 |
2023-08-12 |
Not clear |
| Yoshiyuki Mochida, Duenpim Parisuthiman, Suchaya Pornprasertsuk-Damrongsri, Phimon Atsawasuwan, Marnisa Sricholpech, Adele L Boskey, Mitsuo Yamauch. Decorin modulates collagen matrix assembly and mineralization. Matrix biology : journal of the International Society for Matrix Biology. vol 28. issue 1. 2009-06-19. PMID:19049867. |
to investigate the role of dcn in matrix mineralization, the expression of dcn in mc3t3-e1 (mc) cell cultures and the phenotypes of mc-derived clones expressing higher (sense; s-dcn) or lower (antisense; as-dcn) levels of dcn were characterized. |
2009-06-19 |
2023-08-12 |
Not clear |
| Yoshiyuki Mochida, Duenpim Parisuthiman, Suchaya Pornprasertsuk-Damrongsri, Phimon Atsawasuwan, Marnisa Sricholpech, Adele L Boskey, Mitsuo Yamauch. Decorin modulates collagen matrix assembly and mineralization. Matrix biology : journal of the International Society for Matrix Biology. vol 28. issue 1. 2009-06-19. PMID:19049867. |
these results suggest that dcn regulates matrix mineralization by modulating collagen assembly. |
2009-06-19 |
2023-08-12 |
Not clear |
| Feng-qin Dong, Hong Li, Fang Wu, Hang-ping Ya. [Effects of overexpression of decorin on matrix metalloproteinases 2 and 9 in rat mesangial and tubular cells]. Zhonghua yi xue za zhi. vol 88. issue 48. 2009-06-11. PMID:19159581. |
to investigate the effects of overexpression of decorin (dcn), one of the small leucine-rich proteoglycans, on the expression of extracellular matrix molecules in glomerular mesangial and tubular cells. |
2009-06-11 |
2023-08-12 |
rat |
| Weifeng Ma, Yi Tan, Shaohui Cai, Hongyuan Chen, Jun Du, Shaoxi Ca. [The action of decorin in anti-fibrosis and anti-cancer]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 24. issue 1. 2009-05-21. PMID:17333927. |
many studies indicated that dcn inhibited fibrosis and scar-formation by neutralization of tgf-p and interfering the binding of tgf-beta with its receptor, which induced ectopic deposition of extracellular matrix. |
2009-05-21 |
2023-08-12 |
Not clear |
| K Augoff, K Grabowski, J Rabczynski, A Kolondra, R Tabola, A F Sikorsk. Expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity. Cancer investigation. vol 27. issue 4. 2009-04-23. PMID:19212830. |
to determine the role of the reactive stroma in cancer progression, we investigated decorin (dcn) and transforming growth factor-beta (tgf-beta expression, and matrix metalloproteinase-2 (mmp-2) activity in the tumorous esophagus. |
2009-04-23 |
2023-08-12 |
Not clear |
| Hyuck Joon Kwon, Hidetoshi Akimoto, Yoshihiro Ohmiya, Kenichi Honma, Kazunori Yasud. Gene expression profile of rabbit cartilage by expressed sequence tag analysis. Gene. vol 424. issue 1-2. 2009-01-12. PMID:18723084. |
gene expression profiles based on est frequency show that type ii collagen (col2a1) and type x collagen (col10a1) among collagen clones, proteoglycan 4 (prg4) and decorin (dcn) among proteoglycan clones, and cartilage oligomeric matrix protein (comp) and matrix gla protein (mgp) among other extracellular matrix clones, are highly expressed in rabbit cartilage. |
2009-01-12 |
2023-08-12 |
rabbit |
| Hyuck Joon Kwon, Hidetoshi Akimoto, Yoshihiro Ohmiya, Kenichi Honma, Kazunori Yasud. Gene expression profile of rabbit cartilage by expressed sequence tag analysis. Gene. vol 424. issue 1-2. 2009-01-12. PMID:18723084. |
in addition, gene expression analysis based on real-time pcr of these major extracellular matrix constituents showed that expression of col2a1 and col10a1 remains constant whereas the expression of prg4, dcn, and comp reveals substantial change with rabbit age. |
2009-01-12 |
2023-08-12 |
rabbit |
| Manoranjan Santra, Sutapa Santra, Jing Zhang, Michael Chop. Ectopic decorin expression up-regulates VEGF expression in mouse cerebral endothelial cells via activation of the transcription factors Sp1, HIF1alpha, and Stat3. Journal of neurochemistry. vol 105. issue 2. 2008-05-06. PMID:18021292. |
induction of gelatinases (matrix metalloproteinase 2 and 9), the serine protease tissue plasminogen activator and plasmin by dcn transfection in mce cells leads to extracellular proteolysis and to release of matrix-bound vegf and activation of angiogenesis. |
2008-05-06 |
2023-08-12 |
mouse |
| James M Massey, Jeremy Amps, Mariano S Viapiano, Russell T Matthews, Michelle R Wagoner, Christopher M Whitaker, Warren Alilain, Alicia L Yonkof, Abdelnaby Khalyfa, Nigel G F Cooper, Jerry Silver, Stephen M Onife. Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Experimental neurology. vol 209. issue 2. 2008-04-11. PMID:17540369. |
constitutively expressed cspgs within the extracellular matrix and perineuronal nets of the adult rat dorsal column nuclei (dcn) were characterized using real-time pcr, western blot analysis and immunohistochemistry. |
2008-04-11 |
2023-08-12 |
human |
| Kevin Jon Williams, Gang Qiu, Hitomi Katoaka Usui, Stephen R Dunn, Peter McCue, Erwin Bottinger, Renato V Iozzo, Kumar Sharm. Decorin deficiency enhances progressive nephropathy in diabetic mice. The American journal of pathology. vol 171. issue 5. 2008-01-25. PMID:17884968. |
dcn(-/-) diabetic mice exhibited advanced glomerular lesions, including diffuse mesangial matrix accumulation and fibrin cap formation. |
2008-01-25 |
2023-08-12 |
mouse |
| Francesco G Salerno, Valentina Pinelli, Laura Pini, Bodil Tuma, Renato V Iozzo, Mara S Ludwi. Effect of PEEP on induced constriction is enhanced in decorin-deficient mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 5. 2007-12-20. PMID:17704190. |
decorin (dcn), a small leucine-rich proteoglycan, is present in the extracellular matrix of the airways and lung tissues, contributes to lung mechanical properties, and its deposition is altered in asthma. |
2007-12-20 |
2023-08-12 |
mouse |
| Monte J Radeke, Katie E Peterson, Lincoln V Johnson, Don H Anderso. Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid. Experimental eye research. vol 85. issue 3. 2007-11-09. PMID:17662275. |
one is an rpe cell growth factor (tfpi2), five are extracellular matrix components (dcn, myoc, ogn, smoc2, tfpi2), and six are related to inflammation (ccl19, ccl26, cxcl14, slit2) and/or angiogenesis (cxcl14, slit2, tfpi2, wfdc1). |
2007-11-09 |
2023-08-12 |
human |
| Chun-Xia Zhao, Yin-Tao Zhao, Pei-Hua Wang, Xiao Xiao, Dao-Wen Wan. [Influences of recombinant adeno-associated virus-mediated Decorin gene transfection on cell cycle and apoptosis of SiHa cells]. Ai zheng = Aizheng = Chinese journal of cancer. vol 24. issue 1. 2006-03-31. PMID:15642196. |
decorin (dcn), a multi-efficiency factor, has many important functions, such as influencing fibril stability, and interacting with extracellular matrix molecules to influence cell adhesion. |
2006-03-31 |
2023-08-12 |
Not clear |
| M Goldberg, D Septier, O Rapoport, R V Iozzo, M F Young, L G Amey. Targeted disruption of two small leucine-rich proteoglycans, biglycan and decorin, excerpts divergent effects on enamel and dentin formation. Calcified tissue international. vol 77. issue 5. 2005-12-20. PMID:16283572. |
dentin matrix protein-1 (dmp-1), bone sialoprotein (bsp) and osteopontin (opn) were upregulated in bgn ko and downregulated in the dcn ko. |
2005-12-20 |
2023-08-12 |
mouse |
| Wang Huijun, Chen Long, Zhang Zhigang, Jiang Feng, Guo Muy. Ex vivo transfer of the decorin gene into rat glomerulus via a mesangial cell vector suppressed extracellular matrix accumulation in experimental glomerulonephritis. Experimental and molecular pathology. vol 78. issue 1. 2005-02-01. PMID:15596056. |
these results suggest that the use of dcn can decrease antithymocyte serum glomerulonephritis extracellular matrix (ecm) ingredients and that such use offers a favorable experimental basis for gene therapy for kidney disease. |
2005-02-01 |
2023-08-12 |
rat |
| Yoshiyuki Mochida, Wagner R Duarte, Hideki Tanzawa, Eleftherios P Paschalis, Mitsuo Yamauch. Decorin modulates matrix mineralization in vitro. Biochemical and biophysical research communications. vol 305. issue 1. 2003-06-18. PMID:12732188. |
in order to investigate the potential roles of dcn in collagen matrix mineralization, several stable osteoblastic cell clones expressing higher (sense-dcn, s-dcn) and lower (antisense-dcn, as-dcn) levels of dcn were generated and the mineralized nodules formed by these clones were characterized. |
2003-06-18 |
2023-08-12 |
Not clear |
| Yoshiyuki Mochida, Wagner R Duarte, Hideki Tanzawa, Eleftherios P Paschalis, Mitsuo Yamauch. Decorin modulates matrix mineralization in vitro. Biochemical and biophysical research communications. vol 305. issue 1. 2003-06-18. PMID:12732188. |
these results suggest that dcn may act as an inhibitor of collagen matrix mineralization, thus modulating the timing of matrix mineralization. |
2003-06-18 |
2023-08-12 |
Not clear |
| B Merle, L Durussel, P D Delmas, P Clézardi. Decorin inhibits cell migration through a process requiring its glycosaminoglycan side chain. Journal of cellular biochemistry. vol 75. issue 3. 2000-01-24. PMID:10536375. |
several studies overwhelmingly support the notion that decorin (dcn) is involved in matrix assembly, and in the control of cell adhesion and proliferation. |
2000-01-24 |
2023-08-12 |
Not clear |
| B Merle, L Durussel, P D Delmas, P Clézardi. Decorin inhibits cell migration through a process requiring its glycosaminoglycan side chain. Journal of cellular biochemistry. vol 75. issue 3. 2000-01-24. PMID:10536375. |
dcn impeded the migration-promoting effect of matrix molecules (fibronectin, collagen type i) known to interact with the proteoglycan. |
2000-01-24 |
2023-08-12 |
Not clear |