| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abiramy Jeyagaran, Max Urbanczyk, Daniel Carvajal-Berrio, Teresa Baldissera, Philipp D Kaiser, Laurence Kuhlburger, Stefan Czemmel, Sven Nahnsen, Garry P Duffy, Sara Y Brucker, Shannon L Layland, Katja Schenke-Laylan. ECM Proteins Nidogen-1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions. Advanced healthcare materials. 2024-11-08. PMID:39511898. |
it was previously demonstrated that the extracellular matrix (ecm) proteins nidogen-1 (nid1) and decorin (dcn) improve the functionality and survival of the β-cell line, endoc-βh3, and the viability of human islets post-isolation. |
2024-11-08 |
2024-11-16 |
human |
| Reem Amr Assal, Rowan Bahaa El-Din Abd El-Bary, Rana A Youness, Mohamed Mamdouh Abdelrahman, Hala Zahran, Karim Adel Hosny, Gamal Esmat, Kai Breuhahn, Nada El-Ekiaby, Injie Omar Fawzy, Ahmed Ihab Abdelazi. OncomiR-181a promotes carcinogenesis by repressing the extracellular matrix proteoglycan decorin in hepatocellular carcinoma. BMC gastroenterology. vol 24. issue 1. 2024-10-01. PMID:39350070. |
accordingly, this study aimed at identifying the impact of mir-181a in liver cancer and its regulatory role on the extracellular matrix proteoglycan, dcn, and hence on downstream oncogenes and tumor suppressor genes. |
2024-10-01 |
2024-10-03 |
Not clear |
| Jiangtao Cui, Shiyi Zhang, Kiran Acharya, Yan Xu, Heng Guo, Tong Li, Donghe Fu, Zizhen Yang, Lingnan Hou, Xiaotao Xing, Xiaoyi H. Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling. Experimental dermatology. vol 33. issue 7. 2024-07-24. PMID:39045898. |
this finding suggested that dcn regulates the synthesis of collagen-based extracellular matrix and fibrosis through the tgf-β1/smad3 pathway. |
2024-07-24 |
2024-07-26 |
Not clear |
| Ana M Colino Gallardo, Montserrat De la Torre Serrano, Lorenzo Alarcón García, Isabel Casado Fariñas, David De Pablo Velasco, Javier Martínez-Useros, Rodrigo Barderas, María J Fernández-Aceñer. Histopathologic Changes in Congenital Corneal Stromal Dystrophy: Report of 4 Cases in 2 Families. Applied immunohistochemistry & molecular morphology : AIMM. 2023-09-26. PMID:37751235. |
congenital corneal stromal dystrophy is a very rare autosomal dominant dystrophy that is caused by a mutation in the dcn gene that encodes decorin (a proteoglycan of the extracellular matrix). |
2023-09-26 |
2023-10-07 |
Not clear |
| Malabika Maulik, Kassandra Looschen, Colton Smith, Khyla Johnson, Alaina F Carman, Cherishma Nagisetty, Katilyn Corriveau, Colin Salisbury, Kayla Deschepper, Madison Michels, Angela N Henderson-Redmond, Daniel J Morgan, Swarup Mitr. Postpartum scarcity-adversity inflicts sex-specific cerebellar adaptations and reward behaviors in adolescence. Pharmacology, biochemistry, and behavior. 2023-08-25. PMID:37625522. |
since bmal1 has recently been implicated in extracellular matrix modulation, we examined perineuronal nets (pnn) and observed depleted pnn in the dcn of males but not female lbn mice. |
2023-08-25 |
2023-09-07 |
mouse |
| Xiaoyu Zou, He Zhang, Jamie M Benson, Hanyuan Gao, David L Burris, Joseph M Fox, Xinqiao Ji. Modeling the Maturation of the Vocal Fold Lamina Propria Using a Bioorthogonally Tunable Hydrogel Platform. Advanced healthcare materials. 2023-08-02. PMID:37530909. |
compared to the nlp controls, slp7 conditions upregulated the expression of fibrous matrix proteins (col i, dcn, and fn eda), classic fibroblastic markers (tnc, fap, and fsp1), and matrix remodeling enzymes (mmp2, timp1, and has3). |
2023-08-02 |
2023-08-14 |
Not clear |
| Max Urbanczyk, Abiramy Jeyagaran, Aline Zbinden, Chuan-En Lu, Julia Marzi, Laurence Kuhlburger, Sven Nahnsen, Shannon L Layland, Garry Duffy, Katja Schenke-Laylan. Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro. Matrix biology : journal of the International Society for Matrix Biology. 2023-01-02. PMID:36592738. |
here, we assessed for the first time the regulatory role of the small leucine-rich proteoglycan decorin (dcn) in insulin secretion in human β-cells, and its impact on pancreatic extracellular matrix (ecm) protein expression in vitro. |
2023-01-02 |
2023-08-14 |
human |
| S Huber, S Günther, E Cambria, M Leunig, S J Ferguso. Physiological stretching induces a differential extracellular matrix gene expression response in acetabular labrum cells. European cells & materials. vol 44. 2022-10-03. PMID:36189917. |
physiological stretching upregulated decorin (dcn) (1.8548 ± 0.4883, p = 0.002) as well as proteoglycan 4 (prg4) (1.7714 ± 0.6600, p = 0.029) and downregulated biglycan (bgn) (0.7018 + 0.1567, p = 0.008), cartilage oligomeric matrix protein (comp) (0.5747 ± 0.2650, p = 0.029), fibronectin (fn1) (0.5832 ± 0.0996, p < 0.001) and spondin 1 (spon1) (0.6282 ± 0.3624, p = 0.044) gene expression. |
2022-10-03 |
2023-08-14 |
cattle |
| Jiaquan Chen, Weilun Wang, Qihong Ni, Lan Zhang, Xiangjiang Gu. Interleukin 6-regulated macrophage polarization controls atherosclerosis-associated vascular intimal hyperplasia. Frontiers in immunology. vol 13. 2022-08-15. PMID:35967343. |
next, hub genes were predicted in these 122 genes, from which we detected 3 candidates, interleukin 6 (il6), decorin (dcn) and tissue inhibitor matrix metalloproteinase 1 (timp1). |
2022-08-15 |
2023-08-14 |
Not clear |
| Rongfen Gao, Jungen Tang, Yuanji Dong, Bingxia Ming, Zhihua Yu, Jixin Zhong, Lingli Don. The Aberrant Levels of Decorin Induce Damages of Human Salivary Gland Epithelial Cells and Polarization of Macrophages. Modern rheumatology. 2022-04-19. PMID:35438773. |
this study aimed to preliminarily address the levels of decorin (dcn, a critical component of extracellular matrix), and its potential roles in primary sjögren's syndrome (pss). |
2022-04-19 |
2023-08-13 |
human |
| Tokuko Hosoya, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, Tadashi Hosoya, Megumi Ishiguro, Toshiaki Ishikawa, Hiroyuki Uetak. Plasma Levels of Decorin Increased in Patients during the Progression of Breast Cancer. Journal of clinical medicine. vol 10. issue 23. 2021-12-10. PMID:34884232. |
decorin (dcn), an extracellular matrix proteoglycan found in tumor surrounding tissues, is a natural inhibitor of tumor cell proliferation and invasion. |
2021-12-10 |
2023-08-13 |
Not clear |
| Lejo Johnson Chacko, Hanae Lahlou, Claudia Steinacher, Said Assou, Yassine Messat, József Dudás, Albert Edge, Berta Crespo, Moira Crosier, Consolato Sergi, Anneliese Schrott-Fischer, Azel Zin. Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639189. |
), in addition to a number of novel genes encoding extracellular matrix (ecm) (col3a1, col5a2, dcn, etc.) |
2021-10-25 |
2023-08-13 |
human |
| Sama Abdulmalik, Daisy Ramos, Swetha Rudraiah, Yeshavanth Kumar Banasavadi-Siddegowda, Sangamesh G Kumba. The glucagon-like peptide 1 receptor agonist Exendin-4 induces tenogenesis in human mesenchymal stem cells. Differentiation; research in biological diversity. vol 120. 2021-08-23. PMID:34062407. |
collectively, the levels of tendon-related transcription factors (mkx and scx) and extracellular matrix (col-i, dcn, bgn, and tnc) genes and proteins were elevated compared to media without ex-4 and other controls including insulin and igf-1 treatments. |
2021-08-23 |
2023-08-13 |
human |
| Tai-Wei Zhang, Ze-Fang Li, Wang Ding, Hui-Ren Wang, Sheng-Long Ding, Guan-Jie Han, Xi-Lei Li, Jian Dong, Li-Bo Jian. Decorin inhibits nucleus pulposus apoptosis by matrix-induced autophagy via the mTOR pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 8. 2021-08-09. PMID:33034924. |
dcn treatment also decreased the expression of matrix metalloproteinase-3 and -13 and decreased the il-1β-induced attenuation of collagen type ii and aggrecan levels. |
2021-08-09 |
2023-08-13 |
rat |
| Moritoshi Hirono, Fuyuki Karube, Yuchio Yanagaw. Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:34194302. |
second, we review the physiological roles of perineuronal nets (pnns), which are organized components of the extracellular matrix and enwrap the cell bodies and proximal processes, in gaba release from pcs to large glutamatergic dcn neurons and in cerebellar motor learning. |
2021-07-16 |
2023-08-13 |
Not clear |
| Toini Pemmari, Larisa Ivanova, Ulrike May, Prakash Lingasamy, Allan Tobi, Anja Pasternack, Stuart Prince, Olli Ritvos, Shreya Makkapati, Tambet Teesalu, Mitchell S Cairo, Tero A H Järvinen, Yanling Lia. Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa. Molecular therapy : the journal of the American Society of Gene Therapy. vol 28. issue 8. 2021-07-12. PMID:32497513. |
fusion of the truncated crk (tcrk) peptide to the c terminus of an extracellular matrix protein decorin (dcn), a natural tgf-β inhibitor, resulted in a skin-homing therapeutic molecule (dcn-tcrk). |
2021-07-12 |
2023-08-13 |
mouse |
| Xiaoding Hu, Emilly S Villodre, Richard Larson, Omar M Rahal, Xiaoping Wang, Yun Gong, Juhee Song, Savitri Krishnamurthy, Naoto T Ueno, Debu Tripathy, Wendy A Woodward, Bisrat G Debe. Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Communications biology. vol 4. issue 1. 2021-06-28. PMID:33452400. |
herein, we report that decorin (dcn), a small leucine-rich extracellular matrix proteoglycan, is downregulated in tumors from patients with ibc. |
2021-06-28 |
2023-08-13 |
mouse |
| Alexes C Daquinag, Zhanguo Gao, Cale Fussell, Kai Sun, Mikhail G Koloni. Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly. Cells. vol 9. issue 12. 2021-06-21. PMID:33317052. |
we demonstrate that mice ubiquitously lacking dcn gag (ngdcn mice) have reduced matrix rigidity, enlarged adipocytes, fragile skin, as well as skeletal muscle hypotrophy, fibrosis, and dysfunction. |
2021-06-21 |
2023-08-13 |
mouse |
| Alexes C Daquinag, Zhanguo Gao, Cale Fussell, Kai Sun, Mikhail G Koloni. Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly. Cells. vol 9. issue 12. 2021-06-21. PMID:33317052. |
this study reveals that the gag of dcn functions to regulate collagen assembly in adipose tissue and skeletal muscle and uncovers a new mechanism of matrix dysfunction in obesity and aging. |
2021-06-21 |
2023-08-13 |
mouse |
| Margareta Žlajpah, Nina Hauptman, Emanuela Boštjančič, Nina Zida. Differential expression of extracellular matrix‑related genes DCN, EPHA4, FN1, SPARC, SPON2 and SPP1 in colorectal carcinogenesis. Oncology reports. vol 42. issue 4. 2021-04-26. PMID:31524274. |
the present study validated the diagnostic and prognostic significance of 6 components of the extracellular matrix (ecm) that were identified in the previous bioinformatics analysis [decorin (dcn), erythropoietin‑producing hepatoma receptor a4 (epha4), fibronectin 1 (fn1), secreted protein acidic and cysteine rich (sparc), spondin 2 (spon2) and secreted phosphoprotein 1 (spp1)], by analyzing their gene and protein expression levels in all samples. |
2021-04-26 |
2023-08-13 |
Not clear |