| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiaoling Sun, Heng Li, Jing Lv, Weilin Shi, Yanfeng Bai, Ke Pan, Alice Che. Dopamine β-hydroxylase shapes intestinal inflammation through modulating T cell activation. Cellular immunology. vol 401-402. 2024-06-08. PMID:38850753. |
however, the role of dopamine beta-hydroxylase (dbh), an enzyme converting dopamine into norepinephrine, in modulating intestinal inflammation is not well defined. |
2024-06-08 |
2024-06-11 |
Not clear |
| Jovana Zlatkovic, Adrià Dalmau Gasull, Daniel Hägg, Ferran Font-Gironès, Jakob Bellman, Björn Meister, Vilborg Palsdottir, Johan Ruud, Claes Ohlsson, Suzanne L Dickson, Fredrik Anesten, John-Olov Jansso. Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary tract. Journal of neuroendocrinology. 2023-10-27. PMID:37885347. |
these neurones also expressed tyrosine hydroxylase (th) and dopamine-beta-hydroxylase (dbh), a pattern typical of norepinephrine neurones. |
2023-10-27 |
2023-11-08 |
mouse |
| Toshiharu Nagats. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-28. PMID:37638996. |
the author identified the genes and proteins of human enzymes involved in the biosynthesis of catecholamines (dopamine, norepinephrine, epinephrine) and tetrahydrobiopterin (bh4): tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), dopamine β-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt), and gtp cyclohydrolase i (gch1). |
2023-08-28 |
2023-09-07 |
human |
| Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Che. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Molecular brain. vol 16. issue 1. 2023-02-08. PMID:36750928. |
lncrna aabr07042999.1 and mrna tph2, slc6a4, dbh and th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both pfc and hip after emp exposure. |
2023-02-08 |
2023-08-14 |
rat |
| Mehmet Evren Öztürk, Anıl Yirün, Selinay Başak Erdemli-Köse, Aylin Balcı-Özyurt, Deniz Arca Çakır, Didem Oral, Pınar Erkekoğl. Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell line. Human & experimental toxicology. vol 41. 2022-11-21. PMID:36411272. |
nuclear factor erythroid 2-associated factor 2 (nrf2), norepinephrine (ne), dopamine transporter (dat) and dopamine beta β-hydroxylase (dbh) levels were measured by sandwich elisa kits while 8-hydroxy deoxyguanosine (8-ohdg) and dopamine levels were determined by competitive elisa kits. |
2022-11-21 |
2023-08-14 |
Not clear |
| Masahiro Nezu, Yosuke Hirotsu, Kenji Amemiya, Toru Tateno, Soichi Takizawa, Masaharu Inoue, Hitoshi Mochizuki, Kyoko Hosaka, Constance Chik, Toshio Oyama, Masao Omat. Paraganglioma with High Levels of Dopamine, Dopa Decarboxylase Suppression, Dopamine β-hydroxylase Upregulation and Intra-tumoral Melanin Accumulation: A Case Report with a Literature Review. Internal medicine (Tokyo, Japan). 2022-11-17. PMID:36384901. |
in this condition, intratumoral dopamine β-hydroxylase (dbh), which controls the conversion of norepinephrine from dopamine, is impaired, resulting in suppressed norepinephrine and epinephrine production. |
2022-11-17 |
2023-08-14 |
Not clear |
| Cristina S Fonseca, Nayara S S Aquino, Gleisy K N Goncalves, Lucas R Drummond, Laisa T M Hipolito, Juneo F Silva, Kaoma S C Silva, Patricia C Henriques, Talita E Domingues, Ana C R Lacerda, Silvia Guatimosim, Candido C Coimbra, Raphael E Szawka, Adelina M Rei. Norepinephrine modulation of heat dissipation in female rats lacking estrogen. Journal of neuroendocrinology. vol 34. issue 10. 2022-10-28. PMID:36306200. |
in the arc, the density of dopamine-ß-hydroxylase (dbh)-immunoreactive (ir) fibers was not altered by e2 but, importantly, dbh-ir terminals were found in close apposition to kisspeptin cells, revealing norepinephrine inputs to arc kisspeptin neurons. |
2022-10-28 |
2023-08-14 |
rat |
| Steven Lehrer, Peter H Rheinstei. α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. Journal of proteins and proteomics. vol 13. issue 2. 2022-10-24. PMID:36277464. |
a third enzyme, dopamine ß-hydroxylase (dbh), catalyzes the conversion of dopamine to norepinephrine. |
2022-10-24 |
2023-08-14 |
Not clear |
| Khulekani Mncube, Marisa Möller, Brian H Harve. Post-weaning Social Isolated Flinders Sensitive Line Rats Display Bio-Behavioural Manifestations Resistant to Fluoxetine: A Model of Treatment-Resistant Depression. Frontiers in psychiatry. vol 12. 2021-12-07. PMID:34867504. |
post-mortem cortico-hippocampal norepinephrine (ne), serotonin (5-ht), and dopamine (da), as well as plasma interleukin 6 (il-6), tumour necrosis factor alpha (tnf-α), corticosterone (cort), and dopamine-beta-hydroxylase (dbh) levels were assayed. |
2021-12-07 |
2023-08-13 |
rat |
| Sharonda Harris, Renee Afram, Takashi Shimano, Bozena Fyk-Kolodziej, Paul D Walker, Rod D Braun, Avril Genene Hol. Dopamine in Auditory Nuclei and Lemniscal Projections is Poised to Influence Acoustic Integration in the Inferior Colliculus. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:33746717. |
immunolabeling for dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyltransferase (pnmt), enzymes responsible for the synthesis of norepinephrine (ne) and epinephrine (e), respectively, were evaluated. |
2021-07-16 |
2023-08-13 |
rat |
| Meijia Li, Miren Dong, Weilin Wang, Huan Li, Zhaoqun Liu, Lingling Wang, Kejian Wang, Linsheng Son. A membrane-bound dopamine β-hydroxylase highly expressed in granulocyte of Pacific oyster Crassostrea gigas. Developmental and comparative immunology. vol 104. 2021-06-23. PMID:31785266. |
dopamine β-hydroxylase (dbh) is one of key rate-limiting enzymes converting dopamine to norepinephrine. |
2021-06-23 |
2023-08-13 |
mouse |
| Wei-Chien Tang, Ya-Wen Chang, Mingtian Che, Mei-Hui Wang, Keith K Lai, Patrick T Fueger, Wendong Huang, Shwu-Bin Lin, Keane K Y La. Thioacetamide-induced norepinephrine production by hepatocytes is associated with hepatic stellate cell activation and liver fibrosis. Current molecular pharmacology. 2021-05-05. PMID:33845730. |
such persistent hsc activation could be mediated by norepinephrine (ne), a reaction product of dopamine beta-hydroxylase (dbh). |
2021-05-05 |
2023-08-13 |
Not clear |
| Zhong-Wen Chang, Yi-Chun Yeh, Chin-Chyuan Chan. Role of novel protein kinase C in neuroendocrine-immune regulatory network in haemocytes of Litopenaeus vannamei: An in vitro approach. Fish & shellfish immunology. vol 105. 2021-04-16. PMID:32645515. |
the same deviated pattern was observed in tyrosine, dopamine, and norepinephrine levels, and in dopamine β-hydroxylase (dbh) activity and gene expressions of tyrosine hydroxylase, dopa decarboxylase, and dbh involving in ba biosynthesis. |
2021-04-16 |
2023-08-13 |
Not clear |
| Toyanji J Punchaichira, Anirban Mukhopadhyay, Prachi Kukshal, Triptish Bhatia, Smita N Deshpande, B K Thelm. Association of regulatory variants of dopamine β-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects. Journal of psychopharmacology (Oxford, England). vol 34. issue 3. 2021-02-03. PMID:31913053. |
dopamine-β-hydroxylase (dbh, ec 1.14.17.1), which converts dopamine to norepinephrine, is a candidate gene in neuropsychiatric diseases. |
2021-02-03 |
2023-08-13 |
human |
| Kenichi Katsurada, Masanori Nakata, Toshinobu Saito, Boyang Zhang, Yuko Maejima, Shyam S Nandi, Neeru M Sharma, Kaushik P Patel, Kazuomi Kario, Toshihiko Yad. Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31537818. |
in parallel, it suppressed urinary norepinephrine excretion, and induced c-fos expressions in the area postrema (ap) and nucleus tractus solitarius (nts) of brainstem including the nts neurons immunoreactive to dopamine beta-hydroxylase (dbh). |
2020-10-22 |
2023-08-13 |
rat |
| Bruno Igreja, Nuno Pires, Ana Loureiro, Lyndon Wright, Patrício Soares-da-Silv. Cardiometabolic and Inflammatory Benefits of Sympathetic Down-Regulation with Zamicastat in Aged Spontaneously Hypertensive Rats. ACS pharmacology & translational science. vol 2. issue 5. 2020-09-28. PMID:32259069. |
one strategy to mitigate the sns overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine β-hydroxylase (dbh). |
2020-09-28 |
2023-08-13 |
rat |
| Bruno Igreja, Nuno Pires, Ana Loureiro, Lyndon Wright, Patrício Soares-da-Silv. Cardiometabolic and Inflammatory Benefits of Sympathetic Down-Regulation with Zamicastat in Aged Spontaneously Hypertensive Rats. ACS pharmacology & translational science. vol 2. issue 5. 2020-09-28. PMID:32259069. |
zamicastat is a new dbh inhibitor that decreases norepinephrine and increases dopamine levels in peripherally sympathetic-innervated tissues. |
2020-09-28 |
2023-08-13 |
rat |
| Bruno Igreja, Nuno Pires, Ana Loureiro, Lyndon Wright, Patrício Soares-da-Silv. Cardiometabolic and Inflammatory Benefits of Sympathetic Down-Regulation with Zamicastat in Aged Spontaneously Hypertensive Rats. ACS pharmacology & translational science. vol 2. issue 5. 2020-09-28. PMID:32259069. |
in conclusion, dbh inhibition decreased norepinephrine levels, reduced end-organ damage, and improved cardiometabolic and inflammatory biomarkers in aged male shrs. |
2020-09-28 |
2023-08-13 |
rat |
| Shubhrajit Roy, Sampurna Ghosh, Sreyashi Bhattacharya, Arpan Saha, Shyamal Kumar Das, Prasanta Kumar Gangopadhyay, Ashish Bavdekar, Kunal Ray, Mainak Sengupta, Jharna Ra. Dopamine β hydroxylase (DBH) polymorphisms do not contribute towards the clinical course of Wilson's disease in Indian patients. The journal of gene medicine. vol 21. issue 9. 2020-07-17. PMID:31265749. |
dopamine β hydroxylase (dbh) encodes a copper-dependent mono-oxygenase that converts dopamine to norepinephrine, thereby regulating the endogenous dopamine content in the neurons. |
2020-07-17 |
2023-08-13 |
Not clear |
| Wiebke Bensmann, Nicolas Zink, Larissa Arning, Christian Beste, Ann-Kathrin Stoc. The Presynaptic Regulation of Dopamine and Norepinephrine Synthesis Has Dissociable Effects on Different Kinds of Cognitive Conflicts. Molecular neurobiology. vol 56. issue 12. 2020-04-06. PMID:31183808. |
we investigated the effects of presynaptic differences in dopamine and norepinephrine synthesis with the help of the tyrosine hydroxylase (th) rs10770141 and the dopamine-β-hydroxylase (dbh) rs1611115, rs6271, and rs1611122 polymorphisms. |
2020-04-06 |
2023-08-13 |
human |