| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuqing Chen, Gen Wen, Fangwen Rao, Kuixing Zhang, Lei Wang, Juan L Rodriguez-Flores, Amber P Sanchez, Manjula Mahata, Laurent Taupenot, Ping Sun, Sushil K Mahata, Bamidele Tayo, Nicholas J Schork, Michael G Ziegler, Bruce A Hamilton, Daniel T O'Conno. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. Journal of hypertension. vol 28. issue 1. 2010-03-09. PMID:20009769. |
dopamine beta-hydroxylase (dbh) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. |
2010-03-09 |
2023-08-12 |
human |
| Sudhirkumar U Yanpallewar, Kimberly Fernandes, Swananda V Marathe, Krishna C Vadodaria, Dhanisha Jhaveri, Karen Rommelfanger, Uma Ladiwala, Shanker Jha, Verena Muthig, Lutz Hein, Perry Bartlett, David Weinshenker, Vidita A Vaidy. Alpha2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 3. 2010-02-05. PMID:20089918. |
these effects persist in dopamine beta-hydroxylase knock-out (dbh(-/-)) mice lacking norepinephrine, supporting a role for alpha(2)-heteroceptors on progenitor cells, rather than alpha(2)-autoreceptors on noradrenergic neurons that inhibit norepinephrine release. |
2010-02-05 |
2023-08-12 |
mouse |
| Ljubica Gavrilovic, Natasa Spasojevic, Sladjana Dronja. Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats. Autonomic neuroscience : basic & clinical. vol 150. issue 1-2. 2009-11-16. PMID:19482560. |
in this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyltransferase (pnmt) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. |
2009-11-16 |
2023-08-12 |
rat |
| Jena J Steinle, Timothy S Kern, Steven A Thomas, Lisa S McFadyen-Ketchum, Christopher P Smit. Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice. Experimental eye research. vol 88. issue 6. 2009-10-08. PMID:19176214. |
to test this, retinas from non-diabetic dopamine beta hydroxylase (dbh, dbh(-/-)) knockout mice and their littermate controls were assessed for diabetic-like capillary and neural changes at 5 months of age. |
2009-10-08 |
2023-08-12 |
mouse |
| Mitsuhiro Kamata, Akihito Suzuki, Yoshihiko Matsumoto, Naoshi Shibuya, Hitoshi Togashi, Kaoru Goto, Koichi Otan. Association study between the -1021C/T polymorphism of the dopamine-beta-hydroxylase gene promoter and personality traits in healthy subjects. Neuroscience letters. vol 462. issue 1. 2009-10-07. PMID:19560519. |
dopamine-beta-hydroxylase (dbh) is the enzyme responsible for conversion of dopamine to norepinephrine, and thus plays an important role in controlling dispositions of these neurotransmitters. |
2009-10-07 |
2023-08-12 |
human |
| Yan Fan, Jingjing Huang, Niamh Kieran, Meng-Yang Zh. Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells. Journal of neurochemistry. vol 110. issue 5. 2009-09-21. PMID:19573018. |
in the present study, we examined the possible effect of phox2a/2b on the in vitro expression of the norepinephrine transporter (net) and dopamine beta-hydroxylase (dbh), two important markers of the noradrenergic system. |
2009-09-21 |
2023-08-12 |
human |
| Diana C Parrish, Eric N Alston, Hermann Rohrer, Sam M Hermes, Sue A Aicher, Paul Nkadi, William R Woodward, Jutta Stubbusch, Ryan T Gardner, Beth A Habecke. Absence of gp130 in dopamine beta-hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias. American journal of physiology. Heart and circulatory physiology. vol 297. issue 3. 2009-09-21. PMID:19592611. |
to examine the effect of gp130 cytokines on cardiac nerves, we used gp130(dbh-cre/lox) mice, which have a selective deletion of the gp130 cytokine receptor in neurons expressing dopamine beta-hydroxylase (dbh). |
2009-09-21 |
2023-08-12 |
mouse |
| F Fernandez, N Colson, S Quinlan, J MacMillan, R A Lea, L R Griffith. Association between migraine and a functional polymorphism at the dopamine beta-hydroxylase locus. Neurogenetics. vol 10. issue 3. 2009-09-16. PMID:19219470. |
our laboratory has previously reported association of migraine with a promoter str marker in the dopamine beta hydroxylase (dbh) gene. |
2009-09-16 |
2023-08-12 |
Not clear |
| F Fernandez, N Colson, S Quinlan, J MacMillan, R A Lea, L R Griffith. Association between migraine and a functional polymorphism at the dopamine beta-hydroxylase locus. Neurogenetics. vol 10. issue 3. 2009-09-16. PMID:19219470. |
varying dbh activity levels have been postulated to be involved in migraine process with an increase of dopamine, resulting from a lower dbh activity shown positively correlated with migraine severity. |
2009-09-16 |
2023-08-12 |
Not clear |
| D Russo, C Mongardi Fantaguzzi, G Di Guardo, P Clavenzani, G Lalatta Costerbosa, C Ligios, R Chiocchett. Characterization of sheep (Ovis aries) palatine tonsil innervation. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19364524. |
immunoreactivity (ir) for tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), neuronal nitric oxide synthase (nnos), calcitonin gene-related peptide (cgrp), substance p (sp), and calcium-binding protein s100 (s100), was observed in the fibers around and within pt lymphoid nodules. |
2009-08-24 |
2023-08-12 |
Not clear |
| David S Goldstein, Courtney S Holmes, Stephen G Kale. Relative efficiencies of plasma catechol levels and ratios for neonatal diagnosis of menkes disease. Neurochemical research. vol 34. issue 8. 2009-08-20. PMID:19234788. |
menkes disease can be detected by relatively high concentrations of dopamine (da) and its metabolites compared to norepinephrine (ne) and its metabolites, presumably because dopamine-beta-hydroxylase (dbh) requires copper as a co-factor. |
2009-08-20 |
2023-08-12 |
Not clear |
| A Bai, N Lu, Y Guo, J Chen, Z Li. Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis. Clinical and experimental immunology. vol 156. issue 2. 2009-06-24. PMID:19250273. |
the expression of tyrosine hydroxylase (th) and dopamine b-hydroxylase (dbh), two rate-limiting enzymes in catecholamine synthesis, was detected by immunohistochemistry in murine colitis. |
2009-06-24 |
2023-08-12 |
mouse |
| Xun Tang, Song Guo, Hongqiang Sun, Xuemei Song, Zuonin Jiang, Lixiang Sheng, Dongfeng Zhou, Yonghua Hu, Dafang Che. Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. Pharmacogenetics and genomics. vol 19. issue 5. 2009-06-17. PMID:19415821. |
in this study, we investigated the association and multilocus gene-gene interactions of cytochrome p450 2a6 (cyp2a6), dopamine beta-hydroxylase (dbh), catechol o-methyl transferase (comt), and monoamine oxidase a (maoa) polymorphisms with smoking behavior in a community-based chinese male population. |
2009-06-17 |
2023-08-12 |
Not clear |
| Ralf Gilsbach, Christoph Röser, Nadine Beetz, Marc Brede, Kerstin Hadamek, Miriam Haubold, Jost Leemhuis, Melanie Philipp, Johanna Schneider, Michal Urbanski, Bela Szabo, David Weinshenker, Lutz Hei. Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells. Molecular pharmacology. vol 75. issue 5. 2009-05-05. PMID:19251826. |
to determine whether alpha(2)-adrenoceptors on adrenergic neurons or alpha(2)-adrenoceptors on nonadrenergic neurons mediate the physiological and pharmacological responses of alpha(2)-agonists, we used the dopamine beta-hydroxylase (dbh) promoter to drive expression of alpha(2a)-adrenoceptors exclusively in noradrenergic and adrenergic cells of transgenic mice. |
2009-05-05 |
2023-08-12 |
mouse |
| C Hess, A Reif, A Strobel, A Boreatti-Hümmer, M Heine, K-P Lesch, C P Jaco. A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 2. 2009-04-30. PMID:18982239. |
moreover, information about the role of dopamine beta-hydroxylase (dbh) genotype, which explains a large part of the variance of enzymatic activity, in affective disorders and personality dimensions is limited. |
2009-04-30 |
2023-08-12 |
human |
| Owen A Ross, Michael G Heckman, Alexandra I Soto, Nancy N Diehl, Kristoffer Haugarvoll, Carles Vilariño-Güell, Jan O Aasly, Sigrid Sando, J Mark Gibson, Timothy Lynch, Anna Krygowska-Wajs, Grzegorz Opala, Maria Barcikowska, Krzysztof Czyzewski, Ryan J Uitti, Zbigniew K Wszolek, Matthew J Farre. Dopamine beta-hydroxylase -1021C>T association and Parkinson's disease. Parkinsonism & related disorders. vol 14. issue 7. 2009-04-14. PMID:18722802. |
a single nucleotide polymorphism in the promoter region of the dopamine beta-hydroxylase gene (dbh -1021c>t; rs1611115) is reported to regulate plasma enzyme activity levels. |
2009-04-14 |
2023-08-12 |
Not clear |
| Ciara M Greene, Mark A Bellgrove, Michael Gill, Ian H Robertso. Noradrenergic genotype predicts lapses in sustained attention. Neuropsychologia. vol 47. issue 2. 2009-04-13. PMID:18973765. |
the balance of dopamine and noradrenaline in the cortex is controlled by the dbh gene. |
2009-04-13 |
2023-08-12 |
human |
| Patrick Slama, Jean-Luc Boucher, Marius Réglie. N-Hydroxyguanidines oxidation by a N3S copper-complex mimicking the reactivity of Dopamine beta-Hydroxylase. Journal of inorganic biochemistry. vol 103. issue 3. 2009-04-10. PMID:19178946. |
some of these compounds are substrates for the heme-containing enzymes nitric-oxide synthases (nos) and act as reducing co-substrates for the copper-containing enzyme dopamine beta-hydroxylase (dbh) [p. slama, j.l. |
2009-04-10 |
2023-08-12 |
Not clear |
| Patrick Slama, Jean-Luc Boucher, Marius Réglie. N-Hydroxyguanidines oxidation by a N3S copper-complex mimicking the reactivity of Dopamine beta-Hydroxylase. Journal of inorganic biochemistry. vol 103. issue 3. 2009-04-10. PMID:19178946. |
dbh catalyses the hydroxylation of the important neurotransmitter dopamine into norepinephrine in the presence of both molecular oxygen and a reducing co-substrate. |
2009-04-10 |
2023-08-12 |
Not clear |
| Lina Almarestani, Geraldine Longo, Alfredo Ribeiro-da-Silv. Autonomic fiber sprouting in the skin in chronic inflammation. Molecular pain. vol 4. 2009-03-20. PMID:19014600. |
antibodies directed towards calcitonin gene-related peptide (cgrp) and dopamine beta-hydroxylase (dbh) were used for the staining of peptidergic and sympathetic fibers, respectively. |
2009-03-20 |
2023-08-12 |
rat |