| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Che-Hung Yen, Mei-Chen Shih, Cheng-Yi Cheng, Kuo-Hsing Ma, Ru-Band Lu, San-Yuan Huan. Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence. Medicine. vol 95. issue 33. 2017-02-07. PMID:27537550. |
the dopamine transporter (dat) plays a crucial role in the pathogenesis of alcohol dependence (ad) and major depression (md), and males have more risk factors for the development of ad. |
2017-02-07 |
2023-08-13 |
human |
| Carlo Rossi, Dario Genovesi, Paolo Marzullo, Assuero Giorgetti, Elena Filidei, Giovanni Umberto Corsini, Ubaldo Bonuccelli, Roberto Ceravol. Striatal Dopamine Transporter Modulation After Rotigotine: Results From a Pilot Single-Photon Emission Computed Tomography Study in a Group of Early Stage Parkinson Disease Patients. Clinical neuropharmacology. vol 40. issue 1. 2017-01-24. PMID:27941527. |
several in vitro data have reported negative interference by dopamine-agonists on the expression of dopamine transporter (dat), whereas the majority of imaging studies have shown that neither l-dopa nor dopamine-agonists interfere with dat availability. |
2017-01-24 |
2023-08-13 |
Not clear |
| Nanami Okano, Mamoru Niitsu, Junji Tanaka, Takahiro Sasaki, Kazushi Takahashi, Nobuo Araki, Toshimasa Yamamoto, Shintaro Nakano, Shigeyuki Nishimura, Takaaki Senbonmatsu, Ichiro Matsunar. Comparison of Dopamine Transporter SPECT and 123I-MIBG Myocardial Scintigraphy to Assess Clinical Severity in Patients With Parkinson Disease. Clinical nuclear medicine. vol 42. issue 1. 2017-01-18. PMID:27775946. |
the aim of our study was to evaluate the use of dopamine transporter (dat) spect and i-mibg myocardial scintigraphy to determine the clinical severity of parkinson disease (pd), with a focus on motor impairments affecting activities of daily living (adls). |
2017-01-18 |
2023-08-13 |
Not clear |
| Wolfgang H Oertel, Guenther Deuschl, Karla Egger. [The Competence Network Parkinson (CNP)]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. vol 59. issue 4. 2017-01-17. PMID:26961981. |
the cnp designed and established one of the first electronic internet-based data entry systems (secutrial®) - fulfilling the legal standards of data safety and security - a material bank for genetic research on parkinson's disease (pd), implemented and investigated new methods for early diagnosis of pd and related atypical ps including in vivo dopamine transporter imaging (dat spect), established the german parkinson study group (gps-pharma) with 40 certified trial centres for pharmacotherapeutical trials and the german interdisciplinary parkinson study group (neurology and neurosurgery) for deep brain stimulation (gps-dbs), and carried out several pharmacoeconomic and health care studies on pd in germany. |
2017-01-17 |
2023-08-13 |
Not clear |
| Dustin P Brown, Dennis T Rogers, Francois Pomerleau, Kirin B Siripurapu, Manish Kulshrestha, Greg A Gerhardt, John M Littleto. Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis. Fitoterapia. vol 111. 2017-01-17. PMID:27105955. |
in vivo electrochemical studies in urethane-anesthetized rats demonstrated that lobinaline locally applied in the striatum significantly prolonged clearance of exogenous da by the dopamine transporter (dat). |
2017-01-17 |
2023-08-13 |
rat |
| Takuya Konno, Owen A Ross, Robert E Wharen, Ryan J Uitti, Zbigniew K Wszole. Deep brain stimulation for levodopa-refractory benign tremulous parkinsonism. Neurologia i neurochirurgia polska. vol 50. issue 5. 2017-01-13. PMID:27591066. |
the dopamine transporter (dat) imaging showed reduced tracer uptake in the putamen bilaterally, more so on the right side. |
2017-01-13 |
2023-08-13 |
Not clear |
| Takuya Konno, Owen A Ross, Robert E Wharen, Ryan J Uitti, Zbigniew K Wszole. Deep brain stimulation for levodopa-refractory benign tremulous parkinsonism. Neurologia i neurochirurgia polska. vol 50. issue 5. 2017-01-13. PMID:27591066. |
the dat imaging abnormalities indicate the presynaptic dopamine deficiency. |
2017-01-13 |
2023-08-13 |
Not clear |
| Chang Soon Choi, Pitna Kim, Jin Hee Park, Edson Luck T Gonzales, Ki Chan Kim, Kyu Suk Cho, Mee Jung Ko, Sung Min Yang, Hana Seung, Seol-Heui Han, Jong Hoon Ryu, Jae Hoon Cheong, Chan Young Shi. High sucrose consumption during pregnancy induced ADHD-like behavioral phenotypes in mice offspring. The Journal of nutritional biochemistry. vol 26. issue 12. 2016-12-13. PMID:26452319. |
in the striatum, a significantly increased dopamine transporter (dat) mrna expression was found in the suc9 group along with dose-dependent decreases in the drd1, drd2 and drd4 dopamine receptor subtypes. |
2016-12-13 |
2023-08-13 |
mouse |
| Elina Jaakkola, Juho Joutsa, Valtteri Kaasine. Predictors of normal and abnormal outcome in clinical brain dopamine transporter imaging. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 3. 2016-12-13. PMID:26676600. |
brain dopamine transporter (dat) imaging with [(123)i]fp-cit spect can be used to evaluate the integrity of the mesostriatal dopaminergic system in patients with clinically uncertain parkinsonism. |
2016-12-13 |
2023-08-13 |
Not clear |
| Blake A Hutsell, Michael H Baumann, John S Partilla, Matthew L Banks, Rakesh Vekariya, Richard A Glennon, S Stevens Negu. Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26738428. |
for neurochemical studies, drug effects were evaluated on monoamine release through dopamine, norepinephrine, and serotonin transporters (dat, net and sert, respectively) in rat brain synaptosomes. |
2016-12-13 |
2023-08-13 |
rat |
| Pedro Barroso-Chinea, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Javier Castro-Hernández, Josmar Salas-Hernández, Abdelwahed Chtarto, Diego Luis-Ravelo, Marie Humbert-Claude, Liliane Tenenbaum, Tomás González-Hernánde. Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. Neurobiology of disease. vol 88. 2016-12-13. PMID:26777664. |
the dopamine (da) transporter (dat) is a plasma membrane glycoprotein expressed in dopaminergic (da-) cells that takes back da into presynaptic neurons after its release. |
2016-12-13 |
2023-08-13 |
human |
| Jae Jung Lee, Jungsu S Oh, Jee H Ham, Dong H Lee, Injoo Lee, Young H Sohn, Jae S Kim, Phil Hyu Le. Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease. Neurobiology of aging. vol 38. 2016-12-13. PMID:26827658. |
the relationships between bmi and dopamine transporter (dat) activity were analyzed using linear regression analysis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Matthew L Banks, Douglas A Smith, Bruce E Bloug. Methamphetamine-like discriminative stimulus effects of bupropion and its two hydroxy metabolites in male rhesus monkeys. Behavioural pharmacology. vol 27. issue 2-3 Spec Issue. 2016-12-13. PMID:26886209. |
the dopamine transporter (dat) inhibitor and nicotinic acetylcholine (nach) receptor antagonist bupropion is being investigated as a candidate 'agonist' medication for methamphetamine addiction. |
2016-12-13 |
2023-08-13 |
monkey |
| Jing Xiong, Xiaowei Zhang, Jinsha Huang, Chunnuan Chen, Zhenzhen Chen, Ling Liu, Guoxin Zhang, Jiaolong Yang, Zhentao Zhang, Zhaohui Zhang, Zhicheng Lin, Nian Xiong, Tao Wan. Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25575680. |
decreased tyrosine hydroxylase (th) and vesicular monoamine transporter 2 (vmat2) immunoreactivity, while increased dopamine transporter (dat) immunoreactivity were observed in rats of either i.p or st group 60 days after the last exposure to fenpropathrin. |
2016-11-14 |
2023-08-13 |
rat |
| J D Slade, B E Stavele. Manipulation of components that control feeding behavior in Drosophila melanogaster increases sensitivity to amino acid starvation. Genetics and molecular research : GMR. vol 15. issue 1. 2016-11-11. PMID:26909968. |
a neural hormone regulator, the dopamine transporter (dat), works to clear dopamine from the synapses. |
2016-11-11 |
2023-08-13 |
drosophila_melanogaster |
| Louis J De Felic. Chloride requirement for monoamine transporters. Pflugers Archiv : European journal of physiology. vol 468. issue 3. 2016-11-04. PMID:26794730. |
this review focuses on the cl(-) requirement for dopamine, serotonin, and norepinephrine (da, 5-ht, and ne) transport and induced current via the transporters for these transmitters, dat, sert, and net. |
2016-11-04 |
2023-08-13 |
Not clear |
| Hae Won Kim, Jae Seung Kim, Minyoung Oh, Jungsu S Oh, Sang Joo Lee, Seung Jun Oh, Sun Ju Chung, Chong Sik Le. Different loss of dopamine transporter according to subtype of multiple system atrophy. European journal of nuclear medicine and molecular imaging. vol 43. issue 3. 2016-11-01. PMID:26384682. |
the aim of this study was to evaluate whether striatal dopamine transporter (dat) loss as measured by (18)f-fluorinated-n-3-fluoropropyl-2-b-carboxymethoxy-3-b-(4-iodophenyl) nortropane ([(18)f]fp-cit) pet differs according to the metabolic subtype of multiple system atrophy (msa) as assessed by [(18)f]fdg pet. |
2016-11-01 |
2023-08-13 |
Not clear |
| Paola A Spadaro, Helen L Naug, Eugene F DU Toit, Daniel Donner, Natalie J Colso. A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity. Genetics research. vol 97. 2016-11-01. PMID:26707058. |
real-time pcr was applied to determine any variation in levels of expression of the serotonin (slc6a4 or sert) and dopamine transporter (slc6a3 or dat) genes. |
2016-11-01 |
2023-08-13 |
rat |
| HongNa Yang, Jing Wang, Feng Wang, XiaoDun Liu, Heng Chen, WeiMing Duan, TingYu Q. Dopaminergic Neuronal Differentiation from the Forebrain-Derived Human Neural Stem Cells Induced in Cultures by Using a Combination of BMP-7 and Pramipexole with Growth Factors. Frontiers in neural circuits. vol 10. 2016-10-31. PMID:27147976. |
fluorescent examination showed that about 25% of cells became th-positive neurons at 24 h, about 5% of cells became vmat2 (vascular monoamine transporter 2)-positive neurons, and less than 5% of cells became dat (dopamine transporter)-positive neurons at 72 h following differentiation in cultures. |
2016-10-31 |
2023-08-13 |
human |
| Anna-Maija Penttinen, Ilida Suleymanova, Katrina Albert, Jenni Anttila, Merja H Voutilainen, Mikko Airavaar. Characterization of a new low-dose 6-hydroxydopamine model of Parkinson's disease in rat. Journal of neuroscience research. vol 94. issue 4. 2016-10-25. PMID:26762168. |
this study compares seven experimental settings in a single study on d-amphetamine-induced rotations, tyrosine hydroxylase (th)-positive neurites in the striatum, dopamine transporter (dat)-positive neurites in the striatum, and th-positive cells in the substantia nigra pars compacta (snpc) in rats. |
2016-10-25 |
2023-08-13 |
rat |