| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nora D Volkow, Gene-Jack Wang, Lisa Smith, Joanna S Fowler, Frank Telang, Jean Logan, Dardo Tomas. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. NeuroImage. vol 121. 2016-07-20. PMID:26208874. |
methamphetamine's widepread abuse and concerns that it might increase parkinson's disease led us to assess if the reported loss of dopamine transporters (dat) in methamphetamine abusers (ma) reflected damage to dopamine neurons. |
2016-07-20 |
2023-08-13 |
Not clear |
| Nora D Volkow, Gene-Jack Wang, Lisa Smith, Joanna S Fowler, Frank Telang, Jean Logan, Dardo Tomas. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. NeuroImage. vol 121. 2016-07-20. PMID:26208874. |
using pet with [(11)c]cocaine to measure dat, and with [(11)c]raclopride to measure dopamine release (assessed as changes in specific binding of [(11)c]raclopride between placebo and methylphenidate), which was used as a marker of dopamine neuronal function, we show that ma (n=16), tested during early detoxification, had lower dat (20-30%) but overall normal da release in striatum (except for a small decrease in left putamen), when compared to controls (n=15). |
2016-07-20 |
2023-08-13 |
Not clear |
| Nora D Volkow, Gene-Jack Wang, Lisa Smith, Joanna S Fowler, Frank Telang, Jean Logan, Dardo Tomas. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. NeuroImage. vol 121. 2016-07-20. PMID:26208874. |
ma who remained abstinent nine-months later (n=9) showed significant increases in dat (20%) but methylphenidate-induced dopamine increases did not change. |
2016-07-20 |
2023-08-13 |
Not clear |
| Nora D Volkow, Gene-Jack Wang, Lisa Smith, Joanna S Fowler, Frank Telang, Jean Logan, Dardo Tomas. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. NeuroImage. vol 121. 2016-07-20. PMID:26208874. |
in contrast, in controls, dat did not change when retested 9 months later but methylphenidate-induced dopamine increases in ventral striatum were reduced (p=0.05). |
2016-07-20 |
2023-08-13 |
Not clear |
| Nora D Volkow, Gene-Jack Wang, Lisa Smith, Joanna S Fowler, Frank Telang, Jean Logan, Dardo Tomas. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. NeuroImage. vol 121. 2016-07-20. PMID:26208874. |
the loss of dat in the ma, which was not associated with a concomitant reduction in dopamine release as would have been expected if dat loss reflected da terminal degneration; as well as the recovery of dat after protracted detoxification, which was not associated with increased dopamine release as would have been expected if dat increases reflected terminal regeneration, indicate that the loss of dat in these ma does not reflect degeneration of dopamine terminals. |
2016-07-20 |
2023-08-13 |
Not clear |
| Mia Apuschkin, Sara Stilling, Troels Rahbek-Clemmensen, Gunnar Sørensen, Guillaume Fortin, Freja Herborg Hansen, Jacob Eriksen, Louis-Eric Trudeau, Kristoffer Egerod, Ulrik Gether, Mattias Rickha. A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. The European journal of neuroscience. vol 42. issue 7. 2016-07-20. PMID:26286107. |
here, a bacterial artificial chromosome mouse line [dat1-enhanced green fluorescent protein (egfp)] from the gene expression nervous system atlas (gensat) that expresses egfp under control of the dopamine transporter (dat) promoter was characterized. |
2016-07-20 |
2023-08-13 |
mouse |
| Sandra Noble, Rafael Godoy, Pierre Affaticati, Marc Ekke. Transgenic Zebrafish Expressing mCherry in the Mitochondria of Dopaminergic Neurons. Zebrafish. vol 12. issue 5. 2016-07-19. PMID:26355474. |
to visualize mitochondria in dopaminergic neurons of live zebrafish, we used the regulatory elements of the dopamine transporter (dat) gene to target a reporter, mcherry, after fusion with the mitochondrial localizing signal (mls) of tom20. |
2016-07-19 |
2023-08-13 |
zebrafish |
| Aaron Janowsky, Dilip K Tosh, Amy J Eshleman, Kenneth A Jacobso. Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26813929. |
thirty-two congeneric rigid adenine nucleoside derivatives containing a north (n)-methanocarba ribose substitution and a 2-arylethynyl group either enhanced (up to 760% of control) or inhibited [(125)i] methyl (1r,2s,3s)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (rti-55) binding at the human dopamine (da) transporter (dat) and inhibited da uptake. |
2016-07-19 |
2023-08-13 |
human |
| Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausc. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. PloS one. vol 11. issue 2. 2016-07-14. PMID:26863431. |
to control for this, we evaluated the binding parameters of azidobupramine to known target sites such as the transporters for serotonin (sert), norepinephrine (net), and dopamine (dat). |
2016-07-14 |
2023-08-13 |
Not clear |
| Min Sun Choi, Bang-sub Choi, Sang Heon Kim, Sok Cheon Pak, Chul Ho Jang, Young-Won Chin, Young-Mi Kim, Dong-il Kim, Songhee Jeon, Byung-Soo Ko. Essential Oils from the Medicinal Herbs Upregulate Dopamine Transporter in Rat Pheochromocytoma Cells. Journal of medicinal food. vol 18. issue 10. 2016-07-13. PMID:26295793. |
the dopamine transporter (dat) protein, a component of the dopamine system, undergoes adaptive neurobiological changes from drug abuse. |
2016-07-13 |
2023-08-13 |
rat |
| Min Sun Choi, Bang-sub Choi, Sang Heon Kim, Sok Cheon Pak, Chul Ho Jang, Young-Won Chin, Young-Mi Kim, Dong-il Kim, Songhee Jeon, Byung-Soo Ko. Essential Oils from the Medicinal Herbs Upregulate Dopamine Transporter in Rat Pheochromocytoma Cells. Journal of medicinal food. vol 18. issue 10. 2016-07-13. PMID:26295793. |
our study implies that the essential oils may rehabilitate brain dopamine function through increased dat availability in abstinent former drug users. |
2016-07-13 |
2023-08-13 |
rat |
| Akira Maebatake, Ayaka Imamura, Yui Kodera, Yasuo Yamashita, Kazuhiko Himuro, Shingo Baba, Kenta Miwa, Masayuki Sasak. Evaluation of Iterative Reconstruction Method and Attenuation Correction in Brain Dopamine Transporter SPECT Using an Anthropomorphic Striatal Phantom. Asia Oceania journal of nuclear medicine & biology. vol 4. issue 2. 2016-07-13. PMID:27408895. |
the aim of this study was to determine the optimal reconstruction parameters for iterative reconstruction in different devices and collimators for dopamine transporter (dat) single-photon emission computed tomography (spect). |
2016-07-13 |
2023-08-13 |
Not clear |
| John Caltagarone, Shiqi Ma, Alexander Sorki. Dopamine transporter is enriched in filopodia and induces filopodia formation. Molecular and cellular neurosciences. vol 68. 2016-07-11. PMID:25936602. |
dopamine transporter (dat, slc6a3) controls dopamine (da) neurotransmission by mediating re-uptake of extracellular da into da neurons. |
2016-07-11 |
2023-08-13 |
Not clear |
| C E Wiers, E Shumay, N D Volkow, H Frieling, A Kotsiari, J Lindenmeyer, H Walter, F Bermpoh. Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism. Translational psychiatry. vol 5. 2016-07-11. PMID:26418276. |
the methylation state of the dopamine transporter gene (dat) has been associated with alcohol dependence, craving and depression, but its influence on neural alcohol cue reactivity has not been tested. |
2016-07-11 |
2023-08-13 |
Not clear |
| H E Vuong, L Pérez de Sevilla Müller, C N Hardi, D G McMahon, N C Brech. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines. Neuroscience. vol 307. 2016-07-06. PMID:26335381. |
this report compares transgene expression in the retina of a tyrosine hydroxylase (th)-red fluorescent protein (rfp) mouse line with three catecholamine-related cre recombinase mouse lines [th-bacterial artificial chromosome (bac)-, th-, and dopamine transporter (dat)-cre] that were crossed with a rosa26-tdtomato reporter line. |
2016-07-06 |
2023-08-13 |
mouse |
| P V Lovell, B Kasimi, J Carleton, T A Velho, C V Mell. Living without DAT: Loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles). Scientific reports. vol 5. 2016-06-28. PMID:26364979. |
living without dat: loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles). |
2016-06-28 |
2023-08-13 |
Not clear |
| P V Lovell, B Kasimi, J Carleton, T A Velho, C V Mell. Living without DAT: Loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles). Scientific reports. vol 5. 2016-06-28. PMID:26364979. |
the dopamine transporter (dat) is a major regulator of synaptic dopamine (da) availability. |
2016-06-28 |
2023-08-13 |
Not clear |
| Zachary Freyberg, Mark S Sonders, Jenny I Aguilar, Takato Hiranita, Caline S Karam, Jorge Flores, Andrea B Pizzo, Yuchao Zhang, Zachary J Farino, Audrey Chen, Ciara A Martin, Theresa A Kopajtic, Hao Fei, Gang Hu, Yi-Ying Lin, Eugene V Mosharov, Brian D McCabe, Robin Freyberg, Kandatege Wimalasena, Ling-Wei Hsin, Dalibor Sames, David E Krantz, Jonathan L Katz, David Sulzer, Jonathan A Javitc. Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain. Nature communications. vol 7. 2016-06-28. PMID:26879809. |
amphetamine-induced vesicle deacidification also requires functional dopamine transporter (dat) at the plasma membrane. |
2016-06-28 |
2023-08-13 |
drosophila_melanogaster |
| Ana Isabelle G Queiroz, Maíra Moraes de Araújo, Tatiane da Silva Araújo, Greicy Coelho de Souza, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, David Freitas de Lucena, João Quevedo, Danielle Macêd. GBR 12909 administration as an animal model of bipolar mania: time course of behavioral, brain oxidative alterations and effect of mood stabilizing drugs. Metabolic brain disease. vol 30. issue 5. 2016-06-24. PMID:26073232. |
polymorphisms in the human dopamine transporter (dat) are associated with bipolar endophenotype. |
2016-06-24 |
2023-08-13 |
mouse |
| Weimin C Hong, Theresa A Kopajtic, Lifen Xu, Stacey A Lomenzo, Bernandie Jean, Jeffry D Madura, Christopher K Surratt, Mark L Trudell, Jonathan L Kat. 2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations. The Journal of pharmacology and experimental therapeutics. vol 356. issue 3. 2016-06-22. PMID:26769919. |
previous structure-activity relationship studies indicate that a series of cocaine analogs, 3β-aryltropanes with 2β-diarylmethoxy substituents, selectively bind to the dopamine transporter (dat) with nanomolar affinities that are 10-fold greater than the affinities of their corresponding 2α-enantiomers. |
2016-06-22 |
2023-08-13 |
mouse |