| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashlynn I Gerth, Amber L Alhadeff, Harvey J Grill, Mitchell F Roitma. Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. Brain research. vol 1655. 2017-08-08. PMID:27789280. |
however, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the dat alone. |
2017-08-08 |
2023-08-13 |
Not clear |
| Ashlynn I Gerth, Amber L Alhadeff, Harvey J Grill, Mitchell F Roitma. Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. Brain research. vol 1655. 2017-08-08. PMID:27789280. |
the magnitude of dopamine release ([da]max) as well as the latency to decay to fifty percent of the maximum (t(1/2); index of dat activity) by each stimulation train were recorded. |
2017-08-08 |
2023-08-13 |
Not clear |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
the dopamine transporter (dat) is responsible for clearance of dopamine from the synaptic cleft after its release. |
2017-08-07 |
2023-08-13 |
human |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
imaging dat availability provides a measure of dopamine terminal function and a method for detecting the striatal dopamine terminal dysfunction present in idiopathic parkinson's disease (pd) and atypical neurodegenerative parkinsonian disorders such as multiple system atrophy (msa), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd). |
2017-08-07 |
2023-08-13 |
human |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
dat imaging with positron emission tomography (pet) or single photon emission computed tomography (spect) can be used to support or refute a diagnosis of dopamine deficient parkinsonism in cases where this is unclear and rationalise a trial of dopamine replacement agents as therapy. |
2017-08-07 |
2023-08-13 |
human |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
the presence of normal dat availability on imaging can help categorise "subjects without evidence of dopamine deficiency" (swedds) who on occasion mimic pd and include dystonic tremors, drug-induced and psychogenic parkinsonism in their ranks. |
2017-08-07 |
2023-08-13 |
human |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
reduced levels of baseline striatal dat availability on pet or spect scanning, however, should be regarded as supportive rather than diagnostic of dopamine deficient parkinsonism. |
2017-08-07 |
2023-08-13 |
human |
| Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Free. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-08-07. PMID:27512998. |
in the current study, we have performed multiple rounds of clonal cultures and have identified a dopaminergic cell clone expressing high levels of th and the dopamine transporter (dat). |
2017-08-07 |
2023-08-13 |
rat |
| Yang Li, Felix P Mayer, Peter S Hasenhuetl, Verena Burtscher, Klaus Schicker, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism. The Journal of biological chemistry. vol 292. issue 10. 2017-07-27. PMID:28096460. |
the human dopamine transporter (dat) has a tetrahedral zn |
2017-07-27 |
2023-08-13 |
human |
| Qiang Wang, Nancy Bubula, Jason Brown, Yunliang Wang, Veronika Kondev, Paul Vezin. PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux. Neuroscience letters. vol 622. 2017-07-19. PMID:27113203. |
the da transporter (dat), a phosphoprotein, controls extracellular dopamine (da) levels in the central nervous system through transport or reverse transport (efflux). |
2017-07-19 |
2023-08-13 |
Not clear |
| Armando G Salinas, Margaret I Davis, David M Lovinger, Yolanda Mate. Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum. Neuropharmacology. vol 108. 2017-07-18. PMID:27036891. |
the striatum is also divided into striosome and matrix compartments, based on the differential expression of a number of proteins, including the mu opioid receptor, dopamine transporter (dat), and nr4a1 (nuclear receptor subfamily 4, group a, member 1). |
2017-07-18 |
2023-08-13 |
mouse |
| Armando G Salinas, Margaret I Davis, David M Lovinger, Yolanda Mate. Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum. Neuropharmacology. vol 108. 2017-07-18. PMID:27036891. |
these findings demonstrate a level of exquisite microanatomical regulation of dopamine by the dat in striosomes relative to the matrix. |
2017-07-18 |
2023-08-13 |
mouse |
| Jin Yong Hong, Mun Kyung Sunwoo, Jungsu S Oh, Jae Seung Kim, Young H Sohn, Phil Hyu Le. Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging. PloS one. vol 11. issue 6. 2017-07-18. PMID:27294367. |
functional neuroimaging for the dopamine transporter (dat) is used to distinguish drug-induced parkinsonism (dip) from subclinical parkinson's disease (pd). |
2017-07-18 |
2023-08-13 |
human |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brand. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug testing and analysis. vol 9. issue 3. 2017-07-18. PMID:27524685. |
all three substances were also studied for their uptake and releasing properties at dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) using in vitro monoamine transporter assays in rat brain synaptosomes and compared to mephedrone. |
2017-07-18 |
2023-08-13 |
rat |
| Sarah R Mikelman, Bipasha Guptaroy, Margaret E Gneg. Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors. Journal of neurochemistry. vol 141. issue 1. 2017-07-13. PMID:28075498. |
as one of the primary mechanisms by which dopamine signaling is regulated, the dopamine transporter (dat) is an attractive pharmacological target for the treatment of diseases based in dopaminergic dysfunction. |
2017-07-13 |
2023-08-13 |
Not clear |
| Weimin Conrad Hong, Hideaki Yano, Takato Hiranita, Frederick T Chin, Christopher R McCurdy, Tsung-Ping Su, Susan G Amara, Jonathan L Kat. The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. The Journal of biological chemistry. vol 292. issue 27. 2017-07-12. PMID:28495886. |
the dopamine transporter (dat) regulates dopamine (da) neurotransmission by recapturing da into the presynaptic terminals and is a principal target of the psychostimulant cocaine. |
2017-07-12 |
2023-08-13 |
rat |
| Renee Cockerham, Shaolin Liu, Roger Cachope, Emi Kiyokage, Joseph F Cheer, Michael T Shipley, Adam C Puch. Subsecond Regulation of Synaptically Released Dopamine by COMT in the Olfactory Bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 29. 2017-07-11. PMID:27445153. |
in most systems, vesicular release of da is cleared by the dopamine transporter (dat). |
2017-07-11 |
2023-08-13 |
mouse |
| S Stevens Negus, Matthew L Bank. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27696217. |
many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (dat, net, sert, respectively). |
2017-07-11 |
2023-08-13 |
rat |
| Michael H Baumann, Mohammad O Bukhari, Kurt R Lehner, Sebastien Anizan, Kenner C Rice, Marta Concheiro, Marilyn A Huesti. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27830575. |
mdpv acts as a potent uptake inhibitor at plasma membrane transporters for dopamine (dat) and norepinephrine (net) in nervous tissue. |
2017-07-11 |
2023-08-13 |
rat |
| Michael H Baumann, Mohammad O Bukhari, Kurt R Lehner, Sebastien Anizan, Kenner C Rice, Marta Concheiro, Marilyn A Huesti. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27830575. |
mdpv analogs, such as α-pyrrolidinovalerophenone (α-pvp), display similar ability to inhibit dat and increase extracellular dopamine concentrations. |
2017-07-11 |
2023-08-13 |
rat |