| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shyamsunder R Joolakanti, Justin R Nickell, Venumadhav Janganati, Guangrong Zheng, Linda P Dwoskin, Peter A Crook. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. vol 26. issue 10. 2017-11-22. PMID:27080180. |
a series of lobelane and gz-793a analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [(3)h]dopamine (da) uptake at the vesicular monoamine transporter-2 (vmat2) and the dopamine transporter (dat), and [(3)h]serotonin uptake at the serotonin transporter (sert). |
2017-11-22 |
2023-08-13 |
Not clear |
| Arthur S C França, Larissa Muratori, George Carlos Nascimento, Catia Mendes Pereira, Sidarta Ribeiro, Bruno Lobão-Soare. Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice. Behavioural brain research. vol 308. 2017-11-21. PMID:27059337. |
genetically-modified mice without the dopamine transporter (dat) are hyperdopaminergic, and serve as models for studies of addiction, mania and hyperactive disorders. |
2017-11-21 |
2023-08-13 |
mouse |
| Stephanie M Greer, Andrea N Goldstein, Brian Knutson, Matthew P Walke. A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments. Journal of cognitive neuroscience. vol 28. issue 6. 2017-11-16. PMID:26918589. |
combining fmri with an established incentive paradigm and individual genotyping, here, we test the hypothesis that trait differences in the human dopamine transporter (dat) gene-associated with altered synaptic dopamine signalling-govern the impact of sleep deprivation on neural sensitivity to impending monetary gains and losses. |
2017-11-16 |
2023-08-13 |
human |
| Stephanie M Greer, Andrea N Goldstein, Brian Knutson, Matthew P Walke. A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments. Journal of cognitive neuroscience. vol 28. issue 6. 2017-11-16. PMID:26918589. |
only participants carrying a copy of the nine-repeat dat allele-linked to higher phasic dopamine activity-expressed amplified striatal response during anticipation of monetary gain following sleep deprivation. |
2017-11-16 |
2023-08-13 |
human |
| Stephanie M Greer, Andrea N Goldstein, Brian Knutson, Matthew P Walke. A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments. Journal of cognitive neuroscience. vol 28. issue 6. 2017-11-16. PMID:26918589. |
moreover, participants homozygous for the ten-repeat dat allele-linked to lower phasic dopamine activity-selectively demonstrated an increase in sensitivity to monetary loss within anterior insula following sleep loss. |
2017-11-16 |
2023-08-13 |
human |
| T D Purves-Tyson, S J Owens, D A Rothmond, G M Halliday, K L Double, J Stevens, T McCrossin, C Shannon Weicker. Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28094812. |
th and the synaptic dopamine transporter (dat) proteins were examined in post-mortem midbrain (26 antipsychotic-treated schizophrenia cases per 27 controls) using immunoblotting. |
2017-11-16 |
2023-08-13 |
human |
| T D Purves-Tyson, S J Owens, D A Rothmond, G M Halliday, K L Double, J Stevens, T McCrossin, C Shannon Weicker. Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28094812. |
we conclude that, whereas some mrna changes are consistent with increased dopamine action (decreased dat mrna), others suggest reduced dopamine action (increased maoa mrna) in the midbrain in schizophrenia. |
2017-11-16 |
2023-08-13 |
human |
| Naoki Hosoda, Tokimori Iked. Optimization of Reformatting Angle Using Orbitomeatal Base Line in Dopamine Transporter Scintigraphy. Nihon Hoshasen Gijutsu Gakkai zasshi. vol 73. issue 8. 2017-11-16. PMID:28824093. |
recently, dopamine transporter (dat) scintigraphy, which contributes to the early diagnosis of parkinson's disease and lewy body dementia, has been widely spread. |
2017-11-16 |
2023-08-13 |
Not clear |
| Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aok. Age-related effects and gender differences in Japanese healthy controls for [ Annals of nuclear medicine. vol 31. issue 5. 2017-11-13. PMID:28382589. |
age-related effects and gender differences in japanese healthy controls for [ dopamine transporter (dat) imaging with [ |
2017-11-13 |
2023-08-13 |
Not clear |
| Nadhir Litim, Marc Morissette, Donatella Caruso, Roberto C Melcangi, Thérèse Di Paol. Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice. The Journal of steroid biochemistry and molecular biology. vol 174. 2017-11-13. PMID:28982631. |
dutasteride decreased effects of mptp on striatal dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2) and d2 da receptor specific binding while d1 receptor specific binding remained unchanged. |
2017-11-13 |
2023-08-13 |
mouse |
| Michelle G Baladi, Shannon M Nielsen, J Michael McIntosh, Glen R Hanson, Annette E Fleckenstei. Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26871405. |
the findings indicate that nicotine self-administration (0.032 mg/kg/infusion for 14 days) per se did not alter α4β2* and α6β2* nachr expression or dopamine transporter (dat) expression and function. |
2017-11-08 |
2023-08-13 |
rat |
| Yeomoon Sim, Gunhyuk Park, Hyeyoon Eo, Eugene Huh, Pil Sung Gu, Seon-Pyo Hong, Youngmi Kim Pak, Myung Sook O. Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein. Neuroscience. vol 340. 2017-11-06. PMID:27771535. |
further, nurr1 engages in synthesizing and storing dopamine through regulating levels of tyrosine hydroxylase (th), dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2). |
2017-11-06 |
2023-08-13 |
mouse |
| Arman Rahmim, Yousef Salimpour, Saurabh Jain, Stephan A L Blinder, Ivan S Klyuzhin, Gwenn S Smith, Zoltan Mari, Vesna Soss. Application of texture analysis to DAT SPECT imaging: Relationship to clinical assessments. NeuroImage. Clinical. vol 12. 2017-11-02. PMID:27995072. |
dopamine transporter (dat) spect imaging is increasingly utilized for diagnostic purposes in suspected parkinsonian syndromes. |
2017-11-02 |
2023-08-13 |
human |
| Xiupeng Xu, Shengwu Cao, Honglu Chao, Yinlong Liu, Jing J. Sex-related differences in striatal dopaminergic system after traumatic brain injury. Brain research bulletin. vol 124. 2017-10-26. PMID:27210290. |
by contrast, no significant sex-related differences were observed in the mrna and protein levels of striatal dopamine transporter (dat) and vmat-2 and the methamphetamine (ma)-evoked da output. |
2017-10-26 |
2023-08-13 |
mouse |
| Jung-Hoon Koo, Joon-Yong Cho, Ung-Bae Le. Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease. Experimental gerontology. vol 89. 2017-10-26. PMID:28062370. |
treadmill exercise inhibited dopaminergic neuron loss by promoting the expression of tyrosine hydroxylase (th) and dopamine transporter (dat) and seemed to improve cell survival by reducing α-syn expression. |
2017-10-26 |
2023-08-13 |
mouse |
| Zachary D Brodnik, Mark J Ferris, Sara R Jones, Rodrigo A Españ. Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27936579. |
the reinforcing efficacy of cocaine is thought to stem from inhibition of the dopamine transporter (dat) and subsequent increases in extracellular dopamine concentrations in the brain. |
2017-10-24 |
2023-08-13 |
mouse |
| Zachary D Brodnik, Mark J Ferris, Sara R Jones, Rodrigo A Españ. Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27936579. |
in the current studies, we used in vivo and in vitro fast scan cyclic voltammetry in mice to measure dopamine uptake inhibition following varying doses of cocaine as well as two high affinity dat inhibitors. |
2017-10-24 |
2023-08-13 |
mouse |
| Zachary D Brodnik, Mark J Ferris, Sara R Jones, Rodrigo A Españ. Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27936579. |
we then compared dopamine clearance rates following these drug treatments to dopamine clearance obtained from dat knockout mice as a proxy for complete dat blockade. |
2017-10-24 |
2023-08-13 |
mouse |
| Ruth I Versteeg, Anouk Schrantee, Sofie M Adriaanse, Unga A Unmehopa, Jan Booij, Liesbeth Reneman, Eric Fliers, Susanne E la Fleur, Mireille J Serli. Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 10. 2017-10-19. PMID:28679529. |
we studied the effect of a 4 wk hypocaloric diet with either 50% of daily calories consumed at breakfast (bf group) or at dinner (d group) on hypothalamic and thalamic serotonin transporter (sert) binding and on striatal dopamine transporter (dat) binding. |
2017-10-19 |
2023-08-13 |
Not clear |
| Danielle Krout, Akula Bala Pramod, Rejwi Acharya Dahal, Michael J Tomlinson, Babita Sharma, James D Foster, Mu-Fa Zou, Comfort Boatang, Amy Hauck Newman, John R Lever, Roxanne A Vaughan, L Keith Henr. Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochemical pharmacology. vol 142. 2017-10-17. PMID:28734777. |
dopamine transporter (dat) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (da). |
2017-10-17 |
2023-08-13 |
Not clear |