| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M G Murer, G Dziewczapolski, L B Menalled, M C García, Y Agid, O Gershanik, R Raisman-Vozar. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Annals of neurology. vol 43. issue 5. 1998-05-21. PMID:9585350. |
in addition, for rats of the sham-lesioned and severely lesioned groups, immunoradiolabeling for th, the dopamine transporter (dat), and the vesicular monoamine transporter (vmat2) at the striatal level was not significantly different between rats treated with levodopa or vehicle. |
1998-05-21 |
2023-08-12 |
rat |
| R R Gainetdinov, F Fumagalli, Y M Wang, S R Jones, A I Levey, G W Miller, M G Caro. Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572281. |
striatal dopamine (da) content, the levels of da transporter (dat) protein, and the expression of glial fibrillary acidic protein (gfap) mrna, a marker of gliosis, were assessed as markers of mptp neurotoxicity. |
1998-05-18 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, M Jaber, B Giros, R M Wightman, M G Caro. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520487. |
the dopamine transporter (dat) plays an important role in calibrating the duration and intensity of dopamine neurotransmission in the central nervous system. |
1998-05-01 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, M Jaber, B Giros, R M Wightman, M G Caro. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520487. |
we find that removal of the dat dramatically prolongs the lifetime (300 times) of extracellular dopamine. |
1998-05-01 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, M Jaber, B Giros, R M Wightman, M G Caro. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520487. |
within the time frame of neurotransmission, no other processes besides diffusion can compensate for the lack of the dat, and the absence of the dat produces extensive adaptive changes to control dopamine neurotransmission. |
1998-05-01 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, M Jaber, B Giros, R M Wightman, M G Caro. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520487. |
thus, the dat not only controls the duration of extracellular dopamine signals but also plays a critical role in regulating presynaptic dopamine homeostasis. |
1998-05-01 |
2023-08-12 |
mouse |
| A K Dutta, L L Coffey, M E Reit. Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues. Journal of medicinal chemistry. vol 41. issue 5. 1998-04-14. PMID:9513598. |
potent and selective ligands for the dopamine transporter (dat): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues. |
1998-04-14 |
2023-08-12 |
rat |
| A K Dutta, L L Coffey, M E Reit. Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues. Journal of medicinal chemistry. vol 41. issue 5. 1998-04-14. PMID:9513598. |
molecular structural modifications of 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine (1a), a dopamine transporter (dat)-specific ligand, generated several novel analogues. |
1998-04-14 |
2023-08-12 |
rat |
| S R Jones, R R Gainetdinov, R M Wightman, M G Caro. Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 6. 1998-04-13. PMID:9482784. |
amph can act on both vesicular storage of da and directly on the dopamine transporter (dat). |
1998-04-13 |
2023-08-12 |
mouse |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
methamphetamine (meth) is a powerful psychostimulant that produces dopaminergic neurotoxicity manifested by a decrease in the levels of dopamine, tyrosine hydroxylase activity and dopamine transporter (dat) binding sites in the nigrostriatal system. |
1998-04-09 |
2023-08-12 |
mouse |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
dopamine, dopac and hva levels, as well as dat binding site levels, were determined in striatal tissue derived 72 h after the last meth injection. |
1998-04-09 |
2023-08-12 |
mouse |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
this regimen of meth given to nnos(-/-) mice affected neither the tissue content of dopamine and its metabolites nor the number of dat binding sites. |
1998-04-09 |
2023-08-12 |
mouse |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
although a moderate reduction in the levels of dopamine (35%) and dat binding sites (32%) occurred in striatum of heterozygote nnos(+/-) mice, a more profound depletion of the dopaminergic markers (up to 68%) was observed in the wild-type animals. |
1998-04-09 |
2023-08-12 |
mouse |
| S R Sesack, V A Hawrylak, C Matus, M A Guido, A I Leve. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 7. 1998-04-07. PMID:9502827. |
the dopamine transporter (dat) critically regulates the duration of the cellular actions of dopamine and the extent to which dopamine diffuses in the extracellular space. |
1998-04-07 |
2023-08-12 |
rat |
| S R Sesack, V A Hawrylak, C Matus, M A Guido, A I Leve. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 7. 1998-04-07. PMID:9502827. |
we sought to determine whether the reportedly greater diffusion of dopamine in the rat prefrontal cortex (pfc) as compared with the striatum is associated with a more restricted axonal distribution of the cortical dat protein. |
1998-04-07 |
2023-08-12 |
rat |
| S R Sesack, V A Hawrylak, C Matus, M A Guido, A I Leve. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 7. 1998-04-07. PMID:9502827. |
these results suggest that considerable extracellular diffusion of dopamine in the prelimbic pfc may result, at least in part, from a paucity of dat content in mesocortical dopamine axons, as well as a distribution of the dat protein at a distance from synaptic release sites. |
1998-04-07 |
2023-08-12 |
rat |
| S R Sesack, V A Hawrylak, C Matus, M A Guido, A I Leve. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 7. 1998-04-07. PMID:9502827. |
the results further suggest that different populations of dopamine neurons selectively target the dat to different subcellular locations. |
1998-04-07 |
2023-08-12 |
rat |
| S H Dresel, M P Kung, K Plössl, S K Meegalla, H F Kun. Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporters in rats. European journal of nuclear medicine. vol 25. issue 1. 1998-03-05. PMID:9396872. |
the purpose of this study was to investigate the influence of drugs competing for the dopamine transporter (dat) or changing intra- and/or extracellular dopamine levels on the binding of a novel technetium-99m labeled tropane derivative, technetium, [2-[[2-[[[3-(4-chloro- phenyl)-8-methyl-8-azabicyclo[3, 2, 1]oct-2-yl]methyl] (2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3)]-oxo-[1r-(exo -exo)]-, [99mtc]trodat-1, to dat. |
1998-03-05 |
2023-08-12 |
rat |
| S H Dresel, M P Kung, K Plössl, S K Meegalla, H F Kun. Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporters in rats. European journal of nuclear medicine. vol 25. issue 1. 1998-03-05. PMID:9396872. |
the biodistribution studies were performed in the presence of drugs which compete for the binding site, such as cft (win 35,428) and methylphenidate, drugs which influence dopamine levels, such as l-dopa, gamma-hydroxybutyrolactone, and alpha-methyl-p-tyrosine, and d-amphetamine, which both acts as a competitor for dat binding and increases dopamine levels. |
1998-03-05 |
2023-08-12 |
rat |
| S H Dresel, M P Kung, K Plössl, S K Meegalla, H F Kun. Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporters in rats. European journal of nuclear medicine. vol 25. issue 1. 1998-03-05. PMID:9396872. |
competition for [99mtc]trodat-1 binding was observed only with drug treatment that significantly increases dopamine levels or actively competes for binding at dat. |
1998-03-05 |
2023-08-12 |
rat |