| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Nishimura, K Sato, S Shimada, M Tohyam. Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101235. |
we investigated the gene expression of three monoamine transporters (norepinephrine transporter, net; serotonin transporter, sert; and dopamine transporter, dat) in the rat superior cervical ganglion (scg). |
1999-05-21 |
2023-08-12 |
rat |
| W P Melega, G Lacan, D C Harvey, S C Huang, M E Phelp. Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies. Neuroscience letters. vol 258. issue 1. 1999-05-18. PMID:9876041. |
[11c]win 35,428 (win), a cocaine analog that binds to the dopamine transporter (dat), and positron emission tomography (pet) were used to evaluate the potential neuroprotective effects of dizocilpine (mk-801) on methamphetamine (meamp) induced neurotoxicity in the striatal dopamine system of the vervet monkey. |
1999-05-18 |
2023-08-12 |
human |
| F W Telang, N D Volkow, A Levy, J Logan, J S Fowler, C Felder, C Wong, G J Wan. Distribution of tracer levels of cocaine in the human brain as assessed with averaged [11C]cocaine images. Synapse (New York, N.Y.). vol 31. issue 4. 1999-05-07. PMID:10051110. |
the ability of cocaine to block the dopamine transporter (dat) in the nucleus accumbens, as well as its non-striatal and non-dat actions, appears to be crucial for its reinforcing/rewardig effects. |
1999-05-07 |
2023-08-12 |
human |
| Y Itzhak, J L Marti. Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082805. |
assessment of the densities of striatal dopamine transporter (dat) sites (by [3h]mazindol binding) 11 days after the extinction of repeated treatment with either cocaine or ethanol revealed a significant increase (71-108%) in the number of dat binding sites. |
1999-05-06 |
2023-08-12 |
mouse |
| N D Volkow, J S Fowler, S J Gatley, S L Dewey, G J Wang, J Logan, Y S Ding, D Franceschi, A Gifford, A Morgan, N Pappas, P Kin. Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025684. |
though the blockade of dopamine transporters (dat) is associated with cocaine's and methylphenidate's reinforcing effects, it is the stimulation of dopamine (da) receptors, achieved by increases in synaptic da, that enables these effects to occur. |
1999-05-04 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, S J Gatley, S L Dewey, G J Wang, J Logan, Y S Ding, D Franceschi, A Gifford, A Morgan, N Pappas, P Kin. Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025684. |
positron emission tomography (pet) and [11c]raclopride were used to assess the levels of occupancy of da d2 receptors by dopamine achieved by doses of cocaine or methylphenidate previously documented to block over 70% of dat. |
1999-05-04 |
2023-08-12 |
Not clear |
| Y Ito, M Fujita, S Shimada, Y Watanabe, T Okada, H Kusuoka, M Tohyama, T Nishimur. Comparison between the decrease of dopamine transporter and that of L-DOPA uptake for detection of early to advanced stage of Parkinson's disease in animal models. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029235. |
the purpose of this study was to assess the detection of the early changes of pd by either imaging the dopamine transporter (dat) or uptake of l-3,4-dihydroxyphenylalanine (l-dopa). |
1999-05-04 |
2023-08-12 |
rat |
| M Jaber, B Bloch, M G Caron, B Giro. [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101608. |
mice lacking the the plasma membrane dopamine transporter (dat), following gene inactivation or knock out, show an increase in their spontaneous locomotor activity that is of the same magnitude than in normal mice treated with amphetamine or cocaine, known to increase levels of dopamine in the basal ganglia. |
1999-05-03 |
2023-08-12 |
mouse |
| N R Zahniser, G A Larson, G A Gerhard. In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10087014. |
dopamine transporter (dat) inhibitors are expected to decrease dopamine (da) clearance from the extracellular space of the brain. |
1999-04-21 |
2023-08-12 |
rat |
| J K Weatherspoon, L L Werlin. Modulation of amphetamine-stimulated [3H]dopamine release from rat pheochromocytoma (PC12) cells by sigma type 2 receptors. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10087015. |
an important regulatory mechanism of synaptic dopamine (da) levels is activation of the dopamine transporter (dat), which is a target for many drugs of abuse, including amphetamine (amph). |
1999-04-21 |
2023-08-12 |
rat |
| G W Miller, J D Erickson, J T Perez, S N Penland, D C Mash, D B Rye, A I Leve. Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192785. |
the distribution of vmat2 in striatum and its loss in pd paralleled that of the dopamine transporter (dat), a phenotypic marker of dopamine neurons. |
1999-04-21 |
2023-08-12 |
human |
| G W Miller, J D Erickson, J T Perez, S N Penland, D C Mash, D B Rye, A I Leve. Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192785. |
furthermore, the relative expression of vmat2 compared to that of dat may predict the differential vulnerability of dopamine neurons in pd. |
1999-04-21 |
2023-08-12 |
human |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
the plasma membrane dopamine transporter (dat) is responsible for clearing dopamine from the synapse. |
1999-04-20 |
2023-08-12 |
mouse |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
cocaine blockade of dat leads to increased extracellular dopamine, an effect widely considered to be the primary cause of the reinforcing and addictive properties of cocaine. |
1999-04-20 |
2023-08-12 |
mouse |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
in the absence of dat, these mice exhibit high levels of extracellular dopamine, but paradoxically still self-administer cocaine. |
1999-04-20 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
mpp+, which is the oxidation product of mptp, is actively transported into presynaptic dopaminergic nerve terminals through the plasma membrane dopamine transporter (dat). |
1999-04-07 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
thus dopamine cell loss is related to levels of the dat. |
1999-04-07 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
these results shed light on the degenerative process of dopamine neurons and suggest that individual differences in developing parkinson's disease in human may be related to differences of uptake through the dat of a yet unidentified neurotoxin. |
1999-04-07 |
2023-08-12 |
mouse |
| M A Hebert, G A Larson, N R Zahniser, G A Gerhard. Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027875. |
in the present study, we used the potent cocaine analog [3h]win 35, 428 to map and quantify binding to the dopamine transporter (dat) within the dorsal striatum, nucleus accumbens, substantia nigra, and ventral tegmental area in young (6-month-old), middle-aged (12-month-old), and aged (18- and 24-month-old) fischer 344 rats. |
1999-04-01 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wan. Characterization of [125I]RTI-121 binding to dopamine transporter in vitro. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 18. issue 2. 1999-03-25. PMID:10072960. |
to characterize the binding of [125i]3 beta-(4-iodophenyl) tropane-2 beta-carboxylic acid isopropyl ester (rti-121) to the dopamine transporter (dat) under physiologically relevant conditions. |
1999-03-25 |
2023-08-12 |
Not clear |