| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Jones, R R Gainetdinov, X T Hu, D C Cooper, R M Wightman, F J White, M G Caro. Loss of autoreceptor functions in mice lacking the dopamine transporter. Nature neuroscience. vol 2. issue 7. 1999-08-02. PMID:10404198. |
the function of dopamine autoreceptors was assessed in mice lacking the dopamine transporter (dat). |
1999-08-02 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, X T Hu, D C Cooper, R M Wightman, F J White, M G Caro. Loss of autoreceptor functions in mice lacking the dopamine transporter. Nature neuroscience. vol 2. issue 7. 1999-08-02. PMID:10404198. |
genetic deletion of the dat gene in mice results in a persistent elevation in levels of extracellular dopamine. |
1999-08-02 |
2023-08-12 |
mouse |
| Y Itzhak, J L Martin, M D Black, S F Al. Effect of the dopaminergic neurotoxin MPTP on cocaine-induced locomotor sensitization. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340529. |
the blockade of dopamine (da) uptake via the dopamine transporter (dat) in the nucleus accumbens (nac) and striatum by cocaine has a major role in the reinforcing and psychomotor stimulating effects of the drug. |
1999-07-28 |
2023-08-12 |
mouse |
| N D Volkow, G J Wang, J S Fowler, M Fischman, R Foltin, N N Abumrad, S J Gatley, J Logan, C Wong, A Gifford, Y S Ding, R Hitzemann, N Pappa. Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain. Life sciences. vol 65. issue 1. 1999-07-23. PMID:10403500. |
the reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (dat). |
1999-07-23 |
2023-08-12 |
human |
| S Y Ma, B J Ciliax, G Stebbins, S Jaffar, J N Joyce, E J Cochran, J H Kordower, D C Mash, A I Levey, E J Mufso. Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363709. |
unbiased disector stereologic cell counting was applied to sections from the human substantia nigra that were immunostained by using a monoclonal antibody against the dopamine transporter (dat). |
1999-07-20 |
2023-08-12 |
human |
| B J Ciliax, G W Drash, J K Staley, S Haber, C J Mobley, G W Miller, E J Mufson, D C Mash, A I Leve. Immunocytochemical localization of the dopamine transporter in human brain. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363710. |
the dopamine transporter (dat) was localized in normal human brain tissue by light microscopic immunocytochemistry by using highly specific monoclonal antibodies. |
1999-07-20 |
2023-08-12 |
human |
| B J Ciliax, G W Drash, J K Staley, S Haber, C J Mobley, G W Miller, E J Mufson, D C Mash, A I Leve. Immunocytochemical localization of the dopamine transporter in human brain. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363710. |
these findings demonstrate that most mesotelencephalic dopamine neurons of human brain express high levels of dat throughout their entire somatodendritic and axonal domains, whereas a smaller subpopulation of mesencephalic dopamine cells and all hypothalamic dopamine cell groups examined express little or no dat. |
1999-07-20 |
2023-08-12 |
human |
| M Goulet, M Morissette, R Grondin, P Falardeau, P J Bédard, W Rostène, T Di Paol. Neurotensin receptors and dopamine transporters: effects of MPTP lesioning and chronic dopaminergic treatments in monkeys. Synapse (New York, N.Y.). vol 32. issue 3. 1999-07-15. PMID:10340626. |
the effect of denervation with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) of the dopamine (da) nigrostriatal pathway on neurotensin (nt) receptor and da transporter (dat) in basal ganglia of monkeys (macaca fascicularis) was investigated. |
1999-07-15 |
2023-08-12 |
monkey |
| S Chalon, P Emond, S Bodard, M P Vilar, C Thiercelin, J C Besnard, D Guillotea. Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease. Synapse (New York, N.Y.). vol 31. issue 2. 1999-07-12. PMID:10024010. |
the time course of the loss in presynaptic dopamine transporters (dat) and of the increase in postsynaptic dopamine d2 receptors (d2r) was studied in a rat model of parkinson's disease. |
1999-07-12 |
2023-08-12 |
rat |
| A F Hoffman, N R Zahniser, C R Lupica, G A Gerhard. Voltage-dependency of the dopamine transporter in the rat substantia nigra. Neuroscience letters. vol 260. issue 2. 1999-06-18. PMID:10025710. |
the possible voltage-dependence of the dopamine transporter (dat) was investigated using electrophysiological and electrochemical recordings in rat brain slices containing the substantia nigra (sn). |
1999-06-18 |
2023-08-12 |
rat |
| A C Kuhlmann, T R Guilart. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 48. issue 1. 1999-06-18. PMID:10330690. |
the integrity of nigrostriatal dopaminergic terminals in the corpus striatum was assessed by measuring high affinity dopamine transporter (dat) levels and dopamine content. |
1999-06-18 |
2023-08-12 |
Not clear |
| A C Kuhlmann, T R Guilart. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 48. issue 1. 1999-06-18. PMID:10330690. |
dat levels were measured by [3h]-win 35,428 autoradiography, and dopamine content decreased with increasing mptp dose. |
1999-06-18 |
2023-08-12 |
Not clear |
| A C Kuhlmann, T R Guilart. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 48. issue 1. 1999-06-18. PMID:10330690. |
reductions of both indices of dopaminergic terminal integrity correlated with increased levels of [3h]-pk11195-binding in the striatum (r2 = 0.84 for dat and 0.93 for dopamine content). |
1999-06-18 |
2023-08-12 |
Not clear |
| A M Comer, J Qi, D L Christie, H M Gibbons, J Lipsk. Noradrenaline transporter expression in the pons and medulla oblongata of the rat: localisation to noradrenergic and some C1 adrenergic neurones. Brain research. Molecular brain research. vol 62. issue 1. 1999-06-10. PMID:9795140. |
specific transporters have been cloned for both dopamine (dat) and noradrenaline (nat) in the rat. |
1999-06-10 |
2023-08-12 |
rat |
| F I Tarazi, E C Tomasini, R J Baldessarin. Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi. Neuroscience letters. vol 254. issue 1. 1999-06-07. PMID:9780082. |
density of dopamine transporter (dat) and serotonin transporter (5-htt) membrane proteins in the caudate-putamen (cpu) and nucleus accumbens (nac) of rat brain was assessed at seven ages at postnatal days (pd) 7-60, by in vitro quantitative autoradiography. |
1999-06-07 |
2023-08-12 |
rat |
| J T Kuikka, J Tiihonen, K A Bergström, J Karhu, P Räsänen, M Erone. Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis. Neuroscience letters. vol 253. issue 3. 1999-06-07. PMID:9792244. |
our hypothesis was that impulsive violent offenders have also higher heterogeneity of the striatal dopamine transporter (dat) density than controls. |
1999-06-07 |
2023-08-12 |
human |
| S H Dresel, M P Kung, X Huang, K Plössl, C Hou, C Y Shiue, J Karp, H F Kun. In vivo imaging of serotonin transporters with [99mTc]TRODAT-1 in nonhuman primates. European journal of nuclear medicine. vol 26. issue 4. 1999-06-03. PMID:10199939. |
[99mtc]trodat-1 was the first 99mtc-labeled imaging agent to show specific binding to dopamine transporters (dat) in the striatum (str) of human brain. |
1999-06-03 |
2023-08-12 |
human |
| I Lamensdorf, S Porat, R Simantov, J P Finber. Effect of low-dose treatment with selegiline on dopamine transporter (DAT) expression and amphetamine-induced dopamine release in vivo. British journal of pharmacology. vol 126. issue 4. 1999-05-25. PMID:10193780. |
effect of low-dose treatment with selegiline on dopamine transporter (dat) expression and amphetamine-induced dopamine release in vivo. |
1999-05-25 |
2023-08-12 |
rat |
| I Lamensdorf, S Porat, R Simantov, J P Finber. Effect of low-dose treatment with selegiline on dopamine transporter (DAT) expression and amphetamine-induced dopamine release in vivo. British journal of pharmacology. vol 126. issue 4. 1999-05-25. PMID:10193780. |
changes in activity of the dopamine transporter (dat) in vivo following selegiline treatment were evaluated indirectly by microdialysis technique in the rat, from the change in striatal dopamine extracellular concentration following systemic amphetamine administration (4 mg kg(-1), i.p.). |
1999-05-25 |
2023-08-12 |
rat |
| I Lamensdorf, S Porat, R Simantov, J P Finber. Effect of low-dose treatment with selegiline on dopamine transporter (DAT) expression and amphetamine-induced dopamine release in vivo. British journal of pharmacology. vol 126. issue 4. 1999-05-25. PMID:10193780. |
the increase in dat expression, and attenuation of amphetamine-induced dopamine release, were not accompanied by a change in [3h]-dopamine uptake in synaptosomes of selegiline-treated animals. |
1999-05-25 |
2023-08-12 |
rat |