| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Hersch, H Yi, C J Heilman, R H Edwards, A I Leve. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. The Journal of comparative neurology. vol 388. issue 2. 1997-12-12. PMID:9368838. |
these localizations suggest that dat modulates the intracellular and extracellular dopamine levels of nigral dendrites. |
1997-12-12 |
2023-08-12 |
Not clear |
| B S Slusher, C W Tiffany, J L Olkowski, P F Jackso. Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists. Drug and alcohol dependence. vol 48. issue 1. 1997-11-20. PMID:9330920. |
the addictive and euphorogenic properties of cocaine are thought to result from inhibition of the dopamine transporter (dat). |
1997-11-20 |
2023-08-12 |
human |
| B S Slusher, C W Tiffany, J L Olkowski, P F Jackso. Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists. Drug and alcohol dependence. vol 48. issue 1. 1997-11-20. PMID:9330920. |
therefore it should be possible to design drugs which specifically inhibit cocaine recognition by the dat while permitting the transporter to maintain its function of accumulating dopamine. |
1997-11-20 |
2023-08-12 |
human |
| Y Fujiwara, K Yamaguchi, Y Tanaka, H Tomita, Y Shiro, K Kashihara, K Sato, S Kurod. Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases. European neurology. vol 38 Suppl 1. 1997-10-16. PMID:9276194. |
the advances made in studies on the molecular biology of the dopamine transporter (dat) and receptors (d1, d2, d3, d4 and d5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric disorders are discussed. |
1997-10-16 |
2023-08-12 |
human |
| G J Wang, N D Volkow, J S Fowler, M Fischman, R Foltin, N N Abumrad, J Logan, N R Pappa. Cocaine abusers do not show loss of dopamine transporters with age. Life sciences. vol 61. issue 11. 1997-10-15. PMID:9307051. |
cocaine blocks dopamine transporters (dat) and this effect is crucial to its reinforcing properties. |
1997-10-15 |
2023-08-12 |
Not clear |
| M J Nirenberg, J Chan, A Pohorille, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 18. 1997-10-03. PMID:9278525. |
the dopamine transporter (dat) regulates extracellular dopamine concentrations, transports neurotoxins, and acts as a substrate for cocaine reinforcement. |
1997-10-03 |
2023-08-12 |
Not clear |
| R Bossé, F Fumagalli, M Jaber, B Giros, R R Gainetdinov, W C Wetsel, C Missale, M G Caro. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. vol 19. issue 1. 1997-10-02. PMID:9247269. |
deletion of the dopamine transporter (dat) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. |
1997-10-02 |
2023-08-12 |
mouse |
| P C Meltzer, A Y Liang, P Blundell, M D Gonzalez, Z Chen, C George, B K Madra. 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. Journal of medicinal chemistry. vol 40. issue 17. 1997-09-25. PMID:9276012. |
in particular, the 8-amino function on the tropane skeleton of cocaine and cocaine analogs has been assumed to provide an ionic bond to the aspartic acid residue on the dopamine transporter (dat). |
1997-09-25 |
2023-08-12 |
Not clear |
| Q Wu, L L Coffey, M E Reit. Cations affect [3H]mazindol and [3H]WIN 35,428 binding to the human dopamine transporter in a similar fashion. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282933. |
the present study addresses the possibility that there are different cocaine-related and mazindol-related binding domains on the dopamine transporter (dat) that show differential sensitivity to cations. |
1997-09-25 |
2023-08-12 |
human |
| R Betarbet, R Turner, V Chockkan, M R DeLong, K A Allers, J Walters, A I Levey, J T Greenamyr. Dopaminergic neurons intrinsic to the primate striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 17. 1997-09-23. PMID:9254687. |
to establish the dopaminergic nature of the th-i cells, sections were double-labeled with antibodies to dopamine transporter (dat). |
1997-09-23 |
2023-08-12 |
monkey |
| A E Fleckenstein, R R Metzger, D G Wilkins, J W Gibb, G R Hanso. Rapid and reversible effects of methamphetamine on dopamine transporters. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262348. |
reactive oxygen species decrease dopamine transporter (dat) function in vitro. |
1997-09-11 |
2023-08-12 |
rat |
| A E Morgan, S P Porter, F A Clarkson, N D Volkow, J S Fowler, S L Dewe. Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter. Synapse (New York, N.Y.). vol 26. issue 4. 1997-09-09. PMID:9215601. |
these findings indicate that rti-55, a drug that binds directly to the dopamine transporter (dat) with higher affinity than cocaine, does not appear to be effective in attenuating cocaine's effects on nacc dopamine levels. |
1997-09-09 |
2023-08-12 |
rat |
| R Bossé, R Rivest, T Di Paol. Ovariectomy and estradiol treatment affect the dopamine transporter and its gene expression in the rat brain. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191114. |
the impact of gonadal hormone withdrawal and estrogen therapy was investigated on the rat dopamine transporter (dat). |
1997-08-05 |
2023-08-12 |
rat |
| U Scheffel, J R Lever, P Abraham, K R Parham, W B Mathews, T Kopajtic, F I Carroll, M J Kuha. N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter. Synapse (New York, N.Y.). vol 25. issue 4. 1997-07-24. PMID:9097393. |
variously substituted phenyltropanes are proven as superb binding ligands for the dopamine transporter (dat). |
1997-07-24 |
2023-08-12 |
mouse |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
the dopamine transporter (dat) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-07-21 |
2023-08-12 |
rat |
| C Pifl, E Agneter, H Drobny, H Reither, E A Singe. Induction by low Na+ or Cl- of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters. British journal of pharmacology. vol 121. issue 2. 1997-07-16. PMID:9154329. |
cos-7 cells transfected with the cdna of the human dopamine transporter (dat cells) or the human noradrenaline transporter (nat cells) were loaded with [3h]-dopamine or [3h]-noradrenaline and superfused with buffers of different ionic composition. |
1997-07-16 |
2023-08-12 |
human |
| P C Meltzer, P Blundell, A G Jones, A Mahmood, B Garada, R E Zimmerman, A Davison, B L Holman, B K Madra. A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. Journal of medicinal chemistry. vol 40. issue 12. 1997-07-15. PMID:9191960. |
the dopamine transporter (dat), located presynaptically on dopamine neurons, provides a marker for certain neurological diseases. |
1997-07-15 |
2023-08-12 |
monkey |
| P C Meltzer, P Blundell, A G Jones, A Mahmood, B Garada, R E Zimmerman, A Davison, B L Holman, B K Madra. A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. Journal of medicinal chemistry. vol 40. issue 12. 1997-07-15. PMID:9191960. |
in particular, the dat is depleted in parkinson's disease, and the extent of depletion correlates with the loss of dopamine. |
1997-07-15 |
2023-08-12 |
monkey |
| R A Vaughan, R A Huff, G R Uhl, M J Kuha. Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes. The Journal of biological chemistry. vol 272. issue 24. 1997-07-14. PMID:9182590. |
dopamine transport activity in synaptosomes was reduced by all treatments that promoted dat phosphorylation, with comparable dose, time, and inhibitor characteristics. |
1997-07-14 |
2023-08-12 |
rat |