| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Vaughan, R A Huff, G R Uhl, M J Kuha. Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes. The Journal of biological chemistry. vol 272. issue 24. 1997-07-14. PMID:9182590. |
these results suggest that synaptosomal dopamine transport activity is regulated by phosphorylation of dat and present a potential mechanism for local neuronal control of synaptic neurotransmitter levels and consequent downstream neural activity. |
1997-07-14 |
2023-08-12 |
rat |
| V Planté-Bordeneuve, D Taussig, F Thomas, G Said, N W Wood, C D Marsden, A E Hardin. Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease: evidence for association of a DRD2 allele. Neurology. vol 48. issue 6. 1997-07-10. PMID:9191771. |
we assessed the role of four candidate genes encoding proteins involved in dopaminergic transmission, the dopamine transporter (dat), the dopamine receptor d2 (drd2), and the main catabolic enzymes of dopamine, monoamine oxidase a (maoa) and b (maob), through allelic association studies in a population of familial and sporadic parkinson's disease (pd). |
1997-07-10 |
2023-08-12 |
human |
| N H Chen, Y L Wang, M E Reit. Binding of the [125I]3 beta-(iodophenyl)tropan-2 beta-carboxylic acid isopropyl ester to the dopamine transporter at a physiologically relevant temperature: mutually exclusive binding and different ionic requirements for various uptake blockers and substrates. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021896. |
the present study describes the binding of cocaine analog [125i]3 beta-(iodophenyl)tropan-2 beta-carboxylic acid isopropyl ester ([125i]rti-121), a highly selective ligand for the dopamine transporter (dat), to rat striatal synaptosomal membranes at 37 degrees c. saturation analysis of [125i]rti-121 binding revealed a single binding site with similar affinity for rti-121 at both 50 and 134 mm nacl. |
1997-07-07 |
2023-08-12 |
rat |
| N H Chen, Y L Wang, M E Reit. Binding of the [125I]3 beta-(iodophenyl)tropan-2 beta-carboxylic acid isopropyl ester to the dopamine transporter at a physiologically relevant temperature: mutually exclusive binding and different ionic requirements for various uptake blockers and substrates. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021896. |
increasing the nacl concentration from 50 mm to 134 mm enhanced the affinity of the substrate dopamine and amphetamine for the dat, without affecting that of the uptake blockers. |
1997-07-07 |
2023-08-12 |
rat |
| E Gómez-Casero, I Pérez de Castro, J Sáiz-Ruiz, C Llinares, J Fernández-Piquera. No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample. Psychiatric genetics. vol 6. issue 4. 1997-07-07. PMID:9149327. |
we have carried out an association study of a polymorphism in the 3'utr of the dopamine transporter gene (dat) and a polymorphism in the coding region of the d3 receptor gene (drd3) in spanish patients with manic depression and in controls. |
1997-07-07 |
2023-08-12 |
Not clear |
| C E Maggos, R Spangler, Y Zhou, S D Schlussman, A Ho, M J Kree. Quantitation of dopamine transporter mRNA in the rat brain: mapping, effects of "binge" cocaine administration and withdrawal. Synapse (New York, N.Y.). vol 26. issue 1. 1997-06-27. PMID:9097405. |
dopamine transporter (dat) mrna from selected brain regions of individual male fischer rats was quantitated utilizing a sensitive solution hybridization assay in which the levels of rnase-protected 32p-labeled mrna:crna hybrids were measured. |
1997-06-27 |
2023-08-12 |
rat |
| S R Letchworth, J B Daunais, A A Hedgecock, L J Porrin. Effects of chronic cocaine administration on dopamine transporter mRNA and protein in the rat. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098547. |
chronic cocaine administration resulted in dose-dependent decreases in the density of dopamine transporter (dat) mrna in both the substantia nigra pars compacta and ventral tegmental area as shown by in situ hybridization histochemistry. |
1997-06-17 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
the dopamine transporter (dat) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. |
1997-06-10 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-06-10 |
2023-08-12 |
rat |
| E Donnemiller, J Heilmann, G K Wenning, W Berger, C Decristoforo, R Moncayo, W Poewe, G Ransmay. Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. European journal of nuclear medicine. vol 24. issue 3. 1997-06-03. PMID:9143472. |
the aim of this study was therefore to evaluate regional cerebral perfusion [with either technetium-99m hexamethylpropylene amine oxime (99mtc-hmpao) or 99mtc-ethyl cysteinate dimer (99mtc-ecd) spet] and striatal dopamine transporter density [using iodine-123 2 beta-carboxymethoxy-3 beta-[4-iodophenyl]tropane (123i-beta-cit) spet] in patients with dat and dlbd. |
1997-06-03 |
2023-08-12 |
Not clear |
| E Donnemiller, J Heilmann, G K Wenning, W Berger, C Decristoforo, R Moncayo, W Poewe, G Ransmay. Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. European journal of nuclear medicine. vol 24. issue 3. 1997-06-03. PMID:9143472. |
these results suggest that 99mtc-hmpao or 99mtc-ecd and 123i-beta-cit spet may contribute to the differential diagnosis between dat and dlbd, showing different perfusion patterns and more severe impairment of dopamine transporter function in dlbd than in dat. |
1997-06-03 |
2023-08-12 |
Not clear |
| C Adelbrecht, Y Agid, R Raisman-Vozar. Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037545. |
quantitative in situ hybridization of three different dopaminergic markers: dopamine membrane transporter (dat), tyrosine hydroxylase (th), and vesicular monoamine transporter (vmat2) was performed on individual dopaminergic cells of the substantia nigra pars compacta (snc) and the ventral tegmental area (vta) in 2-month-old wv/wv mice, in order to investigate the metabolic state of remaining dopaminergic cell bodies and gain further insight into modifications observed on dopaminergic nerve terminals in the striatum and the nucleus accumbens. |
1997-05-29 |
2023-08-12 |
mouse |
| P A Frohna, B S Neal-Beliveau, J N Joyc. Delayed plasticity of the mesolimbic dopamine system following neonatal 6-OHDA lesions. Synapse (New York, N.Y.). vol 25. issue 3. 1997-05-27. PMID:9068128. |
in this study, we determined the ontogenetic profile (at postnatal days 7, 14, 35, and 90) of tyrodine hydroxylase (th) mrna in the ventral mesencephalon, and the levels of th immunoreactivity (th-ir) and dopamine (da) transporter (dat) sites in the striatum of rats that had received intrastriatal 6-hydroxy dopamine (6-ohda) or vehicle lesions on day of birth (do) or postnatal day 1 (p1). |
1997-05-27 |
2023-08-12 |
rat |
| P Szot, S S White, R C Veit. Effect of pentylenetetrazol on the expression of tyrosine hydroxylase mRNA and norepinephrine and dopamine transporter mRNA. Brain research. Molecular brain research. vol 44. issue 1. 1997-05-22. PMID:9030697. |
in contrast, ptz did not alter the expression of c-fos mrna in the snpc/vta, but reduced the expression of the dopamine transporter (dat) mrna. |
1997-05-22 |
2023-08-12 |
rat |
| I Aubert, C Brana, C Pellevoisin, B Giros, I Caille, D Carles, C Vital, B Bloc. Molecular anatomy of the development of the human substantia nigra. The Journal of comparative neurology. vol 379. issue 1. 1997-05-22. PMID:9057113. |
in situ hybridization, immunohistochemistry and binding studies were used to detect d2 dopamine receptor (d2r) mrna, d2r binding sites, dopamine membrane transporter (dat) mrna, tyrosine hydroxylase (th) protein d1 dopamine receptor (d1r) protein and d1r binding sites. |
1997-05-22 |
2023-08-12 |
human |
| I Aubert, C Brana, C Pellevoisin, B Giros, I Caille, D Carles, C Vital, B Bloc. Molecular anatomy of the development of the human substantia nigra. The Journal of comparative neurology. vol 379. issue 1. 1997-05-22. PMID:9057113. |
from week 12 onward they expressed several other markers of dopamine transmission, i.e., d2r mrna, d2r binding sites and dat mrna. |
1997-05-22 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R W Foltin, J S Fowler, N N Abumrad, S Vitkun, J Logan, S J Gatley, N Pappas, R Hitzemann, C E She. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature. vol 386. issue 6627. 1997-05-22. PMID:9126740. |
cocaine is believed to work by blocking the dopamine transporter (dat) and thereby increasing the availability of free dopamine within the brain. |
1997-05-22 |
2023-08-12 |
human |
| M J Bannon, C J Whitt. Age-related and regional differences in dopamine transporter mRNA expression in human midbrain. Neurology. vol 48. issue 4. 1997-05-15. PMID:9109886. |
we assessed the abundance of dopamine transporter messenger rna (dat mrna) in various human midbrain dopamine cell groups using in situ hybridization. |
1997-05-15 |
2023-08-12 |
human |
| M J Bannon, C J Whitt. Age-related and regional differences in dopamine transporter mRNA expression in human midbrain. Neurology. vol 48. issue 4. 1997-05-15. PMID:9109886. |
the youngest individuals studied (17-23 years of age) exhibited significant regional heterogeneity of dat expression, both in terms of the number of dopamine neurons expressing dat mrna and the abundance of dat mrna per cell, with the highest levels of expression evident within the ventral tier of the substantia nigra and lowest expression within the retrorubral field. |
1997-05-15 |
2023-08-12 |
human |
| M J Bannon, C J Whitt. Age-related and regional differences in dopamine transporter mRNA expression in human midbrain. Neurology. vol 48. issue 4. 1997-05-15. PMID:9109886. |
the age-related decline in dat mrna was due to both a decrease in the abundance of dat mrna per dopamine cell as well as a decrease in the total number of dopamine cells expressing dat mrna, although tyrosine hydroxylase expression was less affected. |
1997-05-15 |
2023-08-12 |
human |