| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Meng, Zejun Song, Lingnan Zhang, Yu Geng, Jing Sun, Guobin Miao, Peng Li. Effects of losartan in patients with NAFLD: A meta-analysis of randomized controlled trial. Open life sciences. vol 18. issue 1. 2023-03-27. PMID:36970603. |
the meta-analysis demonstrated that aspartate transaminase was significantly affected by losartan therapy (mean difference [md] = -5.34, 95% confidence interval [ci] [-6.54, -4.13], |
2023-03-27 |
2023-08-14 |
Not clear |
| Can Zhao, Yuntao Li, Guangyu Pan, Jianping Xu, Shen Liu, Yaqiong Xia. Risk Factors for Postoperative Acute Kidney Injury in Patients Undergoing Redo Cardiac Surgery Using Cardiopulmonary Bypass. Journal of cardiovascular development and disease. vol 9. issue 8. 2023-03-08. PMID:36005408. |
multivariate analysis revealed that high aspartate aminotransferase (or, 1.028, 95% ci, 1.003 to 1.053, p = 0.025), coronary angiogram within 2 weeks before surgery (or, 3.209, 95% ci, 1.307 to 7.878, p = 0.011) and cpb time (or, 1.012, 95% ci, 1.005 to 1.019, p = 0.001) were independent risk factors for postoperative aki. |
2023-03-08 |
2023-08-16 |
Not clear |
| Madeleine L Hart, Evan Quon, Anna-Lena B G Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sulliva. Mitochondrial redox adaptations enable alternative aspartatesynthesis in SDH-deficient cells. eLife. vol 12. 2023-03-08. PMID:36883551. |
interestingly, we find aspartate production and cell proliferation are restored to sdh-impaired cells by concomitant inhibition of etc complex i (ci). |
2023-03-08 |
2023-08-14 |
human |
| Madeleine L Hart, Evan Quon, Anna-Lena B G Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sulliva. Mitochondrial redox adaptations enable alternative aspartatesynthesis in SDH-deficient cells. eLife. vol 12. 2023-03-08. PMID:36883551. |
we determine that the benefits of ci inhibition in this context depend on decreasing mitochondrial nad+/nadh, which drives sdh-independent aspartate production through pyruvate carboxylation and reductive carboxylation of glutamine. |
2023-03-08 |
2023-08-14 |
human |
| Madeleine L Hart, Evan Quon, Anna-Lena B G Vigil, Ian A Engstrom, Oliver J Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M Carlisle, Lucas B Sulliva. Mitochondrial redox adaptations enable alternative aspartatesynthesis in SDH-deficient cells. eLife. vol 12. 2023-03-08. PMID:36883551. |
we also find that genetic loss or restoration of sdh selects for cells with concordant ci activity, establishing distinct modalities of mitochondrial metabolism for maintaining aspartate synthesis. |
2023-03-08 |
2023-08-14 |
human |
| Jennifer Kang, Harishankar Gopakumar, Srinivas R Pul. Prevalence of Osteoporosis in Cirrhosis: A Systematic Review and Meta-Analysis. Cureus. vol 15. issue 1. 2023-02-15. PMID:36788896. |
pooled levels of liver biochemistries were: bilirubin 3.04 mg/dl (95% ci: 2.84-3.25), aspartate aminotransferase (ast) 65.35 u/l (95% ci: 61.39-69.31), alanine aminotransferase (alt) 50.17 u/l (95% ci: 46.18-54.10), alkaline phosphatase 133.31 u/l (95% ci: 124.89-141.73), and albumin 3.25 g/dl (95% ci: 3.05-3.45). |
2023-02-15 |
2023-08-14 |
Not clear |
| Yixi Zhang, Jingyuan Wang, Taobo Hu, Huina Wang, Mengping Long, Baosheng Lian. Adverse Events of PD-1 or PD-L1 Inhibitors in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis. Life (Basel, Switzerland). vol 12. issue 12. 2022-12-23. PMID:36556355. |
for non-serious adverse events, the patients treated with pd-1 or pd-l1 inhibitors had higher risk of aspartate aminotransferase (ast) elevation (or =1.26, 95%ci: 1.02-1.57), hypothyroidism (or = 3.63, 95%ci: 2.92-4.51), pruritus (or = 1.84, 95%ci: 1.30-2.59), rash (or = 1.29, 95%ci: 1.08-1.55), and fever (or = 1.77, 95%ci: 1.13-2.77), compared with chemotherapy alone. |
2022-12-23 |
2023-08-14 |
Not clear |
| Feng-Jing-Ming Cheng, Jian Lyu, Yan-Ming Xi. [Systematic review and Meta-analysis of efficacy and safety of Ganshuang Granules in treatment of liver injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 21. 2022-12-06. PMID:36472014. |
the results of meta-analysis showed that ganshuang granules combined with conventional therapy was superior to the therapy in the control group in reducing alanine aminotransferase(alt)(md=-24.12, 95%ci[-32.17,-16.07], p<0.000 01), aspartate aminotransferase(ast)(md=-23.24, 95%ci[-29.70,-16.78], p<0.000 01), total bilirubin(tbil)(md=-12.42, 95%ci[-14.62,-10.22], p<0.000 01), and gamma-glutamyl transpeptidase(ggt)(md=-21.32, 95%ci[-33.61,-9.03], p=0.000 7). |
2022-12-06 |
2023-08-14 |
Not clear |
| Jin-Cheng Tian, Hui Liu, Lun-Jie Yan, Zi-Niu Ding, Cheng-Long Han, Bao-Wen Tian, Si-Yu Tan, Zhao-Ru Dong, Dong-Xu Wang, Jun-Shuai Xue, Xin-Cheng Mao, Yu-Chuan Yan, Tao L. Adverse events of immune checkpoint inhibitors in hepatocellular carcinoma: a systemic review and meta-analysis. Clinical and experimental medicine. 2022-11-17. PMID:36385419. |
aspartate aminotransferase (ast) increase (38%, 95% ci 35-40%) is the most common traes. |
2022-11-17 |
2023-08-14 |
Not clear |
| Enrique Linden-Torres, Graciela Zambrano-Galván, Amirhossein Sahebkar, Mayela Ríos-Mier, Luis E Simental-Mendí. Coffee consumption has no effect on circulating markers of liver function but increases adiponectin concentrations: A systematic review and meta-analysis of randomized controlled trials. Nutrition research (New York, N.Y.). vol 106. 2022-09-20. PMID:36126527. |
meta-analysis of 14 rcts, including a total of 897 subjects, showed that coffee consumption has no significant effect on alanine aminotransferase (weighted mean difference [wmd], -0.89 mg/ml; 95% ci, -2.90 to 1.12; p = .39), aspartate aminotransferase (wmd, -0.29 mg/ml; 95% ci, -1.25 to 0.66; p = .55), gamma-glutamyl transferase (wmd, .10 mg/ml; 95% ci, -3.94 to 4.15; p = .96), alkaline phosphatase (wmd, -4.60 mg/ml; 95% ci, -9.26 to 0.07; p = .05), and lactate dehydrogenase (wmd, -0.65 mg/ml; 95% ci, -10.80 to 9.49; p = .90). |
2022-09-20 |
2023-08-14 |
human |
| Reema A Karasneh, Basheer Y Khassawneh, Sayer Al-Azzam, Abdel-Hameed Al-Mistarehi, William J Lattyak, Motasem Aldiab, Suad Kabbaha, Syed Shahzad Hasan, Barbara R Conway, Mamoon A Aldeya. Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East. International journal of clinical practice. vol 2022. 2022-09-08. PMID:36072822. |
laboratory abnormalities associated with mortality included hypernatremia (or, 11.37; 95% ci, 4.33-29.81), elevated aspartate aminotransferase (or, 1.81; 95% ci, 1.42-2.31), hypoalbuminemia (or, 1.75; 95% ci, 1.37-2.25), and low platelets level (or, 1.43; 95% ci, 1.05-1.95). |
2022-09-08 |
2023-08-14 |
Not clear |
| Mohammad Reza Amini, Fatemeh Sheikhhossein, Alireza Talebyan, Elham Bazshahi, Farhang Djafari, Azita Hekmatdoos. Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Clinical nutrition research. vol 11. issue 3. 2022-08-11. PMID:35949559. |
pooled analysis of seven randomized controlled trials (rcts) suggested that the artichoke administration has an effect on both alanine aminotransferase (alt) (hedges' g, -1.08; 95% confidence interval [ci], -1.76 to -0.40; p = 0.002), and aspartate aminotransferase (ast) (hedges' g, -1.02; 95% ci, -1.76 to -0.28; p = 0.007). |
2022-08-11 |
2023-08-14 |
Not clear |
| Basma S Ismail, Basant Mahmoud, Eman S Abdel-Reheim, Hanan A Soliman, Tarek M Ali, Basem H Elesawy, Mohamed Y Zak. Cinnamaldehyde Mitigates Atherosclerosis Induced by High-Fat Diet Oxidative medicine and cellular longevity. vol 2022. 2022-07-01. PMID:35774377. |
moreover, ci reduced the elevated serum creatine kinase (ck), creatine kinase-mb (ck-mb), lactate dehydrogenase (ldh), and aspartate aminotransferase (ast) activities. |
2022-07-01 |
2023-08-14 |
rat |
| Mukharram M Bikbov, Timur R Gilmanshin, Rinat M Zainullin, Gyulli M Kazakbaeva, Ellina M Iakupova, Albina A Fakhretdinova, Azaliia M Tuliakova, Songhomitra Panda-Jonas, Leisan I Gilemzianova, Dinar A Khakimov, Liana A Miniazeva, Jost B Jona. Prevalence of non-alcoholic fatty liver disease in the Russian Ural Eye and Medical Study and the Ural Very Old Study. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35551494. |
defining nafld by an absence of regular alcohol consumption, and by abnormally high alanine transaminase (alt) and aspartate transaminase (ast) concentrations or an ast/alt ratio of > 1.0, 2341 out of 5852 uems participants (40.0%; 95% confidence intervals (ci) 38.8, 41.3) had nafld. |
2022-05-13 |
2023-08-13 |
human |
| Catalina M Mascaró, Cristina Bouzas, Sofia Montemayor, Miguel Casares, Cristina Gómez, Lucía Ugarriza, Pere-Antoni Borràs, José Alfredo Martínez, Josep A Tu. Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study. Nutrients. vol 14. issue 5. 2022-03-14. PMID:35268038. |
pa was a risk factor for ast (aspartate aminotransferase) (adjusted or: 7.26; 95% ci: 1.79−29.40) and a protective factor for alt (alanine aminotransferase) (adjusted or: 0.24; 95% ci: 0.12−0.48), ggt (gamma-glutamyl transferase) (adjusted or: 0.52; 95% ci: 0.29−0.94) and ifc-nmr (intrahepatic fat content by nuclear magnetic resonance) (adjusted or: 0.26; 95% ci: 0.12−0.56) when sociodemographic confounders were considered. |
2022-03-14 |
2023-08-16 |
human |
| Sabit Cakmak, Anna Lukina, Subramanian Karthikeyan, Ella Atlas, Robert Dale. The association between blood PFAS concentrations and clinical biochemical measures of organ function and metabolism in participants of the Canadian Health Measures Survey (CHMS). The Science of the total environment. 2022-02-26. PMID:35218824. |
an increase in perfluorooctanoic acid (pfoa) equivalent to the magnitude of its geometric mean (gm) of 2.0 μg/l was associated with percentage (95% ci) increases in serum enzymes reflecting liver function: aspartate aminotransferase (ast) 3.7 (1.1, 6.4), gamma-glutamyl transferase (ggt) 11.8 (2.5, 21.8), alanine aminotransferase (alt) 3.2 (0.5, 5.9), and bilirubin 3.6 (2.7, 4.5). |
2022-02-26 |
2023-08-13 |
human |
| Mahmoud A Khattab, Yehia Zakaria, Eslam Sadek, Aliaa S Abd El Fatah, Magdy Fouad, Muhammed Khattab, Hend M Moness, Nashwa Mohamed Adel, Elham Ahme. Detection of hepatitis C virus (HCV) RNA in the peripheral blood mononuclear cells of HCV-infected patients following sustained virologic response. Clinical and experimental medicine. 2022-01-23. PMID:35066710. |
multiple logistic regression analysis showed that only the higher posttreatment levels of aspartate transaminase (ast) were significantly predictive of hcv rna persistence in the pbmcs (or: 1.29; 95% ci: 1.08-1.55). |
2022-01-23 |
2023-08-13 |
Not clear |
| Mahshid Mostafavi, Iraj Sharifi, Gholamreza Asadikaram, Nozar Nakhaee, Sina Kakooei, Mohammad Reza Aflatoonian, Mehdi Bamorovat, Razieh Tavakoli Oliaee, Ali Karamoozia. The impact of diabetes on cutaneous leishmaniasis: a case-control field assessment. Parasitology research. vol 120. issue 11. 2021-11-25. PMID:34604933. |
data analysis showed that six major risk factors, including female (odds ratio (or) = 3.47, confidence interval (ci) = 1.84-6.53, p < 0.001), total protein in cl group (or = 4.9, ci = 2.3-10.44, p < 0.001), alanine aminotransferase (alt) concentration in cl group (or = 0.87, ci = 0.81-0.93, p < 0.001) and dm co-infected with cl group (or = 0.8, ci = 0.72-0.88, p < 0.001) than healthy group, aspartate aminotransferase (ast) concentration in dm group (or = 0.86, ci = 0.76-0.98, p = 0.02), transforming growth factor beta)tgf-β( level in the cl group (or = 1.03, ci = 1.003-1.05, p = 0.02), and presence of diabetes disease (or = 2.07, ci = 1.16-3.7, p < 0.05), were significantly linked with the induction of cl lesion. |
2021-11-25 |
2023-08-13 |
human |
| Ambrin Farizah Babu, Susanne Csader, Johnson Lok, Carlos Gómez-Gallego, Kati Hanhineva, Hani El-Nezami, Ursula Schwa. Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis. Nutrients. vol 13. issue 9. 2021-11-19. PMID:34579012. |
overall, exercise without significant weight loss significantly reduced the intrahepatic lipid (ihl) content (smd: -0.76, 95% ci: -1.04, -0.48) and concentrations of alanine aminotransaminase (alt) (smd: -0.52, 95% ci: -0.90, -0.14), aspartate aminotransaminase (ast) (smd: -0.68, 95% ci: -1.21, -0.15), low-density lipoprotein cholesterol (smd: -0.34, 95% ci: -0.66, -0.02), and triglycerides (tg) (smd: -0.59, 95% ci: -1.16, -0.02). |
2021-11-19 |
2023-08-13 |
Not clear |
| Samit Ghosal, Debasis Datta, Binayak Sinh. A meta-analysis of the effects of glucagon-like-peptide 1 receptor agonist (GLP1-RA) in nonalcoholic fatty liver disease (NAFLD) with type 2 diabetes (T2D). Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34764398. |
in a pooled population of 615 patients-297 on glp1-ra and 318 in the control arm, glp1-ra produced a significant improvement in alanine aminotransferase [standardised mean difference (sdm), - 0.56, 95% ci - 0.88 to - 0.25, p < 0.01], aspartate aminotransferase (sdm, - 0.44, se, 95% ci - 0.64 to - 0.24, p < 0.01), gamma glutaryl transaminase (sdm, - 0.60, 95% ci - 0.86 to - 0.34, p < 0.01) and reduction in liver fat content (lfc) (sdm, - 0.43, 95% ci - 0.74 to - 0.12, p < 0.01), as well as glycosylated haemoglobin (sdm, - 0.40, 95% ci, - 0.61 to - 0.19, p < 0.01) and weight (sdm, - 0.66, 95% ci, - 0.88 to - 0.44, p < 0.01), in comparison to standard of care or placebo. |
2021-11-18 |
2023-08-13 |
Not clear |