| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chi-Un Pae, Hyun-Kook Lim, Tae-Suk Kim, Jung-Jin Kim, Chang-Uk Lee, Soo-Jung Lee, Chul Lee, In-Ho Pai. Naturalistic observation on the hepatic enzyme changes in patients treated with either risperidone or olanzapine alone. International clinical psychopharmacology. vol 20. issue 3. 2005-08-02. PMID:15812269. |
frequencies of elevation greater than the reference level in any enzyme among aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphotase (alp) were higher in the olanzapine-treated group (26.9%) than in the risperidone-treated group (14.2%) [odds ratio (or)=2.225, 95% confidence interval (ci)=1.362-3.638, p=0.002]. |
2005-08-02 |
2023-08-12 |
Not clear |
| Xavier Duval, Valérie Journot, Catherine Leport, Geneviève Chêne, Michel Dupon, Lise Cuzin, Thierry May, Philippe Morlat, Anne Waldner, Roger Salamon, François Raff. Incidence of and risk factors for adverse drug reactions in a prospective cohort of HIV-infected adults initiating protease inhibitor-containing therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. vol 39. issue 2. 2004-12-29. PMID:15307035. |
among baseline characteristics, plasma human immunodeficiency virus rna levels of >or=5 log(10) copies/ml (hazard ratio [hr], 1.5; 95% ci, 1.1-2.2), elevated aspartate aminotransferase levels (hr, 1.1 for each 20 iu of elevation; 95% ci, 1.1-1.2), creatinine clearance levels of <70 ml/min (hr, 2.1; 95% ci, 1.2-3.7), test results positive for hepatitis c virus antibodies or hepatitis b surface antigenemia (hr, 2.6; 95% ci, 1.8-3.7), and receipt of indinavir (hr, 1.7; 95% ci, 1.2-2.4) were independently predictive of a sadr. |
2004-12-29 |
2023-08-12 |
human |
| Kevin L Kraemer, Michael F Mayo-Smith, David R Calkin. Independent clinical correlates of severe alcohol withdrawal. Substance abuse. vol 24. issue 4. 2004-04-29. PMID:14574086. |
we identified six independent correlates of severe withdrawal: use of a morning eye-opener (adjusted odds ratio [or], 5.6; 95% confidence interval [ci], 1.2-25.9), an initial ciwa-ar score > or =10 (or, 5.1; 95% ci, 2.4-10.6), a serum aspartate aminotransferase > or =80 u/l (or, 4.2; 95% ci, 2.0-8.8), past benzodiazepine use (or, 3.6; 95% ci, 1.3-9.9), self-reported history of "delirium tremens" (or, 2.9; 95% ci, 1.3-6.2), and prior participation in two or more alcohol treatment programs (or, 2.6; 95% ci, 1.3-5.6). |
2004-04-29 |
2023-08-12 |
human |
| E H Gisolf, C Dreezen, S A Danner, J L Weel, G J Weverlin. Risk factors for hepatotoxicity in HIV-1-infected patients receiving ritonavir and saquinavir with or without stavudine. Prometheus Study Group. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. vol 31. issue 5. 2001-01-11. PMID:11073757. |
multivariate analysis, adjusted for baseline levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), showed that hepatitis b surface antigen (hbsag) positivity (relative risk [rr], 8.8; 95% confidence interval [ci], 3.3-23.1) and the use of stavudine (rr, 4.9; 95% ci, 1.5-16.0) were the only significant risk factors for developing lee. |
2001-01-11 |
2023-08-12 |
Not clear |
| L J Wheat, P Chetchotisakd, B Williams, P Connolly, K Shutt, R Hajje. Factors associated with severe manifestations of histoplasmosis in AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. vol 30. issue 6. 2000-09-12. PMID:10854363. |
the following factors were associated with severe disease: black race (odds ratio [or], 2.8; 95% confidence interval [ci], 1.2-6.2); hemoglobin level <9.5 g/dl (or, 2.7; 95% ci, 1.2-6.4), partial thromboplastin time >45 s (or, 3.1; 95% ci, 1.1-9.3); alkaline phosphatase level >2.5 times normal (or, 3.4; 95% ci, 1.3-8.7); aspartate aminotransferase level >2.5 times normal (or, 4.2; 95% ci, 1.7-10.0); bilirubin level concentration >1.5 mg/dl (or, 9.2; 95% ci, 2.5-34.3); creatinine concentration >2.1 mg/dl (or, 8.3; 95% ci, 2.2-31.9); and albumin concentration <3.5 g/dl (or, 4.6; 95% ci, 1.3-16.4). |
2000-09-12 |
2023-08-12 |
Not clear |
| I B Turner, M Myszor, H C Mitchison, M K Bennett, A D Burt, O F Jame. A two year controlled trial examining the effectiveness of ursodeoxycholic acid in primary biliary cirrhosis. Journal of gastroenterology and hepatology. vol 9. issue 2. 1994-07-20. PMID:8003650. |
within the udca group, there was long-term fall in alkaline phosphatase [median fall 116 iu/l (95% ci 93 to 378) at 2 years and aspartate aminotransferase [median fall 18 iu/l (95% ci 6 to 47) at 2 years; however, the major change in bilirubin was a modest rise over 2 years in the placebo group [median rise 2 mumol/l (95% ci 1 to 9)]. |
1994-07-20 |
2023-08-12 |
Not clear |
| I B Turner, M Myszor, H C Mitchison, M K Bennett, A D Burt, O F Jame. A two year controlled trial examining the effectiveness of ursodeoxycholic acid in primary biliary cirrhosis. Journal of gastroenterology and hepatology. vol 9. issue 2. 1994-07-20. PMID:8003650. |
for each parameter, by calculating the difference between the median changes with time between the udca group and the placebo group, it was found that from entry, with respect to placebo, there were differences between median changes (mcd) favouring the udca group in bilirubin (mcd 5 mumol/l [95% confidence interval (ci) 1 to 12] at 1 year and 5 mumol/l (95% ci 1 to 9) at 2 years), alkaline phosphatase mcd 242 iu/l (95% ci 107 to 360) at 1 year and 268 iu/l (95% ci 146 to 424) at 2 years and aspartate aminotransferase mcd 26 iu/l (95% ci 12 to 41) at 1 year and 37 iu/l (95% ci 16 to 64) at 2 years. |
1994-07-20 |
2023-08-12 |
Not clear |
| S H Kubo, B A Walter, D H John, M Clark, R J Cod. Liver function abnormalities in chronic heart failure. Influence of systemic hemodynamics. Archives of internal medicine. vol 147. issue 7. 1987-07-29. PMID:3606280. |
in contrast, group 3 patients (n = 42; ci less than or equal to 1.5 l/min/m2) had the most severe heart failure, as assessed by the lowest ci and highest cardiac filling pressures, and significantly higher levels of aspartate aminotransferase (65 +/- 82 u/l), alanine aminotransferase (77 +/- 102 u/l), lactate dehydrogenase (282 +/- 91 u/l), and total bilirubin (29 +/- 14 mumol/l [1.7 +/- 0.8 mg/dl]). |
1987-07-29 |
2023-08-11 |
Not clear |