| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Man Liu, Dong Pan, MengYa Wang, Han Deng, ZeGang M. JWH133 attenuates behavior deficits and iron accumulation in the 6-OHDA-induced Parkinson's disease model rats. Journal of neurophysiology. 2024-07-17. PMID:39015077. |
growing evidence indicated that activation of cannabinoid type 2 (cb2) receptors protect dopamine neurons in the pathogenesis of parkinson's disease (pd). |
2024-07-17 |
2024-07-19 |
rat |
| Hikari Tachibana, Moeka Nomura, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki, Koichi Uemur. Incomplete autophagy and increased cholesterol synthesis during neuronal cell death caused by a synthetic cannabinoid, CP-55,940. Neurotoxicology. 2024-06-28. PMID:38942151. |
cp-55,940, a synthetic cannabinoid having the ability to activate both cb1 and cb2 receptors, has been shown to induce cell death in neurons as well as other cells. |
2024-06-28 |
2024-07-01 |
mouse |
| Robert C Barnes, Henry Blanton, Canice Lei Dancel, Isabel Castro-Piedras, Boyd R Rorabaugh, Daniel J Morgan, Josée Guindo. Chronic administration of cannabinoid agonists ACEA (CB1), AM1241 (CB2), and CP55,940 (mixed CB1/CB2) induce sex-specific differences in tolerance and sex hormone changes in a chemotherapy-induced peripheral neuropathy. The Journal of pharmacology and experimental therapeutics. 2024-06-27. PMID:38936979. |
chronic administration of cannabinoid agonists acea (cb1), am1241 (cb2), and cp55,940 (mixed cb1/cb2) induce sex-specific differences in tolerance and sex hormone changes in a chemotherapy-induced peripheral neuropathy. |
2024-06-27 |
2024-06-30 |
Not clear |
| Andrea Chicca, Daniel Batora, Christoph Ullmer, Antonello Caruso, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Jürg Gertsc. A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for bioRxiv : the preprint server for biology. 2024-06-21. PMID:38903103. |
a highly potent, orally bioavailable pyrazole-derived cannabinoid cb2 receptor-selective full agonist for the cannabinoid cb2 receptor (cb2r) is a potential therapeutic target for distinct forms of tissue injury and inflammatory diseases. |
2024-06-21 |
2024-06-23 |
Not clear |
| Spyros P Nikas, Lipin Ji, Yingpeng Liu, Markos-Orestis Georgiadis, Amey Dopeshwarkar, Alex Straiker, Shalley Kudalkar, Anastasiia V Sadybekov, Michaela Dvorakova, Vsevolod Katritch, Ken Mackie, Lawrence Marnett, Alexandros Makriyanni. Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2. ACS medicinal chemistry letters. vol 15. issue 6. 2024-06-19. PMID:38894922. |
2-arachidonoyl glycerol (2-ag) is the principal endogenously produced ligand for the cannabinoid cb1 and cb2 receptors (cbrs). |
2024-06-19 |
2024-06-21 |
Not clear |
| Magdalena Smereczańska, Natalia Domian, Alicja Lewandowska, Irena Kasack. Comparative assessment of CacyBP/SIP, β-catenin and cannabinoid receptors in the adrenals of hypertensive rats. Journal of cellular and molecular medicine. vol 28. issue 10. 2024-05-23. PMID:38780511. |
the results of this study show, for the first time, marked differences in the expression of cacybp/sip, β-catenin and cb1 and cb2 cannabinoid receptors in the adrenal glands of rats with primary (shr) and secondary hypertension (2k1c). |
2024-05-23 |
2024-05-27 |
rat |
| Fatima Doganc, Tulin Ozkan, Nazila Farhangzad, Acelya Mavideniz, Ismail Celik, Asuman Sunguroglu, Hakan Göke. Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies. Bioorganic chemistry. vol 148. 2024-05-10. PMID:38728910. |
cannabinoids bind to cannabinoid receptors cb1 and cb2 and their antitumoral activity has been reported against some various cancer cell lines. |
2024-05-10 |
2024-05-27 |
Not clear |
| Fatima Doganc, Tulin Ozkan, Nazila Farhangzad, Acelya Mavideniz, Ismail Celik, Asuman Sunguroglu, Hakan Göke. Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies. Bioorganic chemistry. vol 148. 2024-05-10. PMID:38728910. |
some synthetic cannabinoids possessing indole rings such as jwh-015 and jwh-133 particularly bind to the cannabinoid cb2 receptor and it was reported that they inhibit the proliferation and growth of various cancer cells without their psychoactive effects. |
2024-05-10 |
2024-05-27 |
Not clear |
| Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D Kelly, Matthew Goodson, Danica Lee, Fredric P Manfredsson, Bob M Moore, Malú Gámez Tanse. Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562842. |
cannabinoid receptor-2 (cb2) is highly expressed on activated microglia and peripheral immune cells, is upregulated in the substantia nigra of individuals with pd and in mouse models of nigral degeneration. |
2024-04-02 |
2024-04-04 |
mouse |
| Lindsey Russell, Kayla Condo, Tiffany DeFlorvill. Nutrition, endocannabinoids, and the use of cannabis: An overview for the nutrition clinician. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 2024-03-31. PMID:38555505. |
exogenous cannabinoid (cb) use, either organic or synthetic, stimulates the ecs through cb1 and cb2 receptors. |
2024-03-31 |
2024-04-02 |
Not clear |
| Ruohan Shan, Yuxiang Zhang, Yiping Shi, Xiaowen Wang, Xueke Wang, Guanying Ma, Qian L. Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension. Biomolecules. vol 14. issue 3. 2024-03-28. PMID:38540753. |
our previous studies prove that activating the cannabinoid type 2 (cb2) receptor in the brain can effectively reduce blood pressure in spontaneously hypertensive rats; however, the exact mechanism has not been clarified. |
2024-03-28 |
2024-03-30 |
rat |
| Mathias C Eymery, Ahcène Boumendjel, Andrew A McCarthy, Jens Hausman. Linking the Autotaxin-LPA Axis to Medicinal Cannabis and the Endocannabinoid System. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542186. |
this finding opens new areas of research regarding cannabinoids and endocannabinoids, as it could establish the effect of these compounds at the molecular level, particularly in relation to inflammation, which cannot be explained by the interaction with cb1 and cb2 receptors alone. |
2024-03-28 |
2024-03-30 |
Not clear |
| Natalia Mansur Haddad, Leonardo Peroni De Jesus, Mauricio Serpa, Martinus Van De Bilt, Leda Talib, Alana Costa, Wagner Gattaz, Alexandre Andrade Loc. Endocannabinoid system alterations in schizophrenia: association with cannabis use and antipsychotic medication. European archives of psychiatry and clinical neuroscience. 2024-03-19. PMID:38502208. |
we found for the first time that cannabis use and non-clozapine antipsychotic medication are potentially involved in the modulation of the ecs, specifically influencing 2-ag endocannabinoid and cb2 receptor levels. |
2024-03-19 |
2024-03-23 |
Not clear |
| Barbara Broers, Federica Bianch. Cannabinoids for Behavioral Symptoms in Dementia: An Overview. Pharmacopsychiatry. 2024-03-06. PMID:38447959. |
cannabinoids are lipophilic molecules acting on the cb1 end cb2 receptors, essential for main biological processes such as sleep, appetite, memory, and pain. |
2024-03-06 |
2024-03-09 |
Not clear |
| Dongchen An, Guilherme Salgado Carrazoni, Ben-Hur Souto das Neves, Rudi D'Hooge, Steve Peigneur, Jan Tytga. The Sobering Sting: Oleoyl Serotonin Is a Novel Biomedicines. vol 12. issue 2. 2024-02-24. PMID:38398056. |
the sobering sting: oleoyl serotonin is a novel cannabinoid receptors (cb1 and cb2) are promising targets for a better understanding of neurological diseases. |
2024-02-24 |
2024-02-26 |
mouse |
| Aaliyah Roberts, Mahli Christian, Lizbeth Nivar Dilone, Natania Nelson, Mark Joseph Endrino, Adam Kneebone, Shymaa Embaby, Justin Fernandez, Qing-Rong Liu, Emmanuel S Onaivi, Berhanu Geresu Kibre. Alcohol induced behavioral and immune perturbations are attenuated by activation of CB2 cannabinoid receptors. Advances in drug and alcohol research. vol 3. 2024-02-23. PMID:38389814. |
alcohol induced behavioral and immune perturbations are attenuated by activation of cb2 cannabinoid receptors. |
2024-02-23 |
2024-02-25 |
mouse |
| Laura V de Paus, Yu An, Antonius P A Janssen, Richard J B H N Van den Berg, Laura H Heitman, Mario Van der Stel. Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor. Chembiochem : a European journal of chemical biology. 2024-02-19. PMID:38372466. |
discovery of a photoaffinity probe that captures the active conformation of the cannabinoid cb2 receptor. |
2024-02-19 |
2024-02-21 |
Not clear |
| Stefano Pagano, Chiara Valenti, Paolo Negri, Monia Billi, Alessandro Di Michele, Stefano Bruscoli, Marta Febo, Maddalena Coniglio, Lorella Marinucc. Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-11. PMID:38342230. |
viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, bcl2, p21, and bax) and of endocannabinoid system receptors (cb1, cb2 and gpr55) with real-time pcr and dna damage with phospho-γ-h2ax immunofluorescence detection were analyzed. |
2024-02-11 |
2024-02-14 |
human |
| Sagar A More, Rucha S Deore, Harshal D Pawar, Charu Sharma, Kartik T Nakhate, Sumit S Rathod, Shreesh Ojha, Sameer N Goya. CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338960. |
the primary targets of cannabinoids are cannabinoid type 1 (cb1) and 2 (cb2) receptors. |
2024-02-10 |
2024-02-12 |
Not clear |
| Wen-Hao Liu, Jun-Shang Wu, Li-Bo Hua, Zhi-Feng Pan, Hai-Bo Zhang, Neng-Gui Xu, Yi-Han H. Advances in the study of endocannabinoid receptors in experimental acupuncture analgesia. Zhen ci yan jiu = Acupuncture research. vol 49. issue 1. 2024-01-19. PMID:38239143. |
among which the endocannabinoid receptors ［including type i (cb1) and type ii (cb2) receptors］ play an important role in the regulation of pain and have become an important target in the mechanism research of acupuncture analgesia. |
2024-01-19 |
2024-01-21 |
human |