| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Wu, Yuandai Luo, Lifang Zhen, Xianda Hu, Ying Shang, Yinuo Liao, Huiyuan Xue, Fukai Huang, Wei Xia. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-06-13. PMID:27293454. |
moreover, western blot and quantitative pcr (q-pcr) results indicated that the rsnp could suppress the apoptosis in the hippocampus of the vd animals by increasing the expression ratio of b-cell lymphoma-2 (bcl-2) to bcl-2-associated x protein (bax). |
2016-06-13 |
2023-08-13 |
rat |
| Guiqiang Liang, Huiyan Qin, Li'e Zhang, Shuyan Ma, Xiaowei Huang, Yingnan Lv, Li Qing, Qin Li, Yuxia Xiong, Yifei Huang, Kangcheng Chen, Yuman Huang, Yuefei Shen, Jie Nong, Xiaobo Yang, Yunfeng Zo. Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 83. 2016-06-07. PMID:26164403. |
the levels of plasma bdnf, hippocampal bdnf, camp, protein kinase a, and pcreb were assessed through elisa or western blot. |
2016-06-07 |
2023-08-13 |
rat |
| Tian Tian, Hong Ni, Bao-liang Su. Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals. Biological trace element research. vol 167. issue 2. 2016-06-03. PMID:25778834. |
then hippocampal mossy fiber sprouting and the protein levels of znt3, mt3, apoe, clu, and acat-1 were detected by timm staining and western blot analysis, respectively. |
2016-06-03 |
2023-08-13 |
rat |
| Atsushi Fukushima, Yuji Ogura, Miyako Furuta, Chiaki Kakehashi, Toshiya Funabashi, Tatsuo Akem. Ketogenic diet does not impair spatial ability controlled by the hippocampus in male rats. Brain research. vol 1622. 2016-06-02. PMID:26111645. |
finally, western blot revealed that the hippocampal expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor subunit 1 (glur1) was significantly increased in mice fed a ketogenic diet. |
2016-06-02 |
2023-08-13 |
mouse |
| Jin-Fang Ge, Ya-Yun Xu, Gan Qin, Jiang-Qun Cheng, Fei-Hu Che. Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway. Frontiers in endocrinology. vol 7. 2016-06-02. PMID:27252679. |
the protein expression levels of the wnt/β-catenin in the hippocampus were detected by western blot. |
2016-06-02 |
2023-08-13 |
human |
| F Li, H X Dong, Q H Gong, Q Wu, F Jin, J S Sh. Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice. Neuroscience. vol 304. 2016-05-24. PMID:26079110. |
western blot analysis indicated the downregulation of app expression after icariin treatment, and double staining showed an increased number of 5-bromo-2-deoxyuridine (brdu)/neuron-specific nuclear protein (neun) double-positive cells in the dentate gyrus region of the hippocampus in tg2576+icariin mice compared with the tg2576 mice. |
2016-05-24 |
2023-08-13 |
mouse |
| Lei Zhang, Xiao Han, Xiang Cheng, Xue-Feng Tan, He-Yan Zhao, Xin-Hua Zhan. Denervated hippocampus provides a favorable microenvironment for neuronal differentiation of endogenous neural stem cells. Neural regeneration research. vol 11. issue 4. 2016-05-23. PMID:27212920. |
seven days after fimbria fornix transection, our reverse transcription polymerase chain reaction, western blot assay, and enzyme linked immunosorbent assay results show a significant increase in ciliary neurotrophic factor mrna and protein expression in the denervated hippocampus. |
2016-05-23 |
2023-08-13 |
rat |
| Tao Yi, Li Qi, Ji Li, Jing-Jing Le, Lei Shao, Xin Du, Jing-Cheng Don. Moxibustion upregulates hippocampal progranulin expression. Neural regeneration research. vol 11. issue 4. 2016-05-23. PMID:27212922. |
results from the forced swimming test, open field test, tail suspension test, real-time pcr, enzyme-linked immunosorbent assay, and western blot assay showed that moxibustion treatment decreased mrna expression of corticotropin-releasing hormone in the hypothalamus, and adrenocorticotropic hormone and corticosterone levels in plasma, and markedly increased progranulin mrna and protein expression in the hippocampus. |
2016-05-23 |
2023-08-13 |
rat |
| Talita Tuon, Priscila S Souza, Marcela F Santos, Fernanda T Pereira, Giulia S Pedroso, Thais F Luciano, Claudio T De Souza, Rafael C Dutra, Paulo C L Silveira, Ricardo A Pinh. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2015. 2016-05-18. PMID:26448816. |
mice were euthanized by cervical dislocation and the striatum and hippocampus were homogenized to determine levels of tyrosine hydroxylase (th), nuclear factor kappa b (nf-κb) p65, and sirtuin 1 (sirt1) by western blot; tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), il-17, interferon-γ (ifn-γ), and transforming growth factor β1 (tgf-β1) levels by elisa; no content; and complex i (ci) activity. |
2016-05-18 |
2023-08-13 |
mouse |
| Karim A Alkadhi, Trinh T Tra. Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer's Disease. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25112676. |
western blot analysis of basal protein levels of important signaling molecules in hippocampal area ca1 showed no significant difference between the subclinical ad rat model and control rat. |
2016-05-17 |
2023-08-13 |
human |
| M R King, N J Anderson, C Liu, E Law, M Cundiff, T M Mixcoatl-Zecuatl, C G Jolival. Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats. Neuroscience. vol 303. 2016-05-06. PMID:26149351. |
fresh sciatic nerve and hippocampus from control and diabetic rats were incubated with varied ex vivo concentrations of insulin and phosphorylation levels of insulin receptor and glycogen synthase kinase-3 (gsk3β) were assessed by western blot analysis. |
2016-05-06 |
2023-08-13 |
rat |
| Linli Qiu, Yangang Zhao, Qiang Guo, Yuanyuan Zhang, Li He, Wei Li, Jiqiang Zhan. Dose-dependent regulation of steroid receptor coactivator-1 and steroid receptors by testosterone propionate in the hippocampus of adult male mice. The Journal of steroid biochemistry and molecular biology. vol 156. 2016-05-05. PMID:26607693. |
in the present study, we investigated the expression of hippocampal src-1 after orchidectomy and testosterone treatment using immunohistochemistry and western blot analysis. |
2016-05-05 |
2023-08-13 |
mouse |
| Elizabeth Hanson, Moritz Armbruster, David Cantu, Lauren Andresen, Amaro Taylor, Niels Christian Danbolt, Chris G Dull. Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia. vol 63. issue 10. 2016-05-03. PMID:25914127. |
using astrocytic and neuronal electrophysiology, immunofluorescence, and western blot analysis we show that: (1) glutamate uptake in the neonatal neocortex is slow relative to neonatal hippocampus; (2) astrocytes in the neonatal neocortex undergo a significant maturation of intrinsic membrane properties; (3) slow glutamate uptake is accompanied by lower expression of both glt-1 and glast; (4) glutamate uptake is less dependent on glt-1 in neonatal neocortex than in neonatal hippocampus; and (5) the slow glutamate uptake we report in the neonatal neocortex corresponds to minimal astrocytic control of neuronal nmda receptor activation. |
2016-05-03 |
2023-08-13 |
Not clear |
| Gang Liu, Chao Liu, Xue-Ning Zhan. Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular medicine reports. vol 12. issue 3. 2016-05-03. PMID:25998151. |
the expression levels of p‑at8ser202 and gsk‑3β1h8 in the hippocampus were determined using immunohistochemical staining and western blot analysis. |
2016-05-03 |
2023-08-13 |
rat |
| Chan Chen, Jingjing Cai, Shu Zhang, Lu Gan, Yuanlin Dong, Tao Zhu, Gang Ma, Tao Li, Xiyang Zhang, Qian Li, Xu Cheng, Chaomeng Wu, Jing Yang, Yunxia Zuo, Jin Li. Protective Effect of RNase on Unilateral Nephrectomy-Induced Postoperative Cognitive Dysfunction in Aged Mice. PloS one. vol 10. issue 7. 2016-05-02. PMID:26225860. |
we found that perioperative administration of rnase: 1) attenuated unilateral nephrectomy-induced cognitive impairment at day 3 after surgery; 2) reduced the hippocampal cytokines mrna production and serum cytokines protein production at day 1 and day 7 (for mcp-1) after surgery, and; 3) inhibited hippocampal apoptosis as indicated by cleaved caspase-3 western blot and tunel staining at day 1 after surgery. |
2016-05-02 |
2023-08-13 |
mouse |
| T Ghasemi, K Abnous, F Vahdati, S Mehri, B M Razavi, H Hosseinzade. Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus. Drug research. vol 65. issue 7. 2016-04-26. PMID:24696423. |
the protein expression and transcript levels of bdnf, vgf creb and phospho-creb in rat hippocampus, were evaluated using western blot and quantitative reverse transcription-polymerase chain reaction (qrt-pcr). |
2016-04-26 |
2023-08-13 |
rat |
| Liang Huang, Li-Feng Liu, Juan Liu, Ling Dou, Ge-Ying Wang, Xiao-Qing Liu, Qiong-Lan Yua. Ginsenoside Rg1 protects against neurodegeneration by inducing neurite outgrowth in cultured hippocampal neurons. Neural regeneration research. vol 11. issue 2. 2016-04-13. PMID:27073387. |
in a separate experiment, we exposed cultured hippocampal neurons to aβ25-35 for 30 minutes, before adding rg1 for 48 hours, with or without akt or mapk inhibitors, and assessed neuronal survival using hoechst 33258 staining, and phosphorylation of erk1/2 and akt by western blot analysis. |
2016-04-13 |
2023-08-13 |
rat |
| Xuan Qin, Ye Liu, Minghui Zhu, Zhuo Yan. The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress. Behavioural brain research. vol 290. 2016-04-04. PMID:25958233. |
western blot assay was conducted to test the content of trpc3/5 in hippocampus, and golgi-cox staining was used to observe the morphological changes of neurons in hippocampus. |
2016-04-04 |
2023-08-13 |
rat |
| G Pathak, B A Ibrahim, S A McCarthy, K Baker, M P Kell. Amphetamine sensitization in mice is sufficient to produce both manic- and depressive-related behaviors as well as changes in the functional connectivity of corticolimbic structures. Neuropharmacology. vol 95. 2016-03-24. PMID:25959066. |
western blot analyses revealed a significant increase in methylation of histone 3 at lysine 9 (h3k9), but not lysine 4 (h3k4), in hippocampus of as mice relative to vt mice. |
2016-03-24 |
2023-08-13 |
mouse |
| Younghwan Lee, Qingtao Gao, Eunji Kim, Younghwa Lee, Se Jin Park, Hyung Eun Lee, Dae Sik Jang, Jong Hoon Ry. Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice. Pharmacology, biochemistry, and behavior. vol 134. 2016-03-23. PMID:25922228. |
furthermore, western blot analysis revealed that the levels of phosphorylated ca(2+)/calmodulin-dependent protein kinase ii-α (camkii) and extracellular signal-regulated kinases (erk) were significantly enhanced by the single administration of 5-hmf in the hippocampal tissues. |
2016-03-23 |
2023-08-13 |
mouse |