| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joshua A Bueller, Macksood Aftab, Srijan Sen, Diana Gomez-Hassan, Margit Burmeister, Jon-Kar Zubiet. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biological psychiatry. vol 59. issue 9. 2006-06-28. PMID:16442082. |
a frequent polymorphism of the brain-derived neurotrophic factor (bdnf) gene (val(66)met) has been suggested to modulate hippocampal neuronal plasticity and has been associated with individual variations in emotional reactivity traits and episodic memory. |
2006-06-28 |
2023-08-12 |
human |
| Younglim Lee, Ronald S Duman, Gerard J Mare. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neuroscience letters. vol 398. issue 3. 2006-06-08. PMID:16469447. |
both a 5-hydroxytryptamine2a (5-ht2a) agonist and immobilization stress previously have been shown to differentially alter brain-derived neurotrophic factor (bdnf) mrna expression in the neocortex and hippocampus. |
2006-06-08 |
2023-08-12 |
rat |
| Nadia M Tsankova, Olivier Berton, William Renthal, Arvind Kumar, Rachel L Neve, Eric J Nestle. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature neuroscience. vol 9. issue 4. 2006-06-08. PMID:16501568. |
to better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels of gene expression and chromatin remodeling of five brain-derived neurotrophic factor (bdnf) splice variant mrnas (i-v) and their unique promoters in the hippocampus. |
2006-06-08 |
2023-08-12 |
mouse |
| Shoshanna S Vaynman, Zhe Ying, Dali Yin, Fernando Gomez-Pinill. Exercise differentially regulates synaptic proteins associated to the function of BDNF. Brain research. vol 1070. issue 1. 2006-06-06. PMID:16413508. |
we used a specific immunoadhesin chimera (trkb-igg) that mimics the bdnf receptor, trkb, to selectively block bdnf in the hippocampus during 3 days of voluntary wheel running. |
2006-06-06 |
2023-08-12 |
rat |
| Małgorzata Filip, Agata Faron-Górecka, Maciej Kuśmider, Anna Gołda, Małgorzata Frankowska, Marta Dziedzicka-Wasylewsk. Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal. Brain research. vol 1071. issue 1. 2006-06-05. PMID:16423334. |
on the other hand, bdnf mrna in the rat hippocampus was increased only in the group of rats subjected to cocaine withdrawal. |
2006-06-05 |
2023-08-12 |
rat |
| Małgorzata Filip, Agata Faron-Górecka, Maciej Kuśmider, Anna Gołda, Małgorzata Frankowska, Marta Dziedzicka-Wasylewsk. Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal. Brain research. vol 1071. issue 1. 2006-06-05. PMID:16423334. |
therefore, the increases in the levels of bdnf mrna in the rat hippocampus seem to be correlated with "depressive-like" behavioral effects during withdrawal from repeated cocaine treatment. |
2006-06-05 |
2023-08-12 |
rat |
| Daniela B Pereira, Nelson Rebola, Ricardo J Rodrigues, Rodrigo A Cunha, Arsélio P Carvalho, Carlos B Duart. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477614. |
brain-derived neurotrophic factor (bdnf) modulates glutamatergic excitatory transmission in hippocampal primary cultures by acting at a presynaptic locus. |
2006-06-01 |
2023-08-12 |
rat |
| Daniela B Pereira, Nelson Rebola, Ricardo J Rodrigues, Rodrigo A Cunha, Arsélio P Carvalho, Carlos B Duart. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477614. |
although it has been suggested that bdnf also modulates adult hippocampus glutamatergic transmission, this remains a matter of controversy. |
2006-06-01 |
2023-08-12 |
rat |
| Daniela B Pereira, Nelson Rebola, Ricardo J Rodrigues, Rodrigo A Cunha, Arsélio P Carvalho, Carlos B Duart. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477614. |
to clarify a putative role for this neurotrophin in the modulation of glutamate release we applied exogenous bdnf to isolated adult rat hippocampal nerve terminals. |
2006-06-01 |
2023-08-12 |
rat |
| Daniela B Pereira, Nelson Rebola, Ricardo J Rodrigues, Rodrigo A Cunha, Arsélio P Carvalho, Carlos B Duart. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477614. |
bdnf, at 100 ng/ml, potentiated by 25% the k(+)-evoked release of [(3)h]glutamate from hippocampal synaptosomes. |
2006-06-01 |
2023-08-12 |
rat |
| Daniela B Pereira, Nelson Rebola, Ricardo J Rodrigues, Rodrigo A Cunha, Arsélio P Carvalho, Carlos B Duart. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477614. |
these results indicate that bdnf modulates synaptic transmission presynaptically in a small subset of hippocampal glutamatergic synapses that contain trkb and that express the receptor on the plasma membrane. |
2006-06-01 |
2023-08-12 |
rat |
| Russell W Brown, Marla K Perna, Tori L Schaefer, Michael T William. The effects of adulthood nicotine treatment on D2-mediated behavior and neurotrophins of rats neonatally treated with quinpirole. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408261. |
neonatal quinpirole treatment produced a significant decrease of nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) in the hippocampus that was alleviated by adulthood nicotine treatment. |
2006-05-25 |
2023-08-12 |
mouse |
| Russell W Brown, Marla K Perna, Tori L Schaefer, Michael T William. The effects of adulthood nicotine treatment on D2-mediated behavior and neurotrophins of rats neonatally treated with quinpirole. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408261. |
interestingly, nicotine treatment to controls produced a significant increase of ngf in the frontal cortex, but a significant decrease of both ngf and bdnf in the hippocampus and bdnf in the frontal cortex. |
2006-05-25 |
2023-08-12 |
mouse |
| Russell W Brown, Marla K Perna, Tori L Schaefer, Michael T William. The effects of adulthood nicotine treatment on D2-mediated behavior and neurotrophins of rats neonatally treated with quinpirole. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408261. |
the decreases shown in ngf and bdnf is contrary to past findings that have shown nicotine to produce significant increases of hippocampal ngf and bdnf, but these past studies utilized male rats or mice or were performed in vitro. |
2006-05-25 |
2023-08-12 |
mouse |
| Beth A Luellen, Matthew E Szapacs, Christopher K Materese, Anne M Andrew. The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF. Neuropharmacology. vol 50. issue 3. 2006-05-24. PMID:16288930. |
the neurotoxin 2'-nh2-mptp degenerates serotonin axons and evokes increases in hippocampal bdnf. |
2006-05-24 |
2023-08-12 |
mouse |
| Beth A Luellen, Matthew E Szapacs, Christopher K Materese, Anne M Andrew. The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF. Neuropharmacology. vol 50. issue 3. 2006-05-24. PMID:16288930. |
bdnf protein levels were selectively increased in the hippocampus 3 days post-dose and returned to normal 21 days later. |
2006-05-24 |
2023-08-12 |
mouse |
| Beth A Luellen, Matthew E Szapacs, Christopher K Materese, Anne M Andrew. The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF. Neuropharmacology. vol 50. issue 3. 2006-05-24. PMID:16288930. |
moreover, damage to the hippocampus, a brain region important for learning and memory, and the modulation of anxiety and stress responsiveness, results in a transitory increase in bdnf. |
2006-05-24 |
2023-08-12 |
mouse |
| Enrico Tongiorgi, Luciano Domenici, Michele Simonat. What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development. Molecular neurobiology. vol 33. issue 1. 2006-05-22. PMID:16388108. |
this article reviews recent findings in the context of epileptogenesis and visual cortex maturation that showed that different bdnf messenger rna (mrna) transcripts are localized at different subcellular locations in hippocampal and cortical neurons. |
2006-05-22 |
2023-08-12 |
Not clear |
| Dean-Chuan Wang, Shun-Sheng Chen, Yi-Ching Lee, Tsan-Ju Che. Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons. Neuroscience letters. vol 398. issue 1-2. 2006-05-10. PMID:16412575. |
one member of neurotrophins, brain-derived neurotrophic factor (bdnf), is known to be involved in the hippocampal long-term potentiation (ltp), a cellular model for learning and memory. |
2006-05-10 |
2023-08-12 |
rat |
| Wataru Matsunaga, Kenichi Isobe, Tetsuya Shirokaw. Involvement of neurotrophic factors in aging of noradrenergic innervations in hippocampus and frontal cortex. Neuroscience research. vol 54. issue 4. 2006-05-10. PMID:16448713. |
bdnf expression level increased in the hippocampus, but did not change with age in the frontal cortex. |
2006-05-10 |
2023-08-12 |
rat |