| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanna Pietropaolo, Jean-Charles Paterna, Hansruedi Büeler, Joram Feldon, Benjamin K Ye. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762522. |
alterations in hippocampal brain-derived neurotrophic factor (bdnf) expression have been implicated in the pathogenesis of emotional and cognitive dysfunction. |
2007-10-23 |
2023-08-12 |
rat |
| Susanna Pietropaolo, Jean-Charles Paterna, Hansruedi Büeler, Joram Feldon, Benjamin K Ye. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762522. |
here, we induced bdnf overexpression in the rat hippocampus using recombinant adenovirus-associated viral (raav) vectors, and studied its long-term (2 months postinduction) effects on anxiety-related behaviour, exploration in the open field, and spatial learning in the water maze. |
2007-10-23 |
2023-08-12 |
rat |
| Susanna Pietropaolo, Jean-Charles Paterna, Hansruedi Büeler, Joram Feldon, Benjamin K Ye. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762522. |
although the treatment successfully led to substantial elevation of hippocampal bdnf levels, its effect on spatial learning was bidirectional: a subset of raav-induced bdnf-overexpressing rats performed well above control level, whereas the rest were clearly impaired. |
2007-10-23 |
2023-08-12 |
rat |
| Susanna Pietropaolo, Jean-Charles Paterna, Hansruedi Büeler, Joram Feldon, Benjamin K Ye. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762522. |
the increase in dorsal hippocampal bdnf content achieved in the 'water-maze-impaired' subgroup was twice that attained in the 'water-maze-improved' rats. |
2007-10-23 |
2023-08-12 |
rat |
| Susanna Pietropaolo, Jean-Charles Paterna, Hansruedi Büeler, Joram Feldon, Benjamin K Ye. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762522. |
our results suggest that hippocampal bdnf elevation significantly affects cognitive and emotional behaviours, but the direction and magnitude of the effects critically depend on the precise levels of overexpression. |
2007-10-23 |
2023-08-12 |
rat |
| Susanna Pietropaolo, Jean-Charles Paterna, Hansruedi Büeler, Joram Feldon, Benjamin K Ye. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762522. |
this factor must be taken into account in future studies examining the functional consequences of hippocampal bdnf overexpression. |
2007-10-23 |
2023-08-12 |
rat |
| G de Foubert, M J O'Neill, T S C Zetterströ. Acute onset by 5-HT(6)-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17560041. |
the present study investigated the effects of 5-ht(6)-receptor activation on hippocampal and cortical levels of mrna expression of bdnf and arc in the rat. |
2007-10-19 |
2023-08-12 |
rat |
| G de Foubert, M J O'Neill, T S C Zetterströ. Acute onset by 5-HT(6)-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17560041. |
administration of ly-586713 caused a bell-shaped dose response on hippocampal bdnf mrna expression, having no effect at 0.1 mg/kg, a significant up-regulation at 1 mg/kg and no effect at 10 mg/kg. |
2007-10-19 |
2023-08-12 |
rat |
| Ying Xu, Baoshan Ku, Li Cui, Xuejun Li, Philip A Barish, Thomas C Foster, William O Ogl. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain research. vol 1162. 2007-10-19. PMID:17617388. |
in addition, curcumin significantly prevented the stress-induced decrease in 5-ht(1a) mrna and bdnf protein levels in the hippocampal subfields, two molecules involved in hippocampal neurogenesis. |
2007-10-19 |
2023-08-12 |
rat |
| Ying Xu, Baoshan Ku, Li Cui, Xuejun Li, Philip A Barish, Thomas C Foster, William O Ogl. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain research. vol 1162. 2007-10-19. PMID:17617388. |
moreover, curcumin treatment, via up-regulation of 5-ht(1a) receptors and bdnf, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin. |
2007-10-19 |
2023-08-12 |
rat |
| Matthew R Skelton, Michael T Williams, Tori L Schaefer, Charles V Vorhee. Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits. Psychoneuroendocrinology. vol 32. issue 6. 2007-10-18. PMID:17606327. |
bdnf in ma-treated animals was elevated on p15 and p20 in the hippocampus but not in the hypothalamus and was unchanged on p11 and p21. |
2007-10-18 |
2023-08-12 |
Not clear |
| Matthew R Skelton, Michael T Williams, Tori L Schaefer, Charles V Vorhee. Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits. Psychoneuroendocrinology. vol 32. issue 6. 2007-10-18. PMID:17606327. |
on p68 (1 h after morris water maze testing) ma-treated offspring showed a trend toward higher levels of bdnf in the hippocampus than saline-treated animals. |
2007-10-18 |
2023-08-12 |
Not clear |
| Matthew R Skelton, Michael T Williams, Tori L Schaefer, Charles V Vorhee. Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits. Psychoneuroendocrinology. vol 32. issue 6. 2007-10-18. PMID:17606327. |
the findings indicate that early ma exposure induces hippocampal bdnf increases that precede the later emergence of spatial learning deficits. |
2007-10-18 |
2023-08-12 |
Not clear |
| Nadine N Johnson-Farley, Khushboo Patel, Deborah Kim, Daniel S Cowe. Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt, ERK, and neuronal survival in hippocampal cultures. Brain research. vol 1154. 2007-10-12. PMID:17498671. |
interaction of fgf-2 with igf-1 and bdnf in stimulating akt, erk, and neuronal survival in hippocampal cultures. |
2007-10-12 |
2023-08-12 |
Not clear |
| Nadine N Johnson-Farley, Khushboo Patel, Deborah Kim, Daniel S Cowe. Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt, ERK, and neuronal survival in hippocampal cultures. Brain research. vol 1154. 2007-10-12. PMID:17498671. |
cultured hippocampal neurons were used in the present study to compare the neurotrophic actions of fibroblast growth factor-2 (fgf-2) with the better characterized growth factors, insulin-like growth factor (igf)-1 and brain-derived neurotrophic factor (bdnf). |
2007-10-12 |
2023-08-12 |
Not clear |
| Bríana Fahey, Barry Hickey, Dermot Kelleher, Anne-Marie O'Dwyer, Shane M O'Mar. The widely-used anti-viral drug interferon-alpha induces depressive- and anxiogenic-like effects in healthy rats. Behavioural brain research. vol 182. issue 1. 2007-10-12. PMID:17588681. |
here we investigated the effects of a clinically-comparable treatment regime of ifn-alpha on depressive- and anxiety-like behaviour in rats; and also examined frontal-cortical and hippocampal bdnf levels. |
2007-10-12 |
2023-08-12 |
human |
| Scott E Kanoski, Robert L Meisel, Amanda J Mullins, Terry L Davidso. The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. vol 182. issue 1. 2007-10-12. PMID:17590450. |
the effects of energy-rich diets on discrimination reversal learning and on bdnf in the hippocampus and prefrontal cortex of the rat. |
2007-10-12 |
2023-08-12 |
rat |
| Scott E Kanoski, Robert L Meisel, Amanda J Mullins, Terry L Davidso. The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. vol 182. issue 1. 2007-10-12. PMID:17590450. |
we evaluated the effects of these dietary manipulations on discrimination and reversal performance and on post-training levels of brain-derived neurotrophic factor (bdnf) in the prefrontal cortex and the ventral and dorsal hippocampus. |
2007-10-12 |
2023-08-12 |
rat |
| Scott E Kanoski, Robert L Meisel, Amanda J Mullins, Terry L Davidso. The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. vol 182. issue 1. 2007-10-12. PMID:17590450. |
however, prior unrestricted access to the hfd diet impaired discrimination reversal learning and reduced bdnf in the prefrontal cortex and ventral hippocampus. |
2007-10-12 |
2023-08-12 |
rat |
| Yaowared Sumanont, Yukihisa Murakami, Michihisa Tohda, Opa Vajragupta, Hiroshi Watanabe, Kinzo Matsumot. Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biological & pharmaceutical bulletin. vol 30. issue 9. 2007-10-12. PMID:17827730. |
caused seizures and increased the expression of neurotoxic markers, immediate early genes [c-jun, cyclooxygenase 2 (cox-2), brain-derived neurotrophic factor (bdnf), and heat shock protein 70 (hsp70)] and a delayed response gene [inducible nitric oxide synthase (inos)], which were measured at 6 and 72 h after ka injection, respectively, in the hippocampus. |
2007-10-12 |
2023-08-12 |
rat |