| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Syed Hamid Ali, Rajaram Mohanrao Madhana, Athira K V, Eshvendar Reddy Kasala, Lakshmi Narendra Bodduluru, Sathish Pitta, Jalandhar Reddy Mahareddy, Mangala Lahka. Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. Steroids. vol 101. 2016-04-06. PMID:26048446. |
since brain derived neurotrophic factor (bdnf) has been implicated in antidepressant activity of many drugs, we also evaluated the effect of resveratrol on bdnf in the hippocampus. |
2016-04-06 |
2023-08-13 |
mouse |
| Syed Hamid Ali, Rajaram Mohanrao Madhana, Athira K V, Eshvendar Reddy Kasala, Lakshmi Narendra Bodduluru, Sathish Pitta, Jalandhar Reddy Mahareddy, Mangala Lahka. Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. Steroids. vol 101. 2016-04-06. PMID:26048446. |
further, there was a significant increase in serum corticosterone level and a significant decrease in hippocampus bdnf level in cort-treated mice. |
2016-04-06 |
2023-08-13 |
mouse |
| Syed Hamid Ali, Rajaram Mohanrao Madhana, Athira K V, Eshvendar Reddy Kasala, Lakshmi Narendra Bodduluru, Sathish Pitta, Jalandhar Reddy Mahareddy, Mangala Lahka. Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. Steroids. vol 101. 2016-04-06. PMID:26048446. |
these results suggest that resveratrol produces an antidepressant-like effect in cort-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (hpa) axis dysfunction paradigm and upregulation of hippocampal bdnf levels. |
2016-04-06 |
2023-08-13 |
mouse |
| Michelle S Antunes, Jossana Rodrigues Ruff, Dieniffer de Oliveira Espinosa, Manuela Bastos Piegas, Maicon Lenon Otenio de Brito, Kellen Athaíde Rocha, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Leandro Cattelan Souza, Franciele Donato, Silvana Peterini Boeira, Cristiano R Jess. Neuropeptide Y administration reverses tricyclic antidepressant treatment-resistant depression induced by ACTH in mice. Hormones and behavior. vol 73. 2016-04-06. PMID:26122290. |
the levels of serum corticosterone, tryptophan (trp), kynurenine (kyn), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf) and indoleamine 2,3-dioxygenase (ido) activity in the hippocampus were analyzed. |
2016-04-06 |
2023-08-13 |
mouse |
| Michelle S Antunes, Jossana Rodrigues Ruff, Dieniffer de Oliveira Espinosa, Manuela Bastos Piegas, Maicon Lenon Otenio de Brito, Kellen Athaíde Rocha, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Leandro Cattelan Souza, Franciele Donato, Silvana Peterini Boeira, Cristiano R Jess. Neuropeptide Y administration reverses tricyclic antidepressant treatment-resistant depression induced by ACTH in mice. Hormones and behavior. vol 73. 2016-04-06. PMID:26122290. |
in addition, acth administration decreased the bdnf and ngf levels in the hippocampus of mice. |
2016-04-06 |
2023-08-13 |
mouse |
| Tatiana V Ilchibaeva, Elena M Kondaurova, Anton S Tsybko, Rimma V Kozhemyakina, Nina K Popova, Vladimir S Naumenk. Brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) in genetically defined fear-induced aggression. Behavioural brain research. vol 290. 2016-04-04. PMID:25934485. |
significant increase of bdnf mrna level in the frontal cortex and increase of bdnf level in the hippocampus of aggressive rats was revealed. |
2016-04-04 |
2023-08-13 |
rat |
| Marie Lou Camara, Frances Corrigan, Emily J Jaehne, M Catharine Jawahar, Helen Anscomb, Bernhard T Baun. Tumor necrosis factor alpha and its receptors in behaviour and neurobiology of adult mice, in the absence of an immune challenge. Behavioural brain research. vol 290. 2016-04-04. PMID:25934492. |
elisa hippocampal levels of nerve growth factor (ngf) and brain derived neurotrophic factor (bdnf) and qpcr mrna levels of tnfa, tnfr1, tnfr2, il10 and il1β were measured. |
2016-04-04 |
2023-08-13 |
mouse |
| Marie Lou Camara, Frances Corrigan, Emily J Jaehne, M Catharine Jawahar, Helen Anscomb, Bernhard T Baun. Tumor necrosis factor alpha and its receptors in behaviour and neurobiology of adult mice, in the absence of an immune challenge. Behavioural brain research. vol 290. 2016-04-04. PMID:25934492. |
additionally, tnf(-/-) mice expressed significantly lower levels of bdnf than wt mice in the hippocampus while tnf-r1(-/-) mice displayed significantly lower bdnf levels compared to both wt and tnf-r2(-/-) mice. |
2016-04-04 |
2023-08-13 |
mouse |
| Allan C Calsavara, Frederico M Soriani, Leda Q Vieira, Priscila A Costa, Milene A Rachid, Antônio L Teixeira, Antônio L Teixier. TNFR1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal BDNF. Metabolic brain disease. vol 30. issue 3. 2016-04-01. PMID:25148914. |
tnfr1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal bdnf. |
2016-04-01 |
2023-08-13 |
mouse |
| Allan C Calsavara, Frederico M Soriani, Leda Q Vieira, Priscila A Costa, Milene A Rachid, Antônio L Teixeira, Antônio L Teixier. TNFR1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal BDNF. Metabolic brain disease. vol 30. issue 3. 2016-04-01. PMID:25148914. |
our next step was to determine the expression of inflammatory cytokines, bdnf and trkb in the hippocampus. |
2016-04-01 |
2023-08-13 |
mouse |
| Allan C Calsavara, Frederico M Soriani, Leda Q Vieira, Priscila A Costa, Milene A Rachid, Antônio L Teixeira, Antônio L Teixier. TNFR1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal BDNF. Metabolic brain disease. vol 30. issue 3. 2016-04-01. PMID:25148914. |
the absence of tnfr1 in mice subjected to polymicrobial sepsis resulted in higher bdnf expression in the hippocampus. |
2016-04-01 |
2023-08-13 |
mouse |
| Allan C Calsavara, Frederico M Soriani, Leda Q Vieira, Priscila A Costa, Milene A Rachid, Antônio L Teixeira, Antônio L Teixier. TNFR1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal BDNF. Metabolic brain disease. vol 30. issue 3. 2016-04-01. PMID:25148914. |
this finding was associated with increased bdnf expression in the hippocampus. |
2016-04-01 |
2023-08-13 |
mouse |
| Ning Jia, Qinghong Li, Hongli Sun, Qian Song, Guokui Tang, Qinru Sun, Weixi Wang, Rui Chen, Hui Li, Zhongliang Zh. Alterations of Group I mGluRs and BDNF Associated with Behavioral Abnormity in Prenatally Stressed Offspring Rats. Neurochemical research. vol 40. issue 5. 2016-04-01. PMID:25894678. |
in addition, the reduced bdnf mrna level was detected in the hippocampus and prefrontal cortex in the lps rats, and in the striatum of the female rats in lps group. |
2016-04-01 |
2023-08-13 |
rat |
| Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming X. Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42. PloS one. vol 10. issue 4. 2016-03-31. PMID:25849905. |
because bdnf plays a critical role in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, the up-regulation of bdnf may rescue cognitive impairments and learning deficits in ad. |
2016-03-31 |
2023-08-13 |
rat |
| Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming X. Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42. PloS one. vol 10. issue 4. 2016-03-31. PMID:25849905. |
in the present study, we investigated the effects of hippocampal bdnf in a rat model of ad produced by a ventricle injection of amyloid-β1-42 (aβ1-42). |
2016-03-31 |
2023-08-13 |
rat |
| Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming X. Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42. PloS one. vol 10. issue 4. 2016-03-31. PMID:25849905. |
we found that a ventricle injection of aβ1-42 caused learning deficits in rats subjected to the morris water maze and decreased bdnf expression in the hippocampus. |
2016-03-31 |
2023-08-13 |
rat |
| Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming X. Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42. PloS one. vol 10. issue 4. 2016-03-31. PMID:25849905. |
together, our data suggest that the up-regulation of bdnf in the hippocampus via activation of the erk signaling pathway can ameliorate aβ1-42-induced learning deficits, thus identifying a novel pathway through which bdnf protects against ad-related cognitive impairments. |
2016-03-31 |
2023-08-13 |
rat |
| F Harrisberger, R Smieskova, A Schmidt, C Lenz, A Walter, K Wittfeld, H J Grabe, U E Lang, P Fusar-Poli, S Borgward. BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 55. 2016-03-31. PMID:25956254. |
bdnf val66met polymorphism and hippocampal volume in neuropsychiatric disorders: a systematic review and meta-analysis. |
2016-03-31 |
2023-08-13 |
Not clear |
| F Harrisberger, R Smieskova, A Schmidt, C Lenz, A Walter, K Wittfeld, H J Grabe, U E Lang, P Fusar-Poli, S Borgward. BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 55. 2016-03-31. PMID:25956254. |
brain-derived neurotrophic factor (bdnf) is a neurotrophin involved in neurogenesis and synaptic plasticity in the central nervous system, especially in the hippocampus, and has been implicated in the pathophysiology of several neuropsychiatric disorders. |
2016-03-31 |
2023-08-13 |
Not clear |
| F Harrisberger, R Smieskova, A Schmidt, C Lenz, A Walter, K Wittfeld, H J Grabe, U E Lang, P Fusar-Poli, S Borgward. BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 55. 2016-03-31. PMID:25956254. |
its val66met polymorphism (refsnp cluster report: rs6265) is a functionally relevant single nucleotide polymorphism affecting the secretion of bdnf and is implicated in differences in hippocampal volumes. |
2016-03-31 |
2023-08-13 |
Not clear |