| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| René A Girard, Prashant S Chauhan, Torry A Tucker, Tim Allen, Jaswinder Kaur, Ann Jeffers, Kathleen Koenig, Galina Florova, Andrey A Komissarov, Tatiana A Gaidenko, Mignote B Chamiso, James Fowler, Danna E Morris, Krishna Sarva, Karan P Singh, Steven Idell, Richard D Idel. Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice. Experimental brain research. vol 237. issue 12. 2020-04-24. PMID:31734788. |
furthermore, these studies suggest that urokinase-type plasminogen activator may serve as an astrocyte pa reservoir, able to promote cleavage of brain-derived neurotrophic factor (bdnf) during stress or inflammation. |
2020-04-24 |
2023-08-13 |
mouse |
| Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olse. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1. eLife. vol 8. 2020-02-11. PMID:31433295. |
astrocyte morphogenesis is dependent on bdnf signaling via astrocytic trkb.t1. |
2020-02-11 |
2023-08-13 |
mouse |
| Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olse. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1. eLife. vol 8. 2020-02-11. PMID:31433295. |
herein, we demonstrate astrocytes express high levels of bdnf's receptor, trkb (in the top 20 of protein-coding transcripts), with nearly exclusive expression of the truncated isoform, trkb.t1, which peaks in expression during astrocyte morphological maturation. |
2020-02-11 |
2023-08-13 |
mouse |
| Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olse. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1. eLife. vol 8. 2020-02-11. PMID:31433295. |
using a novel culture paradigm, we show that astrocyte morphological complexity is increased in the presence of bdnf and is dependent upon bdnf/trkb.t1 signaling. |
2020-02-11 |
2023-08-13 |
mouse |
| Cynthia L Winham, Timmy Le, Evan R Jellison, Adam C Silver, Aime A Levesque, Andrew O Koo. γ-Synuclein Induces Human Cortical Astrocyte Proliferation and Subsequent BDNF Expression and Release. Neuroscience. vol 410. 2020-01-31. PMID:31078687. |
γ-synuclein induces human cortical astrocyte proliferation and subsequent bdnf expression and release. |
2020-01-31 |
2023-08-13 |
human |
| Adnan Khan, Bushra Shal, Muhammad Naveed, Fawad Ali Shah, Ayesha Atiq, Naseem Ullah Khan, Yeong Shik Kim, Salman Kha. Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury. Neurotoxicology. vol 72. 2020-01-06. PMID:30738807. |
acute pretreatment of matrine enhanced neurogenesis by increasing the number of gfaf (glial fibrillary acidic protein) positive astrocyte, bdnf (brain-derived neurotrophic factor), and vegf (vascular endothelial growth factor) in the hippocampus of ccl4-treated mice. |
2020-01-06 |
2023-08-13 |
mouse |
| John S. Rudge, Ralph F. Alderson, Elizabeth Pasnikowski, Joyce McClain, Nancy Y. Ip, Ronald M. Lindsa. Expression of Ciliary Neurotrophic Factor and the Neurotrophins-Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin 3-in Cultured Rat Hippocampal Astrocytes. The European journal of neuroscience. vol 4. issue 6. 2019-11-20. PMID:12106332. |
in order to examine which factors may be responsible for these activities, we have examined the expression of the genes for four known neurotrophic factors-ciliary neurotrophic factor (cntf), nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt3)-in purified astrocyte cultures derived from neonatal rat hippocampus. |
2019-11-20 |
2023-08-12 |
rat |
| Julieta Saba, Juan Turati, Delia Ramírez, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Carus. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29851427. |
we hypothesize that bdnf may prevent astrocyte death resulting in neuroprotection. |
2019-06-26 |
2023-08-13 |
Not clear |
| Julieta Saba, Juan Turati, Delia Ramírez, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Carus. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29851427. |
we found that bdnf increased astrocyte viability, preventing apoptosis induced by serum deprivation by decreasing active caspase 3 and p53 expression. |
2019-06-26 |
2023-08-13 |
Not clear |
| Cai Zhang, Yong-Ping Zhang, Yu-Yu Li, Bai-Ping Liu, Hao-Yin Wang, Kang-Wei Li, Shannon Zhao, Cai Son. Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat. Behavioural brain research. vol 356. 2019-04-16. PMID:30003978. |
meanwhile, cums inhibited the expressions of astrocyte marker glial fibrillary acidic protein (gfap), brain-derived neurotrophic factor (bdnf) and trkb. |
2019-04-16 |
2023-08-13 |
rat |
| Xiaoni Zhan, Fengrui Li, Qiaohong Chu, Hao Pan. Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process. International journal of molecular medicine. vol 42. issue 6. 2019-02-25. PMID:30280190. |
secretogranin iii may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of bdnf during this process. |
2019-02-25 |
2023-08-13 |
Not clear |
| Andrea Becerra-Calixto, Rafael Posada-Duque, Gloria Patricia Cardona-Góme. Recovery of Neurovascular Unit Integrity by CDK5-KD Astrocyte Transplantation in a Global Cerebral Ischemia Model. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29564811. |
we found that the effects of cdk5-kd were sustained for 4 months, preventing neuronal and astrocyte loss, facilitating the recovery of the bbb via the production of bdnf by endogenous astrocytes (gfp |
2018-12-17 |
2023-08-13 |
rat |
| Changhui Qian, Dandan Tan, Xianghai Wang, Lixia Li, Jinkun Wen, Mengjie Pan, Yuanyuan Li, Wutian Wu, Jiasong Gu. Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration. Neural plasticity. vol 2018. 2018-11-26. PMID:29849572. |
additionally, we found that the expression of neurotrophins, including brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), and neurotrophin-3 (nt-3), also accompanied with astrocyte activation. |
2018-11-26 |
2023-08-13 |
human |
| Cheng Cao, Junyuan Xiao, Mengqiu Liu, Zishuo Ge, Renjie Huang, Mingzhu Qi, Hongliang Zhu, Yue Zhu, Jin-Ao Dua. Active components, derived from Kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor NGF and BDNF on mouse astrocyte primary cultures via cAMP-dependent signaling pathway. Journal of ethnopharmacology. vol 224. 2018-11-13. PMID:29890314. |
active components, derived from kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor ngf and bdnf on mouse astrocyte primary cultures via camp-dependent signaling pathway. |
2018-11-13 |
2023-08-13 |
mouse |
| Yeyang Wang, Wenjun Li, Mingsen Wang, Chuangxin Lin, Guitao Li, Xiaozhong Zhou, Junnan Luo, Dadi Ji. Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865131. |
taken together, que promoted locomotor and electrophysiological functional recovery, astrocyte activation and axonal regeneration after acute sci, possibly through bdnf and jak2/stat3 signaling pathways. |
2018-10-15 |
2023-08-13 |
rat |
| Kazue Hisaoka-Nakashima, Chie Matsumoto, Honami Azuma, Sayaka Taki, Minoru Takebayashi, Yoshihiro Nakata, Norimitsu Moriok. Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes. Biological & pharmaceutical bulletin. vol 40. issue 10. 2018-06-12. PMID:28966248. |
treatment of astrocyte with either mastoparan or compound48/80 increased brain-derived neurotrophic factor (bdnf) mrna expression as well as gdnf. |
2018-06-12 |
2023-08-13 |
rat |
| Fabiana Galland, Elisa Negri, Carollina Da Ré, Fernanda Fróes, Liliane Strapazzon, Maria Cristina Guerra, Lucas Silva Tortorelli, Carlos-Alberto Gonçalves, Marina Concli Leit. Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus. Neurotoxicology. vol 62. 2018-05-30. PMID:28506823. |
hippocampal bdnf was reduced in hyperammonemic rats via a mechanism that may involve astrocyte production, since the same effect was observed in astrocyte cultures exposed to ammonia. |
2018-05-30 |
2023-08-13 |
rat |
| Jian-Bin Zhong, Xie Li, Si-Ming Zhong, Jiu-Di Liu, Chi-Bang Chen, Xiao-Yan W. Knockdown of long noncoding antisense RNA brain-derived neurotrophic factor attenuates hypoxia/reoxygenation-induced nerve cell apoptosis through the BDNF-TrkB-PI3K/Akt signaling pathway. Neuroreport. vol 28. issue 14. 2018-05-02. PMID:28777258. |
following downregulation of bdnf-as by sirna in human cortical neurons and human astrocyte cells, bdnf expression was significantly upregulated and the h/r-induced upregulation of bdnf-as was significantly attenuated. |
2018-05-02 |
2023-08-13 |
human |
| Zhiming Tu, Yawei Li, Yuliang Dai, Lei Li, Guohua Lv, Ivan Chen, Bing Wan. MiR-140/BDNF axis regulates normal human astrocyte proliferation and LPS-induced IL-6 and TNF-α secretion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-19. PMID:28501777. |
in the present study, brain-derived neurotrophic factor (bdnf), a regulator of astrocyte proliferation and differentiation, confirmed as a direct target of mir-140 in nha. |
2018-03-19 |
2023-08-13 |
human |
| Tomoya Kitayama, Katsuya Morita, Naoyo Motoyama, Toshihiro Doh. Down-regulation of zinc transporter-1 in astrocytes induces neuropathic pain via the brain-derived neurotrophic factor - K Neurochemistry international. vol 101. 2018-01-12. PMID:27818163. |
znt1 kd increased intracellular zinc concentrations in primary astrocyte cultures, and this was followed by enhanced pkcα membrane translocation and nfκb nuclear translocation as well as increases in the levels of il-6 and bdnf expressed and the phosphorylation of creb in vitro. |
2018-01-12 |
2023-08-13 |
mouse |