| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norimitsu Morioka, Syun Kondo, Nanase Harada, Tomoyo Takimoto, Nozomi Tokunaga, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33665818. |
how changes in cx43 expression affect astrocyte function, including bdnf production, is poorly understood. |
2021-11-29 |
2023-08-13 |
rat |
| Hang Yin, Hao Qin, Tiantian Wang, Qiang Zhuang, Qixia Yan. The Protective Effects of Apremilast Against Oxygen-Glucose Deprivation/Reperfusion (OGD/R)-Induced Inflammation and Apoptosis in Astroglia Mediated by CREB/BDNF. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33826130. |
importantly, we found that creb phosphorylation was required for the increases in bdnf and bcl-2 induced by apremilast as well as the decrease in astrocyte apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Adam J Lundquist, Tyler J Gallagher, Giselle M Petzinger, Michael W Jakowe. Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice. Journal of neuroscience research. vol 99. issue 5. 2021-11-18. PMID:33629362. |
using in vitro primary astrocyte cell culture, administration of l-lactate increased the expression of the neurotrophic factors bdnf, gdnf, cntf, and the immediate early gene cfos. |
2021-11-18 |
2023-08-13 |
mouse |
| Lin Guo, Tianyu Gao, Ce Gao, Xiaoxia Jia, Jing Ni, Chaojun Han, Yun Wan. Stimulation of astrocytic sigma-1 receptor is sufficient to ameliorate inflammation- induced depression. Behavioural brain research. vol 410. 2021-10-18. PMID:33961912. |
besides, specific stimulation of astrocytic sig-1r decreased the activation of astrocyte and microglia, as well as increased brain-derived neurotrophic factor (bdnf) in lps-induced depression. |
2021-10-18 |
2023-08-13 |
Not clear |
| Roberta Passos Palazzo, Iraci L S Torres, Ágnis Iohana Grefenhagen, Bruno Batista da Silva, Louisiana Carolina Ferreira de Meireles, Kethleen Costa de Vargas, Zingara Alves, Lenir Orlandi Pereira Silva, Ionara Rodrigues Siqueir. Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32926590. |
early life exposure to hypercaloric diet impairs eating behavior during weaning: the role of bdnf signaling and astrocyte marks. |
2021-08-26 |
2023-08-13 |
rat |
| Roberta Passos Palazzo, Iraci L S Torres, Ágnis Iohana Grefenhagen, Bruno Batista da Silva, Louisiana Carolina Ferreira de Meireles, Kethleen Costa de Vargas, Zingara Alves, Lenir Orlandi Pereira Silva, Ionara Rodrigues Siqueir. Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32926590. |
the aim of the present study was to evaluate the impact of gestational and lactational exposure to cafeteria diet on eating behavior and neurochemical parameters, bdnf signaling, epigenetic and astrocyte marks in the hippocampus and olfactory bulb during the weaning phase. |
2021-08-26 |
2023-08-13 |
rat |
| Roberta Passos Palazzo, Iraci L S Torres, Ágnis Iohana Grefenhagen, Bruno Batista da Silva, Louisiana Carolina Ferreira de Meireles, Kethleen Costa de Vargas, Zingara Alves, Lenir Orlandi Pereira Silva, Ionara Rodrigues Siqueir. Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32926590. |
our results showed that changes in interrelated neurochemical signaling, bdnf, and astrocyte marks, induced by hypercaloric diet in early stages of development may be related to impairment in the temporal distribution of eating pattern and consequent amounts of consumed food during the weaning phase. |
2021-08-26 |
2023-08-13 |
rat |
| Romain Barus, Sandrine Bergeron, Florent Auger, Charlotte Laloux, Emilie Skrobala, Antonino Bongiovanni, Camille Potey, Régis Bordet, Yaohua Chen, Sophie Gautie. Sex Differences in Cognitive Impairment Induced by Cerebral Microhemorrhage. Translational stroke research. vol 12. issue 2. 2021-07-30. PMID:32440818. |
the cmh also exerted spatial remote effects in the hippocampus by increasing the number of astrocytes in both sexes, increasing the mean area occupied by each astrocyte in males, and decreasing hippocampal bdnf in females suggesting a cortical-hippocampal network impairment. |
2021-07-30 |
2023-08-13 |
mouse |
| Yue Jia, Dandan Zhang, Haoran Li, Shaolei Luo, Yuhuan Xiao, Li Han, Fuchun Zhou, Chuanyue Wang, Lei Feng, Gang Wang, Peng Wu, Chunjie Xiao, Haijing Yu, Jing Du, Hongkun Ba. Activation of FXR by ganoderic acid A promotes remyelination in multiple sclerosis via anti-inflammation and regeneration mechanism. Biochemical pharmacology. vol 185. 2021-07-01. PMID:33482151. |
in these two independent ms animal models, gaa modulated neuroimmune to enhance the anti-inflammatory and regeneration markers il-4 and bdnf, inhibited inflammatory markers il-1β and il-6, followed by down-regulation of microglia activation and astrocyte proliferation. |
2021-07-01 |
2023-08-13 |
mouse |
| Xiaohui Jiang, Lina Chen, Zhongyuan Zheng, Ying Chen, Xiaogang Weng, Yuan Guo, Kai Li, Ting Yang, Shuiqing Qu, Hui Liu, Yujie Li, Xiaoxin Zh. Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria. ACS infectious diseases. vol 6. issue 9. 2021-06-23. PMID:32786270. |
this combination downregulated the expression of adhesion molecules and sequestration of parasitized red blood cells (prbcs), increased cerebral blood flow, nerve growth factor (b-ngf), vascular endothelial growth factor a (vegf-a), and neurotrophin (brain-derived neurotrophic factor (bdnf), neurotrophic factor-3 (nt-3)) levels, and alleviated hippocampal neuronal damage and astrocyte activation. |
2021-06-23 |
2023-08-13 |
mouse |
| Fei Huang, Taiying Chen, Jun Chang, Chi Zhang, Faxue Liao, Linwei Wu, Wenbin Wang, Zongsheng Yi. A conductive dual-network hydrogel composed of oxidized dextran and hyaluronic-hydrazide as BDNF delivery systems for potential spinal cord injury repair. International journal of biological macromolecules. vol 167. 2021-04-19. PMID:33278434. |
furthermore, results from immunostaining and real-time pcr demonstrated that bdnf@ta-plga/dex-ha hydrogel could promote the differentiation of neural stem cells (nscs) into neurons and inhibit astrocyte differentiation in vitro. |
2021-04-19 |
2023-08-13 |
Not clear |
| Yujiao Lu, Gangadhara R Sareddy, Jing Wang, Quanguang Zhang, Fu-Lei Tang, Uday P Pratap, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Bran. Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32817249. |
the compromised astrocyte activation in fbn-aro-ko mice was associated with robust downregulation of the astrocyte-derived neurotrophic factors, bdnf and igf-1, as well as the astrocytic glutamate transporter, glt-1. |
2021-01-15 |
2023-08-13 |
mouse |
| Jun An, Jun-Jun Yin, Yan He, Ruo-Xuan Sui, Qiang Miao, Qing Wang, Jie-Zhong Yu, Jing-Wen Yu, Fu-Dong Shi, Cun-Gen Ma, Bao-Guo Xia. Temporal and Spatial Dynamics of Astroglial Reaction and Immune Response in Cuprizone-Induced Demyelination. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31721051. |
at the 4th and 6th weeks of feeding, cpz caused astrocyte activation and upregulated the expression of bdnf, cntf, and igf-ii, providing a neurotrophic microenvironment in the brain. |
2020-12-04 |
2023-08-13 |
Not clear |
| Dipro Bose, Ayan Mondal, Punnag Saha, Diana Kimono, Sutapa Sarkar, Ratanesh K Seth, Patricia Janulewicz, Kimberly Sullivan, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterje. TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model. Brain sciences. vol 10. issue 8. 2020-09-28. PMID:32784362. |
ssnb also decreased neuronal inflammation by decreasing il-1β and hmgb1, while increasing brain-derived neurotrophic factor (bdnf), with a parallel decrease in astrocyte activation in vitro. |
2020-09-28 |
2023-08-13 |
mouse |
| Nathan T Fiore, Paul J Austi. Peripheral Nerve Injury Triggers Neuroinflammation in the Medial Prefrontal Cortex and Ventral Hippocampus in a Subgroup of Rats with Coincident Affective Behavioural Changes. Neuroscience. vol 416. 2020-09-24. PMID:31401182. |
microglial and astrocyte morphology, as well as il-1β, il-6, il-10, mcp-1, p38 mapk and bdnf expression was quantified throughout the mpfc and hp using protein multiplex assays and immunofluorescence. |
2020-09-24 |
2023-08-13 |
rat |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
astrocyte activation was examined by immunohistochemical staining and western blotting for glial fibrillary acid protein (gfap), while expression levels of the pro-inflammatory cytokine-tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β), the apoptosis effector cysteinyl aspartate specific proteinase-3 (caspase-3), and the neuroprotectant brain-derived neurotrophic factor (bdnf) and the trkb receptor were estimated by western blotting. |
2020-08-31 |
2023-08-13 |
rat |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
andrographolide treatment during cch suppressed astrocyte activation as evidenced by reduced gfap expression, enhanced expression of bdnf and trkb, improved impaired spatial learning and memory, and reversed upregulated tnf-α, il-1β, and caspase-3 expression. |
2020-08-31 |
2023-08-13 |
rat |
| Hyesook Yoon, Chan-Il Choi, Erin M Triplet, Monica R Langley, Laurel S Kleppe, Ha Neui Kim, Whitney L Simon, Isobel A Scarisbric. Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 7. 2020-08-19. PMID:31911460. |
in cell culture, the promyelinating effects of par1 loss of function are consistent with possible direct effects on the myelinating potential of oligodendrocyte progenitor cells (opcs), in addition to opc-indirect effects involving enhanced astrocyte expression of promyelinating factors, such as bdnf. |
2020-08-19 |
2023-08-13 |
mouse |
| Tomoyuki Kurose, Shinya Takahashi, Takashi Otsuka, Kei Nakagawa, Takeshi Imura, Taijiro Sueda, Louis Yug. Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats. Stem cell research. vol 41. 2020-06-02. PMID:31731179. |
glial fibrillary acidic protein (gfap)-positive (reactive) astrocyte numbers were increased in all three groups, and brain-derived neurotrophic factor (bdnf) was colocalized with gfap-positive cells in spinal ventral horn. |
2020-06-02 |
2023-08-13 |
rat |
| Rita Machaalani, Melisande Thawley, Jessica Huang, Hui Che. Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem. Neurotoxicology. vol 74. 2020-05-12. PMID:31121239. |
using a mouse model of pre- into post- natal cigarette smoke exposure (se), we aimed to determine the effects on brain derived neurotrophic factor (bdnf) and its receptor trkb, neuropeptide pituitary adenylate cyclase activating polypeptide (pacap) and its receptor pac1, and astrocyte (gfap) and microglia (iba-1) immunohistochemical expression, in seven nuclei of the medulla and the facial (fac) nucleus of the pons. |
2020-05-12 |
2023-08-13 |
mouse |