| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jenni Ho, Suriyan Sukati, Tamara Taylor, Sherry Carter, Brittany Fuller, Amy Marmo, Caryn Sorge, John D'Orazio, D Allan Butterfield, Subbarao Bondada, Heidi Weiss, Daret K St Clair, Luksana Chaiswin. Extracellular vesicles released by ALL patients contain HNE-adducted proteins: implications of collateral damage. Free radical biology & medicine. 2024-12-06. PMID:39643137. |
evs were measured throughout the collection points for: 1) number of ev particles generated using nanoparticle tracking analysis (nta); 2) markers of neurons (neun), astrocyte activation (gfap), neuronal stability (bdnf), 3) markers of pre-b cell all (cd19 and cd22); and ) 4-hydroxy-2-nonenal (hne) adducted proteins. |
2024-12-06 |
2024-12-10 |
Not clear |
| Jeong Heon Gong, Chu-Sook Kim, Jeongmin Park, Soeun Kang, Yumi Jang, Min-Seon Kim, Hun Taeg Chung, Yeonsoo Joe, Rina Y. Filbertone-Induced Nrf2 Activation Ameliorates Neuronal Damage via Increasing BDNF Expression. Neurochemical research. vol 50. issue 1. 2024-12-05. PMID:39636503. |
in our study, filbertone markedly elevated the expression of neurotrophic factors, including bdnf, glial cell line-derived neurotrophic factor (gdnf), and nerve growth factor (ngf), in human neuroblastoma sh-sy5y cells, mouse astrocyte c8-d1a cells, and mouse hypothalamus mhypoe-n1 cells. |
2024-12-05 |
2024-12-08 |
mouse |
| Beatriz T C Pinkston, Jack L Browning, Michelle L Olse. Astrocyte TrkB.T1 deficiency disrupts glutamatergic synaptogenesis and astrocyte-synapse interactions. bioRxiv : the preprint server for biology. 2024-11-01. PMID:39484608. |
herein, we demonstrate a role for the astrocyte trkb.t1 receptor, a truncated isoform of the canonical receptor for brain derived neurotrophic factor (bdnf), in modulating astrocyte-synapse interactions and excitatory synapse development. |
2024-11-01 |
2024-11-03 |
mouse |
| Maria V Zakharova, Anna A Kovalenko, Olga E Zubareva, Alexander P Schwarz, Tatiana Y Postnikova, Alina M Trofimova, Aleksey V Zaitse. Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-21. PMID:39305083. |
an increase in the expression of the gfap, slc1a2, slc1a1, il1b, tnfa, bdnf, and fgf2 genes, and the a2 astrocyte condition marker s100a10, was observed. |
2024-09-21 |
2024-09-24 |
rat |
| Ji-Yun Kang, Jin-Seok Lee, Jing-Hua Wang, Chang-Gue So. Sleep deprivation in adolescent mice impairs long-term memory till early adulthood via suppression of hippocampal astrocytes. Sleep. 2024-06-27. PMID:38934552. |
furthermore, the hippocampal region exhibited significantly diminished protein expressions of astrocyte, characterized by lowered levels of aquaporin 4 (aqp4), a representative molecule involved in brain clearance processes, and reduced protein expressions of brain-derived neurotrophic factor (bdnf). |
2024-06-27 |
2024-06-29 |
mouse |
| Sahand Ashrafpour, Mohammad-Javad Nasr-Taherabadi, Alie Sabouri-Rad, Soheila Hosseinzadeh, Fereshteh Pourabdolhossei. Arbutin Intervention Ameliorates Memory Impairment in a Rat Model of lysolecethin induced Demyelination: Neuroprotective and Anti-Inflammatory Effects. Behavioural brain research. 2024-05-09. PMID:38723674. |
arbutin also diminished astrocyte activation, decreased inos, enhanced anti-oxidative factors (nrf2, ho-1), and exhibited neuroprotective effects by elevating myelin markers (mbp) and brain derived neurotrophic factor (bdnf). |
2024-05-09 |
2024-05-27 |
rat |
| Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Li. Inflammatory Pathogenesis of Post-stroke Depression. Aging and disease. 2024-02-20. PMID:38377025. |
emerging evidence suggests that microglial activation, astrocyte responses, nuclear factor κb(nf-κb) signaling, dysregulation of the hypothalamic pituitary adrenal (hpa) axis, alterations in brain-derived neurotrophic factor (bdnf) expression, neurotransmitter imbalances, adenosine triphosphate (atp) and its receptors and oxidative stress are intricately linked to the pathogenesis of psd. |
2024-02-20 |
2024-02-23 |
Not clear |
| Lan Lei, Ya-Ting Wang, Die Hu, Cong Gai, Yi Zhan. Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation. Cellular and molecular neurobiology. 2023-10-24. PMID:37875763. |
the pathogenesis of mdd is related to astrocyte dysfunction, with reduced cx43 expression, gj dysfunction, decreased gjic and reduced bdnf expression in the depressed brain. |
2023-10-24 |
2023-11-08 |
Not clear |
| Thomas Jacobus Geus, Glenn Franken, Bert Bert Jooste. Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. Molecular pain. 2023-07-25. PMID:37488684. |
the inflammatory balance and glial response were analyzed in the dorsal spinal cord based on rna expression of pro- and anti-inflammatory cytokines (tnf-α, il-1ß, il-4, il-10), a microglia marker (itgam), an astrocyte marker (gfap), a t-cell marker (cd3d), microglia proliferation markers (irf8, adgre1) and p2x4, p13-mapk, bdnf signaling markers (p2x4, mapk14, bdnf). |
2023-07-25 |
2023-08-14 |
Not clear |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |
| Arianne S Gravesteijn, Heleen Beckerman, Eline Aj Willemse, Hanneke E Hulst, Brigit A de Jong, Charlotte E Teunissen, Vincent de Groo. Brain-derived neurotrophic factor, neurofilament light and glial fibrillary acidic protein do not change in response to aerobic training in people with MS-related fatigue - a secondary analysis of a randomized controlled trial. Multiple sclerosis and related disorders. vol 70. 2023-01-09. PMID:36621163. |
brain-derived neurotrophic factor (bdnf), neurofilament light (nfl), and glial fibrillary acidic protein (gfap) are blood-based biomarkers for neurogenesis, axonal damage and astrocyte reactivity, respectively. |
2023-01-09 |
2023-08-14 |
Not clear |
| Darshan Sapkota, Mandy S J Kater, Kristina Sakers, Kayla R Nygaard, Yating Liu, Sarah K Koester, Stuart B Fass, Allison M Lake, Rohan Khazanchi, Rana R Khankan, Mitchell C Krawczyk, August B Smit, Susan E Maloney, Mark H G Verheijen, Ye Zhang, Joseph D Doughert. Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process. Cell reports. vol 41. issue 3. 2022-10-19. PMID:36261025. |
we show that seizure activity rapidly changes the transcripts on astrocyte ribosomes, some predicted to be downstream of bdnf signaling. |
2022-10-19 |
2023-08-14 |
Not clear |
| Chen Hong, Zhi Wang, Si-Li Zheng, Wen-Jun Hu, Shu-Na Wang, Yan Zhao, Chao-Yu Mia. Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice. Acta pharmacologica Sinica. 2022-10-13. PMID:36229598. |
during aging process, the decrease of brain-derived neurotrophic factor (bdnf) and the impairment of astrocyte function contribute to the cognitive impairment. |
2022-10-13 |
2023-08-14 |
mouse |
| Chunshuai Wu, Guanhua Xu, Guofeng Bao, Hong Gao, Jiajia Chen, Jinlong Zhang, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Yang Liu, Jiayi Huang, Yue Sun, Jiawei Fu, Yiqiu Li, Zhiming Cu. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotropin. The Journal of biological chemistry. 2022-09-02. PMID:36055408. |
we also show using flow cytometry and astrocyte/neuronal co-culture assays that triad1 overexpression promoted ptn protein levels, neurotrophic growth factor (ngf) expression, brain-derived neurotrophic factor (bdnf) expression, astrocyte and neuronal viability, and neurite outgrowth, but suppressed astrocyte apoptosis, while shrna-mediated knockdown of triad1 and ptn had the opposite effects. |
2022-09-02 |
2023-08-14 |
rat |
| Salvatore Saieva, Giulio Taglialatel. Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice. Scientific reports. vol 12. issue 1. 2022-06-27. PMID:35761012. |
after sacrifice, brain slices were subjected to free-floating immunofluorescence for microglia and astrocyte markers to evaluate glial activation and quantitative real-time polymerase chain reaction (pcr) to evaluate expression levels of inflammatory cytokines and brain-derived neurotrophic factor (bdnf). |
2022-06-27 |
2023-08-14 |
mouse |
| Marika Cordaro, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Livia Interdonato, Gianluca Franco, Alessia Arangia, Enrico Gugliandolo, Rosalia Crupi, Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzer. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740470. |
here, we found that vad caused brain injury, lipid peroxidation, and neuronal death in the hippocampus, as well as astrocyte and microglial activation, and reduced bdnf neurotrophic factor expression together with behavioral alterations. |
2022-06-24 |
2023-08-14 |
mouse |
| Marika Cordaro, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Livia Interdonato, Gianluca Franco, Alessia Arangia, Enrico Gugliandolo, Rosalia Crupi, Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzer. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740470. |
fisetin attenuated histological injury, malondialdehyde levels, inflammasome pathway activation, apoptosis, as well as increased bdnf expression, reduced astrocyte, microglial activation, and cognitive deficits. |
2022-06-24 |
2023-08-14 |
mouse |
| Yong Li, Yujie Cheng, Yuan Zhou, Hongmei Du, Cui Zhang, Zhentao Zhao, Yuenan Chen, Zhongnan Zhou, Jinyu Mei, Wenning Wu, Ming Che. High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy. Experimental neurology. 2021-12-13. PMID:34902357. |
we further found activated microglia and astrocyte, increased neuroinflammation, decreased autophagy and bdnf levels in mice after high-fat feeding. |
2021-12-13 |
2023-08-13 |
mouse |
| Miwako Fujisawa, Yukio Takeshita, Susumu Fujikawa, Kinya Matsuo, Masashi Okamoto, Masaya Tamada, Fumitaka Shimizu, Yasuteru Sano, Michiaki Koga, Takashi Kand. Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model. Journal of neuroimmunology. vol 362. 2021-12-13. PMID:34902709. |
we utilized an in vitro bbb model-a tri-culture of a human endothelial cell line, a pericyte cell line, and an astrocyte cell line-to study the effect of twenty candidate lipophilic compounds on stimulating bdnf secretion in pericytes and astrocytes. |
2021-12-13 |
2023-08-13 |
human |
| Miwako Fujisawa, Yukio Takeshita, Susumu Fujikawa, Kinya Matsuo, Masashi Okamoto, Masaya Tamada, Fumitaka Shimizu, Yasuteru Sano, Michiaki Koga, Takashi Kand. Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model. Journal of neuroimmunology. vol 362. 2021-12-13. PMID:34902709. |
the prostaglandin e2 receptor 4 agonist and sphingosine-1-phosphate receptor 5 agonist facilitated secretion of bdnf in the astrocyte, but did not decrease the transendothelial electrical resistance. |
2021-12-13 |
2023-08-13 |
human |