| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' A Komersov\\xc3\\xa1, K Komers, P Zdrazilov\\xc3\\xa. Kinetics of hydrolysis of acetylthiocholine and acetylcholine by cholinesterases. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16498728.' |
kinetics of hydrolysis of acetylthiocholine (atch) and acetylcholine (ach) by butyrylcholinesterase (bche) and acetylcholinesterase (ache) are studied. |
2006-02-24 |
2023-08-12 |
Not clear |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| Onofre Combarros, José A Riancho, Jon Infante, Carolina Sañudo, Javier Llorca, María T Zarrabeitia, José Bercian. Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 20. issue 2-3. 2005-10-13. PMID:16020944. |
bche is a hydrolytic enzyme associated with acetylcholine synaptic degradation, and the bche k genetic variant confers some protective effect for ad by reducing the activity of the enzyme. |
2005-10-13 |
2023-08-12 |
human |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| Michael Adler, Heather A Manley, Angela L Purcell, Sharad S Deshpande, Tracey A Hamilton, Robert K Kan, George Oyler, Oksana Lockridge, Ellen G Duysen, Robert E Sherida. Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice. Muscle & nerve. vol 30. issue 3. 2004-09-21. PMID:15318343. |
three mechanisms--including a reliance on bche activity for termination of ach action, downregulation of nicotinic acetylcholine receptors (nachrs), and morphological remodeling of the endplate region--were identified. |
2004-09-21 |
2023-08-12 |
mouse |
| Chris Meier, Christian Ducho, Ulf Görbig, Robert Esnouf, Jan Balzarin. Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship. Journal of medicinal chemistry. vol 47. issue 11. 2004-07-02. PMID:15139762. |
cyclosal pronucleotides showed strong competitive inhibition with respect to the substrate acetylcholine chloride (k(i)/k(m): approximately 2 x 10(-5)) and acted by time-dependent irreversible inhibition of the human serum bche. |
2004-07-02 |
2023-08-12 |
mouse |
| Yuxia Wang, Andreea Ticu Boeck, Ellen G Duysen, Margaret Van Keuren, Thomas L Saunders, Oksana Lockridg. Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase. Toxicology and applied pharmacology. vol 196. issue 3. 2004-05-27. PMID:15094306. |
the human butyrylcholinesterase (bche) mutant g117h was chosen for study because it has the unusual ability to hydrolyze op as well as acetylcholine, and it is resistant to inhibition by op. |
2004-05-27 |
2023-08-12 |
mouse |
| b' Jasmina Minic, Arnaud Chatonnet, Eric Krejci, Jordi Molg\\xc3\\xb. Butyrylcholinesterase and acetylcholinesterase activity and quantal transmitter release at normal and acetylcholinesterase knockout mouse neuromuscular junctions. British journal of pharmacology. vol 138. issue 1. 2003-07-15. PMID:12522088.' |
bche apparently is not implicated in limiting the duration of acetylcholine action on postsynaptic receptors, but is involved in a presynaptic modulatory step of the release process. |
2003-07-15 |
2023-08-12 |
mouse |
| b' Jean Massouli\\xc3\\xa. The origin of the molecular diversity and functional anchoring of cholinesterases. Neuro-Signals. vol 11. issue 3. 2002-09-25. PMID:12138250.' |
vertebrates possess two cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche) which both hydrolyze acetylcholine, but differ in their specificity towards other substrates, and in their sensitivity to inhibitors. |
2002-09-25 |
2023-08-12 |
mouse |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholinesterase (ache) is distinguished from butyrylcholinesterase (bche) by its greater specificity for hydrolysing acetylcholine. |
1996-12-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholine has been shown to influence cell proliferation and neurite outgrowth through nicotinic and muscarinic receptor-mediated mechanisms and thus, that the expression of ache and bche at non-synaptic sites may be associated with a cholinergic function. |
1996-12-30 |
2023-08-12 |
Not clear |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| H Zakut, Y Lapidot-Lifson, R Beeri, A Ballin, H Sore. In vivo gene amplification in non-cancerous cells: cholinesterase genes and oncogenes amplify in thrombocytopenia associated with lupus erythematosus. Mutation research. vol 276. issue 3. 1992-06-09. PMID:1374519. |
the ache and bche genes, encoding the acetylcholine hydrolysing enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche), co-amplify with several oncogenes in leukemic patients with platelet deficiency (thrombocytopenia). |
1992-06-09 |
2023-08-11 |
Not clear |