| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Ankit Ganeshpurkar, Ravi Singh, Devendra Kumar, Pravin Gore, Shalini Shivhare, Divya Sardana, Swetha Rayala, Ashok Kumar, Sushil Kumar Sing. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International journal of biological macromolecules. 2022-01-29. PMID:35090939. |
butyrylcholinesterase (bche), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (ache) in the synaptic cleft of the brain. |
2022-01-29 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
acylcholines are metabolized by a class of cholinesterases, including acetylcholinesterase (a specific regulator of acetylcholine levels) and butyrylcholinesterase (bche, an enigmatic enzyme whose function has not been resolved by genetic knockout models). |
2021-11-11 |
2023-08-13 |
Not clear |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
bche provides reserve capacity to hydrolyze acetylcholine, but its importance is arguable given acetylcholinesterase is the most catalytically efficient enzyme characterized to date. |
2021-11-11 |
2023-08-13 |
Not clear |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
acylcholines then provide a link between bche and non-neuronal acetylcholine signaling, filling a gap in understanding around how imbalances between acylcholines and bche could modulate inflammatory disease, such as the "cytokine storm" identified in severe covid-19. |
2021-11-11 |
2023-08-13 |
Not clear |
| Shuaishuai Xing, Qi Li, Baichen Xiong, Yao Chen, Feng Feng, Wenyuan Liu, Haopeng Su. Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism. Medicinal research reviews. vol 41. issue 2. 2021-10-28. PMID:33103262. |
the increased level of bche in progressed alzheimer's disease patients made it a promising target to elevate acetylcholine level and attenuate cognitive status. |
2021-10-28 |
2023-08-13 |
mouse |
| Qi Li, Ying Chen, Shuaishuai Xing, Qinghong Liao, Baichen Xiong, Yuanyuan Wang, Weixuan Lu, Siyu He, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Su. Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection. Journal of medicinal chemistry. vol 64. issue 10. 2021-06-21. PMID:33973470. |
butyrylcholinesterase (bche) has been considered as a potential therapeutic target for alzheimer's disease (ad) because of its compensation capacity to hydrolyze acetylcholine (ach) and its close association with aβ deposit. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jayeong Hwang, Kumju Youn, Gyutae Lim, Jinhyuk Lee, Dong Hyun Kim, Mira Ju. Discovery of Natural Inhibitors of Cholinesterases from Nutrients. vol 13. issue 1. 2021-04-27. PMID:33477276. |
the loss of cognitive functions is mostly characterized by the rapid hydrolysis of acetylcholine by cholinesterases including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2021-04-27 |
2023-08-13 |
Not clear |
| Jacek Jasiecki, Monika Targońska, Bartosz Wasą. The Role of Butyrylcholinesterase and Iron in the Regulation of Cholinergic Network and Cognitive Dysfunction in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33670778. |
our observations indicate that the butyrylcholinesterase (bche) level seems to be iron-dependent, and reports show that bche produced by reactive astrocytes can make cognitive functions worse by accelerating the decay of acetylcholine in aging brains. |
2021-04-15 |
2023-08-13 |
mouse |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| Aleksandar R Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A Weigand, Stefan Kleinschmidt, Stefan Hofe. Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31320703. |
serum cholinesterase (butyrylcholinesterase, bche) is an enzyme that hydrolyses acetylcholine. |
2020-10-29 |
2023-08-13 |
human |
| Si Chen, Zhengdong Lin, Kai-Leng Tan, Risheng Chen, Wenfang Su, Haishan Zhao, Qiwen Tan, Wen Ta. Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice. Frontiers in psychiatry. vol 11. 2020-10-22. PMID:33061920. |
butyrylcholinesterase (bche) efficiently hydrolyzes acetylcholine (ach) at high concentrations when acetylcholinesterase (ache) is substrate-inhibited. |
2020-10-22 |
2023-08-13 |
mouse |
| Ramachandra S Naik, Tatyana Belinskaya, C R Vinayaka, Ashima Saxen. Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish between acetylcholinesterases from ruminant and non-ruminant species. Chemico-biological interactions. vol 330. 2020-10-14. PMID:32795450. |
while ache regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions, bche in plasma has been suggested to be involved in detoxifying toxic compounds. |
2020-10-14 |
2023-08-13 |
mouse |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| Cuneyt Caglayan, Yeliz Demir, Sefa Kucukler, Parham Taslimi, Fatih Mehmet Kandemir, İlhami Gulçi. The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. Journal of food biochemistry. vol 43. issue 2. 2020-06-12. PMID:31353640. |
in our work, it was purposed to investigate the effects of sodium arsenite (sa) and hesperidin (hsp) administered to rats on some metabolic enzymes including carbonic anhydrase (ca), aldose reductase (ar), paraoxonase-1 (pon1), α-glycosidase (α-gly), butyrylcholine esterase (bche), acetylcholine esterase (ache) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. |
2020-06-12 |
2023-08-13 |
human |
| Azime Berna Özçelik, Zeynep Özdemir, Suat Sari, Semra Utku, Mehtap Uysa. A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies. Pharmacological reports : PR. vol 71. issue 6. 2020-04-27. PMID:31675671. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach). |
2020-04-27 |
2023-08-13 |
Not clear |
| b' Kre\\xc5\\xa1imir Baumann, Lorena Kordi\\xc4\\x87, Marko Mo\\xc4\\x8dibob, Goran \\xc5\\xa0inko, Sr\\xc4\\x91anka Tomi\\xc4\\x8. Synthesis and In Vitro Screening of Novel Heterocyclic \\xce\\xb2-d-Gluco- and \\xce\\xb2-d-Galactoconjugates as Butyrylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-14. PMID:31382668.' |
the development of selective butyrylcholinesterase (bche) inhibitors may improve the treatment of alzheimer's disease by increasing lower synaptic levels of the neurotransmitter acetylcholine, which is hydrolysed by acetylcholinesterase, as well as by overexpressed bche. |
2020-01-14 |
2023-08-13 |
Not clear |
| Fikret Türkan, Parham Taslimi, Fatma Zerrin Salta. Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease. Journal of biochemical and molecular toxicology. vol 33. issue 8. 2020-01-13. PMID:30974029. |
in this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (ache), α-glycosidase, α-amylase, and butyrylcholinesterase (bche). |
2020-01-13 |
2023-08-13 |
Not clear |