| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Ana-Lourdes Oropesa, Carlos Gravato, Susana Sánchez, Francisco Sole. Characterization of plasma cholinesterase from the White stork (Ciconia ciconia) and its in vitro inhibition by anticholinesterase pesticides. Ecotoxicology and environmental safety. vol 97. 2013-11-27. PMID:23962622. |
the results indicated that propionylthiocholine was the preferred substrate by plasma cholinesterase followed by acetylcholine and butyrylcholine and the predominant enzymatic activity in plasma of white storks was bche. |
2013-11-27 |
2023-08-12 |
Not clear |
| Ganiyu Oboh, Odunayo M Agunloye, Ayodele J Akinyemi, Adedayo O Ademiluyi, Stephen A Adefegh. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats' brain-in vitro. Neurochemical research. vol 38. issue 2. 2013-10-17. PMID:23184188. |
inhibition of ache and bche activities slows down acetylcholine and butyrylcholine breakdown in the brain. |
2013-10-17 |
2023-08-12 |
rat |
| Nir Waiskopf, Itzhak Shweky, Itai Lieberman, Uri Banin, Hermona Sore. Quantum dot labeling of butyrylcholinesterase maintains substrate and inhibitor interactions and cell adherence features. ACS chemical neuroscience. vol 2. issue 3. 2013-08-16. PMID:22778863. |
butyrylcholinesterase (bche) is the major acetylcholine hydrolyzing enzyme in peripheral mammalian systems. |
2013-08-16 |
2023-08-12 |
human |
| Márcio M Costa, Aleksandro S da Silva, Francine C Paim, Raqueli França, Guilherme L Dornelles, Gustavo R Thomé, Jonas D S Serres, Roberta Schmatz, Rosélia M Spanevello, Jamile F Gonçalves, Maria Rosa C Schetinger, Cinthia M A Mazzanti, Sonia T A Lopes, Silvia G Monteir. Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits. Anais da Academia Brasileira de Ciencias. vol 84. issue 4. 2013-07-11. PMID:23011112. |
the increased activities of ache and bche probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. |
2013-07-11 |
2023-08-12 |
rat |
| I Erdogan Orha. Current concepts on selected plant secondary metabolites with promising inhibitory effects against enzymes linked to Alzheimer's disease. Current medicinal chemistry. vol 19. issue 14. 2012-10-18. PMID:22414107. |
shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) that break down acetylcholine and butyrylcholine has become a standard approach for ad treatment. |
2012-10-18 |
2023-08-12 |
human |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
accordingly, deficiency of the neuromediator called "acetylcholine" excessive amount of bche has been well-described in the brains of ad patients. |
2012-02-15 |
2023-08-12 |
Not clear |
| Xi Chen, Lei Fang, Junjun Liu, Chang-Guo Zha. Reaction pathway and free energy profile for butyrylcholinesterase-catalyzed hydrolysis of acetylcholine. The journal of physical chemistry. B. vol 115. issue 5. 2011-05-23. PMID:21175195. |
a catalytic mechanism for the butyrylcholinesterase (bche)-catalyzed hydrolysis of acetylcholine (ach) has been studied by performing pseudobond first-principles quantum mechanical/molecular mechanical-free energy calculations on both acylation and deacylation of bche. |
2011-05-23 |
2023-08-12 |
Not clear |
| Liu Xue, Mei-Chuan Ko, Min Tong, Wenchao Yang, Shurong Hou, Lei Fang, Junjun Liu, Fang Zheng, James H Woods, Hsin-Hsiung Tai, Chang-Guo Zha. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Molecular pharmacology. vol 79. issue 2. 2011-02-22. PMID:20971807. |
an ideal, therapeutically valuable mutant of human bche should have not only a significantly improved catalytic activity against (-)-cocaine but also certain selectivity for (-)-cocaine over neurotransmitter acetylcholine (ach), such that one would not expect systemic administration of the bche mutant to interrupt cholinergic transmission. |
2011-02-22 |
2023-08-12 |
mouse |
| Erez Podoly, Deborah E Shalev, Shani Shenhar-Tsarfaty, Estelle R Bennett, Einor Ben Assayag, Harvey Wilgus, Oded Livnah, Hermona Sore. The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology. The Journal of biological chemistry. vol 284. issue 25. 2009-10-20. PMID:19383604. |
here, we report that bche-k is inherently unstable as compared with the "usual" bche (bche-u), resulting in reduced hydrolytic activity and predicting prolonged acetylcholine maintenance and protection from ad. |
2009-10-20 |
2023-08-12 |
human |
| Ellen G Duysen, Bin Li, Oksana Lockridg. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 5. issue 5. 2009-07-08. PMID:19416087. |
bche serves as a backup for acetylcholinesterase by hydrolyzing the neurotransmitter acetylcholine in acetylcholinesterase knockout mice. |
2009-07-08 |
2023-08-12 |
mouse |
| Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Francesco Menichin. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Current medicinal chemistry. vol 15. issue 12. 2008-06-30. PMID:18473814. |
ad and other forms of dementia could be treated by the use of agents which restore the level of acetylcholine through inhibition of both two major forms of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2008-06-30 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Alexander Koehler, Ignaz Wessler, Paul G Laye. Expression and possible functions of the cholinergic system in a murine embryonic stem cell line. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17459421. |
we have demonstrated that embryonic stem cells express ach, acetylcholine receptors, choline acetyltransferase (chat), acetyl- and butyryl-cholinesterase (ache and bche). |
2007-08-01 |
2023-08-12 |
mouse |
| b' Emmanuelle Girard, V\\xc3\\xa9ronique Bernard, Jasmina Minic, Arnaud Chatonnet, Eric Krejci, Jordi Molg\\xc3\\xb. Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17467011.' |
at the neuromuscular junction (nmj) acetylcholinesterase (ache) and butyrylcholinesterase (bche) can hydrolyze acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
mouse |
| Daquan Gao, Chang-Guo Zha. Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases. The journal of physical chemistry. B. vol 109. issue 48. 2007-07-18. PMID:16854005. |
molecular dynamics (md) simulations and hydrogen bonding energy (hbe) calculations have been performed on the prereactive enzyme-substrate complexes (es), transition states (ts1), and intermediates (int1) for acetylcholinesterase (ache)-catalyzed hydrolysis of acetylcholine (ach), butyrylcholinesterase (bche)-catalyzed hydrolysis of ach, and bche-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. |
2007-07-18 |
2023-08-12 |
human |
| Ellen G Duysen, Bin Li, Sultan Darvesh, Oksana Lockridg. Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Toxicology. vol 233. issue 1-3. 2007-05-29. PMID:17194517. |
in conclusion, we propose that the protective effect of bche is explained by hydrolysis of excess acetylcholine in physiologically relevant regions such as diaphragm, cardiac muscle, and brain. |
2007-05-29 |
2023-08-12 |
mouse |
| Susana Nieto-Cerón, Luis F Sánchez del Campo, Encarnación Muñoz Delgado, Cecilio J Vidal, Francisco Javier Campo. Thymus acetylcholinesterase activity is reduced in mice with congenital muscular dystrophy. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192623. |
ache and bche are involved through catalytic and noncatalytic actions in multiple processes, such as hydrolysis of acetylcholine (ach), morphogenesis, hematopoiesis, and tumorigenesis (soreq and seidman, 2001). |
2007-02-23 |
2023-08-12 |
mouse |
| María Fernanda Montenegro, Francisco Ruiz-Espejo, Francisco Javier Campoy, Encarnación Muñoz-Delgado, María Páez de la Cadena, Juan Cabezas-Herrera, Cecilio J Vida. Acetyl- and butyrylcholinesterase activities decrease in human colon adenocarcinoma. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192624. |
apart from the hydrolysis of acetylcholine (ach), acetyl- (ache) and butyrylcholinesterase (bche), through noncatalytic mechanisms, intervene in hematopoiesis, morphogenesis, and neurogenesis (layer and willbold, 1995; soreq and seidman, 2001). |
2007-02-23 |
2023-08-12 |
human |
| b' Emmanuelle Girard, V\\xc3\\xa9ronique Bernard, Shelley Camp, Palmer Taylor, Eric Krejci, Jordi Molg\\xc3\\xb. Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192646.' |
at the vertebrate skeletal neuromuscular junction (nmj), two closely related enzymes can hydrolyze acetylcholine (ach): acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2007-02-23 |
2023-08-12 |
mouse |