| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grażyna Budryn, Joanna Grzelczyk, Andrzej Jaśkiewicz, Dorota Żyżelewicz, Horacio Pérez-Sánchez, José P Cerón-Carrasc. Evaluation of butyrylcholinesterase inhibitory activity by chlorogenic acids and coffee extracts assed in ITC and docking simulation models. Food research international (Ottawa, Ont.). vol 109. 2019-11-07. PMID:29803450. |
after introducing acetylcholine into the model system, the strongest ability to inhibit hydrolytic activity of bche was again observed for ferulic acid and additionally for 3-caffeoylquinic acid, and among coffee brews the most active were light roasted arabica and green robusta. |
2019-11-07 |
2023-08-13 |
Not clear |
| Géssica Perin, Nathieli B Bottari, Anielen D Silva, Antonise M Jaguezeski, Teane M A Gomes, Thalison F Lopes, Maria Rosa C Schetinger, Vera M Morsch, Aleksandro S Da Silv. Cholinesterase's activities of infected mice by Brucella ovis. Microbial pathogenesis. vol 132. 2019-08-06. PMID:31028864. |
the increase in ache and bche characterized a pro-inflammatory response, since these enzymes regulate levels of acetylcholine (ach) and butyrylcholine (busch), molecules with anti-inflammatory properties. |
2019-08-06 |
2023-08-13 |
mouse |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Jamshed Iqbal, Muhammad S A Abbasi, Sumera Zaib, Saifullah Afridi, Norbert Furtmann, Jürgen Bajorath, Peter Lange. Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 14. issue 8. 2019-03-05. PMID:29473519. |
this devastating disorder is generally associated with the gradual memory loss, specified by a decrease of acetylcholine level in the cortex hippocampus of the brain due to hyperactivation of cholinesterases (acetylcholinesterase (ache) and butyrylcholinesterase (bche)). |
2019-03-05 |
2023-08-13 |
Not clear |
| Adriana Ferreira Lopes Vilela, Cláudia Seidl, Juliana Maria Lima, Carmen Lúcia Cardos. An improved immobilized enzyme reactor-mass spectrometry-based label free assay for butyrylcholinesterase ligand screening. Analytical biochemistry. vol 549. 2019-03-05. PMID:29550345. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. |
2019-03-05 |
2023-08-13 |
Not clear |
| Aleksandar R Zivkovic, Sebastian O Decker, Anne C Zirnstein, Annette Sigl, Karsten Schmidt, Markus A Weigand, Stefan Hofer, Thorsten Brenne. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of inflammation. vol 2018. 2018-10-01. PMID:29853783. |
serum cholinesterase (bche), an enzyme that hydrolyzes acetylcholine, plays an important role during inflammatory response and serves as an accurate index of cholinergic activity. |
2018-10-01 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| N D Josviak, M S Batistela, R K M Souza, N R Wegner, G F Bono, C D Sulzbach, D P Simão-Silva, M R Piovezan, R L R Souza, L Furtado-All. Plasma butyrylcholinesterase activity: a possible biomarker for differential diagnosis between Alzheimer's disease and dementia with Lewy bodies? The International journal of neuroscience. vol 127. issue 12. 2018-06-04. PMID:28504037. |
butyrylcholinesterase (bche) is an enzyme encoded by bche gene, responsible for secondary hydrolysis of the acetylcholine. |
2018-06-04 |
2023-08-13 |
Not clear |
| Taibi Ben Hadda, Oualid Talhi, Artur S M Silva, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdur Rauf, Yahia N Mabkhot, Khaldoun Bachari, Ismail Warad, Thoraya A Farghaly, Ismail I Althagafi, Mohammad S Mubara. Cholinesterase Inhibitory Activity of Some semi-Rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site. Mini reviews in medicinal chemistry. vol 18. issue 8. 2018-05-04. PMID:28714400. |
cholinesterase family consists of two sister enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) which hydrolyze acetylcholine. |
2018-05-04 |
2023-08-13 |
Not clear |
| Aleksandar R Zivkovic, Kevin M Tourelle, Thorsten Brenner, Markus A Weigand, Stefan Hofer, Karsten Schmid. Reduced serum cholinesterase activity indicates splenic modulation of the sterile inflammation. The Journal of surgical research. vol 220. 2017-12-11. PMID:29180192. |
serum cholinesterase (butyrylcholinesterase [bche]) is an enzyme that hydrolyzes acetylcholine. |
2017-12-11 |
2023-08-13 |
Not clear |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
the serine hydrolase butyrylcholinesterase (bche), like the related enzyme acetylcholinesterase (ache), co-regulates metabolism of the neurotransmitter acetylcholine. |
2017-10-02 |
2023-08-13 |
mouse |
| İlhami Gülçin, Andrea Scozzafava, Claudiu T Supuran, Zeynep Koksal, Fikret Turkan, Songül Çetinkaya, Zeynebe Bingöl, Zübeyir Huyut, Saleh H Alwase. Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-03-06. PMID:26864149. |
3.1.1.7) is intimately associated with the normal neurotransmission by catalysing the hydrolysis of acetylcholine to acetate and choline and acts in combination with butyrylcholinesterase (bche) to remove acetylcholine from the synaptic cleft. |
2017-03-06 |
2023-08-13 |
Not clear |
| Emin Garibov, Parham Taslimi, Afsun Sujayev, Zeynebe Bingol, Songul Çetinkaya, İlhami Gulçin, Sukru Beydemir, Vagif Farzaliyev, Saleh H Alwasel, Claudiu T Supura. Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue sup3. 2017-02-23. PMID:27329935. |
these cyclic thioureas showed good inhibitory action against acetylcholine esterase (ache), butyrylcholine esterase (bche), and human (h) carbonic anhydrase (ca) isoforms i and ii. |
2017-02-23 |
2023-08-13 |
human |
| Katsuyoshi Mizukami, Hiroyasu Akatsu, Eric E Abrahamson, Zhiping Mi, Milos D Ikonomovi. Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26293308. |
studies of acetylcholine degrading enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) in alzheimer's disease (ad) have suggested their potential role in the development of fibrillar amyloid-β (aβ) plaques (amyloid plaques). |
2017-01-09 |
2023-08-13 |
Not clear |
| Malte Haupt, Vivien Kauschke, Jonas Sender, Marian Kampschulte, Anna Kovtun, Lutz Dürselen, Christian Heiss, Katrin Susanne Lip. Bone status of adult female butyrylcholinesterase gene-deficient mice. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26138460. |
butyrylcholinesterase (bche) degrades acetylcholine in addition to acetylcholinesterase (ache) which is involved in embryonic development of limbs. |
2016-09-14 |
2023-08-13 |
mouse |
| Fang Zheng, Liu Xue, Shurong Hou, Junjun Liu, Max Zhan, Wenchao Yang, Chang-Guo Zha. A highly efficient cocaine-detoxifying enzyme obtained by computational design. Nature communications. vol 5. 2015-12-14. PMID:24643289. |
we engineer e30-6 from human butyrylcholinesterase (bche), which is specific for cocaine hydrolysis, and obtain a much higher catalytic efficiency for cocaine conversion than for conversion of the natural bche substrate, acetylcholine (ach). |
2015-12-14 |
2023-08-12 |
mouse |
| Takeru Murakawa, Yuki Matsushita, Tomoya Suzuki, Mahmud Tareq Hassan Khan, Noriyuki Kurit. Ab initio molecular simulations for proposing potent inhibitors to butyrylcholinesterases. Journal of molecular graphics & modelling. vol 54. 2015-09-01. PMID:25259414. |
butyrylcholinesterase (bche) exists mainly at neuromuscular junctions and plays an important role in the hydrolyzing mechanism of neurotransmitter acetylcholine. |
2015-09-01 |
2023-08-13 |
Not clear |
| Vishakantha Murthy, Yang Gao, Liyi Geng, Nathan LeBrasseur, Thomas White, Stephen Brimijoi. Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24085526. |
because mutated bche is approximately 70 % as efficient in hydrolyzing acetylcholine as wild-type enzyme, it is important to examine the impact on cholinergic function. |
2015-04-06 |
2023-08-12 |
mouse |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| Shurong Hou, Liu Xue, Wenchao Yang, Lei Fang, Fang Zheng, Chang-Guo Zha. Substrate selectivity of high-activity mutants of human butyrylcholinesterase. Organic & biomolecular chemistry. vol 11. issue 43. 2014-07-25. PMID:24077614. |
in the present study, we carried out both computational modeling and experimental kinetic analysis on the catalytic activities of these promising new bche mutants against other known substrates, including neurotransmitter acetylcholine (ach), acetylthiocholine (atc), butyrylthiocholine (btc), and (+)-cocaine, in comparison with the corresponding catalytic activity against (-)-cocaine. |
2014-07-25 |
2023-08-12 |
human |