All Relations between bche and acetylcholine

Publication Sentence Publish Date Extraction Date Species
Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). 2024-02-10 2024-02-12 Not clear
Musa Dirak, Jefferson Chan, Safacan Koleme. Optical imaging probes for selective detection of butyrylcholinesterase. Journal of materials chemistry. B. 2024-01-10. PMID:38196348. butyrylcholinesterase (bche), a member of the human serine hydrolase family, is an essential enzyme for cholinergic neurotransmission as it catalyzes the hydrolysis of acetylcholine. 2024-01-10 2024-01-13 human
Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. 2023-12-23 2023-12-25 Not clear
Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. 2023-08-14 2023-09-07 Not clear
Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. 2023-07-05 2023-08-14 human
Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. 2023-06-26 2023-08-14 Not clear
Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. to reduce acetylcholine degradation and help restore the pool of the neurotransmitter, specific and potent bche inhibitors are sought. 2023-06-26 2023-08-14 Not clear
Joanna Grzelczyk, Dominik Szwajgier, Ewa Baranowska-Wójcik, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Bożena Sosnowska, Grażyna Budry. Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242249. butyrylcholinesterase (bche) is a major enzyme from the alpha-glycoprotein family that catalyzes the hydrolysis of neurotransmitter acetylcholine (ach), lowering the concentration of ach in the nervous system, which could cause aggravation of alzheimer's disease (ad). 2023-05-27 2023-08-14 Not clear
Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. 2023-05-02 2023-08-14 Not clear
Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. 2023-01-17 2023-08-14 human
Asma Gholami, Dariush Minai-Tehrani, Leif A Eriksso. In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635365. studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) may lead to reduced communication between neuron cells. 2023-01-12 2023-08-14 Not clear
Xia Tong, Guihan Cai, Lianwu Xie, Tongtao Wang, Yongfeng Zhu, Yuqing Peng, Chaoying Tong, Shuyun Shi, Ying Gu. Threaded 3D microfluidic paper analytical device-based ratiometric fluorescent sensor for background-free and visual detection of organophosphorus pesticides. Biosensors & bioelectronics. vol 222. 2022-12-12. PMID:36473422. butyrylcholinesterase (bche) hydrolyzed acetylcholine into thiocholine (tch), which reduced mno 2022-12-12 2023-08-14 Not clear
Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. 2022-09-20 2023-08-14 human
Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. 2022-09-19 2023-08-14 Not clear
H F Seabra, A C Campello, E F G Chagas, L P A Martins, R B Suzuki, M O Ruiz, E A Donadi, W Baleot. The role of cholinesterases in chagas disease. Parasitology international. 2022-08-27. PMID:36029960. acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze acetylcholine (ach) in neural synaptic clefts and are primarily found in erythrocytes and blood plasma, respectively. 2022-08-27 2023-08-14 Not clear
Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. 2022-06-15 2023-08-14 Not clear
Ankit Ganeshpurkar, Ravi Singh, Devendra Kumar, Pravin Gore, Shalini Shivhare, Divya Sardana, Swetha Rayala, Ashok Kumar, Sushil Kumar Sing. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International journal of biological macromolecules. 2022-01-29. PMID:35090939. butyrylcholinesterase (bche), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (ache) in the synaptic cleft of the brain. 2022-01-29 2023-08-13 Not clear
Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). 2021-12-04 2023-08-13 Not clear
Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. acylcholines are metabolized by a class of cholinesterases, including acetylcholinesterase (a specific regulator of acetylcholine levels) and butyrylcholinesterase (bche, an enigmatic enzyme whose function has not been resolved by genetic knockout models). 2021-11-11 2023-08-13 Not clear
Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. bche provides reserve capacity to hydrolyze acetylcholine, but its importance is arguable given acetylcholinesterase is the most catalytically efficient enzyme characterized to date. 2021-11-11 2023-08-13 Not clear