| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Chen, Jiahui Qian, Xinyu Zhao, Xuyang Han, Xu Tang, Junfeng Gao, Yan Liu, Jinzhu Jiang, Binyu We. Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using UPLC-Q-TOF-MS: A metabolomic and mechanistic approach. Biomedical chromatography : BMC. 2022-07-29. PMID:35904380. |
aspartate aminotransferase and direct bilirubin serum biomarkers for liver toxicity were significantly increased and liver histopathology revealed cholestasis and necrosis in rats given emodin only, whereas ast and total bile acid in rats given emodin and silybin simultaneously were changed compared to rats given emodin. |
2022-07-29 |
2023-08-14 |
rat |
| Danielle Lee, Laura Chiavaroli, Sabrina Ayoub-Charette, Tauseef A Khan, Andreea Zurbau, Fei Au-Yeung, Annette Cheung, Qi Liu, Xinye Qi, Amna Ahmed, Vivian L Choo, Sonia Blanco Mejia, Vasanti S Malik, Ahmed El-Sohemy, Russell J de Souza, Thomas M S Wolever, Lawrence A Leiter, Cyril W C Kendall, David J A Jenkins, John L Sievenpipe. Important Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials. Nutrients. vol 14. issue 14. 2022-07-28. PMID:35889803. |
secondary outcomes were alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2022-07-28 |
2023-08-16 |
Not clear |
| Xueqin Wang, Huahua Yu, Ronge Xing, Pengcheng L. Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897657. |
the results demonstrate that ethanol administration could increase the activities of aspartate aminotransferase (ast), alanine transaminase (alt), γ-glutamyl transferase (ggt), reactive oxygen species (ros), malondialdehyde (mda), and triglycerides (tg), as well as increase the interleukin-1β (il-1β), interleukin-6 (il-6), and tumor necrosis factor (tnf-α) levels ( |
2022-07-28 |
2023-08-14 |
mouse |
| Ewelina Młynarska, Julia Krzemińska, Magdalena Wronka, Beata Franczyk, Jacek Rys. Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897810. |
markers of muscle damage, such as ck, lactate dehydrogenase (ldh), myoglobin, troponins, and aspartate aminotransferase (ast), are important in diagnosis. |
2022-07-28 |
2023-08-14 |
Not clear |
| Roxana Banc, Daniela-Saveta Popa, Anamaria Cozma-Petruţ, Lorena Filip, Béla Kiss, Anca Fărcaş, Andras Nagy, Doina Miere, Felicia Loghi. Protective Effects of Wine Polyphenols on Oxidative Stress and Hepatotoxicity Induced by Acrylamide in Rats. Antioxidants (Basel, Switzerland). vol 11. issue 7. 2022-07-27. PMID:35883838. |
hepatic damage due to acrylamide intoxication (the administered dose being 250 µg/kg body weight, for 28 days, by intragastric gavage) was assessed by employing biochemical parameters (aspartate aminotransferase (ast) and alanine aminotransferase (alt)) and by histopathological studies. |
2022-07-27 |
2023-08-14 |
rat |
| Qiuping Guo, Lingyu Zhang, Yunju Yin, Saiming Gong, Yuhuan Yang, Sisi Chen, Mengmeng Han, Yehui Dua. Taurine Attenuates Oxidized Fish Oil-Induced Oxidative Stress and Lipid Metabolism Disorder in Mice. Antioxidants (Basel, Switzerland). vol 11. issue 7. 2022-07-27. PMID:35883883. |
compared to the con group, ofo mice showed increased liver index, aspartate aminotransferase (ast) and malondialdehyde (mda) levels in serum ( |
2022-07-27 |
2023-08-14 |
mouse |
| Robert Nowak, Konrad Rój, Andrzej Ciechanowicz, Klaudyna Lewandowska, Dorota Kostrzewa-Nowa. Capillary Blood Recovery Variables in Young Swimmers: An Observational Case Study. International journal of environmental research and public health. vol 19. issue 14. 2022-07-27. PMID:35886433. |
alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh) and alkaline phosphatase (alp) activities and creatinine (cr), c-reactive protein (crp), ferritin, total bilirubin (tb), direct bilirubin (db) and iron concentrations were measured for 10 weeks and compared with the traditional sport diagnostic markers of creatine kinase (ck) activity and urea (u) concentration. |
2022-07-27 |
2023-08-14 |
human |
| Ruijing Liu, Boping Liu, Lingmin Tian, Xinwei Jiang, Xusheng Li, Dongbao Cai, Jianxia Sun, Weibin Bai, Yulong Ji. Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887390. |
moreover, a high dose of bpa caused a significant increase in serum alanine aminotransferase (alt), aspartate aminotransferase (ast), total cholesterol (tc), and low-density lipoprotein cholesterol (ldl-c), while high-density lipoprotein cholesterol (hdl-c) was significantly decreased in bpa-treated rats. |
2022-07-27 |
2023-08-14 |
rat |
| Yahui Zhang, Xiuying Tan, Yuan Cao, Xin An, Jihua Chen, Lina Yan. Punicalagin Protects against Diabetic Liver Injury by Upregulating Mitophagy and Antioxidant Enzyme Activities. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889739. |
simultaneously, the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), total cholesterol (tc), triglyceride (tg), low-density lipoprotein cholesterol (ldl-c), free fatty acids (ffa), malondialdehyde (mda), and total superoxide dismutase (t-sod) in the serum and liver were significantly decreased, with reductions in fat lesions and inflammatory cells. |
2022-07-27 |
2023-08-14 |
mouse |
| Xiujing Dou, Di Yan, Siqi Liu, Lujia Gao, Anshan Sha. Thymol Alleviates LPS-Induced Liver Inflammation and Apoptosis by Inhibiting NLRP3 Inflammasome Activation and the AMPK-mTOR-Autophagy Pathway. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889766. |
in addition, elevated levels of the liver damage indicators (alanine transaminase (alt), aspartate transaminase (ast), and total bilirubin (tbil)) dropped after thymol administration. |
2022-07-27 |
2023-08-14 |
mouse |
| Doaa I Mohamed, Samar F Ezzat, Wael M Elayat, Omnyah A El-Kharashi, Hanaa F Abd El-Kareem, Hebatallah H Abo Nahas, Basel A Abdel-Wahab, Samar Zuhair Alshawwa, Asmaa Saleh, Yosra A Helmy, Eman Khairy, Essa M Saie. Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study. Pharmaceuticals (Basel, Switzerland). vol 15. issue 7. 2022-07-27. PMID:35890131. |
the biochemical analysis revealed that the ischemic liver injury following ahf significantly elevated the activity of alanine aminotransferase (alt), aspartate aminotransferase (ast), and alkaline phosphatase (alp) enzymes, the level of total and direct bilirubin, and the expression of hepatic mitogen-activated protein kinase (mapk), dynamin-1-like protein (dnm1l), and hepatic mirna-17. |
2022-07-27 |
2023-08-14 |
Not clear |
| Masood Khaksar Toroghi, Nidal Al-Huniti, John D Davis, A Thomas DiCioccio, Ronda Rippley, Alina Baum, Christos A Kyratsous, Sumathi Sivapalasingam, Joel Kantrowitz, Mohamed A Kama. A Drug-Disease Model for Predicting Survival in an Ebola Outbreak. Clinical and translational science. 2022-07-27. PMID:35895082. |
using discrete indirect response models, the antiviral mechanism of action was used as a forcing function to drive the reversal of key ebola disease hallmarks over time, e.g., liver and kidney damage (elevated alanine [alt] and aspartate aminotransferases [ast], blood urea nitrogen [bun] and creatinine), and hemorrhage (decreased platelet count). |
2022-07-27 |
2023-08-14 |
human |
| Guanghua Mao, Junjie Tang, Taotao Liao, Xiaoxiang Shi, FangYuan Dong, Weiwei Feng, Yao Chen, Ting Zhao, Xiangyang Wu, Liuqing Yan. Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance. Environmental science and pollution research international. 2022-07-27. PMID:35896870. |
besides, it also could cause cell damage by increasing the levels of aspartate transaminase (ast), alanine aminotransferase (alt), and malondialdehyde (mda) in cells. |
2022-07-27 |
2023-08-14 |
human |
| Ziwei Xiong, Yushun Cui, Jiahui Wu, Lingyu Shi, Quan Wen, Shilin Yang, Yulin Fen. Luteolin-7-O-rutinoside from Pteris cretica L. var. nervosa attenuates LPS/D-gal-induced acute liver injury by inhibiting PI3K/AKT/AMPK/NF-κB signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2022-07-26. PMID:35881166. |
it was found that lut could not only reduce alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, but also significantly reduce the release of tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), and interleukin-1β (il-1β), and inhibit pi3k/akt/ampk/nf-κb pathway. |
2022-07-26 |
2023-08-14 |
mouse |
| M Gharehbeglou, S Yazdani, K White, M R Haeri, N Masoumzade. Atorvastatin Rapidly Reduces Hepatitis B Viral Load in Combination with Tenofovir: A Prospective Clinical Trial. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale. vol 2022. 2022-07-25. PMID:35873362. |
serum aspartate aminotransferase (ast), alanine aminotransferase (alt), and hbv dna copy numbers were measured at the beginning of the treatment and 1, 3, 6, 9, 12 months later. |
2022-07-25 |
2023-08-14 |
Not clear |
| Omotayo B Ilesanmi, Esther F Adeogun, Temitope T Odewale, Bruno Chiker. Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement. Environmental analysis, health and toxicology. vol 37. issue 2. 2022-07-25. PMID:35878915. |
animals were sacrificed 24 h after the last administration and blood were collected via cardiac puncture and processed for hematological parameters and assessment of alanine aminotransferase (alt), aspartate aminotransferase (ast), and albumin (alb). |
2022-07-25 |
2023-08-14 |
human |
| Ying Lan, Chi Wang, Cheng Zhang, Pengju Li, Jinding Zhang, Hong Ji, Haibo Y. Dietary sea buckthorn polysaccharide reduced lipid accumulation, alleviated inflammation and oxidative stress, and normalized imbalance of intestinal microbiota that was induced by high-fat diet in zebrafish Danio rerio. Fish physiology and biochemistry. 2022-07-25. PMID:35879492. |
results showed that adding 2 and 4 g/kg of sp in the hfd significantly improved the survival rate of zebrafish; reduced the levels of serum triglyceride (tg), total cholesterol (tc), aspartate aminotransferase (ast), and alanine transaminase (alt); and alleviated the lipid accumulation in the liver of zebrafish. |
2022-07-25 |
2023-08-14 |
zebrafish |
| Wenjie Zhu, Meizhu Yan, Haibin Cao, Jun Zhou, Zhongqing X. Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869734. |
moreover, the observation group had remarkably lower levels of total cholesterol (tc), triglyceride (tg), free fatty acids (ffa), total bilirubin (tbil), direct bilirubin (dbil), alanine aminotransferase (alt), aspartate aminotransferase (ast), procollagen iii peptide (piiip), collagen-iv (c-iv), hyaluronicacid (ha) and laminin (ln) as well as lower levels of tumor necrosis factor-alpha (tnf-α), catabolite activator protein (cap) and interleukin-6 (il-6) in serum than the control group (p<0.05). |
2022-07-23 |
2023-08-14 |
human |
| Zhicheng Li, Biao Jiang, Zhihong Zhong, Jizhen Cao, Han Li, Chenxi Wang, Anxing L. Skin transcriptomic analysis and immune-related gene expression of golden pompano (Trachinotus ovatus) after Amyloodinium ocellatum infection. Fish & shellfish immunology. 2022-07-23. PMID:35870749. |
in addition, the serum of the primary infection group had significantly higher concentrations of triglyceride (tg), higher alanine transaminase (alt), aspartate transaminase (ast), and lactate dehydrogenase (ldh) activities than the control group. |
2022-07-23 |
2023-08-14 |
Not clear |
| Cai Zhang, Sudan Meng, Qi Shao, Xueying Wang, Chenxu Li, Wenbin Chen, Yuanxiao Li, Shucheng Huang, Yanbo M. Protective effects of monoammonium glycyrrhizinate on fatty deposit degeneration induced in primary calf hepatocytes by sodium oleate administration in vitro. Research in veterinary science. vol 150. 2022-07-22. PMID:35868152. |
to evaluate the effect of mag on fat-induced degradation of primary hepatocytes, we evaluated lipid deposition, cell viability, apoptosis rate, alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity in the culture supernatant, and expression of oxidant and antioxidant enzymes (ldh, mda, gsh, and cat), as well as the expression of lipid metabolism-related genes (pparα, srebp-1c, chrebp, cpt1, cpt2, and mtp) and apoptosis-related genes (cyt-c, caspase 9, caspase 8, caspase 3, bax, and bcl-2). |
2022-07-22 |
2023-08-14 |
cat |