| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng-Jing-Ming Cheng, Jian Lyu, Yan-Ming Xi. [Systematic review and Meta-analysis of efficacy and safety of Ganshuang Granules in treatment of liver injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 21. 2022-12-06. PMID:36472014. |
the results of meta-analysis showed that ganshuang granules combined with conventional therapy was superior to the therapy in the control group in reducing alanine aminotransferase(alt)(md=-24.12, 95%ci[-32.17,-16.07], p<0.000 01), aspartate aminotransferase(ast)(md=-23.24, 95%ci[-29.70,-16.78], p<0.000 01), total bilirubin(tbil)(md=-12.42, 95%ci[-14.62,-10.22], p<0.000 01), and gamma-glutamyl transpeptidase(ggt)(md=-21.32, 95%ci[-33.61,-9.03], p=0.000 7). |
2022-12-06 |
2023-08-14 |
Not clear |
| Hui-Min Sun, Ting Zhang, Zhen-Yu Li, Xue-Mei Qi. [Toxicity comparison of raw and vinegar-processed Bupleuri Radix based on ~1H-NMR metabolomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 19. 2022-12-06. PMID:36472029. |
the results showed that, as compared with the control group, alanine aminotransferase(alt), aspartate aminotransferase(ast), and alkaline phosphatase(alp) in the raw br group were increased significantly, while alt and alp in the r-vpbr and s-vpbr groups were significantly decreased(p<0.05), which indicated that br showed certain hepatotoxicity, and vinegar processing reduced its hepatotoxicity. |
2022-12-06 |
2023-08-14 |
rat |
| Wen-Zhang Dai, Zhao-Fang Bai, Ting-Ting He, Xiao-Yan Zhan, Qiang Li, Jing Zhao, Xiao-He Xia. [Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 19. 2022-12-06. PMID:36472037. |
in the apap-induced liver injury mouse model, we found that sinc can relieve hepatic histopathological lesions and significantly reduce the activities of alanine aminotransferase(alt), aspartate aminotransferase(ast) and alkaline phosphatase(alp). |
2022-12-06 |
2023-08-14 |
mouse |
| Yulia Khruleva, Zhanna Kobalava, Olga Arisheva, Marina Efremovtseva, Irina Garmash, Maria Vatsik-Gorodetskaya, Mohammed Al Jarallah, Peter A Brady, Ibrahim Al-Zakwani, Rajesh Raja. Clinical Outcome and Risk Assessment in Hospitalized COVID-19 Patients with Elevated Transaminases and Acute Kidney Injury:
A Single Center Study. Oman medical journal. vol 37. issue 6. 2022-12-02. PMID:36458236. |
initial reports indicate a high incidence of abnormal aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels in patients with covid-19 and possible association with acute kidney injury (aki). |
2022-12-02 |
2023-08-14 |
Not clear |
| Shunsuke Fukui, Kohei Ikeda, Mayu Kobayashi, Keigo Nishida, Keita Yamada, Shotaro Horie, Yasuaki Shimada, Hiroto Miki, Hiroki Goto, Koken Hayashi, Yuuichi Nakazawa, Hiroki Mizutani, Toshitaka Kamon, Yusuke Tanigaito, Shuji Kodama, Takashi Kato, Yuuki Nishiura, Daisuke Suga, Toshikazu Terashima, Yuhuko Ichikawa, Isao Moritani, Akitaka Yamamoto, Kei Takaba, Kouji Yasumoto, Hideo Wada, Katsuya Shirak. Predictive prognostic biomarkers in patients with COVID‑19 infection. Molecular medicine reports. vol 27. issue 1. 2022-12-01. PMID:36453231. |
neutrophil count, aspartate aminotransferase (ast), alanine aminotransferase, lactate dehydrogenase (ldh), c‑reactive protein (crp), sialylated carbohydrate antigen kl‑6 (kl‑6), procalcitonin (pct), presepsin (psp) and d‑dimer levels were significantly higher, and lymphocyte count and platelet count were significantly lower in the non‑severe group compared with the severe group. |
2022-12-01 |
2023-08-14 |
Not clear |
| Zhijia Fang, Yongbin Li, Jingwen Wang, Xinran Wang, Linru Huang, Lijun Sun, Qi Den. Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice. Biological trace element research. 2022-12-01. PMID:36454454. |
the results showed that thr significantly reduced the elevation of aspartate aminotransferase (ast) and alanine aminotransferase (alt) in cd-exposed mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Koichi Tsuboi, Hiroko Watayo, Takafumi Tsukui, Kazuto Suda, Eri Abe, Takamori Fujimoto, Takanori Ochi, Geoffrey J Lane, Hiroyuki Koga, Atsuyuki Yamatak. Native liver survivors of portoenterostomy for biliary atresia with excellent outcome: redefining "successful" portoenterostomy. Pediatric surgery international. vol 39. issue 1. 2022-12-01. PMID:36454515. |
native liver survivors (nls) after portoenterostomy (pe) for biliary atresia (ba) with normal biomarkers defined as total bilirubin (t-bil), aspartate aminotransferase (ast)/alanine aminotransferase (alt) for liver function (lf), cholinesterase (che), platelet count (pc), and absence of portal hypertension (pht) were reviewed to redefine "successful" pe. |
2022-12-01 |
2023-08-14 |
Not clear |
| Muhammed Enes Inanc, Fatma Nur Guzel, Sukru Gungor, Mine Herdogan, Feyza Nur Mart, Durmus Kahraman, Hasan Ali Cay, Ayhan At. The interaction between seminal plasma biochemical constituents and short-term semen preservation in Honamli and Hair goats. Reproduction in domestic animals = Zuchthygiene. 2022-11-30. PMID:36447389. |
diluted semen samples were cooled to +4°c; the samples were stored at this temperature; the spermatological parameters (i.e., motility, plasma membrane and acrosome integrity (pmai), viability, and high mitochondrial membrane potential) were assessed at 0, 24, 48, 72, and 144 h. a significant positive correlation was determined between the pmai, motility and viability with globulin, chlorine, alanine aminotransferase (ast), and aspartate aminotransferase (alt). |
2022-11-30 |
2023-08-14 |
Not clear |
| Sajad Badiei, Seyed Jalal Hashemi, Abdolrahim Masjedizadeh, Jalal Sayyah, Zahra Mohammadi, Sanam Hariri, Farnaz Hashemi, Zahra Rahimi, Leila Danehchin, Farhad Abolnezhadian, Reza Malihi, Yousef Paridar, Seyyed Ali Mard, Bahman Cheraghian, Hossein Poustchi, Ali Akbar Shayeste. Association between physical activity and serum liver aminotransferases in Southwestern Iran: A Cross-sectional study. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. vol 27. 2022-11-28. PMID:36438076. |
the main aim of the present study is to investigate the independent association objectively measured level of physical activity (pa) and serum concentration of liver aminotransferases (alanine aminotransferase [alt] and aspartate aminotransferase [ast]) among seemingly healthy individuals. |
2022-11-28 |
2023-08-14 |
Not clear |
| Martha Hoffman, Soon Hon Cheong, Tracy Stoko. Transient increases in glutamate dehydrogenase (GLDH) activity occur in neonatal foals. Veterinary clinical pathology. 2022-11-28. PMID:36443639. |
liver injury in horses is recognized by increased glutamate dehydrogenase (gldh), sorbitol dehydrogenase (sdh), and aspartate aminotransferase (ast) activities, whereas biliary pathology is identified by increased alkaline phosphatase and γ-glutamyl transferase (ggt) activities or bilirubin concentrations. |
2022-11-28 |
2023-08-14 |
Not clear |
| Mohamed Saleh Al-Anazi, Khaled Meghawry El-Zahar, Nourhan Abdel-Hamid Rabi. Nutritional and Therapeutic Properties of Fermented Camel Milk Fortified with Red Molecules (Basel, Switzerland). vol 27. issue 22. 2022-11-26. PMID:36431797. |
blood glucose, malondialdehyde (mda), low-density lipoprotein (ldl), cholesterol, triglyceride, aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase (alp), creatinine, and urea levels decreased dramatically in comparison to the positive control group, while high-density lipoprotein (hdl), albumin, and total protein concentrations increased significantly. |
2022-11-26 |
2023-08-14 |
rat |
| Mohammed A El-Magd, Amina M G Zedan, Nahla S Zidan, Mohamed I Sakran, Omar Bahattab, Atif Abdulwahab A Oyouni, Osama M Al-Amer, Adel I Alalawy, Amira M Elmosleman. Avocado Seeds-Mediated Alleviation of Cyclosporine A-Induced Hepatotoxicity Involves the Inhibition of Oxidative Stress and Proapoptotic Endoplasmic Reticulum Stress. Molecules (Basel, Switzerland). vol 27. issue 22. 2022-11-26. PMID:36431959. |
oral administration of 5% avs powder for 4 weeks ameliorated csa-induced hepatotoxicity, as evidenced by (1) decreased levels of liver damage parameters (alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), and bilirubin), (2) resumed redox balance in the liver (reduced malondialdehyde (mda) and increased superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gpx)), (3) downregulated hepatic expression of endoplasmic reticulum (er) stress-related genes (x-box binding protein 1 ( |
2022-11-26 |
2023-08-14 |
rat |
| Bernard Nsengimana, Edozie Samuel Okpara, Wanqing Hou, Chuyun Yan, Shuxin Ha. Involvement of oxidative species in cyclosporine-mediated cholestasis. Frontiers in pharmacology. vol 13. 2022-11-25. PMID:36425570. |
additionally, cyclosporine exerts adverse effects on liver function and redox balance responses in treated rats, as evidenced by its increasing levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), and bilirubin while also decreasing the levels of glutathione and nadph. |
2022-11-25 |
2023-08-14 |
rat |
| Flavia Urbano, Mariangela Chiarito, Crescenza Lattanzio, Angela Messa, Marco Ferrante, Mariantonietta Francavilla, Irsida Mehmeti, Giuseppe Lassandro, Paola Giordano, Maria Felicia Faienz. Sex Hormone-Binding Globulin (SHBG) Reduction: The Alarm Bell for the Risk of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome. Children (Basel, Switzerland). vol 9. issue 11. 2022-11-24. PMID:36421197. |
thirty-two girls were assessed for anthropometric and biochemical markers: total cholesterol (tc), high density lipoprotein cholesterol (hdl-c), low density lipoprotein cholesterol (ldl-c), triglycerides (tg), glucose, insulin, alanine aminotransferase (alt), aspartate aminotransferase (ast) and gamma glutamyl transpeptidase (γgt). |
2022-11-24 |
2023-08-14 |
human |
| Qixin Wang, Yuwen Huang, Yu Li, Luyun Zhang, Huan Tang, Junzhe Zhang, Guangqing Cheng, Minghong Zhao, Tianming Lu, Qian Zhang, Piao Luo, Yinhua Zhu, Fei Xia, Ying Zhang, Dandan Liu, Chen Wang, Haiyan Li, Chong Qiu, Jigang Wang, Qiuyan Gu. Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress. Metabolites. vol 12. issue 11. 2022-11-24. PMID:36422270. |
the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (akp), superoxide dismutase (sod), malondialdehyde (mda), glutathione (gsh), catalase (cat), lactate dehydrogenase (ldh), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β) and interleukin-6 (il-6) were quantified. |
2022-11-24 |
2023-08-14 |
cat |
| Panpan Zhao, Yan Wang, Qiankun Yang, Guili Yu, Fenfen Ma, Jingquan Don. Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death. Environmental science and pollution research international. 2022-11-23. PMID:36418824. |
abamectin exposure caused cardiac dysfunction by upregulating lactate dehydrogenase (ldh), aspartate aminotransferase (ast), creatine kinase (ck), creatine kinase mb isoenzyme (ck-mb) and white blood cells (wbcs), and decreasing red blood cells (rbcs) and hemoglobin (hb). |
2022-11-23 |
2023-08-14 |
Not clear |
| Luan Manh Chu, Chandima Karunanayake, Palok Aich, Markus Hecker, Punam Pahw. Association between liver enzymes and metabolic syndrome in Canadian adults: results from the Canadian health measures survey - cycles 3 &4. Journal of diabetes and metabolic disorders. vol 21. issue 2. 2022-11-21. PMID:36404860. |
the biomarkers selected were gamma-glutamyl transferase (ggt), aspartate aminotransferase (ast), and alkaline phosphatase (alkp). |
2022-11-21 |
2023-08-14 |
Not clear |
| Anuoluwapo Adelodun, Amro Abdellatief, Oyedotun Babajid. Epstein-Barr Virus Hepatitis Masquerading as Painless Jaundice. Cureus. vol 14. issue 10. 2022-11-21. PMID:36407142. |
she had elevated transaminases: alanine transaminase (alt) of 1287u/l and aspartate aminotransferase of (ast) 1057u/l but her alkaline phosphatase (alp) was only slightly above normal at 109u/l (normal range 35-104u/l), with a direct hyperbilirubinemia - total bilirubin 9.5mg/dl, direct bilirubin 6.8mg/dl; the abdominal ultrasound revealed non-dilated bile ducts. |
2022-11-21 |
2023-08-14 |
Not clear |
| Haijing Zhang, Yifei Yang, Feifei Guo, Rong He, Shuangrong Gao, Chunyu Cao, Chunhui Zhao, Bing Xia, Qihua Xu, Ping Gong, Lifang Wang, Ping Su, Ting Li. Danlu tongdu tablets: Preclinical safety evaluation and mechanism of hepatotoxicity. Frontiers in pharmacology. vol 13. 2022-11-21. PMID:36408216. |
the wide application of danlu tongdu in therapy has raised some clinical adverse reactions, such as significant elevation of alanine transaminase (alt) and aspartate transaminase (ast) in individual patients after use. |
2022-11-21 |
2023-08-14 |
rat |
| Guoxin Xu, Yanping Gong, Fenying Lu, Bin Wang, Zaixing Yang, Long Chen, Jingyu Min, Cuie Cheng, Tingwang Jian. Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis. Scientific reports. vol 12. issue 1. 2022-11-18. PMID:36396948. |
alanine transaminase (alt), alkaline phosphatase (alp), aspartate transaminase (ast), and γ-glutamyltranspetidase (ggt) (4 liver function indexes) serum levels were detected with corresponding activity assay kits. |
2022-11-18 |
2023-08-14 |
mouse |