| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongkun Xue, Yu Wang, Hongwei Xiang, Qi Song, Guowei Zhang, Jianguo Wang, Shaoqin G. Exploring the Protective Effects and Mechanism of Huaji Jianpi Decoction against Nonalcoholic Fatty Liver Disease by Network Pharmacology and Experimental Validation. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-06. PMID:36199550. |
compared with the model group, the liver wet weight, liver/body ratio, the levels of total cholesterol (tc), triglyceride (tg), aspartate aminotransferase (ast), alanine aminotransferase (alt), and high-density lipoprotein (hdl) in serum in the hjjpd low-dose (17.52 g/kg·d), medium-dose (35.04 g/kg·d), and high-dose (70.07 g/kg·d) groups significantly decreased ( |
2022-10-06 |
2023-08-14 |
mouse |
| Meiling Zuo, Yue Shang, Ye Guo, Yuxuan Sun, Gaoqi Xu, Jingtao Chen, Liqin Zh. Population Pharmacokinetics of Tacrolimus in Umbilical Cord Blood Transplant Pediatrics. Journal of clinical pharmacology. 2022-10-05. PMID:36196568. |
the impact of demographic features, biological characteristics, and concomitant medications, including sex, age, body weight, postoperative day, white blood cell (wbc), red blood cell (rbc), hemoglobin (hb), platelet (plt), hematocrit (hct), urea nitrogen (bun), creatinine (cr), aspartate transaminase (ast), alanine transaminase (alt), total bilirubin (tbil), albumin (alb), and total protein (tp) were investigated. |
2022-10-05 |
2023-08-14 |
Not clear |
| Anjali Pitamberwale, Tariq Mahmood, Azmat Kamal Ansari, Shabana Andleeb Ansari, Kirti Limgaokar, Lalit Singh, Geeta Kark. Biochemical Parameters as Prognostic Markers in Severely Ill COVID-19 Patients. Cureus. vol 14. issue 8. 2022-10-03. PMID:36185918. |
results of the 178 severely ill covid-19 patients enrolled in the study, 86 were controls and 92 were cases (52% mortality). serum urea (p<0.0001), creatinine (p=0.0019), aspartate transaminase (ast) (p=0.0104), lactate dehydrogenase (ldh) (p=0.0001), procalcitonin (pct) (p=0.0344), and interleukin 6 (il-6) (p=0.0311) levels were significantly higher (p<0.05), while total protein (p=0.0086), albumin (p<0.0001), and indirect bilirubin (p=0.0147) levels were significantly lower (p<0.05) in cases as compared to controls. |
2022-10-03 |
2023-08-14 |
Not clear |
| Yongchao Gao, Chao Sun, Ting Gao, Zhiyong Liu, Zhao Yang, Hui Deng, Peng Fan, Junhong Ga. Taurine ameliorates volatile organic compounds-induced cognitive impairment in young rats Frontiers in veterinary science. vol 9. 2022-10-03. PMID:36187803. |
moreover, taurine decreased malondialdehyde (mda), γ-aminobutyric acid (gaba), aspartate aminotransferase (ast), alanine aminotransferase (alt), urea, creatinine (crea) and injury biomarker level, enhanced superoxide dismutase (sod), reduced glutathione (gsh) and glutamic acid (glu) activities, up-regulated the protein expression of brain derived neurotrophic factor (bdnf) and n-methyl-d-aspartate receptor 1 (nmdar1) in model rats, and in most of cases 1% but not 0.5%, ameliorated the defects induced by vocs. |
2022-10-03 |
2023-08-14 |
rat |
| Bo Zhang, Zeben Wang, Chenxuan Huang, Dehe Wang, Dongmei Chang, Xiaowei Shi, Yifan Chen, Hui Che. Positive effects of Mulberry leaf extract on egg quality, lipid metabolism, serum biochemistry, and antioxidant indices of laying hens. Frontiers in veterinary science. vol 9. 2022-10-03. PMID:36187805. |
hens were fed a basal diet supplemented with 0 (control diet), 0.4, 0.8, or 1.2% mle for 56 d. results showed that the addition of 0.4-1.2% mle to the diet improved aspartate transaminase (ast) activity in the serum of laying hens, reduced low-density lipoprotein (ldl-c) content in the serum, and significantly decreased yolk triglyceride (tg) and total cholesterol (tc) contents ( |
2022-10-03 |
2023-08-14 |
Not clear |
| Xenophon Theodoridis, Georgios Kalopitas, Andreas Vadarlis, Dimitra Rafailia Bakaloudi, Νikolaos Gkiourtzis, Georgios Dionysopoulos, Evangelia Karanika, Eirini Tsekitsidi, Michail Chourdaki. Comparative efficacy of different treatment modalities in the management of pediatric non-alcoholic fatty liver disease: A systematic review and network meta-analysis. Pharmacology & therapeutics. 2022-10-02. PMID:36183848. |
secondary outcomes were changes in aspartate aminotransferase (ast), lipidemic and other biochemical parameters concentrations and body mass index (bmi) values. |
2022-10-02 |
2023-08-14 |
human |
| Changqing Zhang, Chenqinyao Li, Kechun Liu, Yun Zhan. Characterization of zearalenone-induced hepatotoxicity and its mechanisms by transcriptomics in zebrafish model. Chemosphere. 2022-10-01. PMID:36181844. |
first, we found zearalenone exposure can specifically cause liver injury, as evidenced by reduced liver size, decreased liver-specific fluorescence, increased aspartate aminotransferase (ast) activity, delayed yolk sac absorption and lipid accumulation. |
2022-10-01 |
2023-08-14 |
human |
| Yucong Wang, Tao Xu, Hui Zhao, Chunxiao Gu, Zhongzheng L. Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise. Frontiers in physiology. vol 13. 2022-09-30. PMID:36176774. |
we assessed serum creatine kinase (ck), ck isoenzyme, lactate dehydrogenase (ldh), aspartate transaminase (ast), tumor necrosis factor-alpha (tnf-alpha), and interleukin-6 (il-6). |
2022-09-30 |
2023-08-14 |
human |
| Chen Zhu, Xinwei Cheng, Ping Gao, Qianyan Gao, Ximin Wang, Dong Liu, Xiuhua Ren, Chengliang Zhan. Model establishment and microarray analysis of mice with oxaliplatin‑induced hepatic sinusoidal obstruction syndrome. Molecular medicine reports. vol 26. issue 5. 2022-09-30. PMID:36177905. |
the serum levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast) were determined. |
2022-09-30 |
2023-08-14 |
mouse |
| Fei Teng, Xiang-Wei Li, Min Li, Dong-Dong Fan, Jing-Jing Zhu, Hui-Min Gao, Zhi-Min Wan. [Components and lipid-lowering effect of total saponins from underground part of Gynostemma pentaphyllum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 18. 2022-09-27. PMID:36164912. |
furthermore, the levels of tc, tg, low-density lipoprotein cholesterol(ldl-c), high-density lipoprotein cholesterol(hdl-c), alanine transaminase(alt), aspartate transaminase(ast), bilirubin, and total bile acids in serum, as well as the levels of superoxide dismutase(sod), malondialdehyde(mda), peroxidase proliferator-activated receptor(ppar-γ) in the liver tissue, were determined. |
2022-09-27 |
2023-08-14 |
rat |
| Y Kaçar, Z Mecitoğlu, H Batma. Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning. Australian veterinary journal. 2022-09-27. PMID:36165420. |
blood samples were collected on days 0 and 7, and aspartate aminotransferase (ast), gamma-glutamyltranspeptidase (ggt) and creatinine levels were evaluated. |
2022-09-27 |
2023-08-14 |
Not clear |
| Marawan Abd Elbaset, Maha Nasr, Bassant M M Ibrahim, Omar A H Ahmed-Farid, Rofanda M Bakeer, Nabila S Hassan, Rania F Ahme. Curcumin nanoemulsion counteracts hepatic and cardiac complications associated with high-fat/high-fructose diet in rats. Journal of food biochemistry. 2022-09-27. PMID:36165438. |
results revealed that the high dose level of cur nanoemulsion was superior to conventional cur in ameliorating the hfhf-induced insulin resistance status and hyperlipidemia, with beneficial impact on rats' recorded electrocardiogram (ecg), serum aspartate aminotransferase (alt) and alanine aminotransferase (ast) levels, leptin, adiponectin, creatine phosphokinase, lactate dehydrogenase and cardiac troponin-i. |
2022-09-27 |
2023-08-14 |
rat |
| Huiwen Wang, Jian Zhang, Xiaoxun Zhang, Nan Zhao, Zongtao Zhou, Lijian Tao, Lei Fu, Shifang Peng, Jin Cha. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-26. PMID:36154893. |
we found that akf-pd significantly reduced the levels of serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and total bile salts (tba), as well as hepatic bile acids (bas) levels. |
2022-09-26 |
2023-08-14 |
mouse |
| Ruiqiang Li, Wenqiang Zhan, Jingyi Ren, Xian Gao, Xin Huang, Yuxia M. Associations between organophosphate esters concentrations and markers of liver function in US adolescents aged 12-19 years: A mixture analysis. Environmental pollution (Barking, Essex : 1987). 2022-09-26. PMID:36155224. |
liver function tests (lfts) include aspartate aminotransferase (ast), albumin (alb), alanine aminotransferase (alt), alkaline phosphatase (alp), gamma-glutamyl transferase (ggt), total bilirubin (tbil), total protein (tp), and ast/alt. |
2022-09-26 |
2023-08-14 |
human |
| Dong Sub Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Youngsang Park, Bonglee Kim, Bumsang Shim, Sung-Hoon Ki. The underlying hepatoprotective mechanism of PKC#963 in alcohol or carbon tetrachloride induced liver injury via inhibition of iNOS, COX-2, and p-STAT3 and enhancement of SOD and catalase. Phytotherapy research : PTR. 2022-09-24. PMID:36151597. |
here, pkc#963 significantly suppressed aspartate aminotransferase (ast), alanine aminotransferase (alt), phosphorylated signal transducer and activator of transcription 3 (p-stat3), inducible nitric oxide synthase (inos), and cyclooxygenase (cox-2) in ccl4-treated hepg2 cells. |
2022-09-24 |
2023-08-14 |
rat |
| Jiaji Hu, Yigang Zheng, Hanglu Ying, Huabin Ma, Long Li, Yufen Zha. Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation. Nutrients. vol 14. issue 18. 2022-09-23. PMID:36145172. |
the results showed that ala-gln treatment significantly attenuated mcd-induced hepatic pathological changes, lowered nafld activity score, and reduced plasma alanine transaminase (alt), aspartate transaminase (ast) and lactate dehydrogenase (ldh) levels. |
2022-09-23 |
2023-08-14 |
mouse |
| Jin-Yu Gong, Huan Ren, Hui-Qing Chen, Kai Xing, Chen-Lin Xiao, Jian-Quan Lu. Magnesium Isoglycyrrhizinate Attenuates Anti-Tuberculosis Drug-Induced Liver Injury by Enhancing Intestinal Barrier Function and Inhibiting the LPS/TLRs/NF-κB Signaling Pathway in Mice. Pharmaceuticals (Basel, Switzerland). vol 15. issue 9. 2022-09-23. PMID:36145350. |
the results demonstrated that intraperitoneal injection of mgig (40 mg/kg) significantly ameliorated hrze-induced liver injury by reducing alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (akp), and malondialdehyde (mda) levels and improved liver pathological changes. |
2022-09-23 |
2023-08-14 |
mouse |
| Chirayu Padhiar, Muthuraman Muthuchamy, Vignesh Ganesan, Swathi Desireddy, Mayur Abhaya, Ramanujam Siva, Kalaivani Periyathamb. Dehydrated Human Amnion/Chorion Membrane Allografts as an Adjunct Wound Healing Therapy in Diabetic Rats. The international journal of lower extremity wounds. 2022-09-22. PMID:36131388. |
also, in the animals of g5 and g6 of the diabetic group, there was no statistically significant difference (p > 0.05) in the levels of glucose, urea, creatinine, aspartate aminotransferase (ast), alanine aminotransferase (alt), and alkaline phosphate (alp), when compared to g4 animals during the experiment. |
2022-09-22 |
2023-08-14 |
human |
| Young-Jun Seo, Young Suk Shim, Hae Sang Lee, Jin Soon Hwan. Updated reference ranges for aminotransferase levels of Korean children and young adolescents based on the risk factors for metabolic syndrome. Scientific reports. vol 12. issue 1. 2022-09-21. PMID:36131081. |
overall, aspartate aminotransferase (ast), alanine aminotransferase (alt), and the ast/alt ratio varied with sex and age. |
2022-09-21 |
2023-08-14 |
human |
| Qianqian Luo, Yuanyi Ling, Yufei Li, Xiaoqin Qu, Qiaoqing Shi, Shuangyan Zheng, Yanhong Li, Yonghong Huang, Xiaoyan Zho. Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120358. |
we demonstrated that pebp4 cko aggravated ccl4-triggered liver fibrosis, as evidenced by altered histopathology, an increase in the activities of alanine aminotransferase (alt), aspartate aminotransferase (ast) and hydroxyproline (hyp) levels, and more collagen deposition, as well as by enhanced expression of fibrotic markers including α-smooth muscle actin (α-sma), collagen i and collagen iii. |
2022-09-19 |
2023-08-14 |
mouse |