| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C McDonald, H Mota-Filipe, J A Wright, M Abdelrahman, M D Threadgill, A S Thompson, C Thiemerman. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. British journal of pharmacology. vol 130. issue 4. 2000-08-02. PMID:10864891. |
haemorrhage and resuscitation resulted (within 4 h after resuscitation) in a delayed fall in blood pressure (circulatory failure) as well as in rises in the serum levels of (i) urea and creatinine (renal dysfunction), (ii) aspartate aminotransferase (ast), alanine aminotransferase (alt), and gamma-glutamyl-transferase (gamma-gt) (liver injury and dysfunction), (iii) lipase (pancreatic injury) and (iv) creatine kinase (ck) (neuromuscular injury) (n=10). |
2000-08-02 |
2023-08-12 |
human |
| Y Kurata, F Makinodan, J Matsumoto, N Toyota, K Tanak. Partial hepatectomy of marmoset: clinical and pathological effects and utility in microsomal enzyme analysis. Experimental animals. vol 49. issue 2. 2000-08-01. PMID:10889947. |
although the plasma aspartate aminotransferase (ast) activities tended to decrease from 1 to 4 weeks post-surgery, no abnormality was noted in clinical sign, body weight, the hematocrit value or other blood chemical values. |
2000-08-01 |
2023-08-12 |
marmoset |
| K M Leung, V E Oo. Studies on thallium toxicity, its tissue distribution and histopathological effects in rats. Chemosphere. vol 41. issue 1-2. 2000-07-27. PMID:10819194. |
male albino rats exhibited a markedly dose-dependent increase in the serum levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) at 16 h after an intraperitoneal injection of 30, 60 or 120 mg/kg tl. |
2000-07-27 |
2023-08-12 |
rat |
| G J Park, B P Lin, M C Ngu, D B Jones, P H Katelari. Aspartate aminotransferase: alanine aminotransferase ratio in chronic hepatitis C infection: is it a useful predictor of cirrhosis? Journal of gastroenterology and hepatology. vol 15. issue 4. 2000-07-27. PMID:10824882. |
the clinical usefulness of the ratio of serum aspartate aminotransferase (ast) to alanine aminotransferase (alt) has been explored in several liver disorders. |
2000-07-27 |
2023-08-12 |
Not clear |
| J B Lopez, M Balasegaram, V Thambyrajah, J Timo. The value of liver function tests in hepatocellular carcinoma. The Malaysian journal of pathology. vol 18. issue 2. 2000-07-27. PMID:10879229. |
sera from 80 hcc, 76 benign liver disease (bld) and 152 healthy adult (ha) subjects were assayed for alkaline phosphatase (alp), gamma-glutamyltransferase (ggt), aspartate aminotransferase (ast), alanine aminotransferase and lactate dehydrogenase, bilirubin and albumin. |
2000-07-27 |
2023-08-12 |
human |
| M A Mansou. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life sciences. vol 66. issue 26. 2000-07-20. PMID:10883736. |
induced hepatotoxicity, manifested biochemically by significant elevation of activities of serum enzymes, such as alanine transaminase (alt, ec: 2.6.1.2) , aspartate transaminase (ast, ec: 2.6.1.1) and lactate dehydrogenase (ldh, ec: 1.1.1.27). |
2000-07-20 |
2023-08-12 |
mouse |
| M K Zomborszky, F Vetési, I Repa, F Kovács, A Bata, P Horn, A Tóth, R Romvár. Experiment to determine limits of tolerance for fumonisin B1 in weaned piglets. Journal of veterinary medicine. B, Infectious diseases and veterinary public health. vol 47. issue 4. 2000-07-19. PMID:10861196. |
the haematological parameters examined revealed no change attributable to toxic effects, while with respect to the biochemical parameters, an increase in aspartate aminotransferase (ast) activity dependent on dosage, indicating a pathological change in the liver, was ascertained in all three experimental groups. |
2000-07-19 |
2023-08-12 |
Not clear |
| E C Lam, R M Janzen, R M Meloche, P J Trepanier, E M Yoshid. Acute pseudohepatitis in a chronic substance abuser secondary to occult seat belt injury. Canadian journal of gastroenterology = Journal canadien de gastroenterologie. vol 13. issue 2. 2000-07-11. PMID:10203436. |
causes of a massive elevation in serum aminotransferases (aspartate aminotransferase [ast] and alanine aminotransferase [alt]) in the substance-abusing patient include viral hepatitis and drug hepatotoxicity. |
2000-07-11 |
2023-08-12 |
Not clear |
| C C Barton, D A Hill, S B Yee, E X Barton, P E Ganey, R A Rot. Bacterial lipopolysaccharide exposure augments aflatoxin B(1)-induced liver injury. Toxicological sciences : an official journal of the Society of Toxicology. vol 55. issue 2. 2000-07-11. PMID:10828277. |
hepatic parenchymal cell injury was evaluated as increased alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities in serum and from histologic examination of liver sections. |
2000-07-11 |
2023-08-12 |
rat |
| T Inafuku, H Nozak. [Liver function of the most elderly patients]. Rinsho byori. The Japanese journal of clinical pathology. vol 48. issue 3. 2000-07-06. PMID:10804830. |
to determine the decision level of liver function in the most elderly patients, we compared serum albumin, aspartate aminotransferase(ast), alanine aminotransferase(alt) and alkaline phosphatase(alp) values of the most elderly patients > 85 years with those of healthy young adults. |
2000-07-06 |
2023-08-12 |
Not clear |
| C C Lin, P C Huang, J M Li. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. The American journal of Chinese medicine. vol 28. issue 1. 2000-06-29. PMID:10794120. |
on acetaminophen-intoxicated model, the increased levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) by acetaminophen administration were reduced by treatment with these two herbs. |
2000-06-29 |
2023-08-12 |
rat |
| S C Lin, T C Chung, T H Ueng, Y H Lin, S H Hsu, C L Chiang, C C Li. The hepatoprotective effects of Solanum alatum Moench. on acetaminophen-induced hepatotoxicity in mice. The American journal of Chinese medicine. vol 28. issue 1. 2000-06-29. PMID:10794122. |
decreased the elevation of serum alanine aminotransferase (alt; gpt) and aspartate aminotransferase (ast; got) induced by acetaminophen (paracetamol) (600 mg/kg, i.p.) |
2000-06-29 |
2023-08-12 |
mouse |
| E R Almeida, A M Melo, H Xavie. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytotherapy research : PTR. vol 14. issue 2. 2000-06-23. PMID:10685105. |
the hydro-alcohol extract of the dry leaves of peumus boldus and boldine, showed abortive and teratogenic action and changes in the blood levels of bilirubin, cholesterol, glucose, alanine aminotransferase (alt), aspartate aminotransferase (ast) and urea in rats. |
2000-06-23 |
2023-08-12 |
rat |
| A J Czaja, H A Carpenter, P J Santrach, S B Moor. Autoimmune cholangitis within the spectrum of autoimmune liver disease. Hepatology (Baltimore, Md.). vol 31. issue 6. 2000-06-21. PMID:10827147. |
patients with autoimmune cholangitis were distinguished from type 1 autoimmune hepatitis (aih) by lower serum levels of aspartate transaminase (ast), gamma-globulin, and immunoglobulin g; higher serum levels of alkaline phosphatase; and lower frequencies of autoantibodies. |
2000-06-21 |
2023-08-12 |
Not clear |
| H T Kim, G Stoica, F W Bazer, T L Ot. Interferon tau-induced hepatocyte apoptosis in sheep. Hepatology (Baltimore, Md.). vol 31. issue 6. 2000-06-21. PMID:10827153. |
histopathology revealed acute hepatopathy including cellular swelling, cytoplasmic aggregates, and apoptosis in all ifn-tau-treated lambs, which were accompanied by elevation of aspartate transaminase (ast) (p <.01). |
2000-06-21 |
2023-08-12 |
Not clear |
| P B Müller, J Taboada, G Hosgood, B P Partington, J L VanSteenhouse, H W Taylor, K J Wolfsheime. Effects of long-term phenobarbital treatment on the liver in dogs. Journal of veterinary internal medicine. vol 14. issue 2. 2000-06-13. PMID:10772488. |
serum alkaline phosphatase (alp), alanine transaminase (alt), aspartate transaminase (ast), gamma-glutamyltransferase (ggt), fasted bile acids (fba), total bilirubin, and albumin were determined before and during treatment. |
2000-06-13 |
2023-08-12 |
Not clear |
| T Nakamura, J Kido, R Kido, K Ohishi, N Yamauchi, M Kataoka, T Nagat. The association of calprotectin level in gingival crevicular fluid with gingival index and the activities of collagenase and aspartate aminotransferase in adult periodontitis patients. Journal of periodontology. vol 71. issue 3. 2000-06-13. PMID:10776922. |
in the present study, the association of gcf calprotectin level with gcf volume, gingival index (gi), and levels of biochemical markers including collagenase and aspartate aminotransferase (ast) in gcf was investigated to clarify the relationship between gcf calprotectin level and periodontal inflammation. |
2000-06-13 |
2023-08-12 |
human |
| L Comanor, J Minor, H S Conjeevaram, E A Roberts, F Alvarez, E M Bern, P Goyens, P Rosenthal, A Lachaux, M Shelton, J Sarles, E M Soka. Statistical models for predicting response to interferon-alpha and spontaneous seroconversion in children with chronic hepatitis B. Journal of viral hepatitis. vol 7. issue 2. 2000-06-06. PMID:10760045. |
commonly collected clinical data included age, gender, serum aminotransferase (aspartate aminotransferase [ast] and alanine aminotransferase [alt]) and hepatitis b virus (hbv) dna levels, and ifn-alpha dose. |
2000-06-06 |
2023-08-12 |
Not clear |
| K M Olsen, J A Rebuck, T Weidenbach, D N Fis. Pharmacokinetics of intravenous trovafloxacin in critically ill adults. Pharmacotherapy. vol 20. issue 4. 2000-05-31. PMID:10772370. |
seven patients (3 men, 4 women; mean +/- sd age 59.4 +/- 20.6 yrs; baseline aspartate aminotransferase [ast]/alanine aminotransferase [alt] 66.0 +/- 40.6/51.5 +/-37.5 iu/l; median acute physiology and chronic health evaluation [apache ii] score 27, range 15-32) were studied at estimated steady state. |
2000-05-31 |
2023-08-12 |
Not clear |
| N Yamanaka, M Takada, T Tanaka, J Yamanaka, C Yasui, T Ando, S Maeda, K Matsushita, E Okamot. Viral serostatus and coexisting inflammatory activity affect metachronous carcinogenesis after hepatectomy for hepatocellular carcinoma. A further report. Journal of gastroenterology. vol 35. issue 3. 2000-05-16. PMID:10755690. |
in the patients overall and also in the patients with a single nodular hcc, the hcv group had significantly higher hai scores and preoperative serum aspartate aminotransaminase (ast) levels than the other two groups. |
2000-05-16 |
2023-08-12 |
Not clear |