| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hussam H Ajamieh, Eduardo Candelario-Jalil, Olga Sonia León Fernández, Alexander L Gerbe. Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats. Clinical science (London, England : 1979). vol 115. issue 2. 2008-07-10. PMID:18307414. |
hepatic damage was evaluated by transaminase [ast (aspartate transaminase), alt (alanine transaminase)] release; inflammation was assessed by hepatic mpo (myeloperoxidase) and serum tnfalpha (tumour necrosis factor alpha) and no; oxidative stress was estimated by mda (malondialdehyde) and 4-hda (4-hydroxyalkenals), sod (superoxide dismutase) activity, gsh and ada (adenosine deaminase) as adenosine metabolism. |
2008-07-10 |
2023-08-12 |
rat |
| Phyllis C Tien, Donald P Kotler, E Turner Overton, Cora E Lewis, David Rimland, Peter Bacchetti, Rebecca Scherzer, Barbara Gripshove. Regional adipose tissue and elevations in serum aminotransferases in HIV-infected individuals. Journal of acquired immune deficiency syndromes (1999). vol 48. issue 2. 2008-07-08. PMID:18285711. |
the association of fat distribution with alanine aminotransferase (alt) and aspartate aminotransferase (ast) elevations is not well-defined in hiv-infected individuals. |
2008-07-08 |
2023-08-12 |
Not clear |
| L Pari, A Prasat. Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. Chemico-biological interactions. vol 173. issue 2. 2008-07-08. PMID:18405891. |
ni induced liver damage was clearly shown by the increased activities of serum hepatic enzymes namely aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase (alp), gamma glutamyl transferase (ggt) and lactate dehydrogenase (ldh) along with increased elevation of lipid peroxidation indices (thiobarbituric reactive acid substances (tbars) and lipid hydroperoxides). |
2008-07-08 |
2023-08-12 |
rat |
| Stephanie Venn-Watson, Cynthia R Smith, Eric D Jense. Assessment of increased serum aminotransferases in a managed Atlantic bottlenose dolphin (Tursiops truncatus) population. Journal of wildlife diseases. vol 44. issue 2. 2008-07-08. PMID:18436664. |
we identified bottlenose dolphins in our current population with episodic increases in serum aminotransferases, specifically alanine aminotransferase (alt) and aspartate aminotransferase (ast), and we hypothesized that hematologic and serum biochemical changes in these animals may provide clues as to potential causes of liver disease in cetaceans. |
2008-07-08 |
2023-08-12 |
Not clear |
| Carlos André Nunes Jatobá, Adriana Augusto de Rezende, Sarah Jane de Paiva Rodrigues, Maria Margareth de Almeida Câmara, Maria das Graças Almeida, Francisco Freire-Neto, Luiz Reginaldo Menezes da Rocha, Aldo Cunha da Medeiros, José Brandão-Neto, Maria Célia de Carvalho Formiga, Italo Medeiros de Azevedo, Ana Maria de Oliveira Ramo. Liver iron overload induced by tamoxifen in diabetic and non-diabetic female Wistar rats. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 21. issue 2. 2008-07-01. PMID:17636394. |
sixty days after induced dm, blood samples were collected for glucose, alanine aminotransferase (alt), aspartate aminotransferase (ast) alkaline phosphatase (alp) and bilirubin measures. |
2008-07-01 |
2023-08-12 |
rat |
| Li-Ping Yuan, Fei-Hu Chen, Lu Ling, Peng-Fei Dou, Hu Bo, Ming-Mei Zhong, Li-Juan Xi. Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis. Journal of ethnopharmacology. vol 116. issue 3. 2008-06-26. PMID:18313245. |
liver index (liver weight/body weight), serum levels of transaminases (alanine aminotransferase, alt and aspartate aminotransferase, ast), hepatic malondialdehyde (mda) content, superoxide dismutase (sod) and glutathione peroxidase (gsh-px) activities were evaluated following the 10 days treatment in mice. |
2008-06-26 |
2023-08-12 |
mouse |
| Pronobesh Chattopadhyay, Navneet Verma, Anurag Verma, Tirath Kamboj, Nazam Ali Khan, Arun Kumar Wah. L-arginine protects from pringle manoeuvere of ischemia-reperfusion induced liver injury. Biological & pharmaceutical bulletin. vol 31. issue 5. 2008-06-19. PMID:18451513. |
ischemic and reperfusion hepatocellular injury occurred as indicated by increased-alanine transaminase (alt), aspartate transaminase (ast). |
2008-06-19 |
2023-08-12 |
rat |
| Liang-Ming Liu, Ji-Xiang Zhang, Jie Luo, Hong-Xing Guo, Huan Deng, Jian-Yong Chen, Sui-Lin Su. A role of cell apoptosis in lipopolysaccharide (LPS)-induced nonlethal liver injury in D-galactosamine (D-GalN)-sensitized rats. Digestive diseases and sciences. vol 53. issue 5. 2008-06-17. PMID:17934810. |
blood biochemistry indexes, including those of alanine aminotransferase (alt), aspartate aminotransferase (ast) and total bilirubin (tbil), had risen by 6 h post-lps/d-galn injection, reached a peak at 24 h and sustained high levels at 48 h. an abnormal liver appearance was found at 24 and 48 h post-injection. |
2008-06-17 |
2023-08-12 |
rat |
| Ozer Sehirli, Yahya Ozel, Ender Dulundu, Umit Topaloglu, Feriha Ercan, Goksel Sene. Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats. Phytotherapy research : PTR. vol 22. issue 1. 2008-06-17. PMID:18165941. |
serum aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were determined to assess liver functions. |
2008-06-17 |
2023-08-12 |
rat |
| Jeng-Hsiu Hung, Chi-Jen Chu, Pi-Lin Sung, Chih-Yao Chen, Kuan-Chong Chao, Ming-Jie Yang, Selena Chia-Yi Hun. Lamivudine therapy in the treatment of chronic hepatitis B with acute exacerbation during pregnancy. Journal of the Chinese Medical Association : JCMA. vol 71. issue 3. 2008-06-17. PMID:18364269. |
serum aspartate aminotransferase (ast) dropped to 757 u/l at 15+0 gestational weeks, but serum alanine aminotransferase (alt) flared up to 2,230 u/l and ast to 2,250 u/l at 17+1 gestational weeks. |
2008-06-17 |
2023-08-12 |
Not clear |
| N M Martins, N A G Santos, C Curti, M L P Bianchi, A C Santo. Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver. Journal of applied toxicology : JAT. vol 28. issue 3. 2008-06-12. PMID:17604343. |
hepatotoxicity was evidenced in the cisplatin group by the increased serum levels of alanine (alt) and aspartate (ast) aminotransferases. |
2008-06-12 |
2023-08-12 |
rat |
| Ana P Ardais, Francielli W Santos, Cristina W Nogueir. Ebselen attenuates cadmium-induced testicular damage in mice. Journal of applied toxicology : JAT. vol 28. issue 3. 2008-06-12. PMID:17624921. |
a number of toxicological parameters were evaluated in the testes of mice, such as delta-aminolevulinic acid dehydratase (delta-ala-d) activity, lipid peroxidation, ascorbic acid levels and alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities. |
2008-06-12 |
2023-08-12 |
mouse |
| Michael L Pritt, David Greg Hall, Justin Recknor, Kelly M Credille, Donna D Brown, Nathan P Yumibe, Albert Eric Schultze, David E Watso. Fabp3 as a biomarker of skeletal muscle toxicity in the rat: comparison with conventional biomarkers. Toxicological sciences : an official journal of the Society of Toxicology. vol 103. issue 2. 2008-06-12. PMID:18308699. |
in addition, the combination of fabp3 and aspartate aminotransferase (ast) had greater diagnostic value than the conventional combination of creatine kinase-mm isoenzyme (ck) and ast. |
2008-06-12 |
2023-08-12 |
rat |
| Deborah A Fauquier, Jonna A K Mazet, Frances M D Gulland, Terry R Spraker, Mary M Christophe. Distribution of tissue enzymes in three species of pinnipeds. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. vol 39. issue 1. 2008-06-12. PMID:18432090. |
enzymes evaluated were alanine aminotransferase (alt), aspartate aminotransferase (ast), sorbitol dehydrogenase (sdh), lactate dehydrogenase (ldh), creatine kinase (ck), alkaline phosphatase (alp), and gamma-glutamyl transferase (ggt) in tissues from california sea lions (zalophus californianus) (n = 5), harbor seals (phoca vitulina) (n = 5), and northern elephant seals (mirounga angustirostris) (n = 5) that stranded and then died at a rehabilitation center. |
2008-06-12 |
2023-08-12 |
Not clear |
| Chen-Sheng Lin, Chi-Sen Chang, Sheng-Shun Yang, Hong-Zen Yeh, Cheng-Wen Li. Retrospective evaluation of serum markers APRI and AST/ALT for assessing liver fibrosis and cirrhosis in chronic hepatitis B and C patients with hepatocellular carcinoma. Internal medicine (Tokyo, Japan). vol 47. issue 7. 2008-06-11. PMID:18379139. |
aspartate aminotransferase-to-platelet ratio index (apri), aspartate aminotransferase-to-alanine aminotransferase (ast/alt) ratio, platelet count, ast, albumin, bilirubin and alkaline phosphatase were retrospectively evaluated for the prediction of advanced liver fibrosis and cirrhosis in patients with resectable hepatocellular carcinoma in this study. |
2008-06-11 |
2023-08-12 |
Not clear |
| Sun-Young Jeong, Jung-Sun Lim, Han-Jin Park, Jae-Woo Cho, Suresh V S Rana, Seokjoo Yoo. Effects of acetaminophen on hepatic gene expression in mice. Physiological chemistry and physics and medical NMR. vol 38. issue 2. 2008-06-11. PMID:18472468. |
they were sacrificed after 6 hr and 24 hr for assessment of alanine aminotransferase (alt) and aspartate aminotransferase (ast), total rna isolation, cdna microarray analysis and histopathological analysis of liver injury. |
2008-06-11 |
2023-08-12 |
mouse |
| Oluwatosin Adaramoye, Bayo Ogungbenro, Oluchi Anyaegbu, Michael Fafuns. Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. Journal of radiation research. vol 49. issue 2. 2008-06-10. PMID:18250564. |
treatment with vit c and va (800 mg/kg) significantly (p < 0.05) decreased the gamma radiation-induced increases in serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities at 24 hours after irradiation, whereas, hs (400 mg/kg) significantly (p < 0.05) decreased the serum alt activity only. |
2008-06-10 |
2023-08-12 |
rat |
| Jin Seok Kang, Hideki Wanibuchi, Keiichirou Morimura, Rawiwan Wongpoomchai, Yaowares Chusiri, Frank J Gonzalez, Shoji Fukushim. Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity. Toxicology and applied pharmacology. vol 228. issue 3. 2008-06-10. PMID:18374380. |
serum levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp) and lactate dehydrogenase (ldh) in cyp2e1-null mice were significantly different at both time points compared to wild-type mice (p<0.01). |
2008-06-10 |
2023-08-12 |
mouse |
| Mitsuaki Kitano, Dai Watanabe, Shigehito Oda, Hiroshi Kubo, Hideyuki Kishida, Kenji Fujii, Mikio Kitahara, Kazunori Hoso. Subchronic oral toxicity of ubiquinol in rats and dogs. International journal of toxicology. vol 27. issue 2. 2008-06-10. PMID:18404543. |
these findings were accompanied by slight increases in blood chemistry enzymes (aspartate aminotransferase [ast], alanine aminotransferase [alt], and lactate dehydrogenase [ldh]), which was suggestive of either potential hepatotoxicity or a normal physiological response to ubiguinol loading. |
2008-06-10 |
2023-08-12 |
rat |
| Tapan K Jain, Maram K Reddy, Marco A Morales, Diandra L Leslie-Pelecky, Vinod Labhasetwa. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Molecular pharmaceutics. vol 5. issue 2. 2008-06-09. PMID:18217714. |
serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (akp) levels, and total iron-binding capacity (tibc) were also measured with time to assess the effect of mnps on liver function. |
2008-06-09 |
2023-08-12 |
rat |