| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min He, Shijun Zhang, Yang Jiao, Xing Lin, Jianchun Huang, Chunxia Chen, Zhaoni Chen, Renbin Huan. Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 9. 2013-01-15. PMID:22727860. |
pretreatment with rifampin significantly decreased serum alanine transaminase (alt) activities, aspartate transaminase (ast) activities and prevented severe liver necrosis following acetaminophen overdose. |
2013-01-15 |
2023-08-12 |
mouse |
| Muhammad Chaudhry, Abrar Maqsood, Samer Diab-Agha, Joshua Rosenber. Nicardipine-induced acute hepatitis in an intensive care unit patient. American journal of therapeutics. vol 16. issue 1. 2013-01-14. PMID:19092642. |
on the fourth day after operation, he started to have fever with progressive elevation of liver enzymes [aspartate amino transferase (ast) 450, alanine amino transferase (alt) 356, and alkaline phosphatase 299]. |
2013-01-14 |
2023-08-12 |
Not clear |
| Rosie J Naylor, Leanda Livesey, John Schumacher, Nicole Henke, Claire Massey, Kenny V Brock, Marta Fernandez-Fuente, Richard J Pierc. Allele copy number and underlying pathology are associated with subclinical severity in equine type 1 polysaccharide storage myopathy (PSSM1). PloS one. vol 7. issue 7. 2013-01-14. PMID:22860112. |
resting and post-exercise plasma creatine kinase (ck) and aspartate aminotransferase (ast) enzyme activity measurements and muscle pathology were assessed in matched cohorts of pssm1 homozygotes, heterozygotes or control horses. |
2013-01-14 |
2023-08-12 |
human |
| X Joya, B Friguls, S Ortigosa, E Papaseit, S E Martínez, A Manich, O Garcia-Algar, R Pacifici, O Vall, S Pichin. Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: a review. Journal of pharmaceutical and biomedical analysis. vol 69. 2013-01-10. PMID:22300909. |
these biomarkers include classical biomarkers (albeit indirect) of alcohol-induced pathology (mean corpuscular volume (mcv), gamma glutamyltransferase (ggt), aspartate aminotransferase (ast) and alanine aminotransferase (alt)) acetaldehyde-derived conjugates, and finally derivatives of non-oxidative ethanol metabolism (fatty acid ethyl esters (faees), ethyl glucuronide (etg), ethyl sulphate (ets) and phosphaditylethanol (peth)). |
2013-01-10 |
2023-08-12 |
Not clear |
| Tao Wang, Jie Hai, Xuehui Chen, Hua Peng, He Zhang, Lake Li, Qinggui Zhan. Inhibition of GHRH aggravated acetaminophen-induced acute mice liver injury through GH/IGF-I axis. Endocrine journal. vol 59. issue 7. 2013-01-10. PMID:22572547. |
our results showed that twelve-hour treatment with apap caused obvious liver injury, elevated serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, increased oxidative stress, reduced expressions of antioxidant enzymes, accumulated expression of pro-inflammatory cytokines, and increased circulating levels of growth hormone (gh) and insulin-like growth factor-i (igf-i). |
2013-01-10 |
2023-08-12 |
mouse |
| Zouhir Djerrou, Y Hamdi-Pacha, A M Belkhiri, H Djaalab, F Riachi, M Serakta, A Boukeloua, Z Maamer. Evaluation of Pistacia lentiscus fatty oil effects on glycemic index, liver functions and kidney functions of New Zealand rabbits. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 8. issue 5 Suppl. 2013-01-09. PMID:22754077. |
biochemical analysis showed that aspartate transaminase (ast) and alanine transaminase (alt) were significantly decreased in blood plasma at (p< 0.05) and (p< 0.01) respectively in plfo group (mann-whitney test). |
2013-01-09 |
2023-08-12 |
Not clear |
| Miquel Porta, José Pumarega, Luisa Guarner, Núria Malats, Ricard Solà, Francisco X Rea. Relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in pancreatic cancer. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 17. issue 6. 2013-01-09. PMID:22793268. |
bilirubin, aspartate aminotransferase (ast), γ-glutamyltransferase (ggt) and alkaline phosphatase were lower in tumor stage iv. |
2013-01-09 |
2023-08-12 |
Not clear |
| Li-Sha Yang, Lin-Ling Wu, Dong-Xiang Jiang, Ji-Ye Wang, Ya-Qin Huan. [Genotypes distribution among hepatitis B virus infected patients with different immune statuses in Guangxi north region]. Bing du xue bao = Chinese journal of virology. vol 28. issue 5. 2013-01-08. PMID:23233930. |
the different immune state genotype proportion difference don't have statistical significance; immune state and genotypic correlation isn't statistically significant; type b hbv-dna load is higher than that of type c, groups of persons aged 30 years or older with type c are significantly higher than that of < 30 years of age, the difference was statistically significant; among the genotypes of alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin (tbil) positive rate showed no significant difference between male and female; there was no significant difference in genotype distribution. |
2013-01-08 |
2023-08-12 |
Not clear |
| Astrid G M van Boxtel, Sander Bramer, Mohamed A Soliman Hamad, Albert H M van Strate. Perioperative serum aspartate aminotransferase level as a predictor of survival after coronary artery bypass grafting. The Annals of thoracic surgery. vol 94. issue 5. 2013-01-07. PMID:22841017. |
this study aims to investigate the predictive value of aspartate aminotransferase (ast) with respect to early and late mortality after cabg. |
2013-01-07 |
2023-08-12 |
Not clear |
| T Annadurai, A R Muralidharan, T Joseph, M J Hsu, P A Thomas, P Geraldin. Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin-nicotinamide-induced experimental diabetic rats. Journal of physiology and biochemistry. vol 68. issue 3. 2013-01-04. PMID:22234849. |
untreated diabetic rats revealed the following in comparison with normal rats: significantly higher mean levels of blood glucose and glycosylated hemoglobin, significantly lower mean levels of serum insulin, significantly lower mean activities of pancreatic antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase), significantly lower mean levels of plasma non-enzymatic antioxidants (reduced glutathione, vitamin c , vitamin e), significantly elevated mean levels of pancreatic malondialdehyde (mda) and significantly elevated mean activities of serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and lactate dehydrogenase (ldh). |
2013-01-04 |
2023-08-12 |
rat |
| Mariel R B Betto, Lais F Lazarotto, Tatiane T N Watanabe, David Driemeier, Carlos E Leite, Maria M Campo. Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 385. issue 9. 2013-01-04. PMID:22752270. |
macroscopic and histological liver alterations, serum alanine transaminase (alt) and aspartate transaminase (ast) activity, liver catalase activity (cat), reduced glutathione concentrations (gsh), hepatic measurement of neutrophil migration (myeloperoxidase, mpo activity), and caspase-3 liver expression were evaluated. |
2013-01-04 |
2023-08-12 |
mouse |
| Dan Yang, Kai-Bin Tan, Yun-Hua Gao, Hong Liu, Wei-Xiao Yan. Effects of diagnostic ultrasound-targeted microbubble destruction on permeability of normal liver in rats. Ultrasonics. vol 52. issue 8. 2013-01-04. PMID:23021237. |
blood chemical analysis indicated that the effect of diagnostic ultrasound-targeted microbubble destruction on the rats' serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels was transient and recoverable and that this technique had no obvious effect on renal function. |
2013-01-04 |
2023-08-12 |
rat |
| Ali Akbar Hajiaghamohammadi, Amir Ziaee, Rasoul Samim. The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Phytotherapy research : PTR. vol 26. issue 9. 2013-01-03. PMID:22308054. |
in the case group, the mean alanine aminotransferase (alt) level decreased from 64.09 to 51.27 iu/ml and the aspartate aminotransferase (ast) level decreased from 58.18 to 49.45 iu/ml, which were statistically significant (p < 0.001 and p < 0.001). |
2013-01-03 |
2023-08-12 |
Not clear |
| H I Toprak, T Şahin, S Aslan, K Karahan, M Şanli, M Ö Erso. Effects of desflurane and isoflurane on hepatic and renal functions and coagulation profile during donor hepatectomy. Transplantation proceedings. vol 44. issue 6. 2013-01-03. PMID:22841233. |
aspartate aminotransferase (ast), alanine aminotransferase (alt), international normalized ratio (inr), albumin, total bilirubin, blood urea nitrogen, creatinine, platelet count, and hemoglobin levels were analyzed preoperatively at end of the operation, and on postoperative days (pods) 1, 2, 3, 5, 7, and 30. |
2013-01-03 |
2023-08-12 |
Not clear |
| Abdulsamad Alsalahi, Mahmood Ameen Abdulla, Mohammed Al-Mamary, Mohamed Ibrahim Noordin, Siddig Ibrahim Abdelwahab, Aied M Alabsi, Abdrabuh Shwter, Mohammed A Alshaws. Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-12-24. PMID:23259000. |
results in khat-fed rats showed hepatic enlargement, abnormal findings in serum aspartate aminotransferase (ast), and alkaline phosphatase (alp) of male and female sd-rats and serum albumin (a) and serum creatinine (cr) of female as compared to controls. |
2012-12-24 |
2023-08-12 |
rat |
| Nandini Bhattacharjee, Anisur Rahman Khuda-Bukhs. Two homeopathic remedies used intermittently provide additional protective effects against hepatotoxicity induced by carcinogens in mice. Journal of acupuncture and meridian studies. vol 5. issue 4. 2012-12-19. PMID:22898065. |
hepatotoxicity was assessed through biomarkers like aspartate and alanine aminotransferases (ast and alt), acid and alkaline phosphatases (acp and alkp), reduced glutathione content (gsh), glucose 6-phosphate dehydrogenase (g6pd), gamma glutamyl transferase (ggt), lactate dehydrogenase (ldh), and analysis of lipid peroxidation (lpo) at 30, 60, 90, and 120 days and antioxidant biomarkers like superoxide dismutase (sod), catalase (cat), and glutathione reductase (gr) were assayed. |
2012-12-19 |
2023-08-12 |
mouse |
| Gaigai Deng, Junzhi Wang, Qiaoyin Zhang, Haibo He, Fangfang Wu, Tianyan Feng, Jigang Zhou, Kun Zou, Masao Hattor. Hepatoprotective effects of phloridzin on hepatic fibrosis induced by carbon tetrachloride against oxidative stress-triggered damage and fibrosis in rats. Biological & pharmaceutical bulletin. vol 35. issue 7. 2012-12-18. PMID:22791160. |
phl significantly improved hepatic function; remarkably decreased serum hyaluronic acid (ha), transforming growth factor-β1 (tgf-β1), aspartate aminotransferase (ast), alanine aminotransferase (alt) and liver tissues hydroxyproline, malondialdehyde (mda) levels, increased glutathione peroxidase (gsh-px), total-antioxygen capacity (t-aoc) and total-superoxide dismutase (t-sod) contents of liver tissues; real-time polymerase chain reaction (pcr) and immunohisto-chemical results showed phl might markedly reverse the up-regulated mrna and protein expressions of the α-smooth muscle actin (sma), tgf-β1 and tissue inhibitor of metalloproteinase-1 (timp1), up-regulate the matrix metalloproteinase-1 (mmp1) mrna and protein expressions. |
2012-12-18 |
2023-08-12 |
rat |
| Renan Qin, Jianyu Zhang, Chuyuan Li, Xiaoqi Zhang, Aihua Xiong, Feng Huang, Zhen Yin, Kongyan Li, Wenyu Qin, Mingzhen Chen, Shubing Zhang, Lingyi Liang, Huiye Zhang, Hong Nie, Wencai Y. Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Archives of pharmacal research. vol 35. issue 7. 2012-12-18. PMID:22864747. |
compared with model group, levels of serum triglyceride (tg), total cholesterol (tc), free fatty acid (ffa), and low density lipoprotein cholesterol (ldl-c) level, malondialdehyde (mda), serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (hdl-c), superoxide dismutase (sod) activity in both serum and hepatic tissue and mrna and protein level of peroxisome proliferator-activated receptor α (ppar-α) were significantly increased. |
2012-12-18 |
2023-08-12 |
rat |
| Amparo Vayá, José Miguel De la Fuente, Marta Montero, Rafael Perez, Jose M Ricar. Erythrocyte deformability in naïve HIV-infected patients. Clinical hemorheology and microcirculation. vol 51. issue 4. 2012-12-17. PMID:22258455. |
when compared with controls, naïve hiv-infected patients showed lower total cholesterol, iron, bilirubin and folic acid (p = 0.009, p = 0.003, p = 0.004, p = 0.004, respectively) and higher triglycerides (tg), aspartate aminotransferase (ast) and gamma glutamyl transferase (γgt) levels (p = 0.017, p = 0.042, p = 0.004, respectively). |
2012-12-17 |
2023-08-12 |
human |
| José Luís Brandão, J Pinheiro, D Pinho, D Correia da Silva, E Fernandes, G Fragoso, M I Costa, A Silv. [Mushroom poisoning in Portugal]. Acta medica portuguesa. vol 24 Suppl 2. 2012-12-17. PMID:22849912. |
the developmental profile of the rate of prothrombin time (pt), aspartate aminotransferase (ast) and bilirubin, was an important setting for diagnosis and prognosis. |
2012-12-17 |
2023-08-12 |
Not clear |