| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Zimmerman, Eunyoung Tak, Maria Kaplan, Mercedes Susan Mandell, Holger K Eltzschig, Almut Gren. Use of a hanging-weight system for liver ischemia in mice. Journal of visualized experiments : JoVE. issue 66. 2012-10-22. PMID:22895458. |
systematic evaluation of this model by performing different ischemia and reperfusion times revealed a close correlation of hepatic ischemia time with liver damage as measured by alanine (alt) and aspartate (ast) aminotransferase serum levels. |
2012-10-22 |
2023-08-12 |
mouse |
| O Awodele, E B Patrick, Esther Oluwatoyin Agbaje, A A Oremosu, S C Gbotoloru. Assessing the risk of birth defects associated with exposure to fixed-dose combined antituberculous agents during pregnancy in rats. TheScientificWorldJournal. vol 2012. 2012-10-19. PMID:22629151. |
significant (p ≤ 0.05) elevations in the levels of aspartate aminotransferase (ast) and alkaline phosphatase (alp) in the foetuses of the animals treated with fixed-dose combined antituberculous agents were also observed. |
2012-10-19 |
2023-08-12 |
rat |
| A H Harrill, J Roach, I Fier, J S Eaddy, C L Kurtz, D J Antoine, D M Spencer, T K Kishimoto, D S Pisetsky, B K Park, P B Watkin. The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers. Clinical pharmacology and therapeutics. vol 92. issue 2. 2012-10-18. PMID:22739141. |
heparins have been reported to cause elevations in serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) but have not been associated with clinically significant liver injury. |
2012-10-18 |
2023-08-12 |
human |
| Kambiz Jahanbin, Aliakbar Hedayati, Sohrab Moini, Ahmad Reza Gohari, Zahra Emam-Djomeh, Antonio Esposito, Tahere Bagher. The first application of a new polysaccharide from Acanthophyllum bracteatum for the health improvement of Atlantic salmon exposed to mercury chloride. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:21911428. |
the polysaccharide had an adjustment effect on lymphocytes, granulocytes, red blood cells (rbcs), hemoglobin (hb), mean corpuscular volume (mcv), mean corpuscular hemoglobin (mch), alanine aminotransferase (alt), aspartate aminotransferase (ast), protein, chlorine (cl), sodium (na), and glucose. |
2012-10-17 |
2023-08-12 |
Not clear |
| Gumaro Cano-Gutiérrez, Sandra Acevedo-Nava, Abel Santamaría, Mario Altamirano-Lozano, María Concepción Cano-Rodríguez, Teresa I Fortou. Hepatic megalocytosis due to vanadium inhalation: participation of oxidative stress. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:22033424. |
alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels were also significantly increased (p < 0.05). |
2012-10-17 |
2023-08-12 |
mouse |
| Christophe Corpechot, Fabrice Carrat, Armelle Poujol-Robert, Farid Gaouar, Dominique Wendum, Olivier Chazouillères, Raoul Poupo. Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22271046. |
te showed high performance and was significantly superior to biochemical markers (e.g., aspartate aminotransferase [ast]/platelet ratio, fib-4, hyaluronic acid, ast/alanine aminotransferase ratio, and mayo score) in diagnosing significant fibrosis, severe fibrosis, or cirrhosis. |
2012-10-17 |
2023-08-12 |
Not clear |
| Jae-Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf, Pierre-Alain Clavie. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22290718. |
liver injury was assessed by the levels of plasma aspartate aminotransferase (ast), alanine aminotransferase (alt) and tissue necrosis. |
2012-10-17 |
2023-08-12 |
mouse |
| Amanda Mello, Maria Carla Medeiros, Denise dos Santos Lacerda, Rodrigo B de Andrade, Tanise Gemelli, Robson Brum Guerra, Clovis Milton Duval Wannmacher, Rosane Gomez, Cláudia Funcha. Toxicological evaluation of chronic exposure to the organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one in male rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 7. 2012-10-12. PMID:22579607. |
the compound also increased aspartate aminotransferase (ast) and urea levels in serum of rats at 500 μg/kg. |
2012-10-12 |
2023-08-12 |
rat |
| Nancy J Gad. Probable Anticonvulsant Hypersensitivity Syndrome Due to Fosphenytoin in a Pediatric Patient with Streptococcus pneumoniae Meningitis. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. vol 12. issue 4. 2012-10-12. PMID:23055857. |
her sudden and dramatic rise in aspartate aminotransferase (ast) and alanine aminotransferase (alt) to greater than 80 times the upper limit of normal in combination with an elevated inr were very concerning. |
2012-10-12 |
2023-08-12 |
Not clear |
| Ru-Ping Lee, Yi-Maun Subeq, Chung-Jen Lee, Bang-Gee Hsu, Tai-Chu Pen. Freshwater clam extract decreased hemorrhagic shock-induced liver injury by attenuating TNF-α production. Biological research for nursing. vol 14. issue 3. 2012-10-11. PMID:21586492. |
the authors measured the blood levels of white blood cells (wbc), aspartate aminotransferase (ast), alanine aminotransferase (alt), lactate dehydrogenase (ldh), and tumor necrosis factor-alpha (tnf-α) at several time points during the experiment. |
2012-10-11 |
2023-08-12 |
rat |
| Christopher H Remien, Frederick R Adler, Lindsey Waddoups, Terry D Box, Norman L Sussma. Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death. Hepatology (Baltimore, Md.). vol 56. issue 2. 2012-10-11. PMID:22331703. |
the model for acetaminophen-induced liver damage (mald) uses a patient's aspartate aminotransferase (ast), alanine aminotransferase (alt), and international normalized ratio (inr) measurements on admission to estimate overdose amount, time elapsed since overdose, and outcome. |
2012-10-11 |
2023-08-12 |
Not clear |
| Xiaodong Liu, Peipei Cao, Chaofeng Zhang, Xianghong Xu, Mian Zhan. Screening and analyzing potential hepatotoxic compounds in the ethanol extract of Asteris Radix by HPLC/DAD/ESI-MS(n) technique. Journal of pharmaceutical and biomedical analysis. vol 67-68. 2012-10-11. PMID:22609370. |
the hepatotoxic effects of fr-2 were proved by the level elevation of alanine aminotransferase (alt), aspartate aminotransferase (ast) and alkaline phosphatase (alp) in mice serum and further confirmed by the histopathological examination on mice liver. |
2012-10-11 |
2023-08-12 |
mouse |
| Tao Liu, Xinjin Guo, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Xiaochi Ma, Taiichi Kaku, Kexin Li. Effect of JBP485 on obstructive jaundice is related to regulation of renal Oat1, Oat3 and Mrp2 expression in ANIT-treated rats. Peptides. vol 36. issue 1. 2012-10-09. PMID:22521734. |
the anit-induced increases in bilirubin (bil), alanine aminotransferase (alt) and aspartate transaminase (ast) in rat serum were inhibited significantly by oral administration of jbp485. |
2012-10-09 |
2023-08-12 |
rat |
| C Castillo, J Hernández, M García Vaquero, M López Alonso, V Pereira, M Miranda, I Blanco, J L Benedit. Effect of moderate Cu supplementation on serum metabolites, enzymes and redox state in feedlot calves. Research in veterinary science. vol 93. issue 1. 2012-10-03. PMID:21724218. |
this study compared beef calves fed concentrates with an average cu basal content of 5 and 8 mg/kg in growing and finishing periods (10 animals) or supplemented with 15 mg/kg for each phase (20 animals) as regards production indices, metabolic parameters [glucose, nonesterified fatty acids (nefa), cholesterol, serum urea nitrogen (sun), creatinine, total serum protein (tsp), albumin, aspartate transaminase (ast) and γ-glutamyl transferase (ggt)] and markers of oxidative stress (reactive oxygen species (ros) and serum antioxidant capacity (sac)). |
2012-10-03 |
2023-08-12 |
Not clear |
| K N Chidambara Murthy, J Rajesha, A Vanitha, M Mahadeva Swamy, G A Ravishanka. Protective effect of Dunaliella salina-A marine micro alga, against carbon tetrachloride-induced hepatotoxicity in rats. Hepatology research : the official journal of the Japan Society of Hepatology. vol 33. issue 4. 2012-10-02. PMID:16890175. |
the degree of hepatoprotection was measured up on challenging animals with toxin (2.0gkg(-1) of carbon tetrachloride) by estimation of biochemical parameters like, serum transaminases (serum aspartate transaminase (s)ast and serum alanine transaminase (s)alt), serum alkaline phosphatase and total protein. |
2012-10-02 |
2023-08-12 |
rat |
| Ethel A Wilhelm, Cristiano R Jesse, Marlon R Leite, Cristina W Nogueir. Studies on preventive effects of diphenyl diselenide on acetaminophen-induced hepatotoxicity in rats. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 16. issue 1. 2012-10-02. PMID:19162454. |
twenty-four hours after the last administration of aa, plasma was used for biochemical assays aspartate (ast) and alanine aminotransferases (alt), alkaline phosphatase (alp), lactate dehydrogenase (ldh), γ-glutamyl transferase (γ-gt) activities. |
2012-10-02 |
2023-08-12 |
rat |
| T S Shanmugarajan, N Prithwish, I Somasundaram, M Arunsundar, M Niladri, J P Lavande, V Ravichandira. Mitigation of azathioprine-induced oxidative hepatic injury by the flavonoid quercetin in wistar rats. Toxicology mechanisms and methods. vol 18. issue 8. 2012-10-02. PMID:20020851. |
hepatotoxicity, evident from increased levels of aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase (alp), lactate dehydrogenase (ldh), and gamma glutamyl transpeptidase (ggt) in serum 24 h after aza treatment, was significantly (p < 0.05) normalized by qe pretreatment. |
2012-10-02 |
2023-08-12 |
rat |
| S Karthigayan, M Sri Balasubashini, T Balasubramanian, S T Somasundara. PGE from Octopus aegina Induces Apoptosis in Ehrlich's Ascites Carcinoma of Mice. Toxicology mechanisms and methods. vol 17. issue 8. 2012-10-02. PMID:20020871. |
apart from the antitumor effect, octopus venom reduced the tumor burden on the liver and altered the changes in the activities of alanine transaminase (alt), aspartate transaminase (ast), and alkaline phosphatase (alp). |
2012-10-02 |
2023-08-12 |
mouse |
| F S Hatipoglu, M S Gulay, A Balic, O Yildiz-Gulay, S Volka. Subacute oral toxicity of endosulfan in male new zealand white rabbits. Toxicology mechanisms and methods. vol 18. issue 9. 2012-10-02. PMID:20020928. |
serum alkaline phosphatase (alp) and aspartate aminotransferase (ast) levels were significantly elevated in the 3 mg/kg dose group. |
2012-10-02 |
2023-08-12 |
Not clear |
| Aruna Kode, Rukkumani Rajagopalan, Suresh Varma Penumastha, Venugopal P Meno. Role of an aminothiazole derivative on ethanol-induced toxicity. Toxicology mechanisms and methods. vol 17. issue 1. 2012-10-02. PMID:20020985. |
our results showed increased activity of aspartate transaminase (ast), alkaline phosphatase (alp), and gamma glutamyl transferase (ggt) and increased levels of cholesterol, triglycerides, and phospholipids in the plasma of alcohol-given group when compared with normal control group. |
2012-10-02 |
2023-08-12 |
rat |