| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuaijun Li, Caiting Meng, Qian Hao, Ruina Zhou, Luyao Dai, Yucheng Guo, Sitong Zhao, Xin Zhou, Chunju Lou, Ji Xu, Peng Xu, Jinfan Yang, Yifan Ding, Yanni Lv, Shengli Han, Shuai Li, Jing Li, Huafeng Kang, Zhengtao Xiao, Mingqian Tan, Xiaobin Ma, Hao W. "On/off"-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX. Biomaterials. vol 307. 2024-03-16. PMID:38492523. |
compared to nab-ptx, bpm-pd@ptx demonstrates improved therapeutic efficacy with a reduced tumor area (only 14.6%) and extended survival duration, while mitigating adverse reactions (over 83.7%) in aspartate aminotransferase (ast) and alanine aminotransferase (alt), offering a promising approach for the treatment of nsclc brain metastases. |
2024-03-16 |
2024-03-19 |
Not clear |
| Yaqi Xue, Yang Peng, Litian Zhang, Yi Ba, Gang Jin, Ge Li. Effect of different exercise modalities on nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Scientific reports. vol 14. issue 1. 2024-03-15. PMID:38485714. |
resistance training is the best mode to improve aspartate transaminase (ast) (sucra = 81.7). |
2024-03-15 |
2024-03-17 |
Not clear |
| Yali Xu, Ting Su, Hricha Mishra, Reiko Ando, Yutaka Furutani, Jun Lu, Muyi Cai, Harukazu Suzuki, Wenkui Yu, Xian-Yang Qi. Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway. Journal of agricultural and food chemistry. 2024-03-15. PMID:38489847. |
oral administration of cp significantly reduced body weight gain by 2.95%, serum cholesterol by 22.54%, and liver injury, as evidenced by a reduction of 32.19% in serum aspartate aminotransferase (ast) and 49.10% in alanine aminotransferase (alt) levels in mice subjected to a high-fat diet (hfd). |
2024-03-15 |
2024-03-18 |
mouse |
| Muhammad Asghar, Noor Khan, Mahroze Fatima, Murat Arslan, Simon John Davies, Naveed Ul Haqu. Feasibility of replacing fish oil with sunflower oil on the growth, body composition, fatty acid profile, antioxidant activity, stress response, and blood biomarkers of Labeo rohita. PloS one. vol 19. issue 3. 2024-03-14. PMID:38483972. |
globulin (glo) levels decreased significantly (p<0.05), while alanine transaminase (alt) and aspartate transaminase (ast) activity showed nonsignificant increases (p>0.05). |
2024-03-14 |
2024-03-17 |
cat |
| Lidan Zhang, Ge Kuang, Xia Gong, Rui Huang, Zizuo Zhao, Yan Li, Jingyuan Wan, Bin Wan. Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice. Transplant immunology. 2024-03-14. PMID:38484898. |
the results showed that plasma aminotransferase (alt), aspartate aminotransferase (ast), hepatocyte apoptosis, oxidative stress, and inflammatory cell infiltration significantly increased in hiri mice. |
2024-03-14 |
2024-03-17 |
mouse |
| Jian Song, Bo-Feng Qin, Jin-Jin Zhang, Qi-Yuan Feng, Guan-Cheng Liu, Gui-Yun Zhao, Hai-Ming Su. Regulation of the Nur77-P2X7r Signaling Pathway by Nodakenin: A Potential Protective Function against Alcoholic Liver Disease. Molecules (Basel, Switzerland). vol 29. issue 5. 2024-03-13. PMID:38474588. |
in vivo, histopathological alterations were markedly alleviated by nk, accompanied by reductions in serum triglyceride (tg), aspartate aminotransferase (ast), and alanine aminotransferase (alt) levels and the modulation of lipin-1, srebp1, and nur77 levels in comparison to the etoh-exposed group ( |
2024-03-13 |
2024-03-15 |
mouse |
| Vítor Macedo Silva, Marta Freitas, Sofia Xavier, Pedro Boal Carvalho, Joana Magalhães, Carla Marinho, José Cotte. The New FibroScan-AST (FAST) Score: Enhancing Diabetes Mellitus Impact on Metabolic-Associated Fatty Liver Disease. GE Portuguese journal of gastroenterology. vol 30. issue 6. 2024-03-13. PMID:38476150. |
in 2020, the fibroscan-ast (fast) score was internationally validated as a new tool able to identify patients with steatohepatitis who benefit the most from further therapies, based on liver transient elastography (lte) findings and serum levels of aspartate aminotransferase (ast). |
2024-03-13 |
2024-03-15 |
Not clear |
| Asmaa Elebishehy, Mohamed M Ahmed, Badr Aldahmash, Mostafa Abdelgaber Mohamed, Aya A Shetaia, Shaden A M Khalifa, Mabrouk Attia Abd Eldaim, Hesham R El-Seedi, Nermeen Yosr. Cymbopogon schoenanthus (L) extract ameliorates high fat diet-induced obesity and dyslipidemia via reducing expression of lipogenic and thermogenic proteins. Fitoterapia. 2024-03-13. PMID:38479618. |
supplementation of hfd significantly increased the body weight, levels of serum triacylglycerol, total cholesterol, very low-density lipoprotein, low density lipo-protein, glucose, serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities. |
2024-03-13 |
2024-03-16 |
rat |
| Ayed A Shati, Refaat A Eid, Attalla F El-Kott, Youssef A Alqahtani, Abdullah S Shatoor, Mohamed Samir Ahmed Zak. Curcumin attenuates doxorubicin-induced cardiotoxicity Heliyon. vol 10. issue 5. 2024-03-12. PMID:38468941. |
lipid peroxidation assessed as malondialdehyde (mda), aspartate aminotransferase (ast), alanine aminotransferase (alt), oxidative stress markers as catalase (cat), superoxide dismutase (sod), and inflammatory markers as tumor necrosis factor-alpha (tnf-α) in heart homogenates, each one was assessed. |
2024-03-12 |
2024-03-14 |
rat |
| Karla Falconí, Édgar Zapata-Vívenes, César Lodeiro. Inorganic osmolytes and enzymatic biomarkers from the manabi oyster (Crassostrea cf. corteziensis) in response to saline stress. Marine environmental research. vol 196. 2024-03-10. PMID:38461608. |
aspartate aminotransferase (ast), alanine aminotransferase (alt), lactate dehydrogenase (ldh), alkaline phosphatase (alp) and catalase (cat) activity were analysed. |
2024-03-10 |
2024-03-14 |
cat |
| Ramanachary Namoju, Kavitha N Chilak. Protective effect of alpha‑lipoic acid against in utero cytarabine exposure-induced hepatotoxicity in rat female neonates. Naunyn-Schmiedeberg's archives of pharmacology. 2024-03-09. PMID:38459988. |
the pups exposed to cytarabine showed a significant and dose-dependent (a) decrease in body weight, liver weight, hepatosomatic index, catalase, superoxide dismutase, glutathione, glutathione peroxidase, serum albumin levels and (b) increase in malondialdehyde, alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase, ast/alt ratio, and histopathological anomalies. |
2024-03-09 |
2024-03-12 |
rat |
| Li Luo, Jiajie Ni, Jiahui Zhang, Jinxian Lin, Sixin Chen, Feihai Shen, Zhiying Huan. Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis. Toxicology letters. 2024-03-09. PMID:38460807. |
tsn decreased cell viability, increased lactate dehydrogenase (ldh) production in vitro, and elevated serum aspartate transaminase (ast) and alanine aminotransferase (alt) levels as well as liver lesions in vivo, suggesting tsn had significant hepatotoxicity. |
2024-03-09 |
2024-03-12 |
mouse |
| Bardia Karim, Motahare Arabameri, Fatemeh Alimoradi, Razieh Mansoori, Ali A Moghadamnia, Sohrab Kazemi, Seyed M Hossein. Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5-fluorouracil in rats. Drug development research. vol 85. issue 2. 2024-03-09. PMID:38459752. |
5-fu caused body weight loss, ecg changes (increased st segment, prolonged qrs, and qtc), increased cardiac enzymes (aspartate aminotransferase [ast], creatine kinase-myocardial band [ck-mb], and lactate dehydrogenase [ldh]), oxidative stress (increased malondialdehyde, myeloperoxidase, nitric acid; decreased glutathione peroxidase enzyme activity), and histological damage such as necrosis, hyperemia, and tissue hyalinization in rats. |
2024-03-09 |
2024-03-11 |
rat |
| Yuanyuan Tao, Wanqing Zhou, Cheng Chen, Qian Zhang, Zhuoyi Liu, Pingping Xia, Zhi Ye, Chunling L. O-sialoglycoprotein Endopeptidase (OSGEP) Suppresses Hepatic Ischemia-Reperfusion Injury-Induced Ferroptosis Through Modulating the MEK/ERK Signaling Pathway. Molecular biotechnology. 2024-03-08. PMID:38456959. |
at one day after hepatectomy, the negative association of osgep expression level with the elevated serum levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) was noted. |
2024-03-08 |
2024-03-10 |
mouse |
| Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghan. Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury. Drug research. 2024-03-08. PMID:38458224. |
finally, serum levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), and also albumin were assessed. |
2024-03-08 |
2024-03-11 |
Not clear |
| Yaru Bi, Yang Yang, Xiaojie Yuan, Jiping Wang, Tuo Wang, Zhiyuan Liu, Suyan Tian, Chenglin Su. Association between liver enzymes and type 2 diabetes: a real-world study. Frontiers in endocrinology. vol 15. 2024-03-06. PMID:38444589. |
this study aimed to examine the association of liver enzymes, including alanine aminotransferase (alt), aspartate aminotransferase (ast), and gamma-glutamyl-transferase (ggt), with type 2 diabetes (t2d) risk, particularly their dose-response relationship. |
2024-03-06 |
2024-03-08 |
Not clear |
| Faouzia Derouiche, Randa Djemil, Fatima Zohra Sebihi, Lilia Douaouya, Hichem Maamar, Katia Benjeman. High methionine diet mediated oxidative stress and proteasome impairment causes toxicity in liver. Scientific reports. vol 14. issue 1. 2024-03-06. PMID:38448604. |
total homocysteine (thcy), total oxidant status (tos), total antioxidant status (tas), hepatic enzymes levels: aspartate aminotransferase (ast), alanine aminotransferase (alt), lactate dehydrogenase (ldh), alkaline phosphatase (alp), with total bilirubin (tbil), albumin (alb), and c-reactive protein (crp) were determined in plasma by biochemical assays. |
2024-03-06 |
2024-03-09 |
rat |
| Jia He, Qing Ma, Zhongqiu Teng, Jingzhu Zhou, Na Zhao, Wenqin Liang, Miao Lu, Shijun Li, Tian Qi. Epidemiological and clinical characteristics of scrub typhus in Guizhou Province, China: An outbreak study of scrub typhus. PLoS neglected tropical diseases. vol 18. issue 3. 2024-03-05. PMID:38442086. |
the major clinical symptoms of these patients showed fever, chills, headache, eschar, fatigue and pneumonia, which were accompanied by a rise in c-reactive protein, neutrophils, alanine transaminase (alt) and aspartate aminotransferase (ast). |
2024-03-05 |
2024-03-08 |
mouse |
| Yu Sun, Qingfang Deng, Qiurong Zhang, Xin Zhou, Ruhai Chen, Siyu Li, Qing Wu, Huaguo Che. Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis. Marine environmental research. vol 196. 2024-03-05. PMID:38442589. |
the meta-analysis results indicate that compared to the control group, exposure to microplastics significantly affects fish liver indicators: aspartate aminotransferase (ast) (p < 0.001), alanine aminotransferase (alt) (p < 0.001), alkaline phosphatase (alp) (p < 0.001), total protein (tp) (p < 0.001), and lactate dehydrogenase (ldh) (p < 0.001), including oxidative stress indicators: superoxide dismutase (sod) (p < 0.001), glutathione s-transferase (gst) (p < 0.001), glutathione (gsh) (p < 0.001), and malondialdehyde (mda) (p < 0.001) in fish liver. |
2024-03-05 |
2024-03-08 |
Not clear |
| Mitsuyoshi Yamagata, Mutsumi Tsuchishima, Takashi Saito, Mikihiro Tsutsumi, Joseph Georg. Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis. Clinical science (London, England : 1979). vol 138. issue 5. 2024-03-05. PMID:38381799. |
serum aspartate aminotransferase (ast), alanine aminotransferase (alt), hepatic malondialdehyde (mda), and glutathione content were measured. |
2024-03-05 |
2024-03-07 |
human |