All Relations between ache and cholinergic

Publication Sentence Publish Date Extraction Date Species
Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. 2024-04-12 2024-04-14 Not clear
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. 2024-04-12 2024-04-14 mouse
Zahra Nekoukar, Homa Talabaki, Zakaria Zakariaei, Mahdi Mesri, Hossein Azade. Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. Clinical and experimental emergency medicine. 2024-04-07. PMID:38583865. inhibition of ache results in the accumulation of acetylcholine (ach) in synapses and stimulation of cholinergic receptors. 2024-04-07 2024-04-10 Not clear
Sathish Thandivel, Poovarasan Rajan, Tamizharasan Gunasekar, Abisek Arjunan, Sulekha Khute, Srinivasa Rao Kareti, Subash Paranthama. Heliyon. vol 10. issue 7. 2024-04-01. PMID:38560123. acetylcholinesterase (ache) is a promising target for symptomatic improvement in ad due to its consistent and early cholinergic deficit. 2024-04-01 2024-04-04 Not clear
William K Clay, Anne K Buck, Yiran He, Dalyanne N Hernández Sánchez, Nathan A Ward, Jeremy M Lear, Kenny Q Nguyen, Benjamin H Clark, Ryan J Sapia, Remy F Lalisse, Aishwarya Sriraman, C Linn Cadieux, Craig A McElroy, Christopher S Callam, Christopher M Hada. Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase. Chemical research in toxicology. 2024-04-01. PMID:38556765. organophosphorus (op) nerve agents inhibit acetylcholinesterase (ache), creating a cholinergic crisis in which death can occur. 2024-04-01 2024-04-03 Not clear
Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. 2024-03-28 2024-03-30 Not clear
Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. 2024-03-28 2024-03-31 human
Asmaa E Kassab, Ehab M Gedawy, Alaa S Saye. Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation. International journal of biological macromolecules. 2024-03-22. PMID:38518928. consequently, a frequent therapy approach for ad is the suppression of ache and bche to improve cholinergic neurotransmission and reduce cognitive symptoms. 2024-03-22 2024-03-25 Not clear
Folake Olubukola Asejeje, Michael Abayomi Abiola, Oluwatobi Adewumi Adeyemo, Olalekan Bukunmi Ogunro, Abayomi Mayowa Ajay. Exogenous monosodium glutamate exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in rat brain. Neuroscience letters. 2024-03-03. PMID:38432355. moreover, msg aggravated lps-induced cholinergic dysfunction, as demonstrated by increased activity of acetylcholinesterase (ache) in the brain. 2024-03-03 2024-03-06 rat
Charles Neu, Ricardo Esper Treml, Philipp Baumbach, Markus Engelmann, Claudius Gebhardt, Juliane Götze, Sina M Coldewe. Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2024-03-01. PMID:38429621. blood acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities have been proposed as surrogate parameters for the cholinergic function of the central nervous system. 2024-03-01 2024-03-04 Not clear
Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbos. Antioxidant responses driven by Hesperetin and Hesperidin Counteract Parkinson's Disease-like Phenotypes in Drosophila melanogaster. Neurotoxicology. 2024-02-29. PMID:38423185. in addition to in vivo parameters, we assayed some markers of oxidative stress (lipid peroxidation, protein carbonylation, thiol content, hydrogen peroxide, and nitrate/nitrite levels, mrna expression of keap-1 (kelch-like ech associated protein 1)/nrf2 (nuclear factor erythroid 2 related factor 2), catalase (cat), glutathione-s-transferase (gst) activities), and cholinergic (acetyl cholinesterase activity (ache) and dopaminergic signaling (content and the mrna expression of tyrosine hydroxylase (th), monoamine oxidase (mao) activity). 2024-02-29 2024-03-03 cat
Juan Pablo Munafó, Brunella Biscussi, Diego Obiol, Marcelo Costabel, Cecilia Bouzat, Ana Paula Murray, Silvia Antollin. New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System. ACS chemical neuroscience. 2024-02-26. PMID:38407056. our results show that the new compounds can inhibit ache and activate nachr with greater potency than caffeine and provide further information on the modulation mechanisms of pharmacological targets for the design of novel therapeutic interventions in cholinergic deficit. 2024-02-26 2024-02-28 Not clear
Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik, Adem Necip, İsmail Bolat, Serkan Yildirim, Sukru Beydemir, Mahmut Bayka. Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity. Journal of cellular and molecular medicine. vol 28. issue 4. 2024-02-09. PMID:38332529. mtt, pon1 activity and total thiol levels for its effect on oxidative stress, ache and bche activities for its effect on the cholinergic system, and tnf, il-8 and il-10 gene levels for its neuroinflammation effect were determined. 2024-02-09 2024-02-11 Not clear
F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. 2024-02-09 2024-02-11 human
Lei Xing, Pinyi Ma, Fangfang Che. A novel turn-on near-infrared fluorescent probe for highly sensitive in vitro and in vivo detection of acetylcholinesterase activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 310. 2024-01-30. PMID:38290281. acetylcholinesterase (ache) is a key enzyme in the cholinergic pathway of the nervous systems, with its aberrant expression linked to various diseases. 2024-01-30 2024-02-02 mouse
Antonio D'Errico, Rosarita Nasso, Antimo Di Maro, Nicola Landi, Angela Chambery, Rosita Russo, Stefania D'Angelo, Mariorosario Masullo, Rosaria Arcon. Identification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Nutrients. vol 16. issue 2. 2024-01-26. PMID:38276545. identification and characterization of neuroprotective properties of thaumatin-like protein 1a from alzheimer's disease (ad) and parkinson's disease (pd) are multifactorial neurodegenerative disorders that are mostly treated with drugs inhibiting key enzymes of cholinergic and aminergic neurotransmission, such as acetyl and butyryl cholinesterase (ache, buche) or monoamine oxidases (mao)-a/b, and of a 2024-01-26 2024-01-28 Not clear
Ali Naderi, Akın Akıncıoğlu, Ahmet Çağan, Hilal Çelikkaleli, Hülya Akıncıoğlu, Süleyman Göks. Design, synthesis and anticholinergic properties of novel α-benzyl dopamine, tyramine, and phenethylamine derivatives. Bioorganic chemistry. vol 144. 2024-01-23. PMID:38262088. within the scope of this study, the inhibition effects of dopamine-derived carbamates and amine salts on the cholinergic enzymes ache and bche were examined. 2024-01-23 2024-01-26 Not clear
b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. 2024-01-11 2024-01-13 Not clear
Mikael Ham Sembiring, Okta Nursanti, Tesia Aisyah Rahmani. Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE). Journal of receptor and signal transduction research. 2024-01-08. PMID:38189350. acetylcholinesterase (ache) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. 2024-01-08 2024-01-10 Not clear
Ya-Nan Zhang, Xin-Lu Chen, Ling-Yu Guo, Pei-Ran Jiang, Hui Lu, Kai Pan, Lei Guo, Yu-Ting Hu, Ai-Min Ba. Downregulation of peripheral luteinizing hormone rescues ovariectomy-associated cognitive deficits in APP/PS1 mice. Neurobiology of aging. vol 135. 2024-01-07. PMID:38185053. we and others found that the transcription factor early growth response-1 (egr1) regulates cholinergic function including the expression of acetylcholinesterase (ache) and plays a significant role in cognitive decline of ad. 2024-01-07 2024-01-10 mouse