| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
therefore, it is crucial to develop efficient ache inhibitors capable of increasing acetylcholine levels, ultimately leading to improved cholinergic neurotransmission. |
2024-07-22 |
2024-07-25 |
Not clear |
| Sofía Pastene-Burgos, Evelyn Muñoz-Nuñez, Soledad Quiroz-Carreño, Edgar Pastene-Navarrete, Luis Espinoza Catalan, Luis Bustamante, Julio Alarcón-Eno. Ceanothanes Derivatives as Peripheric Anionic Site and Catalytic Active Site Inhibitors of Acetylcholinesterase: Insights for Future Drug Design. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000410. |
acetylcholinesterase (ache) plays a key role in the regulation of the cholinergic system and particularly in the formation of amyloid plaques; therefore, the inhibition of ache has become one of the most promising strategies for the treatment of ad, particularly concerning ache inhibitors that interact with the peripheral anionic site (pas). |
2024-07-13 |
2024-07-15 |
Not clear |
| Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Mauric. The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-18. PMID:38887858. |
clinically available drugs mainly target acetylcholinesterase (ache) and indirectly sustain cholinergic neuronal tonus. |
2024-06-18 |
2024-06-21 |
mouse |
| Zuzana Kohoutova, Eliska Prchalova, Karolina Knittelova, Kamil Musilek, David Malina. Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds. Bioorganic chemistry. vol 150. 2024-06-15. PMID:38878749. |
while ache inhibition can be life threatening due to cholinergic overstimulation and crisis, selective bche inhibition has presumably no adverse effects. |
2024-06-15 |
2024-06-18 |
human |
| Jie Yang, Xi Wen, Jie Zou, Xingrui Huang, Tao Wu, Xinglong Huan. De novo transcriptome analysis of Protohermes xanthodes Navás (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes. Pesticide biochemistry and physiology. vol 202. 2024-06-15. PMID:38879304. |
these results suggested that sublethal exposure to cpf can disrupt the expression of cholinergic neuronal genes in p. xanthodes larvae, and implied that long-term sublethal cpf exposure may cause toxic effects on p. xanthodes larvae by inhibiting ache activity. |
2024-06-15 |
2024-06-18 |
Not clear |
| Jun-Tao Guo, Han-Yu Li, Chao Cheng, Jia-Xue Shi, Hai-Nan Ruan, Jun Li, Chan-Min Li. Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-06-14. PMID:38876379. |
icaa successfully mitigated the pb-induced deficits in the cholinergic system in the brain through the reduction of ach levels and the enhancement of ache and bche activities. |
2024-06-14 |
2024-06-17 |
mouse |
| B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Raman Pachaiappan, Rashid Ayub, Hossam M Aljawdah, Selvaraj Arokiyaraj, Ajay Guru, Jesu Arockiara. Prophylactic effects of apigenin against hyperglycemia-associated amnesia via activation of the Nrf2/ARE pathway in zebrafish. European journal of pharmacology. vol 976. 2024-05-31. PMID:38810716. |
ag also reduces blood glucose levels, brain oxidative stress, and ache activity, enhancing cholinergic neurotransmission. |
2024-05-31 |
2024-06-02 |
zebrafish |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. |
2024-04-12 |
2024-04-14 |
mouse |
| Zahra Nekoukar, Homa Talabaki, Zakaria Zakariaei, Mahdi Mesri, Hossein Azade. Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. Clinical and experimental emergency medicine. 2024-04-07. PMID:38583865. |
inhibition of ache results in the accumulation of acetylcholine (ach) in synapses and stimulation of cholinergic receptors. |
2024-04-07 |
2024-04-10 |
Not clear |
| Sathish Thandivel, Poovarasan Rajan, Tamizharasan Gunasekar, Abisek Arjunan, Sulekha Khute, Srinivasa Rao Kareti, Subash Paranthama. Heliyon. vol 10. issue 7. 2024-04-01. PMID:38560123. |
acetylcholinesterase (ache) is a promising target for symptomatic improvement in ad due to its consistent and early cholinergic deficit. |
2024-04-01 |
2024-04-04 |
Not clear |
| William K Clay, Anne K Buck, Yiran He, Dalyanne N Hernández Sánchez, Nathan A Ward, Jeremy M Lear, Kenny Q Nguyen, Benjamin H Clark, Ryan J Sapia, Remy F Lalisse, Aishwarya Sriraman, C Linn Cadieux, Craig A McElroy, Christopher S Callam, Christopher M Hada. Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase. Chemical research in toxicology. 2024-04-01. PMID:38556765. |
organophosphorus (op) nerve agents inhibit acetylcholinesterase (ache), creating a cholinergic crisis in which death can occur. |
2024-04-01 |
2024-04-03 |
Not clear |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. |
2024-03-28 |
2024-03-30 |
Not clear |
| Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. |
chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. |
2024-03-28 |
2024-03-31 |
human |
| Asmaa E Kassab, Ehab M Gedawy, Alaa S Saye. Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation. International journal of biological macromolecules. 2024-03-22. PMID:38518928. |
consequently, a frequent therapy approach for ad is the suppression of ache and bche to improve cholinergic neurotransmission and reduce cognitive symptoms. |
2024-03-22 |
2024-03-25 |
Not clear |
| Folake Olubukola Asejeje, Michael Abayomi Abiola, Oluwatobi Adewumi Adeyemo, Olalekan Bukunmi Ogunro, Abayomi Mayowa Ajay. Exogenous monosodium glutamate exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in rat brain. Neuroscience letters. 2024-03-03. PMID:38432355. |
moreover, msg aggravated lps-induced cholinergic dysfunction, as demonstrated by increased activity of acetylcholinesterase (ache) in the brain. |
2024-03-03 |
2024-03-06 |
rat |
| Charles Neu, Ricardo Esper Treml, Philipp Baumbach, Markus Engelmann, Claudius Gebhardt, Juliane Götze, Sina M Coldewe. Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2024-03-01. PMID:38429621. |
blood acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities have been proposed as surrogate parameters for the cholinergic function of the central nervous system. |
2024-03-01 |
2024-03-04 |
Not clear |
| Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbos. Antioxidant responses driven by Hesperetin and Hesperidin Counteract Parkinson's Disease-like Phenotypes in Drosophila melanogaster. Neurotoxicology. 2024-02-29. PMID:38423185. |
in addition to in vivo parameters, we assayed some markers of oxidative stress (lipid peroxidation, protein carbonylation, thiol content, hydrogen peroxide, and nitrate/nitrite levels, mrna expression of keap-1 (kelch-like ech associated protein 1)/nrf2 (nuclear factor erythroid 2 related factor 2), catalase (cat), glutathione-s-transferase (gst) activities), and cholinergic (acetyl cholinesterase activity (ache) and dopaminergic signaling (content and the mrna expression of tyrosine hydroxylase (th), monoamine oxidase (mao) activity). |
2024-02-29 |
2024-03-03 |
cat |
| Juan Pablo Munafó, Brunella Biscussi, Diego Obiol, Marcelo Costabel, Cecilia Bouzat, Ana Paula Murray, Silvia Antollin. New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System. ACS chemical neuroscience. 2024-02-26. PMID:38407056. |
our results show that the new compounds can inhibit ache and activate nachr with greater potency than caffeine and provide further information on the modulation mechanisms of pharmacological targets for the design of novel therapeutic interventions in cholinergic deficit. |
2024-02-26 |
2024-02-28 |
Not clear |
| Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik, Adem Necip, İsmail Bolat, Serkan Yildirim, Sukru Beydemir, Mahmut Bayka. Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity. Journal of cellular and molecular medicine. vol 28. issue 4. 2024-02-09. PMID:38332529. |
mtt, pon1 activity and total thiol levels for its effect on oxidative stress, ache and bche activities for its effect on the cholinergic system, and tnf, il-8 and il-10 gene levels for its neuroinflammation effect were determined. |
2024-02-09 |
2024-02-11 |
Not clear |