All Relations between acetylcholinesterase and cholinergic

Publication Sentence Publish Date Extraction Date Species
Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. 2024-04-12 2024-04-14 Not clear
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. we therefore assessed whether long-term pre-exposure with the acetylcholinesterase inhibitor rivastigmine alone and in conjunction with the tau aggregation inhibitor hmtm can reverse cholinergic deficits in l1. 2024-04-12 2024-04-14 mouse
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. 2024-04-12 2024-04-14 mouse
Gumpeny R Sridhar, Lakshmi Gumpen. Emerging significance of butyrylcholinesterase. World journal of experimental medicine. vol 14. issue 1. 2024-04-09. PMID:38590305. its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its primary hydrolytic enzyme, acetylcholinesterase, is absent. 2024-04-09 2024-04-11 human
Abdallah E Abdalla. Review on anti-alzheimer drug development: approaches, challenges and perspectives. RSC advances. vol 14. issue 16. 2024-04-08. PMID:38586442. there is no concrete evidence to identify the exact reason behind the disease, so several relevant hypotheses emerged, highlighting many possible therapeutic targets, such as acetylcholinesterase, cholinergic receptors, 2024-04-08 2024-04-10 Not clear
A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. acetylcholinesterase is an enzyme that breaks down acetylcholine to an inactive form and causes the death of cholinergic neurons. 2024-04-03 2024-04-05 Not clear
Sathish Thandivel, Poovarasan Rajan, Tamizharasan Gunasekar, Abisek Arjunan, Sulekha Khute, Srinivasa Rao Kareti, Subash Paranthama. Heliyon. vol 10. issue 7. 2024-04-01. PMID:38560123. acetylcholinesterase (ache) is a promising target for symptomatic improvement in ad due to its consistent and early cholinergic deficit. 2024-04-01 2024-04-04 Not clear
William K Clay, Anne K Buck, Yiran He, Dalyanne N Hernández Sánchez, Nathan A Ward, Jeremy M Lear, Kenny Q Nguyen, Benjamin H Clark, Ryan J Sapia, Remy F Lalisse, Aishwarya Sriraman, C Linn Cadieux, Craig A McElroy, Christopher S Callam, Christopher M Hada. Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase. Chemical research in toxicology. 2024-04-01. PMID:38556765. organophosphorus (op) nerve agents inhibit acetylcholinesterase (ache), creating a cholinergic crisis in which death can occur. 2024-04-01 2024-04-03 Not clear
Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. 2024-03-28 2024-03-30 Not clear
Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. 2024-03-28 2024-03-31 human
Kim Alfred E Inting, Anthony N Pian. Irinotecan-Induced Transient Dysarthria in a Patient With Metastatic Colorectal Cancer: A Case Report. Cureus. vol 16. issue 2. 2024-03-21. PMID:38510900. this temporal correlation suggests a drug-induced effect, proposed to be related to cholinergic hyperactivity associated with the drug's reversible inhibition of acetylcholinesterase. 2024-03-21 2024-03-23 Not clear
Folake Olubukola Asejeje, Michael Abayomi Abiola, Oluwatobi Adewumi Adeyemo, Olalekan Bukunmi Ogunro, Abayomi Mayowa Ajay. Exogenous monosodium glutamate exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in rat brain. Neuroscience letters. 2024-03-03. PMID:38432355. moreover, msg aggravated lps-induced cholinergic dysfunction, as demonstrated by increased activity of acetylcholinesterase (ache) in the brain. 2024-03-03 2024-03-06 rat
Charles Neu, Ricardo Esper Treml, Philipp Baumbach, Markus Engelmann, Claudius Gebhardt, Juliane Götze, Sina M Coldewe. Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2024-03-01. PMID:38429621. blood acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities have been proposed as surrogate parameters for the cholinergic function of the central nervous system. 2024-03-01 2024-03-04 Not clear
Yazhong Ma, Xiaotong Wang, Xin Li, Xi Chen, Zhifeng Teng, Xuekun Wang, Jie Yang, Guoyun Li. COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. Molecular neurobiology. 2024-02-12. PMID:38347285. for brain protection, cop-22 could resist d-gal-induced oxidative stress by increasing the activity of antioxidative defense enzymes and enhancing antioxidant capacity in the brain tissue; cop-22 could improve the dysfunction of the cholinergic system by decreasing the increased activity of acetylcholinesterase and increasing the reduced content of acetylcholine induced by d-gal; and cop-22 could protect nerve cells of the brain. 2024-02-12 2024-02-15 mouse
F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. 2024-02-09 2024-02-11 human
Lei Xing, Pinyi Ma, Fangfang Che. A novel turn-on near-infrared fluorescent probe for highly sensitive in vitro and in vivo detection of acetylcholinesterase activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 310. 2024-01-30. PMID:38290281. acetylcholinesterase (ache) is a key enzyme in the cholinergic pathway of the nervous systems, with its aberrant expression linked to various diseases. 2024-01-30 2024-02-02 mouse
Yonat Tzur, Serafima Dubnov, Nimrod Madrer, Adi Bar, Bettina Nadorp, Nibha Mishra, Paul Heppenstall, Estelle R Bennett, David S Greenberg, Katarzyna Winek, Hermona Sore. Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-23. PMID:38261097. to investigate the mechanism(s) underlying the expression of primate-specific micrornas (mirs), we sought dna regulatory elements and proteins mediating expression of the primate-specific hsa-mir-608 (mir-608), which is located in the sema4g gene and facilitates the cholinergic blockade of inflammation by targeting acetylcholinesterase mrna. 2024-01-23 2024-01-25 mouse
b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. 2024-01-11 2024-01-13 Not clear
Mikael Ham Sembiring, Okta Nursanti, Tesia Aisyah Rahmani. Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE). Journal of receptor and signal transduction research. 2024-01-08. PMID:38189350. acetylcholinesterase (ache) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. 2024-01-08 2024-01-10 Not clear
Ya-Nan Zhang, Xin-Lu Chen, Ling-Yu Guo, Pei-Ran Jiang, Hui Lu, Kai Pan, Lei Guo, Yu-Ting Hu, Ai-Min Ba. Downregulation of peripheral luteinizing hormone rescues ovariectomy-associated cognitive deficits in APP/PS1 mice. Neurobiology of aging. vol 135. 2024-01-07. PMID:38185053. we and others found that the transcription factor early growth response-1 (egr1) regulates cholinergic function including the expression of acetylcholinesterase (ache) and plays a significant role in cognitive decline of ad. 2024-01-07 2024-01-10 mouse