| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sofía Pastene-Burgos, Evelyn Muñoz-Nuñez, Soledad Quiroz-Carreño, Edgar Pastene-Navarrete, Luis Espinoza Catalan, Luis Bustamante, Julio Alarcón-Eno. Ceanothanes Derivatives as Peripheric Anionic Site and Catalytic Active Site Inhibitors of Acetylcholinesterase: Insights for Future Drug Design. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000410. |
acetylcholinesterase (ache) plays a key role in the regulation of the cholinergic system and particularly in the formation of amyloid plaques; therefore, the inhibition of ache has become one of the most promising strategies for the treatment of ad, particularly concerning ache inhibitors that interact with the peripheral anionic site (pas). |
2024-07-13 |
2024-07-15 |
Not clear |
| Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali, Lisa M Monteggi. Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-07-02. PMID:38956176. |
we studied this premise using systemic administration of the acetylcholinesterase inhibitor physostigmine, which has been shown to rapidly elicit a shorter-term period of depressed mood in humans via cholinergic mechanisms. |
2024-07-02 |
2024-07-06 |
mouse |
| Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Mauric. The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-18. PMID:38887858. |
clinically available drugs mainly target acetylcholinesterase (ache) and indirectly sustain cholinergic neuronal tonus. |
2024-06-18 |
2024-06-21 |
mouse |
| Zora-Maya Keith, Crystal Munoz, Cindy Acon-Chen, Tsung-Ming Shi. Seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A Toxicology and applied pharmacology. 2024-05-22. PMID:38777098. |
seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine a soman produces excitotoxic effects by inhibiting acetylcholinesterase in the cholinergic synapses and neuromuscular junctions and resulting in soman-induced sustained status epilepticus (sse). |
2024-05-22 |
2024-05-27 |
rat |
| Tamara Bernauer, Valentin Nitsche, Jesko Kaiser, Christoph G W Gertzen, Georg Höfner, Karin V Niessen, Thomas Seeger, Dirk Steinritz, Franz Worek, Holger Gohlke, Klaus T Wanner, Franz F Paintne. Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents. Toxicology letters. 2024-05-17. PMID:38759939. |
poisoning with organophosphorus compounds, which can lead to a cholinergic crisis due to the inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine (ach) in the synaptic cleft, is a serious problem for which treatment options are currently insufficient. |
2024-05-17 |
2024-05-27 |
rat |
| Luke Traeger, Sergei Bedrikovetski, Tracy Fitzsimmons, Thuy-My Nguyen, James W Moore, Mark Lewis, Tarik Sammou. Pyridostigmine to Reduce the duration of postoperative Ileus after Colorectal surgery (PyRICo-RCT): randomized clinical trial. The British journal of surgery. vol 111. issue 5. 2024-05-14. PMID:38743864. |
by inhibiting acetylcholinesterase, pyridostigmine can potentially modulate the cholinergic anti-inflammatory pathway and accelerate gastrointestinal recovery. |
2024-05-14 |
2024-05-27 |
Not clear |
| Ayaka Suzuki, Taku Mayahara, Tomohiro Katayama, Hiroyuki Arai, Kazuyoshi Matsuura, Kentaro Nagata, Eisaku Maru. Cholinergic Crisis with Normal Serum Cholinesterase Levels due to Excessive Galantamine Ingestion: A Case Report. JMA journal. vol 7. issue 2. 2024-05-10. PMID:38721068. |
unlike other cholinesterase inhibitors that typically reduce serum cholinesterase levels during cholinergic crises, galantamine appears to selectively inhibit acetylcholinesterase, possibly sparing butyrylcholinesterase. |
2024-05-10 |
2024-05-27 |
Not clear |
| Qiyun Wu, Yingjie Xia, Maggie Suisui Guo, Tsz Yu Au, Gary K W Yuen, Ivan Kong, Zhengqi Wang, Yingyi Lin, Tina T X Dong, Karl W K Tsi. Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-01. PMID:38690717. |
acetylcholinesterase is regulated by exposure of ultraviolet b in skin keratinocytes: a potential inducer of cholinergic urticaria. |
2024-05-01 |
2024-05-03 |
Not clear |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
we therefore assessed whether long-term pre-exposure with the acetylcholinesterase inhibitor rivastigmine alone and in conjunction with the tau aggregation inhibitor hmtm can reverse cholinergic deficits in l1. |
2024-04-12 |
2024-04-14 |
mouse |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. |
2024-04-12 |
2024-04-14 |
mouse |
| Gumpeny R Sridhar, Lakshmi Gumpen. Emerging significance of butyrylcholinesterase. World journal of experimental medicine. vol 14. issue 1. 2024-04-09. PMID:38590305. |
its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its primary hydrolytic enzyme, acetylcholinesterase, is absent. |
2024-04-09 |
2024-04-11 |
human |
| Abdallah E Abdalla. Review on anti-alzheimer drug development: approaches, challenges and perspectives. RSC advances. vol 14. issue 16. 2024-04-08. PMID:38586442. |
there is no concrete evidence to identify the exact reason behind the disease, so several relevant hypotheses emerged, highlighting many possible therapeutic targets, such as acetylcholinesterase, cholinergic receptors, |
2024-04-08 |
2024-04-10 |
Not clear |
| A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. |
acetylcholinesterase is an enzyme that breaks down acetylcholine to an inactive form and causes the death of cholinergic neurons. |
2024-04-03 |
2024-04-05 |
Not clear |
| Sathish Thandivel, Poovarasan Rajan, Tamizharasan Gunasekar, Abisek Arjunan, Sulekha Khute, Srinivasa Rao Kareti, Subash Paranthama. Heliyon. vol 10. issue 7. 2024-04-01. PMID:38560123. |
acetylcholinesterase (ache) is a promising target for symptomatic improvement in ad due to its consistent and early cholinergic deficit. |
2024-04-01 |
2024-04-04 |
Not clear |
| William K Clay, Anne K Buck, Yiran He, Dalyanne N Hernández Sánchez, Nathan A Ward, Jeremy M Lear, Kenny Q Nguyen, Benjamin H Clark, Ryan J Sapia, Remy F Lalisse, Aishwarya Sriraman, C Linn Cadieux, Craig A McElroy, Christopher S Callam, Christopher M Hada. Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase. Chemical research in toxicology. 2024-04-01. PMID:38556765. |
organophosphorus (op) nerve agents inhibit acetylcholinesterase (ache), creating a cholinergic crisis in which death can occur. |
2024-04-01 |
2024-04-03 |
Not clear |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. |
2024-03-28 |
2024-03-30 |
Not clear |
| Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. |
chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. |
2024-03-28 |
2024-03-31 |
human |
| Kim Alfred E Inting, Anthony N Pian. Irinotecan-Induced Transient Dysarthria in a Patient With Metastatic Colorectal Cancer: A Case Report. Cureus. vol 16. issue 2. 2024-03-21. PMID:38510900. |
this temporal correlation suggests a drug-induced effect, proposed to be related to cholinergic hyperactivity associated with the drug's reversible inhibition of acetylcholinesterase. |
2024-03-21 |
2024-03-23 |
Not clear |
| Folake Olubukola Asejeje, Michael Abayomi Abiola, Oluwatobi Adewumi Adeyemo, Olalekan Bukunmi Ogunro, Abayomi Mayowa Ajay. Exogenous monosodium glutamate exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in rat brain. Neuroscience letters. 2024-03-03. PMID:38432355. |
moreover, msg aggravated lps-induced cholinergic dysfunction, as demonstrated by increased activity of acetylcholinesterase (ache) in the brain. |
2024-03-03 |
2024-03-06 |
rat |