All Relations between 5-ht receptor 2a and serotonin

Publication Sentence Publish Date Extraction Date Species
Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. 5-ht release on single spines induced structural and functional long-term potentiation (ltp), requiring both 5-ht2a and 5-ht7 receptor signals, in a glutamatergic activity-independent manner. 2024-02-16 2024-02-19 mouse
b' Paola Giuliano, Giuliana La Rosa, Serena Capozzi, Emanuele Cassano, Simona Damiano, Francesco Habetswallner, Rosa Iodice, Maurizio Marra, Luigi Michele Pavone, Mario Quarantelli, Giuseppe Vitelli, Mariarosaria Santillo, Roberto Patern\\xc3\\xb. A Blood Test for the Diagnosis of Multiple Sclerosis. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338973.' in this study, since there is evidence connecting the serotonin pathway to ms, we used an elisa (enzyme-linked immunosorbent assay) to detect serum ms-specific auto-antibodies (auto-ab) against the extracellular loop 1 (ecl-1) of the 5-hydroxytryptamine (5-ht) receptor subtype 2a (5-ht2a). 2024-02-10 2024-02-12 Not clear
Alberto Fernández-Teruel, Toni Cañete, Daniel Sampedro-Viana, Ignasi Oliveras, Rafael Torrubia, Adolf Tobeñ. Contribution of the Roman rat lines/strains to personality neuroscience: neurobehavioral modeling of internalizing/externalizing psychopathologies. Personality neuroscience. vol 6. 2023-12-19. PMID:38107777. for example, relative to rla rats, rhas exhibit decreased function of the prefrontal cortex (pfc), hippocampus and amygdala, increased functional tone of the mesolimbic dopamine system, a deficit of central metabotropic glutamate-2 (mglu2) receptors, increased density of serotonin 5-ht2a receptors in the pfc, impairment of gabaergic transmission in the pfc, alterations of several synaptic markers and increased density of pyramidal immature dendrític spines in the pfc. 2023-12-19 2023-12-21 rat
Hector Vargas-Perez, Fernando Minauro-Sanmiguel, Ryan Ting-A-Kee, Taryn Elizabeth Grieder, Mónica Méndez-Díaz, Oscar E Prospéro-García, Derek van der Koo. Rewarding effects in 4-AcO-DMT administration and withdrawal in rats: A challenge to the opponent-process theory. Neuroscience letters. 2023-12-18. PMID:38110146. however, current observational and experimental evidence suggests that the administration of a 5-hydroxytryptamine receptors-type 2a (5-ht2a) agonist, while capable of inducing a positive mental state in humans, may not generate the behavioral patterns typically associated with drugs of abuse. 2023-12-18 2023-12-21 rat
Polona Rus Prelog, Anja Kokalj Palandaci. Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report. BMC psychiatry. vol 23. issue 1. 2023-12-11. PMID:38082232. it functions as a partial agonist with high affinity for dopamine d2 and d3 and serotonin 5-ht1a receptors, an antagonist for 5-ht2a (moderate affinity) and 5-ht2b (high affinity) receptors. 2023-12-11 2023-12-17 Not clear
Jeong-Hee Kim, Hang-Keun Kim, Young-Don Son, Jong-Hoon Ki. In Vivo Serotonin 5-HT2A Receptor Availability and Its Relationship with Aggression Traits in Healthy Individuals: A Positron Emission Tomography Study with C-11 MDL100907. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958691. in vivo serotonin 5-ht2a receptor availability and its relationship with aggression traits in healthy individuals: a positron emission tomography study with c-11 mdl100907. 2023-11-14 2023-11-20 human
Vladimir M Pogorelov, Ramona M Rodriguiz, Bryan L Roth, William C Wetse. The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice. Frontiers in molecular biosciences. vol 10. 2023-10-30. PMID:37900918. the g protein biased serotonin 5-ht2a receptor agonist lisuride exerts anti-depressant drug-like activities in mice. 2023-10-30 2023-11-08 mouse
Raly James Perez Custodio, Darlene Mae Ortiz, Hyun Jun Lee, Leandro Val Sayson, Mikyung Kim, Yong Sup Lee, Kyeong-Man Kim, Jae Hoon Cheong, Hee Jin Ki. Serotonin 2C receptors are also important in head-twitch responses in male mice. Psychopharmacology. 2023-10-26. PMID:37882810. serotonergic psychedelics exert their effects via their high affinity for serotonin (5-ht) receptors, particularly through activating 5-ht2a receptors (5-ht2ar), employing the frontal cortex-dependent head-twitch response (htr). 2023-10-26 2023-11-08 mouse
Sanjay Karki, Mehdi Saadaoui, Valentin Dunsing, Stephen Kerridge, Elise Da Silva, Jean-Marc Philippe, Cédric Maurange, Thomas Lecui. Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages. Nature communications. vol 14. issue 1. 2023-09-08. PMID:37684231. we find that serotonin and serotonin receptors 5ht2a and 5ht2b form a signaling module that quantitatively regulates the amplitude of planar polarized myoii contractility specified by toll receptors and the gpcr cirl. 2023-09-08 2023-10-07 chicken
Francesco Tortora, Abed L Hadipour, Simone Battaglia, Alessandra Falzone, Alessio Avenanti, Carmelo M Vicari. The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626553. the results suggest that elevated levels of 5-ht enhance aversive learning, indicating that the modulation of serotonin 5-ht2a receptors regulates the expression of fear responses in humans. 2023-08-26 2023-09-07 human
Ángeles Prados-Pardo, Elena Martín-González, Santiago Mora, Carlos Martín, Manuela Olmedo-Córdoba, Cristian Pérez-Fernandez, Fernando Sánchez-Santed, Margarita Moreno-Montoy. Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats. Molecular neurobiology. 2023-07-31. PMID:37523044. the compulsive hd rats showed cognitive inflexibility and reduced serotonin 2a (5-ht2a) receptor binding levels in the frontal cortex (fc). 2023-07-31 2023-08-14 rat
Muhammad Ishrat Husain, Daniel M Blumberger, David J Castle, Nicole Ledwos, Elise Fellows, Brett D M Jones, Abigail Ortiz, Stefan Kloiber, Wei Wang, Joshua D Rosenblat, Benoit H Mulsan. Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial. BJPsych open. vol 9. issue 4. 2023-07-25. PMID:37489299. these effects depend on serotonin 2a (5-ht2a) receptor activation, which can be blocked by 5-ht2a receptor antagonists like ketanserin or risperidone. 2023-07-25 2023-08-14 Not clear
Barbara G Ferri, Cintia O de Novais, Raquel S Bonani, Wellington A de Barros, Ângelo de Fátima, Fabiana C Vilela, Alexandre Giusti-Paiv. Psychoactive substances 25H-NBOMe and 25H-NBOH induce antidepressant-like behavior in male rats. European journal of pharmacology. 2023-07-21. PMID:37479015. ring-substituted phenethylamines are believed to induce psychedelic effects primarily by interacting with 5-hydroxytryptamine 2 (5-ht2a) receptors in the brain. 2023-07-21 2023-08-14 rat
Rika Takaba, Daisuke Ibi, Keisuke Yoshida, Eri Hosomi, Ririna Kawase, Hiroko Kitagawa, Hirotaka Goto, Mizuki Achiwa, Kento Mizutani, Kyosuke Maede, Javier González-Maeso, Shinji Kitagaki, Masayuki Hiramats. Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice. Research square. 2023-07-18. PMID:37461593. serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and doi exert a hallucinatory effect through serotonin 5-ht 2a receptor (5-ht2a) activation. 2023-07-18 2023-08-14 mouse
Tongjun Ma, Chenyu Li, Zeyin Nie, Huachun Miao, Feng W. Regulatory effect of electroacupuncture on hypothalamic serotonin and its receptor in rats with cerebral ischemia. Current neurovascular research. 2023-06-13. PMID:37309759. 5-hydroxytryptamine (5-ht)/ 5-ht transporter (5-htt) and 5-ht receptor 2a (5-ht2a) are important in the treatment of cerebrovascular diseases. 2023-06-13 2023-08-14 rat
Yuxiao Chen, Jie Sun, Zhen Yang, Hongyan B. Efficacy and safety of negative allosteric modulators of 5-hydroxytryptamine 2A receptors in the treatment of Alzheimer's disease psychosis: A systematic review and meta-analysis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-05-11. PMID:37166012. the 5-hydroxytryptamine (5-ht2a) receptors are located postsynaptically to serotonergic neurons in the frontal cortex and mediate both excitatory and inhibitory neurotransmissions. 2023-05-11 2023-08-14 Not clear
Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. on this background, we set out to explore (1) the role of serotonin 2a (5-ht2a) and serotonin 1a (5-ht1a) receptors in the effect of psilocybin on marble burying; (2) the effect of staggered versus bolus psilocybin administration and persistence of the effect; (3) the effect of the 5-ht1a partial agonist, buspirone, on marble-burying and the head twitch response (htr) induced by psilocybin, a rodent correlate of psychedelic effects. 2023-05-10 2023-08-14 mouse
Jignesh H Kamadar, D Roza Kumari, Khushal M Kapadiy. Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry: A Last Decades Survey. Mini reviews in medicinal chemistry. 2023-05-09. PMID:37157202. recent studies on serotonin 5-ht2a receptor antagonists in medicinal chemistry: a last decades survey. 2023-05-09 2023-08-14 human
Jignesh H Kamadar, D Roza Kumari, Khushal M Kapadiy. Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry: A Last Decades Survey. Mini reviews in medicinal chemistry. 2023-05-09. PMID:37157202. one of the members of gpcrs is the serotonin 2a (5-ht2a) receptor, which has been associated with complex etiological mental illnesses. 2023-05-09 2023-08-14 human
Akihito Takeda, Mao Fujita, Kengo Funakosh. Distribution of 5HT Receptors During the Regeneration Process After Spinal Cord Transection in Goldfish. Journal of chemical neuroanatomy. 2023-04-29. PMID:37119932. 5ht2a was expressed at the luminal surface, suggesting that it is receptive to 5ht in the cerebrospinal fluid. 2023-04-29 2023-08-14 Not clear