| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Klaas E Stephan, Karl J Friston, Chris D Frit. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophrenia bulletin. vol 35. issue 3. 2009-06-11. PMID:19155345. |
this theory postulates that the core pathology in schizophrenia resides in aberrant n-methyl-d-aspartate receptor (nmdar)-mediated synaptic plasticity due to abnormal regulation of nmdars by neuromodulatory transmitters like dopamine, serotonin, or acetylcholine. |
2009-06-11 |
2023-08-12 |
Not clear |
| Oded Lipa Shor, Pawel Fidzinski, Joachim Beh. Muscarinic acetylcholine receptors and voltage-gated calcium channels contribute to bidirectional synaptic plasticity at CA1-subiculum synapses. Neuroscience letters. vol 449. issue 3. 2009-04-27. PMID:19010390. |
muscarinic acetylcholine receptors and voltage-gated calcium channels contribute to bidirectional synaptic plasticity at ca1-subiculum synapses. |
2009-04-27 |
2023-08-12 |
Not clear |
| Oded Lipa Shor, Pawel Fidzinski, Joachim Beh. Muscarinic acetylcholine receptors and voltage-gated calcium channels contribute to bidirectional synaptic plasticity at CA1-subiculum synapses. Neuroscience letters. vol 449. issue 3. 2009-04-27. PMID:19010390. |
here, we present evidence that this bidirectional plasticity relies upon the co-activation of muscarinic acetylcholine receptors, as scopolamine blocks synaptic plasticity in both cell types. |
2009-04-27 |
2023-08-12 |
Not clear |
| Daniela Puzzo, Lucia Privitera, Elena Leznik, Mauro Fà, Agnieszka Staniszewski, Agostino Palmeri, Ottavio Aranci. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118188. |
the mechanism of action of picomolar abeta(42) on both synaptic plasticity and memory involves alpha7-containing nicotinic acetylcholine receptors. |
2009-04-09 |
2023-08-12 |
Not clear |
| Gonzalo Sánchez, Lucas de Oliveira Alvares, María Victoria Oberholzer, Bruna Genro, Jorge Quillfeldt, Jaderson Costa da Costa, Carlos Cerveñansky, Diana Jerusalinsky, Edgar Kornisiu. M4 muscarinic receptors are involved in modulation of neurotransmission at synapses of Schaffer collaterals on CA1 hippocampal neurons in rats. Journal of neuroscience research. vol 87. issue 3. 2009-03-31. PMID:18816796. |
all five subtypes of muscarinic acetylcholine receptors (machr; m(1)-m(5)) are expressed in the hippocampus, where they are involved both in cognitive functions and in synaptic plasticity, such as long-term potentiation (ltp). |
2009-03-31 |
2023-08-12 |
rat |
| A J Scheen, V Seutin, L F Van Gaa. [Endocannabinoid system in the brain...and elsewhere]. Revue medicale de Liege. vol 63. issue 5-6. 2008-11-14. PMID:18669206. |
in the brain, endocannabinoids and cb1 receptors are almost ubiquitous and play a role in synaptic plasticity: they modulate, through an inhibitory retrograde action, the release of classical neurotransmitters such as amines, acetylcholine or amino acids. |
2008-11-14 |
2023-08-12 |
Not clear |
| Cary L Scheiderer, Caroline C Smith, Eve McCutchen, Portia A McCoy, Erin E Thacker, Krystyna Kolasa, Lynn E Dobrunz, Lori L McMaho. Coactivation of M(1) muscarinic and alpha1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 20. 2008-06-19. PMID:18480291. |
however, much remains unclear about the precise roles of acetylcholine (ach) and norepinephrine (ne) in hippocampal function, particularly in terms of how interactions between these two transmitter systems might play an important role in synaptic plasticity. |
2008-06-19 |
2023-08-12 |
rat |
| John M Power, Pankaj Sa. Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354024. |
acetylcholine (ach) is an important modulator of learning, memory, and synaptic plasticity in the basolateral amygdala (bla) and other brain regions. |
2008-04-25 |
2023-08-12 |
rat |
| Florencia M Gosso, Eco J C de Geus, Tinca J C Polderman, Dorret I Boomsma, Danielle Posthuma, Peter Heutin. Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. BMC medical genetics. vol 8. 2008-01-16. PMID:17996044. |
the chrm2 gene, located on the long arm of chromosome 7 (7q31-35), is involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release, and has been implicated in higher cognitive processing. |
2008-01-16 |
2023-08-12 |
human |
| Lenora J Volk, Brad E Pfeiffer, Jay R Gibson, Kimberly M Hube. Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 43. 2007-11-08. PMID:17959805. |
gq-coupled, m1 muscarinic acetylcholine receptors (machrs) facilitate hippocampal learning, memory, and synaptic plasticity. |
2007-11-08 |
2023-08-12 |
mouse |
| Massimiliano Di Filippo, Alessandro Tozzi, Barbara Picconi, Veronica Ghiglieri, Paolo Calabres. Plastic abnormalities in experimental Huntington's disease. Current opinion in pharmacology. vol 7. issue 1. 2007-04-12. PMID:17071137. |
dopamine, acetylcholine and glutamate signalling, which usually cooperate in the induction of physiological synaptic plasticity, are all disrupted. |
2007-04-12 |
2023-08-12 |
human |
| Nicola Origlia, Nicola Kuczewski, Eugenio Aztiria, Dinesh Gautam, Jürgen Wess, Luciano Domenic. Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex. The Journal of physiology. vol 577. issue Pt 3. 2007-03-09. PMID:17023506. |
in the present report, we focused our attention on the role played by the muscarinic acetylcholine receptors (machrs) in different forms of long-term synaptic plasticity. |
2007-03-09 |
2023-08-12 |
mouse |
| Laura Tapia, Josefina García Eguiagaray, Javier Egea, Antonio García García, Luis Gandí. Enhancement of secretion by threshold nicotinic stimulation in bovine chromaffin cells. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192638. |
desensitized nicotinic acetylcholine receptors (nachrs) and their possible role in this short-term synaptic plasticity was investigated in populations of bovine chromaffin cells. |
2007-02-23 |
2023-08-12 |
cattle |
| M F Gosso, M van Belzen, E J C de Geus, J C Polderman, P Heutink, D I Boomsma, D Posthum. Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. Genes, brain, and behavior. vol 5. issue 8. 2006-12-22. PMID:17081262. |
the chrm2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. |
2006-12-22 |
2023-08-12 |
Not clear |
| Marcelo Rosato-Siri, Antonino Cattaneo, Enrico Cherubin. Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice. The Journal of physiology. vol 576. issue Pt 2. 2006-11-28. PMID:16873411. |
activation of these receptors by nicotine or endogenously released acetylcholine enhances activity-dependent synaptic plasticity processes. |
2006-11-28 |
2023-08-12 |
mouse |
| Paolo Calabresi, Barbara Picconi, Lucilla Parnetti, Massimiliano Di Filipp. A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance. The Lancet. Neurology. vol 5. issue 11. 2006-11-28. PMID:17052664. |
in this personal view, we reconsider the dopamine-acetylcholine balance theory and look at recent clinical findings and the possible cooperative role of dopamine and acetylcholine in the induction and maintenance of the long-lasting changes of striatal and cortical synaptic plasticity. |
2006-11-28 |
2023-08-12 |
Not clear |
| J E Garrett, I Kim, R E Wilson, C L Wellma. Effect of N-methyl-d-aspartate receptor blockade on plasticity of frontal cortex after cholinergic deafferentation in rat. Neuroscience. vol 140. issue 1. 2006-08-10. PMID:16529871. |
acetylcholine modulates glutamatergic activity in cortex, and the n-methyl-d-aspartate subtype of glutamate receptor plays a role in many forms of synaptic plasticity. |
2006-08-10 |
2023-08-12 |
rat |
| Toru Shinoe, Minoru Matsui, Makoto M Taketo, Toshiya Manab. Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 48. 2006-02-27. PMID:16319319. |
modulation of synaptic plasticity by physiological activation of m1 muscarinic acetylcholine receptors in the mouse hippocampus. |
2006-02-27 |
2023-08-12 |
mouse |
| Theodore A Slotkin, Matthew C Southard, Stacey J Adam, Mandy M Cousins, Frederic J Seidle. Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. Brain research bulletin. vol 64. issue 3. 2005-09-30. PMID:15464859. |
alpha7 nicotinic acetylcholine receptors (nachrs) play a role in axonogenesis, synaptogenesis and synaptic plasticity, and are therefore potential targets for developmental neurotoxicants. |
2005-09-30 |
2023-08-12 |
rat |
| Theodore A Slotkin, Mandy M Cousins, Frederic J Seidle. Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. Brain research. vol 1030. issue 1. 2005-02-03. PMID:15567348. |
alpha 7 nicotinic acetylcholine receptors (nachrs) play a role in axonogenesis, synaptogenesis and synaptic plasticity, and are therefore targets for developmental neurotoxicants. |
2005-02-03 |
2023-08-12 |
rat |