| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Rusakov, E Harrison, M G Stewar. Synapses in hippocampus occupy only 1-2% of cell membranes and are spaced less than half-micron apart: a quantitative ultrastructural analysis with discussion of physiological implications. Neuropharmacology. vol 37. issue 4-5. 1999-05-26. PMID:9704992. |
the present electron microscopic study employs unbiased stereological techniques and monte carlo simulations to characterise quantitatively the spatial organisation of synaptic circuitry in the dentate gyrus of the hippocampus, an area of particular importance in mechanisms of learning and the subject of a number of experimental neurobiological models of synaptic plasticity such as long-term potentiation. |
1999-05-26 |
2023-08-12 |
human |
| A Kamal, K Spoelstra, G J Biessels, I J Urban, W H Gispe. Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices. Brain research. vol 824. issue 2. 1999-05-25. PMID:10196454. |
effects of changes in glucose concentration on synaptic plasticity in hippocampal slices. |
1999-05-25 |
2023-08-12 |
rat |
| J J Kim, K S Yoo. Stress: metaplastic effects in the hippocampus. Trends in neurosciences. vol 21. issue 12. 1999-05-24. PMID:9881846. |
in support of this view, stress-induced modifications in learning, synaptic plasticity and endangerment of neurons have been seen in the hippocampus. |
1999-05-24 |
2023-08-12 |
Not clear |
| M Zhuo, W Zhang, H Son, I Mansuy, R A Sobel, J Seidman, E R Kande. A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 8. 1999-05-17. PMID:10200317. |
pharmacological studies have suggested that long-term potentiation (ltp) and long-term depression (ltd) and depotentiation, three forms of synaptic plasticity in the hippocampus, require the activity of the phosphatase calcineurin. |
1999-05-17 |
2023-08-12 |
mouse |
| M Stocker, M Krause, P Pedarzan. An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 8. 1999-05-17. PMID:10200319. |
altogether, these results clarify the discrepancy between the reported high density of apamin-binding sites in the ca1 region and the apparent lack of an apamin-sensitive current in ca1 pyramidal neurons, and they may explain the effects of this toxin on hippocampal synaptic plasticity and learning. |
1999-05-17 |
2023-08-12 |
Not clear |
| L D Pozzo-Miller, T Inoue, D D Murph. Estradiol increases spine density and NMDA-dependent Ca2+ transients in spines of CA1 pyramidal neurons from hippocampal slices. Journal of neurophysiology. vol 81. issue 3. 1999-05-06. PMID:10085365. |
the increase in spine density and the enhanced nmda-dependent ca2+ signals in spines and dendrites induced by est may underlie a threshold reduction for induction of nmda-dependent synaptic plasticity in the hippocampus. |
1999-05-06 |
2023-08-12 |
Not clear |
| P F Chapman, G L White, M W Jones, D Cooper-Blacketer, V J Marshall, M Irizarry, L Younkin, M A Good, T V Bliss, B T Hyman, S G Younkin, K K Hsia. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature neuroscience. vol 2. issue 3. 1999-04-21. PMID:10195221. |
these deficits are accompanied by minimal or no loss of presynaptic or postsynaptic elementary structural elements in the hippocampus, suggesting that impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in alzheimer's patients. |
1999-04-21 |
2023-08-12 |
mouse |
| R D Hawkins, H Son, O Aranci. Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus. Progress in brain research. vol 118. 1999-04-07. PMID:9932440. |
in this chapter we review evidence on the role of no in long-term potentiation (ltp), a type of synaptic plasticity in hippocampus that is believed to contribute to declarative forms of learning such as spatial learning. |
1999-04-07 |
2023-08-12 |
Not clear |
| Y F Lu, N Kojima, K Tomizawa, A Moriwaki, M Matsushita, K Obata, H Matsu. Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice. The European journal of neuroscience. vol 11. issue 1. 1999-04-01. PMID:9987012. |
to elucidate the physiological role of fyn, we analysed the properties of synaptic transmission and synaptic plasticity in hippocampal slices of mice overexpressing either wild-type fyn (w-fyn) or its constitutively active mutant (m-fyn). |
1999-04-01 |
2023-08-12 |
mouse |
| A Caputi, F Gardoni, M Cimino, L Pastorino, F Cattabeni, M Di Luc. CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP. The European journal of neuroscience. vol 11. issue 1. 1999-04-01. PMID:9987018. |
to examine in vivo the implication of camkii activity in synaptic plasticity, we used an animal model characterized by developmentally induced targeted neuronal ablation within the cortex and the hippocampus, and showing, at presynaptic level, molecular alterations leading to facilitation of glutamate release in hippocampal synapses (methylazoxymethanol-treated rats, mam-rats). |
1999-04-01 |
2023-08-12 |
rat |
| S M Fitzjohn, Z A Bortolotto, M J Palmer, A J Doherty, P L Ornstein, D D Schoepp, A E Kingston, D Lodge, G L Collingridg. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology. vol 37. issue 12. 1999-03-23. PMID:9886667. |
the potent mglu receptor antagonist ly341495 identifies roles for both cloned and novel mglu receptors in hippocampal synaptic plasticity. |
1999-03-23 |
2023-08-12 |
human |
| E D'Angelo, P Rossi, S Armano, V Tagliett. Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber-granule cell transmission in rat cerebellum. Journal of neurophysiology. vol 81. issue 1. 1999-03-22. PMID:9914288. |
long-term potentiation (ltp) is a form of synaptic plasticity that can be revealed at numerous hippocampal and neocortical synapses following high-frequency activation of n-methyl--aspartate (nmda) receptors. |
1999-03-22 |
2023-08-12 |
rat |
| L P Baker, M D Nielsen, S Impey, B M Hacker, S W Poser, M Y Chan, D R Stor. Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 1. 1999-02-05. PMID:9870949. |
the presence of ac2 and ac4 in the hippocampus and the ability of each of these enzymes to detect coincident activation of gs- and gi-coupled receptors suggest that they may play a crucial role in certain forms of synaptic plasticity by coordinating such overlapping synaptic inputs. |
1999-02-05 |
2023-08-12 |
mouse |
| M A Kiebler, I Hemraj, P Verkade, M Köhrmann, P Fortes, R M Marión, J Ortín, C G Dott. The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 1. 1999-02-05. PMID:9870958. |
in hippocampal neurons, certain mrnas have been found in dendrites (), and their localization and translation have been implicated in synaptic plasticity (). |
1999-02-05 |
2023-08-12 |
human |
| M Y Chiang, D Misner, G Kempermann, T Schikorski, V Giguère, H M Sucov, F H Gage, C F Stevens, R M Evan. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron. vol 21. issue 6. 1999-01-26. PMID:9883728. |
hippocampal long-term potentiation (ltp) and long-term depression (ltd) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. |
1999-01-26 |
2023-08-12 |
mouse |
| T Nakayama, T Yaoi, G Kuwajim. Localization and subcellular distribution of N-copine in mouse brain. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886090. |
in situ hybridization analysis showed that n-copine mrna was expressed exclusively in neurons of the hippocampus and in the main and accessory olfactory bulb, where various forms of synaptic plasticity and memory formation are known to occur. |
1999-01-21 |
2023-08-12 |
mouse |
| H L Wang, M J Wayner, C Y Chai, E H Le. Corticotrophin-releasing factor produces a long-lasting enhancement of synaptic efficacy in the hippocampus. The European journal of neuroscience. vol 10. issue 11. 1999-01-14. PMID:9824456. |
thus, corticotrophin-releasing factor may play an important role in modulating synaptic plasticity in the hippocampus. |
1999-01-14 |
2023-08-12 |
rat |
| M Barad, R Bourtchouladze, D G Winder, H Golan, E Kande. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 25. 1999-01-14. PMID:9844008. |
in an attempt to improve behavioral memory, we devised a strategy to amplify the signal-to-noise ratio of the camp pathway, which plays a central role in hippocampal synaptic plasticity and behavioral memory. |
1999-01-14 |
2023-08-12 |
mouse |
| C S Woolle. Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus. Hormones and behavior. vol 34. issue 2. 1999-01-08. PMID:9799624. |
estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus. |
1999-01-08 |
2023-08-12 |
rat |
| C S Woolle. Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus. Hormones and behavior. vol 34. issue 2. 1999-01-08. PMID:9799624. |
electrophysiological analyses indicate that these hormone-induced synapses increase hippocampal excitability as well as the potential for synaptic plasticity. |
1999-01-08 |
2023-08-12 |
rat |