| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leann H Brennaman, Gaga Kochlamazashvili, Luminita Stoenica, Randall J Nonneman, Sheryl S Moy, Melitta Schachner, Alexander Dityatev, Patricia F Manes. Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21515372. |
transgenic mice displayed impaired long- and short-term potentiation in the pfc but normal synaptic plasticity in the hippocampus, suggesting that the abnormal synaptic innervation in ncam-ec mice impairs pfc plasticity and alters working memory. |
2012-05-07 |
2023-08-12 |
mouse |
| Heather D Vanguilder, Georgina V Bixler, William E Sonntag, Willard M Freema. Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22269040. |
expression of myelin-associated inhibitors (mais) of synaptic plasticity, including the ligands myelin-associated glycoprotein, neurite outgrowth inhibitor a, and oligodendrocyte myelin glycoprotein, and their common receptor, nogo-66 receptor, was examined in hippocampal synaptosomes and cornu ammonis area (ca)1, ca3 and dentate gyrus subregions derived from adult (12-13 months) and aged (26-28 months) fischer 344 × brown norway rats. |
2012-05-03 |
2023-08-12 |
rat |
| Kotaro Ikarashi, Hiroki Fujiwara, Yoshihiko Yamazaki, Jun-Ichi Goto, Kenya Kaneko, Hiroshi Kato, Satoshi Fujii, Hiroshi Sasaki, Satoshi Fukumoto, Keiko Furukawa, Hatsue Waki, Koichi Furukaw. Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyltransferase gene transgenic mice. Glycobiology. vol 21. issue 10. 2012-04-23. PMID:21733970. |
gangliosides (sialic acid-containing glycosphingolipids) play important roles in many physiological functions, including synaptic plasticity in the hippocampus, which is considered as a cellular mechanism of learning and memory. |
2012-04-23 |
2023-08-12 |
mouse |
| Kotaro Ikarashi, Hiroki Fujiwara, Yoshihiko Yamazaki, Jun-Ichi Goto, Kenya Kaneko, Hiroshi Kato, Satoshi Fujii, Hiroshi Sasaki, Satoshi Fukumoto, Keiko Furukawa, Hatsue Waki, Koichi Furukaw. Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyltransferase gene transgenic mice. Glycobiology. vol 21. issue 10. 2012-04-23. PMID:21733970. |
in the present study, three types of synaptic plasticity, long-term potentiation (ltp), long-term depression (ltd) and reversal of ltp (depotentiation, dp), in the field excitatory post-synaptic potential in ca1 hippocampal neurons and learning behavior were examined in β1,4-n-acetylgalactosaminyltransferase (β1,4 galnac-t; gm2/gd2 synthase) gene transgenic (tg) mice, which showed a marked decrease in b-pathway gangliosides (gq1b, gt1b and gd1b) in the brain and isolated hippocampus compared with wild-type (wt) mice. |
2012-04-23 |
2023-08-12 |
mouse |
| Fritz Kobe, Daria Guseva, Thomas P Jensen, Alexander Wirth, Ute Renner, Dietmar Hess, Michael Müller, Lucian Medrihan, Weiqi Zhang, Mingyue Zhang, Katharina Braun, Sören Westerholz, Andreas Herzog, Konstantin Radyushkin, Ahmed El-Kordi, Hannelore Ehrenreich, Diethelm W Richter, Dmitri A Rusakov, Evgeni Ponimaski. 5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 9. 2012-04-20. PMID:22378867. |
in organotypic preparations from the hippocampus of juvenile mice, stimulation of 5-ht(7)r/g(12) signaling potentiates formation of dendritic spines, increases neuronal excitability, and modulates synaptic plasticity. |
2012-04-20 |
2023-08-12 |
mouse |
| Fritz Kobe, Daria Guseva, Thomas P Jensen, Alexander Wirth, Ute Renner, Dietmar Hess, Michael Müller, Lucian Medrihan, Weiqi Zhang, Mingyue Zhang, Katharina Braun, Sören Westerholz, Andreas Herzog, Konstantin Radyushkin, Ahmed El-Kordi, Hannelore Ehrenreich, Diethelm W Richter, Dmitri A Rusakov, Evgeni Ponimaski. 5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 9. 2012-04-20. PMID:22378867. |
moreover, inhibition of 5-ht(7) receptor had no effect on synaptic plasticity in hippocampus of adult animals. |
2012-04-20 |
2023-08-12 |
mouse |
| N A Kapay, N K Isaev, E V Stelmashook, O V Popova, D B Zorov, V G Skrebitsky, V P Skulache. In vivo injected mitochondria-targeted plastoquinone antioxidant SkQR1 prevents β-amyloid-induced decay of long-term potentiation in rat hippocampal slices. Biochemistry. Biokhimiia. vol 76. issue 12. 2012-04-19. PMID:22150282. |
these data demonstrate that skqr1 therapy is able to compensate the abeta-induced impairments of long-term synaptic plasticity in the hippocampus, which are the main cause of loss of memory and other cognitive functions associated with alzheimer's disease. |
2012-04-19 |
2023-08-12 |
rat |
| Zahid Padamsey, Nigel J Emptag. Imaging synaptic plasticity. Molecular brain. vol 4. 2012-04-16. PMID:21958593. |
here, we review the use of these techniques in recent studies of synaptic plasticity and, in particular, long-term potentiation in the hippocampus. |
2012-04-16 |
2023-08-12 |
Not clear |
| Jennifer Keck-Wherley, Deepak Grover, Sharmistha Bhattacharyya, Xiufen Xu, Derek Holman, Eric D Lombardini, Ranjana Verma, Roopa Biswas, Zygmunt Galdzick. Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes. Developmental neuroscience. vol 33. issue 5. 2012-04-16. PMID:22042248. |
our findings provide insights into mirna-mediated gene regulation in ts65dn mice and their potential contribution to impaired hippocampal synaptic plasticity and neurogenesis, as well as hemopoietic abnormalities observed in ds. |
2012-04-16 |
2023-08-12 |
mouse |
| Ye Liu, Wei Guan, Guogang Ren, Zhuo Yan. The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats. Toxicology letters. vol 209. issue 3. 2012-04-16. PMID:22245254. |
the possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats. |
2012-04-16 |
2023-08-12 |
rat |
| Ye Liu, Wei Guan, Guogang Ren, Zhuo Yan. The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats. Toxicology letters. vol 209. issue 3. 2012-04-16. PMID:22245254. |
this study investigated effects of the ag-np on hippocampal synaptic plasticity and spatial cognition in rats and followed with the research on their possible mechanism. |
2012-04-16 |
2023-08-12 |
rat |
| Tomomi Kiyota, Kaitlin L Ingraham, Michael T Jacobsen, Huangui Xiong, Tsuneya Ikez. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 49. 2012-04-13. PMID:22042871. |
the adult hippocampus plays a central role in memory formation, synaptic plasticity, and neurogenesis. |
2012-04-13 |
2023-08-12 |
mouse |
| Cem Süer, Nazan Dolu, A Seda Artis, Leyla Sahin, Alpaslan Yilmaz, Aysun Ceti. The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats. Neuroscience research. vol 70. issue 1. 2012-04-06. PMID:21256900. |
some evidence suggests that sleep deprivation might impair synaptic plasticity and produce oxidative stress in the hippocampus. |
2012-04-06 |
2023-08-12 |
rat |
| Andrew B McGeachie, Lorenzo A Cingolani, Yukiko God. Stabilising influence: integrins in regulation of synaptic plasticity. Neuroscience research. vol 70. issue 1. 2012-04-06. PMID:21352859. |
hebbian synaptic plasticity, such as hippocampal long-term potentiation (ltp), is thought to be important for particular types of learning and memory. |
2012-04-06 |
2023-08-12 |
Not clear |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
in the hippocampus, insulin improves synaptic plasticity, memory formation, and learning via direct modulation of gabaergic and glutamatergic receptors. |
2012-04-02 |
2023-08-12 |
mouse |
| Keri Martinowich, Robert J Schloesser, Yuan Lu, Dennisse V Jimenez, Daniel Paredes, Joshua S Greene, Nigel H Greig, Husseini K Manji, Bai L. Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping. Biological psychiatry. vol 71. issue 1. 2012-03-30. PMID:21978521. |
this study investigated whether and how p75(ntr), via regulation of the cholinergic system and hippocampal synaptic plasticity, influences stress-related behaviors. |
2012-03-30 |
2023-08-12 |
Not clear |
| Ismael Valladolid-Acebes, Beatriz Merino, Antonio Principato, Alberto Fole, Coral Barbas, María P Lorenzo, Antonia García, Nuria Del Olmo, Mariano Ruiz-Gayo, Victoria Can. High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission. American journal of physiology. Endocrinology and metabolism. vol 302. issue 4. 2012-03-30. PMID:22114023. |
obesity and high-fat (hf) diets have a deleterious impact on hippocampal function and lead to impaired synaptic plasticity and learning deficits. |
2012-03-30 |
2023-08-12 |
mouse |
| Ryoi Tamura, Satoshi Eifuku, Teruko Uwano, Michiya Sugimori, Kumiko Uchiyama, Taketoshi On. A method for recording evoked local field potentials in the primate dentate gyrus in vivo. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20169538. |
in a test for long-term synaptic plasticity by high-frequency stimulation, the slopes of the fepsps and the area of population spikes were increased for more than 1 h. these results indicate that the method developed in the present study is useful for testing theories of hippocampal functions in primates. |
2012-03-26 |
2023-08-12 |
monkey |
| Jessica L Koranda, David N Ruskin, Susan A Masino, J Harry Blais. A ketogenic diet reduces long-term potentiation in the dentate gyrus of freely behaving rats. Journal of neurophysiology. vol 106. issue 2. 2012-03-26. PMID:21613596. |
here, we characterized effects of a ketogenic diet on hippocampal long-term potentiation, a widely studied form of synaptic plasticity. |
2012-03-26 |
2023-08-12 |
rat |
| Ruth M Barrett, Melissa Malvaez, Eniko Kramar, Dina P Matheos, Abraham Arrizon, Sara M Cabrera, Gary Lynch, Robert W Greene, Marcelo A Woo. Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 8. 2012-03-22. PMID:21508930. |
to identify the role of the histone acetyltransferase (hat) creb-binding protein (cbp) in neurons of the ca1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of cbp on histone modifications, gene expression, synaptic plasticity, and long-term memory. |
2012-03-22 |
2023-08-12 |
Not clear |