| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoju Yang, Erin R Ewald, Yuqing Huo, Kellie L Tamashiro, Roberto Salvatori, Akira Sawa, Gary S Wand, Richard S Le. Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochemical and biophysical research communications. vol 420. issue 3. 2012-06-01. PMID:22445894. |
we also focused on the mouse hippocampal dentate gyrus to test whether these changes would be enriched in a region implicated in the hpa-axis stress response, neurogenesis, and synaptic plasticity. |
2012-06-01 |
2023-08-12 |
mouse |
| M-N Quan, N Zhang, Y-Y Wang, T Zhang, Z Yan. Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model. Neuroscience. vol 182. 2012-05-31. PMID:21440043. |
in conclusion, memantine in dose of 20 mg/kg improves the sucrose consumption, reversal learning and prefrontal cortical synaptic plasticity, but impairs spatial memory, which is probably due to different extent of up-regulating nr2b receptor expression in prefrontal cortex and hippocampus in stressed rats. |
2012-05-31 |
2023-08-12 |
rat |
| Oliver Gruber, Alkomiet Hasan, Harald Scherk, Thomas Wobrock, Thomas Schneider-Axmann, Savira Ekawardhani, Andrea Schmitt, Martin Backens, Wolfgang Reith, Jobst Meyer, Peter Falka. Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system. European archives of psychiatry and clinical neuroscience. vol 262. issue 1. 2012-05-31. PMID:21509595. |
the brain-derived neurotrophic factor (bdnf) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. |
2012-05-31 |
2023-08-12 |
human |
| Alejandra Romero-Curiel, Diana López-Carpinteyro, Citlalli Gamboa, Fidel De la Cruz, Sergio Zamudio, Gonzalo Flore. Apamin induces plastic changes in hippocampal neurons in senile Sprague-Dawley rats. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21465567. |
several behavioral and electrophysiological studies indicate that sk-blockade by apamin may enhance neuron excitability, synaptic plasticity, and long-term potentiation in the ca1 hippocampal region, and, for that reason, apamin has been proposed as a therapeutic agent in alzheimer's disease treatment. |
2012-05-30 |
2023-08-12 |
rat |
| Alejandra Romero-Curiel, Diana López-Carpinteyro, Citlalli Gamboa, Fidel De la Cruz, Sergio Zamudio, Gonzalo Flore. Apamin induces plastic changes in hippocampal neurons in senile Sprague-Dawley rats. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21465567. |
our research suggests that apamin may increase the dendritic morphology in the hippocampus, which could be related to the neuronal excitability and synaptic plasticity enhancement induced by apamin. |
2012-05-30 |
2023-08-12 |
rat |
| P H Hutson, E N Finger, B C Magliaro, S M Smith, A Converso, P E Sanderson, D Mullins, L A Hyde, B K Eschle, Z Turnbull, H Sloan, M Guzzi, X Zhang, A Wang, D Rindgen, R Mazzola, J A Vivian, D Eddins, J M Uslaner, R Bednar, C Gambone, W Le-Mair, M J Marino, N Sachs, G Xu, S Parmentier-Batteu. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21619887. |
collectively these data indicate that pf-04447943 is a potent, selective brain penetrant pde9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. |
2012-05-25 |
2023-08-12 |
mouse |
| Douglas Bennion, Tyron Jensen, Curtis Walther, John Hamblin, Andrew Wallmann, Jason Couch, Jacob Blickenstaff, Michael Castle, Lauren Dean, Sam Beckstead, Collin Merrill, Casey Muir, Teresa St Pierre, Bryan Williams, Stephen Daniel, Jeffrey G Edward. Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21645527. |
synaptic plasticity is the cellular mechanism thought to mediate declarative learning and memory in the hippocampus. |
2012-05-25 |
2023-08-12 |
Not clear |
| Douglas Bennion, Tyron Jensen, Curtis Walther, John Hamblin, Andrew Wallmann, Jason Couch, Jacob Blickenstaff, Michael Castle, Lauren Dean, Sam Beckstead, Collin Merrill, Casey Muir, Teresa St Pierre, Bryan Williams, Stephen Daniel, Jeffrey G Edward. Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21645527. |
in summary, our findings support trpv1 agonist involvement in hippocampal synaptic plasticity, including its enhancement of ca1 ltp. |
2012-05-25 |
2023-08-12 |
Not clear |
| Douglas Bennion, Tyron Jensen, Curtis Walther, John Hamblin, Andrew Wallmann, Jason Couch, Jacob Blickenstaff, Michael Castle, Lauren Dean, Sam Beckstead, Collin Merrill, Casey Muir, Teresa St Pierre, Bryan Williams, Stephen Daniel, Jeffrey G Edward. Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21645527. |
we demonstrate that the enhancement mediated by trpv1 agonists requires gaba input to pyramidal cells thus providing a mechanism for how trpv1 agonists modulate hippocampal synaptic plasticity. |
2012-05-25 |
2023-08-12 |
Not clear |
| Lisa Gasperini, Chiara Piubelli, Lucia Carbon. Proteomics of rat hypothalamus, hippocampus and pre-frontal/frontal cortex after central administration of the neuropeptide PACAP. Molecular biology reports. vol 39. issue 3. 2012-05-25. PMID:21687973. |
altered expression levels were observed for proteins involved in cytoskeleton modulation and synaptic plasticity: actin in the hypothalamus; stathmin, dynamin, profilin and cofilin in hippocampus; synapsin in p/fc. |
2012-05-25 |
2023-08-12 |
rat |
| Justin S Catches, Jian Xu, Anis Contracto. Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice. Behavioural brain research. vol 228. issue 2. 2012-05-23. PMID:22203159. |
expression of the gluk4 receptor subunit in the forebrain is restricted to the ca3 region of the hippocampus and dentate gyrus regions where kars are known to modulate synaptic plasticity. |
2012-05-23 |
2023-08-12 |
mouse |
| Glenn Dallérac, Caroline Perronnet, Carine Chagneau, Pascale Leblanc-Veyrac, Nathalie Samson-Desvignes, Elise Peltekian, Olivier Danos, Luis Garcia, Serge Laroche, Jean-Marie Billard, Cyrille Vaillen. Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21624465. |
rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse. |
2012-05-21 |
2023-08-12 |
mouse |
| J L Spencer-Segal, M C Tsuda, L Mattei, E M Waters, R D Romeo, T A Milner, B S McEwen, S Ogaw. Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation. Neuroscience. vol 202. 2012-05-18. PMID:22133892. |
the different effects of estradiol at 6 and 48 h indicate that several mechanisms of estrogen receptor signaling contribute to this female hormone's influence on hippocampal synaptic plasticity. |
2012-05-18 |
2023-08-12 |
mouse |
| Zhaohong Qin, Xun Zhou, Mariana Gomez-Smith, Nihar R Pandey, Kevin F H Lee, Diane C Lagace, Jean-Claude Béïque, Hsiao-Huei Che. LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 12. 2012-05-18. PMID:22442089. |
lim domain only 4 (lmo4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus. |
2012-05-18 |
2023-08-12 |
mouse |
| Aisa Chepkova, Evgenij Yanovsky, Regis Parmentier, Hiroshi Ohtsu, Helmut L Haas, Jian-Sheng Lin, Olga A Sergeev. Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21710252. |
we investigated how brain histamine deficiency in hdc knockout mice (hdc ko) affects hippocampal excitability, synaptic plasticity, and the expression of histamine receptors. |
2012-05-17 |
2023-08-12 |
mouse |
| Brennan D Eadie, Jesse Cushman, Timal S Kannangara, Michael S Fanselow, Brian R Christi. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21049485. |
here we report that fmr1 knockout mice exhibit impaired bidirectional synaptic plasticity in the dentate gyrus (dg) of the hippocampus. |
2012-05-14 |
2023-08-12 |
mouse |
| Theodore C Duma. Postnatal alterations in induction threshold and expression magnitude of long-term potentiation and long-term depression at hippocampal synapses. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21069779. |
to assess possible relationships between modifications in synaptic plasticity and maturation of cognitive ability, we examined excitatory synaptic function in area ca1 of the mouse hippocampus ∼3 weeks of age, when hippocampal-dependent learning and memory abilities first emerge. |
2012-05-14 |
2023-08-12 |
mouse |
| Felisa N van Hasselt, Sandra Cornelisse, Tie Yuan Zhang, Michael J Meaney, Els H Velzing, Harm J Krugers, Marian Joël. Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21240921. |
adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life. |
2012-05-14 |
2023-08-12 |
rat |
| Xiaodi Han, Jing Tong, Jun Zhang, Arash Farahvar, Ernest Wang, Jiankai Yang, Uzma Samadani, Douglas H Smith, Jason H Huan. Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice. Journal of neurotrauma. vol 28. issue 6. 2012-05-14. PMID:21463148. |
previous animal and human studies have demonstrated that chronic treatment with several different antidepressants can stimulate neurogenesis, neural remodeling, and synaptic plasticity in the normal hippocampus. |
2012-05-14 |
2023-08-12 |
mouse |
| Leann H Brennaman, Gaga Kochlamazashvili, Luminita Stoenica, Randall J Nonneman, Sheryl S Moy, Melitta Schachner, Alexander Dityatev, Patricia F Manes. Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21515372. |
transgenic mice displayed impaired long- and short-term potentiation in the pfc but normal synaptic plasticity in the hippocampus, suggesting that the abnormal synaptic innervation in ncam-ec mice impairs pfc plasticity and alters working memory. |
2012-05-07 |
2023-08-12 |
mouse |