| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jose Antonio Troca-Marín, Juan José Casañas, Itziar Benito, María Luz Montesino. The Akt-mTOR pathway in Down's syndrome: the potential use of rapamycin/rapalogs for treating cognitive deficits. CNS & neurological disorders drug targets. vol 13. issue 1. 2014-10-08. PMID:24152334. |
we have recently shown that the aktmtor pathway is hyperactive in the hippocampus of ts1cje mice, a model of down's syndrome, leading to increased local dendritic translation that could interfere with synaptic plasticity. |
2014-10-08 |
2023-08-12 |
mouse |
| Shan-Xue Jin, Christopher Bartolome, Junko A Arai, Laurel Hoffman, B Gizem Uzturk, Rajendra Kumar-Singh, M Neal Waxham, Larry A Fei. Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24755227. |
overall, these findings show that for the three forms of synaptic plasticity that are regulated by grf proteins in the ca1 hippocampus, specificity is encoded in only one or two domains, and a different set of domains for each form of synaptic plasticity. |
2014-10-07 |
2023-08-13 |
mouse |
| Yuguan Ze, Lei Sheng, Xiaoyang Zhao, Xiao Ze, Xuecen Wang, Qiuping Zhou, Jialiang Liu, Yifei Yuan, Suxin Gui, Xuezi Sang, Qingqing Sun, Jie Hong, Xiaohong Yu, Ling Wang, Bingyan Li, Fashui Hon. Neurotoxic characteristics of spatial recognition damage of the hippocampus in mice following subchronic peroral exposure to TiO2 nanoparticles. Journal of hazardous materials. vol 264. 2014-10-06. PMID:24295774. |
hippocampal pathology and neuron ultrastructure, and long-term potentiation (ltp) were then evaluated, and the hippocampal mrna-expression of several genes and their proteins involved in homeostasis of neuronal synaptic plasticity were investigated using a quantitative real-time pcr and elisa method. |
2014-10-06 |
2023-08-12 |
mouse |
| Jie Luo, Su Min, Ke Wei, Jun Cao, Bin Wang, Ping Li, Jun Dong, Yuanyuan Li. Propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression. Neuropsychiatric disease and treatment. vol 10. 2014-10-06. PMID:25285008. |
propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression. |
2014-10-06 |
2023-08-13 |
rat |
| Hongmiao Zhang, Guifen Chen, Hui Kuang, Joe Z Tsie. Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus. PloS one. vol 8. issue 11. 2014-10-01. PMID:24302990. |
therefore, our study has decoded real-time memory contents, timing relationship between cs and us, and temporal organizing patterns of fear memory engrams and demonstrated how hippocampal memory codes are regulated by nmda receptor synaptic plasticity. |
2014-10-01 |
2023-08-12 |
mouse |
| Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togash. Metaplastic regulation of the median raphe nucleus via serotonin 5-HT1A receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. Journal of pharmacological sciences. vol 124. issue 3. 2014-09-30. PMID:24599137. |
metaplastic regulation of the median raphe nucleus via serotonin 5-ht1a receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. |
2014-09-30 |
2023-08-12 |
rat |
| Yusaku Takamura, Kenjiro Ono, Jumpei Matsumoto, Masahito Yamada, Hisao Nishij. Effects of the neurotrophic agent T-817MA on oligomeric amyloid-β-induced deficits in long-term potentiation in the hippocampal CA1 subfield. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24112791. |
in the present study, we investigated the effects of t-817ma on the disturbances in synaptic plasticity induced by oaβ42 and oligomeric photo-cross-linked aβ42 (oxlaβ42) in a slice preparation of the ca1 subfield of mouse hippocampus. |
2014-09-29 |
2023-08-12 |
mouse |
| Jinhua Ma, Bo-Ryoung Choi, ChiHye Chung, Sun Seek Min, Won Kyung Jeon, Jung-Soo Ha. Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus. Molecular brain. vol 7. 2014-09-29. PMID:24761931. |
chronic neuroinflammation results in diminished synaptic plasticity and loss of glun1 n-methyl-d-aspartate (nmda) receptors in the hippocampus, leading to the cognitive deficits that are the most common symptoms of ad. |
2014-09-29 |
2023-08-13 |
rat |
| Jeffrey L Barr, Gina L Forster, Ellen M Unterwal. Repeated cocaine enhances ventral hippocampal-stimulated dopamine efflux in the nucleus accumbens and alters ventral hippocampal NMDA receptor subunit expression. Journal of neurochemistry. vol 130. issue 4. 2014-09-29. PMID:24832868. |
repeated cocaine enhances hippocampal synaptic plasticity, and phasic elevations of accumbal dopamine evoked by unconditioned stimuli are dependent on impulse flow from the ventral hippocampus. |
2014-09-29 |
2023-08-13 |
rat |
| Yoshitaka Hasegawa, Hideo Mukai, Makoto Asashima, Yasushi Hojo, Muneki Ikeda, Yoshimasa Komatsuzaki, Yuuki Ooishi, Suguru Kawat. Acute modulation of synaptic plasticity of pyramidal neurons by activin in adult hippocampus. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24917791. |
acute modulation of synaptic plasticity of pyramidal neurons by activin in adult hippocampus. |
2014-09-24 |
2023-08-13 |
Not clear |
| W Bailey Glen, Bryant Horowitz, Gregory C Carlson, Tyrone D Cannon, Konrad Talbot, J David Jentsch, Antonieta Lavi. Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning. Hippocampus. vol 24. issue 2. 2014-09-23. PMID:24446171. |
because impaired function of the hippocampus is thought to play a role in these memory deficits and because nmdar-dependent synaptic plasticity in this region is a proposed biological substrate for some hippocampal-dependent memory functions in schizophrenia, we hypothesized that reduced dysbindin-1 expression would lead to impairments in nmdar-dependent synaptic plasticity and in contextual fear conditioning. |
2014-09-23 |
2023-08-12 |
mouse |
| Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher, Jian Luo, Lucas K Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A Simmons, Xinmin S Xie, Frank M Longo, Tony Wyss-Cora. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature medicine. vol 20. issue 6. 2014-09-23. PMID:24793238. |
dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. |
2014-09-23 |
2023-08-13 |
mouse |
| N I Medvedev, G Dallérac, V I Popov, J J Rodriguez Arellano, H A Davies, I V Kraev, V Doyère, M G Stewar. Multiple spine boutons are formed after long-lasting LTP in the awake rat. Brain structure & function. vol 219. issue 1. 2014-09-19. PMID:23224218. |
data obtained from cultured hippocampal slices suggest that the long-term maintenance of synaptic plasticity requires the formation of new synaptic contacts on pre-existing synapses. |
2014-09-19 |
2023-08-12 |
rat |
| Tatjana Begenisic, Laura Baroncelli, Gabriele Sansevero, Marco Milanese, Tiziana Bonifacino, Giambattista Bonanno, Giovanni Cioni, Lamberto Maffei, Alessandro Sal. Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome. Neurobiology of disease. vol 63. 2014-09-19. PMID:24269730. |
fluoxetine in adulthood normalizes gaba release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of down syndrome. |
2014-09-19 |
2023-08-12 |
mouse |
| Tatjana Begenisic, Laura Baroncelli, Gabriele Sansevero, Marco Milanese, Tiziana Bonifacino, Giambattista Bonanno, Giovanni Cioni, Lamberto Maffei, Alessandro Sal. Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome. Neurobiology of disease. vol 63. 2014-09-19. PMID:24269730. |
here we employed a multidisciplinary approach spanning from the behavioral to the electrophysiological and molecular level to investigate the effects elicited by fluoxetine on cognitive abilities, hippocampal synaptic plasticity and gaba release in adult ts65dn mice. |
2014-09-19 |
2023-08-12 |
mouse |
| Tatjana Begenisic, Laura Baroncelli, Gabriele Sansevero, Marco Milanese, Tiziana Bonifacino, Giambattista Bonanno, Giovanni Cioni, Lamberto Maffei, Alessandro Sal. Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome. Neurobiology of disease. vol 63. 2014-09-19. PMID:24269730. |
we report that a chronic treatment with fluoxetine administered in the drinking water normalizes gaba release and promotes recovery of spatial memory abilities, spatial working memory for alternation, and hippocampal synaptic plasticity in adult ts65dn mice. |
2014-09-19 |
2023-08-12 |
mouse |
| Kaori Tachibana, Toshikazu Hashimoto, Koichi Takita, Ryoko Ito, Rui Kato, Yuji Morimot. Neonatal exposure to high concentration of carbon dioxide produces persistent learning deficits with impaired hippocampal synaptic plasticity. Brain research. vol 1507. 2014-09-18. PMID:23466457. |
neonatal exposure to high concentration of carbon dioxide produces persistent learning deficits with impaired hippocampal synaptic plasticity. |
2014-09-18 |
2023-08-12 |
rat |
| Kaori Tachibana, Toshikazu Hashimoto, Koichi Takita, Ryoko Ito, Rui Kato, Yuji Morimot. Neonatal exposure to high concentration of carbon dioxide produces persistent learning deficits with impaired hippocampal synaptic plasticity. Brain research. vol 1507. 2014-09-18. PMID:23466457. |
such long-lasting modifications in hippocampal synaptic plasticity may contribute to the learning impairments associated with perinatal hypoxic hypercapnia and acidosis. |
2014-09-18 |
2023-08-12 |
rat |
| Pei-Cheng Shih, Yea-Ru Yang, Ray-Yau Wan. Effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. PloS one. vol 8. issue 10. 2014-09-18. PMID:24205142. |
effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. |
2014-09-18 |
2023-08-12 |
human |
| Pei-Cheng Shih, Yea-Ru Yang, Ray-Yau Wan. Effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. PloS one. vol 8. issue 10. 2014-09-18. PMID:24205142. |
such beneficial effects are often suggested to relate to hippocampal synaptic plasticity, which is important for memory processing. |
2014-09-18 |
2023-08-12 |
human |