| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tine Pooters, Ann Van der Jeugd, Zsuzsanna Callaerts-Vegh, Rudi D'Hoog. Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory. Brain research. vol 1621. 2016-05-23. PMID:25619550. |
two major forms of synaptic plasticity, namely long-term potentiation, a lasting increase in synaptic strength between simultaneously activated neurons, and long-term depression, a decrease in synaptic strength, have been found to occur in hippocampus, dorsal striatum and medial prefrontal cortex. |
2016-05-23 |
2023-08-13 |
human |
| Marc P Baggelaar, Pascal J P Chameau, Vasudev Kantae, Jessica Hummel, Ku-Lung Hsu, Freek Janssen, Tom van der Wel, Marjolein Soethoudt, Hui Deng, Hans den Dulk, Marco Allarà, Bogdan I Florea, Vincenzo Di Marzo, Wytse J Wadman, Chris G Kruse, Herman S Overkleeft, Thomas Hankemeier, Taco R Werkman, Benjamin F Cravatt, Mario van der Stel. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society. vol 137. issue 27. 2016-05-23. PMID:26083464. |
we show that cannabinoid cb1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model can be reduced by lei105. |
2016-05-23 |
2023-08-13 |
mouse |
| Davide Guerrieri, Henriette van Praa. Exercise-mimetic AICAR transiently benefits brain function. Oncotarget. vol 6. issue 21. 2016-05-20. PMID:26286955. |
at the time-points where we observed equivalent running- and aicar-induced muscle pampk levels (7 and 14 days), cell proliferation, synaptic plasticity and gene expression, as well as markers of oxidative stress and inflammation in the dentate gyrus (dg) of the hippocampus and lateral entorhinal cortex (lec) were evaluated. |
2016-05-20 |
2023-08-13 |
mouse |
| N M Pathak, V Pathak, A M Lynch, N Irwin, V A Gault, P R Flat. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Molecular and cellular endocrinology. vol 412. 2016-05-17. PMID:26048772. |
these data demonstrate potential of stable oxm analogues, and particularly (ds(2))oxm(k-γ-glu-pal) to improve metabolic function and enhance neurogenesis, synaptic plasticity, insulin signalling and exert protective effects against oxidative damage in hippocampus and cortex brain regions in hf mice. |
2016-05-17 |
2023-08-13 |
mouse |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
we hypothesized that testosterone replacement improves cognitive function in testosterone-deprived obese rats by restoring brain insulin sensitivity, brain mitochondrial function, and hippocampal synaptic plasticity. |
2016-05-17 |
2023-08-13 |
rat |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
at the end of this protocol, cognitive function, metabolic parameters, brain insulin sensitivity, hippocampal synaptic plasticity, and brain mitochondrial function were determined. |
2016-05-17 |
2023-08-13 |
rat |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
however, testosterone failed to restore hippocampal synaptic plasticity and cognitive function in hfo rats. |
2016-05-17 |
2023-08-13 |
rat |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
in contrast, in ndo rats, testosterone decreased circulation and brain oxidative stress levels, attenuated brain mitochondrial ros production, and restored hippocampal synaptic plasticity as well as cognitive function. |
2016-05-17 |
2023-08-13 |
rat |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
these findings suggest that testosterone replacement improved peripheral insulin sensitivity and decreased oxidative stress levels, but failed to restore hippocampal synaptic plasticity and cognitive function in testosterone-deprived obese rats. |
2016-05-17 |
2023-08-13 |
rat |
| Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S Lee, Walid Soussou, Scott R McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A Lipto. Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nature communications. vol 7. 2016-05-17. PMID:26743041. |
consequent elevation in aβ levels and compromise in mitochondrial bioenergetics result in dysfunctional synaptic plasticity and synapse loss in cortical and hippocampal neurons. |
2016-05-17 |
2023-08-13 |
human |
| Kate Palmano, Angela Rowan, Rozey Guillermo, Jian Guan, Paul McJarro. The role of gangliosides in neurodevelopment. Nutrients. vol 7. issue 5. 2016-05-16. PMID:26007338. |
further, new evidence suggests that the mechanism of action may be through an effect on the neuroplasticity of the brain, mediated through enhanced synaptic plasticity in the hippocampus and nigro-striatal dopaminergic pathway. |
2016-05-16 |
2023-08-13 |
Not clear |
| Mariana Carasatorre, Adrian Ochoa-Alvarez, Giovanna Velázquez-Campos, Carlos Lozano-Flores, Víctor Ramírez-Amaya, Sofía Y Díaz-Cintr. Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus. PloS one. vol 10. issue 8. 2016-05-13. PMID:26244549. |
finally, the measures of hippocampal network coding obtained with catfish correlate significantly with the increased density of synaptophysin staining, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the wm and sc experience is related to the improvement of spatial information processing in the hippocampus. |
2016-05-13 |
2023-08-13 |
rat |
| Jiandong Sun, Guoqi Zhu, Yan Liu, Steve Standley, Angela Ji, Rashmi Tunuguntla, Yubin Wang, Chad Claus, Yun Luo, Michel Baudry, Xiaoning B. UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis. Cell reports. vol 12. issue 3. 2016-05-12. PMID:26166566. |
in ube3a-deficient mice, increased postsynaptic sk2 levels result in decreased nmda receptor activation, thereby impairing hippocampal long-term synaptic plasticity. |
2016-05-12 |
2023-08-13 |
mouse |
| Andrés Miguez, Gerardo García-Díaz Barriga, Verónica Brito, Marco Straccia, Albert Giralt, Silvia Ginés, Josep M Canals, Jordi Alberc. Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation. Human molecular genetics. vol 24. issue 17. 2016-05-11. PMID:26063761. |
fingolimod (fty720) enhances hippocampal synaptic plasticity and memory in huntington's disease by preventing p75ntr up-regulation and astrocyte-mediated inflammation. |
2016-05-11 |
2023-08-13 |
mouse |
| Andrés Miguez, Gerardo García-Díaz Barriga, Verónica Brito, Marco Straccia, Albert Giralt, Silvia Ginés, Josep M Canals, Jordi Alberc. Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation. Human molecular genetics. vol 24. issue 17. 2016-05-11. PMID:26063761. |
in addition, fty720 increased camp levels and promoted phosphorylation of creb and rhoa in the hippocampus of r6/1 mice, further supporting its role in the enhancement of synaptic plasticity. |
2016-05-11 |
2023-08-13 |
mouse |
| D Bhattacharya, E P Dunaway, S Bhattacharya, J Bloemer, M Buabeid, M Escobar, V Suppiramaniam, M Dhanasekara. Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model. PloS one. vol 10. issue 8. 2016-05-11. PMID:26305322. |
impaired ilk function is associated with deficits in hippocampal based memory and synaptic plasticity in a fasd rat model. |
2016-05-11 |
2023-08-13 |
rat |
| D Bhattacharya, E P Dunaway, S Bhattacharya, J Bloemer, M Buabeid, M Escobar, V Suppiramaniam, M Dhanasekara. Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model. PloS one. vol 10. issue 8. 2016-05-11. PMID:26305322. |
synaptic plasticity was assessed in the schaffer collateral pathway, and hippocampal protein lysates were used to evaluate ilk signaling. |
2016-05-11 |
2023-08-13 |
rat |
| Hajime Abe, Fumiyo Saito, Takeshi Tanaka, Sayaka Mizukami, Yasuko Hasegawa-Baba, Nobuya Imatanaka, Yumi Akahori, Toshinori Yoshida, Makoto Shibutan. Developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats. Toxicology and applied pharmacology. vol 290. 2016-05-10. PMID:26577399. |
developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats. |
2016-05-10 |
2023-08-13 |
rat |
| Ana Kim, Anne M Fagan, Alison M Goate, Tammie L S Benzinger, John C Morris, Denise Hea. Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. Cognitive, affective & behavioral neuroscience. vol 15. issue 3. 2016-05-09. PMID:25784293. |
brain-derived neurotrophic factor (bdnf) has been shown to be important for neuronal survival and synaptic plasticity in the hippocampus in nonhuman animals. |
2016-05-09 |
2023-08-13 |
Not clear |
| Eun Joo Kim, Blake Pellman, Jeansok J Ki. Stress effects on the hippocampus: a critical review. Learning & memory (Cold Spring Harbor, N.Y.). vol 22. issue 9. 2016-05-09. PMID:26286651. |
neurally, animal studies have revealed that stress alters ensuing synaptic plasticity and firing properties of hippocampal neurons. |
2016-05-09 |
2023-08-13 |
human |